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NO144848B - ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC EFFECTIVE 4-HYDROXYPHENYLALKANOLAMINE DERIVATIVES - Google Patents

ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC EFFECTIVE 4-HYDROXYPHENYLALKANOLAMINE DERIVATIVES Download PDF

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Publication number
NO144848B
NO144848B NO772245A NO772245A NO144848B NO 144848 B NO144848 B NO 144848B NO 772245 A NO772245 A NO 772245A NO 772245 A NO772245 A NO 772245A NO 144848 B NO144848 B NO 144848B
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Norway
Prior art keywords
coupling
shaft
pump
impeller
pump housing
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Application number
NO772245A
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Norwegian (no)
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NO144848C (en
NO772245L (en
Inventor
Richard Everett Philion
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of NO772245L publication Critical patent/NO772245L/en
Publication of NO144848B publication Critical patent/NO144848B/en
Publication of NO144848C publication Critical patent/NO144848C/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Sentrifugalpumpe. Centrifugal pump.

Den foreliggende oppfinnelse angår en sentrifugalpumpe The present invention relates to a centrifugal pump

som på den ené side av pumpehuset og et fritthengende pumpehjul har et innlop og på den annen side av pumpehuset har en aksel i form av to koaksialt lagrede deler som sammenholdes av en fast kobling, og hvorav den ene bærer pumpehjulet og den annen ved hjelp av en annen kobling kan tilsluttes en drivmotor. Der er kjent en utforelse av denne art hvor pumpehjulet kan demonteres for eftersyn og eventuelle reparasjoner av pumpens indre deler uten at man behover å rore ved motoren, hoveddelen av pumpehuset eller de tilsluttede rørledninger. which on one side of the pump housing and a free-hanging impeller has an inlet and on the other side of the pump housing has a shaft in the form of two coaxially mounted parts held together by a fixed coupling, one of which carries the impeller and the other by means of another coupling can be connected to a drive motor. An embodiment of this kind is known where the impeller can be dismantled for inspection and possible repairs of the pump's internal parts without the need to touch the motor, the main part of the pump housing or the connected pipelines.

De to akseldeler befinner seg her på tilstrekkelig stor innbyrdes avstand til at det blir mulig efter fjernelse av den faste kobling å trekke pumpeh-julet ut mens den annen akseldel blir sittende. Oppfinnelsen tar bl.a. sikte på å skaffe en forbedring av en pumpe av denne art, slik at den partielle demonterbarhet av pumpen ikke influerer på pumpeaggregatets samlede lengde. Dette oppnås hoved-sakelig ved at de tc mot hverandre vendende akselender er utfort med skrått avskårne flater med utstrekning i aksial retning på en slik måte at den annen akseldel efter losning av den faste kobling kan fjernes ved utsvingning av den skråttskårne ende om et sentrum beliggende ved den annen kobling, for å skaffe plass for uttrekning av pumpehjulet i aksial retning fra pumpehuset. The two shaft parts are located here at a sufficiently large distance from each other so that it becomes possible after removing the fixed coupling to pull out the pump wheel while the other shaft part remains in place. The invention takes, among other things, aim to provide an improvement of a pump of this nature, so that the partial demountability of the pump does not influence the overall length of the pump unit. This is mainly achieved by the fact that the shaft ends facing each other are fitted with obliquely cut surfaces extending in the axial direction in such a way that the other shaft part can be removed after loosening the fixed coupling by swinging the obliquely cut end around a centrally located at the second connection, to make room for pulling out the impeller in the axial direction from the pump housing.

Oppfinnelsen vil i det folgende bli nærmere beskrevet under henvisning til tegningen som viser et utforselseseksempel, og i den forbindelse vil også andre trekk ved oppfinnelsen bli omtalt. In the following, the invention will be described in more detail with reference to the drawing which shows an exemplary embodiment, and in this connection other features of the invention will also be discussed.

Pig. 1 viser vertikalt lengdesnitt av en pumpe utfort Pig. 1 shows a vertical longitudinal section of a pump

i henhold til oppfinnelsen. according to the invention.

Pig. 2 viser pumpen, delvis i samme snitt, på et stadium av demonteringen. Pig. 2 shows the pump, partly in the same section, at one stage of disassembly.

På tegningen betegner 10 et pumpehus, som kan være opp-stilt på fotter 12, og som har en sentral aksial innlbpsstuss 14 In the drawing, 10 denotes a pump housing, which can be set up on feet 12, and which has a central axial inlet connection 14

for det medium som skal pumpes. På den motsatte side til innlops-stussen 14 er huset forsynt med et lokk 16. Gjennem dette går der en akseldel 18, og mellem huset og denne akseldel er der anbragt en pakkboks 20. På den indre ende av akselen 18 er der fast anbragt et pumpehjul 22. Videre sitter der på akseldelen 18 et lager 24 av rulletypen. Et hus 26 som omgir dette lager, er festet til. lokket 16 ved skruer 28. En lagerstuss 30 delt i plan gjennem pumpeakselen holdes fast til lokket 16 ved hjelp av skruer 28, og dens to halvdeler er med en omboyet kant holdt innklemt mellem lagerhuset 26 og lokket. for the medium to be pumped. On the opposite side to the inlet connection 14, the housing is provided with a lid 16. Through this there is a shaft part 18, and between the housing and this shaft part there is a stuffing box 20. On the inner end of the shaft 18 there is a fixed impeller 22. Furthermore, there is a bearing 24 of the roller type on the shaft part 18. A housing 26 surrounding this bearing is attached. the lid 16 by screws 28. A bearing spigot 30 divided in plane through the pump shaft is held firmly to the lid 16 by means of screws 28, and its two halves are held with an omboyed edge between the bearing housing 26 and the lid.

På den annen, ytre akseldel 32 er der anbragt en lager-anordning, hensiktsmessig i form av et dobbelt kulelager 34, som om-sluttes av et hus 36. Huset 36 bæres i sin tur av lagerstussen 30. Mellem akseldelen 32 og en aksel 38, som er forbundet med den ikke viste drivmotor, er der anbragt en kobling, generelt betegnet med 4o. Denne utgjores i utforelseseksemplet av en elastisk pinnekobling med to halvdeler 42, 44 sittende på hver sin akselende, og aksialtlopende pinner eller stifter 46 imellem. Pinnene 46 er skiftevis på motsatte ender forsynt med et gummibelegg 48 som passer inn i en aksial ut-tagning av motsvarende form i den annen koblingshalvdel. On the other, outer shaft part 32, a bearing device is placed, suitably in the form of a double ball bearing 34, which is enclosed by a housing 36. The housing 36 is in turn supported by the bearing spigot 30. Between the shaft part 32 and a shaft 38 , which is connected to the drive motor not shown, a coupling, generally denoted by 4o, is placed there. In the exemplary embodiment, this is made of an elastic pin coupling with two halves 42, 44 sitting on each end of the shaft, and axially running pins or pins 46 in between. The pins 46 are alternately provided at opposite ends with a rubber coating 48 which fits into an axial cut-out of corresponding shape in the other coupling half.

Mellem lagrene 24, 34 er der anbragt en fast skålkobling 50 utfort i to halvdeler. Koblingens deler holdes sammen av skrueforbindelser 52. Den faste kobling kan få en fastlagt stilling på endene av de to aksler 18, 32 ved hjelp av foringsstifter 54, resp. Between the bearings 24, 34, a fixed bowl coupling 50 is arranged in two halves. The parts of the coupling are held together by screw connections 52. The fixed coupling can be given a fixed position on the ends of the two shafts 18, 32 by means of liner pins 54, resp.

56. Når den faste kobling 50 er montert, vil åpenbart pumpehjulet 56. When the fixed coupling 50 is fitted, the impeller will obviously

22 bli sentrert av de to lagre 24 og 34, som sitter henholdsvis i lokket l6 og i forlengelsesstussen 30. Pumpehjulets aksiale stilling kan fikseres av det ytre lager 34, samtidig som altså lageret 24 er aksialt innstillbart i sitt hus 26. 22 be centered by the two bearings 24 and 34, which sit respectively in the lid l6 and in the extension spigot 30. The axial position of the impeller can be fixed by the outer bearing 34, at the same time that the bearing 24 is axially adjustable in its housing 26.

De mot hinannen vendende endeflater 58, 60 av de to The mutually facing end surfaces 58, 60 of the two

aksler 18, 32 er skrått avskåret under en vinkel som kan være 45° eller deromkring. Akselendene plaseres med de to skråflater paral-lelt og rett overfor hverandre, enten i innbyrdes kontakt eller i en mindre innbyrdes avstand. Den ved avfasningen fremkommende smaleste kant av akslene kan være skåret bort på et mindre stykke, som antydet ved 62 og 64. shafts 18, 32 are obliquely cut off at an angle which may be 45° or thereabouts. The shaft ends are placed with the two inclined surfaces parallel and directly opposite each other, either in mutual contact or at a smaller distance from each other. The narrowest edge of the shafts resulting from the chamfer can be cut away in a smaller piece, as indicated at 62 and 64.

Ved demontering av pumpen losner man skruene 28 tilstrekkelig til at de to halvdeler av lagerstussen 30 frigjbres fra lokket l6 og dermed kan fjernes. De ikke viste skrueforbindelser som holder de to halvdeler sammen innbyrdes, er naturligvis likeledes fjernet» Skrueforbindelsen 52 for koblingen 50 fjernes, og de to koblings-halvdeler loftes av. Den ytre del 32 av pumpeakselen er nu frilagt, When dismantling the pump, the screws 28 are loosened sufficiently so that the two halves of the bearing spigot 30 are released from the lid l6 and can thus be removed. The screw connections, not shown, which hold the two halves together, have of course also been removed. The screw connection 52 for the coupling 50 is removed, and the two coupling halves are lifted off. The outer part 32 of the pump shaft is now exposed,

og takket være akselendenes skråttskårne flater 58, 60 kan akseldelen 32 svinges utover fra akseldelen 18 i tegningens plan under samtidig adskillelse av de i hinannen inngripende deler av koblingen 40, som vist på fig. 2. Denne svingebevegelse av akseldelen 32 lettes av spillerummet og elastisiteten i koblingen 40. Avstanden mellem pumpeakselens indre del 18 og den på motorakselen 38 gjensittende koblingshalvdel 44 med tilhbrende pinner er nu blitt så stor at pumpe-huslokket 16 og akseldelen 18 med påsittende pumpehjul 22 og lager-organ 24, 26 som en sammenhengende enhet forst kan fores mot hbyre på figurene og derefter lbftes ut av pumpehuset. De enkelte elementer som berbres av demonteringen, er lett håndterlige, og demonteringen kan gjennemfbres på kort tid. Avstanden mellem lagrene 24 og 34 behbver bare å velges ut fra hensynet til riktig lagring av pumpehjulet 22 og altså ikke med tanke på aksial uttrekning av dette. and thanks to the beveled surfaces 58, 60 of the shaft ends, the shaft part 32 can be swung outwards from the shaft part 18 in the plane of the drawing while simultaneously separating the interlocking parts of the coupling 40, as shown in fig. 2. This swinging movement of the shaft part 32 is facilitated by the clearance and elasticity in the coupling 40. The distance between the inner part 18 of the pump shaft and the coupling half 44 remaining on the motor shaft 38 with the associated pins has now become so large that the pump housing cover 16 and the shaft part 18 with the impeller 22 attached and bearing member 24, 26 as a continuous unit can first be lined to the right of the figures and then removed from the pump housing. The individual elements left by the dismantling are easy to handle, and the dismantling can be carried out in a short time. The distance between the bearings 24 and 34 only needs to be chosen based on consideration of the correct storage of the pump wheel 22 and thus not with regard to axial extraction thereof.

Oppfinnelsen er selvsagt ikke begrenset til de viste utforelsesformer, men kan varieres i vide.?te forstand innen rammen av den idé som ligger til grund for den. The invention is of course not limited to the embodiments shown, but can be varied in a broad sense within the scope of the idea that underlies it.

Koblingen 40 kan være av praktisk talt vilkårlig type. The coupling 40 can be of practically any type.

Claims (2)

1. Sentrifugalpumpe som har et fritthengende pumpehjul (22) og et innlop (14) på den ene side av pumpehuset (10) og på den annen side av pumpehuset har en aksel i form av to koaksialt lagrede deler (18, 32) som sammenholdes av en fast kobling (50), og hvorav den ene bærer pumpehjulet og den annen ved hjelp av en annen kobling (40) kan tilsluttes en drivmotor, karakterisert ved at de to mot hverandre vondende akselender er utfort med skrått avskårne flater (58, 60) med utstrekning i aksial retning på en slik måte at den annen akseldel (32) after losning av den faste kobling kan fjernes ved r.tsvingning av den skråttskårne ende om et sentrum beliggende ved den annen kobling (40), for å skaffe plass for uttrekning av pumpehjulet i aksial retning fra pumpehuset.1. Centrifugal pump which has a free-hanging impeller (22) and an inlet (14) on one side of the pump housing (10) and on the other side of the pump housing has a shaft in the form of two coaxially supported parts (18, 32) which are held together of a fixed coupling (50), and one of which carries the impeller and the other by means of another coupling (40) can be connected to a drive motor, characterized in that the two shaft ends facing each other are fitted with obliquely cut surfaces (58, 60 ) with an extension in the axial direction in such a way that the second shaft part (32) after loosening the fixed coupling can be removed by rotating the beveled end about a center located at the second coupling (40), to make room for extraction of the impeller in the axial direction from the pump housing. 2. Sentrifugalpumpe som angitt i krav 1, karakterisert ved at den ene (indre) akseldel (18) har et lager (24) som hensiktsmessig sitter i et lokk (16) som lukker for pumpehuset, og den annen (ytre) akseldel (32) har et lager (34) som sitter i en hensiktsmessig stusslignende forlengelse (30) av lokket, som er utfort delbar og kan tilsluttes lokket ved hjelp av skrueforbindelser.(28).2. Centrifugal pump as specified in claim 1, characterized in that one (inner) shaft part (18) has a bearing (24) which conveniently sits in a cover (16) that closes the pump housing, and the other (outer) shaft part (32 ) has a bearing (34) which sits in a suitable stub-like extension (30) of the lid, which can be further divided and can be connected to the lid by means of screw connections. (28).
NO772245A 1976-06-25 1977-06-24 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC EFFECTIVE 4-HYDROXYPHENYLALKANOLAMINE DERIVATIVES NO144848C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69985676A 1976-06-25 1976-06-25
US80337277A 1977-06-03 1977-06-03

Publications (3)

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NO772245L NO772245L (en) 1977-12-28
NO144848B true NO144848B (en) 1981-08-17
NO144848C NO144848C (en) 1981-11-25

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NO772245A NO144848C (en) 1976-06-25 1977-06-24 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC EFFECTIVE 4-HYDROXYPHENYLALKANOLAMINE DERIVATIVES

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JP (1) JPS5321134A (en)
AR (2) AR220896A1 (en)
AT (1) AT354420B (en)
AU (1) AU512626B2 (en)
CA (1) CA1091245A (en)
CH (2) CH627447A5 (en)
DE (1) DE2728641A1 (en)
DK (1) DK146386C (en)
ES (1) ES460040A1 (en)
FI (1) FI771976A (en)
FR (1) FR2366272A1 (en)
GB (1) GB1544872A (en)
HK (1) HK60184A (en)
IE (1) IE45631B1 (en)
IL (1) IL52353A (en)
LU (1) LU77604A1 (en)
NL (1) NL7707128A (en)
NO (1) NO144848C (en)
PH (2) PH15041A (en)
PT (1) PT66713B (en)
SE (1) SE7707341L (en)

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US4410548A (en) 1980-07-09 1983-10-18 Reckitt & Colman Products Limited Propanolamine derivatives
DE3128117A1 (en) * 1980-07-29 1982-03-11 Yamanouchi Pharmaceutical Co., Ltd., Tokyo NEW PHENYL-AETHYLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF
AU620573B2 (en) * 1987-11-27 1992-02-20 Societe Nationale Elf Aquitaine Process for phenol alkylthiolation and its application to the synthesis of 4-acyl-2-alkylthiophenols
FR2623804B1 (en) * 1987-11-27 1990-03-23 Elf Aquitaine PHENOL ACYLATION
US5101065A (en) * 1991-02-04 1992-03-31 Imperial Chemical Industries Plc Acetophenone intermediates
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AU2474399A (en) 1998-01-26 1999-08-09 Mitokor Mitochondria protecting agents for treating mitochondria associated diseases
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OA12905A (en) 2002-08-19 2006-10-13 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
GT200600381A (en) 2005-08-25 2007-03-28 ORGANIC COMPOUNDS
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
KR101530113B1 (en) * 2009-05-19 2015-07-06 혼슈우 카가쿠고교 가부시키가이샤 Method for producing trisphenols and monoester-substituted products thereof, and 4-acylaralkylphenol derivatives
RU2618628C1 (en) 2013-04-17 2017-05-05 Пфайзер Инк. N-piperidin-3-yl-benzamide derivatives for cardiovascular diseases treatment
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CN104324977A (en) * 2014-10-22 2015-02-04 无锡市得力手机械有限公司 Wire unloading trolley of inverted wire drawing machine
HU231124B1 (en) * 2016-02-10 2020-12-28 Egis Gyógyszergyár Zrt. Method for producing morphologically homogenous mirabegron and mirabegron monohydrochloride
CA3125765A1 (en) 2019-01-18 2020-07-23 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

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Publication number Publication date
AU2636877A (en) 1979-01-04
IE45631L (en) 1977-12-25
FR2366272A1 (en) 1978-04-28
PH14332A (en) 1981-05-29
DK146386B (en) 1983-09-26
CH630068A5 (en) 1982-05-28
IL52353A0 (en) 1977-08-31
ES460040A1 (en) 1978-05-01
FI771976A (en) 1977-12-26
ATA449377A (en) 1979-06-15
AR227126A1 (en) 1982-09-30
IL52353A (en) 1981-07-31
DK281777A (en) 1977-12-26
NL7707128A (en) 1977-12-28
GB1544872A (en) 1979-04-25
JPS5321134A (en) 1978-02-27
DE2728641A1 (en) 1978-01-05
PH15041A (en) 1982-05-20
SE7707341L (en) 1978-02-13
PT66713B (en) 1978-11-21
LU77604A1 (en) 1978-02-01
FR2366272B1 (en) 1981-03-06
AT354420B (en) 1979-01-10
AU512626B2 (en) 1980-10-23
CA1091245A (en) 1980-12-09
AR220896A1 (en) 1980-12-15
IE45631B1 (en) 1982-10-20
NO144848C (en) 1981-11-25
PT66713A (en) 1977-07-01
NO772245L (en) 1977-12-28
CH627447A5 (en) 1982-01-15
DK146386C (en) 1984-03-12
HK60184A (en) 1984-08-10

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