NO155055C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater. - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater.

Info

Publication number: NO155055C
Authority: NO; Norway
Prior art keywords: carbolin; preparation; carboxylic acid; acid derivatives; therapeutic active
Prior art date: 1979-08-29

Application number

NO802546A

Other languages

English (en)

Other versions

NO802546L (no

NO155055B (no

Inventor

Ulrich Eder

Guentyer Neef

Andreas Huth

Dieter Rahtz

Ralph Schmiechen

Claus Thyco Braestrup

Mogens Cherley Nielsen

Joergen Anders Christensen

Mogens Engelstoft

Henning Schou

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-08-29

Filing date

1980-08-28

Publication date

1987-02-04

1980-02-29 Priority claimed from DK88980A external-priority patent/DK88980A/da

1980-04-22 Priority claimed from DE19803015816 external-priority patent/DE3015816A1/de

1980-06-20 Priority claimed from DE19803023567 external-priority patent/DE3023567A1/de

1980-08-28 Application filed by Schering Ag filed Critical Schering Ag

1981-03-02 Publication of NO802546L publication Critical patent/NO802546L/no

1986-10-27 Publication of NO155055B publication Critical patent/NO155055B/no

1987-02-04 Publication of NO155055C publication Critical patent/NO155055C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO802546A 1979-08-29 1980-08-28 Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater. NO155055C (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK362279		1979-08-29
DK88980A DK88980A (da)	1980-02-29	1980-02-29	Beta-carbonline-3-carboxylsyrederivater og fremgangsmaader til fremstilling af samme
DE19803015816 DE3015816A1 (de)	1980-04-22	1980-04-22	4-substituierte- (beta) -carbolin-3-carbonsaeurederivate, ihre herstellung und verwendung
DE19803023567 DE3023567A1 (de)	1980-06-20	1980-06-20	Substituierte (beta) -carbolin-3-carbonsaeurederivate

Publications (3)

Publication Number	Publication Date
NO802546L NO802546L (no)	1981-03-02
NO155055B NO155055B (no)	1986-10-27
NO155055C true NO155055C (no)	1987-02-04

Family

ID=27432526

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO802546A NO155055C (no)	1979-08-29	1980-08-28	Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater.

Country Status (16)

Country	Link
US (2)	US4371536A (no)
EP (1)	EP0030254B1 (no)
CA (1)	CA1150246A (no)
DD (1)	DD152935A5 (no)
DE (1)	DE3069559D1 (no)
ES (1)	ES8106305A1 (no)
FI (1)	FI68829C (no)
HU (1)	HU186744B (no)
IE (1)	IE50229B1 (no)
IL (1)	IL60906A (no)
NO (1)	NO155055C (no)
NZ (1)	NZ194747A (no)
PL (1)	PL226479A1 (no)
PT (1)	PT71744B (no)
RO (1)	RO80265B (no)
YU (1)	YU215580A (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ194747A (en) *	1979-08-29	1988-11-29	Schering Ag	9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS57123180A (en)	1980-12-17	1982-07-31	Schering Ag	3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3240514A1 (de) *	1982-10-29	1984-05-03	Schering AG, 1000 Berlin und 4709 Bergkamen	Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3240513A1 (de) *	1982-10-29	1984-05-03	Schering AG, 1000 Berlin und 4709 Bergkamen	Indolderivate, verfahren zu ihrer herstellung und deren verwendung zur weiterverarbeitung
DK149270C (da) *	1983-05-27	1986-08-25	Schering Ag	Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater
DE3322895A1 (de) *	1983-06-23	1985-01-03	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s)
DE3322894A1 (de) *	1983-06-23	1985-01-03	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h)
DE3335323A1 (de)	1983-09-27	1985-04-04	Schering AG, 1000 Berlin und 4709 Bergkamen	Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2555988A1 (fr) *	1983-12-06	1985-06-07	Centre Nat Rech Scient	Derive de b-carbolines, procede pour leurs preparations et medicament les contenant
DK240184D0 (da) *	1984-05-15	1984-05-15	Ferrosan As	Beta-carboline-3-carboxylic acid derivatives and method of preparing the same
DE3535928A1 (de) *	1985-10-04	1987-04-09	Schering Ag	Tetrahydro-(beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3545776A1 (de) *	1985-12-20	1987-06-25	Schering Ag	5-aminoalkyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3609699A1 (de) *	1986-03-20	1987-09-24	Schering Ag	5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester
DE3608089A1 (de) *	1986-03-08	1987-09-10	Schering Ag	Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3752373T2 (de) *	1986-10-13	2004-03-25	Asahi Kasei Kogyo K.K.	Pyridin-derivate
DE4029389A1 (de) *	1990-09-13	1992-03-26	Schering Ag	Verfahren zur herstellung von (beta)-carbolin-derivaten
US5350750A (en) *	1991-04-27	1994-09-27	Schering Aktiengesellschaft	β-carboline-3-hydroxyalkylcarboxylic acid ester derivatives, process for their production and their use in pharmaceutical agents
GB9508195D0 (en) *	1995-04-20	1995-06-07	Univ British Columbia	Novel biologically active compounds and compositions,their use and derivation
WO1997037658A1 (en) *	1996-04-04	1997-10-16	F.Hoffmann-La Roche Ag	Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
DE69722220T2 (de) *	1996-08-09	2004-02-19	Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield	4-substituierte beta-carboline als immunomodulatoren
UA74826C2 (en)	2000-05-17	2006-02-15	Ortho Mcneil Pharm Inc	?-carboline derivatives as phosphodiesterase inhibitors
AR036040A1 (es)	2001-06-12	2004-08-04	Upjohn Co	Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
IL160884A0 (en)	2001-10-02	2004-08-31	Upjohn Co	Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
CA2466344A1 (en)	2001-11-09	2003-05-22	Pharmacia & Upjohn Company	Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands
US20030176456A1 (en) *	2001-12-21	2003-09-18	June Harry L.	Methods for reducing alcohol cravings in chronic alcoholics
JP2005523288A (ja)	2002-02-19	2005-08-04	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	疾病治療用の縮合した二環式−ｎ−架橋−複素環式芳香族カルボキサミド
PA8586801A1 (es)	2002-10-31	2005-02-04	Pfizer	Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt)	2003-01-27	2006-01-17	Pfizer	Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
CN100503607C (zh) *	2003-06-02	2009-06-24	新疆华世丹药物研究有限责任公司	去氢骆驼蓬碱衍生物类化合物及其应用
JP2007534738A (ja)	2004-04-26	2007-11-29	ファイザー・インク	Ｈｉｖインテグラーゼ酵素の阻害剤
BRPI0510319A (pt)	2004-04-26	2007-10-16	Pfizer	inibidores da enzima integrase de hiv
BRPI0616657A2 (pt) *	2005-10-07	2011-06-28	Pfizer Prod Inc	inibidores da enzima hiv integrase
AU2013205135B2 (en) *	2006-10-28	2015-11-05	Forum Pharmaceuticals Inc.	Inhibitors of histone deacetylase
CA2822776A1 (en)	2006-10-28	2008-05-08	Methylgene Inc.	Inhibitors of histone deacetylase
EP2307410A1 (en)	2008-05-22	2011-04-13	The UWM Research Foundation, Inc	Aza-beta-carbolines and methods of using same
CN104211699A (zh) *	2013-06-05	2014-12-17	首都医科大学	β-咔啉衍生物,其制备,纳米结构,抗肿瘤活性和应用
CN104628722B (zh) *	2015-01-30	2016-06-22	华南农业大学	一种骆驼蓬碱酰胺类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA786351A (en) *		1968-05-28	Leonard Frederick	PROCESS FOR THE PREPARATION OF NEW .beta.-CARBOLIN-CARBOXYLIC ACID AMIDE DERIVATIVES
ES273769A1 (es) *	1961-01-18	1962-06-01	Geigy Ag J R	Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
GB1084257A (no) *	1963-11-06
NZ194747A (en) *	1979-08-29	1988-11-29	Schering Ag	9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS57123180A (en) *	1980-12-17	1982-07-31	Schering Ag	3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3322894A1 (de) *	1983-06-23	1985-01-03	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h)
DK240084D0 (da) *	1984-05-15	1984-05-15	Ferrosan As	New beta-carboline-3-oxadiazolyl derivatives
DK240184D0 (da) *	1984-05-15	1984-05-15	Ferrosan As	Beta-carboline-3-carboxylic acid derivatives and method of preparing the same
DE3504045A1 (de) *	1985-02-04	1986-08-07	Schering AG, 1000 Berlin und 4709 Bergkamen	Verfahren zur herstellung von ss-carbolinen durch dehydrierung

1980
- 1980-08-22 NZ NZ194747A patent/NZ194747A/xx unknown
- 1980-08-23 EP EP80105019A patent/EP0030254B1/en not_active Expired
- 1980-08-23 DE DE8080105019T patent/DE3069559D1/de not_active Expired
- 1980-08-25 IL IL60906A patent/IL60906A/xx unknown
- 1980-08-27 PT PT71744A patent/PT71744B/pt unknown
- 1980-08-27 RO RO102050A patent/RO80265B/ro unknown
- 1980-08-28 HU HU802129A patent/HU186744B/hu unknown
- 1980-08-28 FI FI802720A patent/FI68829C/fi not_active IP Right Cessation
- 1980-08-28 CA CA000359184A patent/CA1150246A/en not_active Expired
- 1980-08-28 US US06/182,244 patent/US4371536A/en not_active Expired - Lifetime
- 1980-08-28 YU YU02155/80A patent/YU215580A/xx unknown
- 1980-08-28 IE IE1806/80A patent/IE50229B1/en not_active IP Right Cessation
- 1980-08-28 NO NO802546A patent/NO155055C/no unknown
- 1980-08-29 DD DD80223673A patent/DD152935A5/de unknown
- 1980-08-29 PL PL22647980A patent/PL226479A1/xx unknown
- 1980-08-29 ES ES494590A patent/ES8106305A1/es not_active Expired
1988
- 1988-04-25 US US07/188,145 patent/US5010077A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IE801806L (en)	1981-02-28
PT71744B (en)	1981-06-08
EP0030254B1 (en)	1984-10-31
NO802546L (no)	1981-03-02
PT71744A (en)	1980-09-01
RO80265A (ro)	1983-04-29
HU186744B (en)	1985-09-30
FI68829C (fi)	1985-11-11
YU215580A (en)	1984-02-29
DD152935A5 (de)	1981-12-16
EP0030254A1 (en)	1981-06-17
NZ194747A (en)	1988-11-29
PL226479A1 (no)	1981-10-30
ES494590A0 (es)	1981-08-16
FI68829B (fi)	1985-07-31
RO80265B (ro)	1983-04-30
FI802720A (fi)	1981-03-01
IE50229B1 (en)	1986-03-05
DE3069559D1 (en)	1984-12-06
US5010077A (en)	1991-04-23
ES8106305A1 (es)	1981-08-16
US4371536A (en)	1983-02-01
IL60906A (en)	1985-11-29
NO155055B (no)	1986-10-27
IL60906A0 (en)	1980-10-26
CA1150246A (en)	1983-07-19

Publication	Publication Date	Title
NO155055C (no)	1987-02-04	Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater.
NO155774C (no)	1987-05-27	Analogifremgangsmaate til fremstilling av terapeutisk aktive imidazo-diazepin-derivater.
NO158679C (no)	1988-10-19	Analogifremgangsmaate til fremstilling av terapeutisk aktive 2-penem-3-karboksylsyreforbindelser.
NO800858L (no)	1980-09-29	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-amino-3-kinolincarboxylsyrederivater
NO150760C (no)	1984-12-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive aminotiazoler.
NO159019C (no)	1988-11-23	Analogifremgangsmaate for fremstilling av farmakologisk aktive 6beta-hydroksyalkylpenicillansyrederivater.
NO151362C (no)	1985-03-27	Analogifremgangsmaate til fremstilling av terapeutisk aktive urinstoffderivater.
NO154058C (no)	1986-07-09	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-heterocyklyl-4-piperidinaminer.
NO156785C (no)	1987-11-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive cyklobutan-derivater.
NO784397L (no)	1979-07-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive ftalazin-4-yl-eddiksyrederivater
NO810675L (no)	1981-08-31	Fremgangsmaate ved fremstilling av terapeutisk aktive tetrazolderivater.
NO153569C (no)	1986-05-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive merkaptoacetyl-prolin-derivater.
NO802015L (no)	1981-01-07	Fremgangsmaate for fremstilling av fysiologisk aktive indolizin-derivater.
NO814055L (no)	1982-06-01	Fremgangsmaate ved fremstilling av terapeutisk aktive thienopyridinonderivater
NO792139L (no)	1979-12-28	Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazoloksamsyre-derivater
NO148644C (no)	1983-11-16	Analogifremgangsmaate til fremstilling av terapeutisk aktive sukkerderivater.
NO157976C (no)	1988-06-22	Analogifremgangsm te ved fremstilling av terapeutisk aktive 3-fenoxy-1-azetidincarboxamider.
NO152089C (no)	1985-08-14	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-pyridon-3-karboksylsyrederivater
NO152787C (no)	1985-11-20	Analogifremgangsmaate ved fremstilling av terapeutisk aktive fenyl-kinolizidiner.
NO159090C (no)	1988-11-30	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridoindol-derivater.
NO158800C (no)	1988-11-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive indenderivater.
NO156167C (no)	1987-08-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive indolinon-derivater.
NO155054C (no)	1987-02-04	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 3-amino-1-benzoxepin-5(2h)-derivater.
NO153141C (no)	1986-01-22	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-aza-17-substituert-5alfa-androstan-3-oner.
NO155842C (no)	1987-06-10	Analogifremgangsmaate ved fremstilling av terapeutiske aktive 2-beta-d-ribofuranosylselenazol-4-carboxamider.