NO132801B - - Google Patents
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- Publication number
- NO132801B NO132801B NO2101/71A NO210171A NO132801B NO 132801 B NO132801 B NO 132801B NO 2101/71 A NO2101/71 A NO 2101/71A NO 210171 A NO210171 A NO 210171A NO 132801 B NO132801 B NO 132801B
- Authority
- NO
- Norway
- Prior art keywords
- dioxatricyclo
- compounds
- belgian patent
- hydrogenated
- activity
- Prior art date
Links
- 238000000034 method Methods 0.000 claims abstract description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 claims description 2
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 12
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- 239000003874 central nervous system depressant Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229940117975 chromium trioxide Drugs 0.000 description 3
- WGLPBDUCMAPZCE-UHFFFAOYSA-N chromium trioxide Inorganic materials O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 3
- GAMDZJFZMJECOS-UHFFFAOYSA-N chromium(6+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Cr+6] GAMDZJFZMJECOS-UHFFFAOYSA-N 0.000 description 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 241000546339 Trioxys Species 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 230000009194 climbing Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 230000004622 sleep time Effects 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229940126062 Compound A Drugs 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- UYXAWHWODHRRMR-UHFFFAOYSA-N hexobarbital Chemical compound O=C1N(C)C(=O)NC(=O)C1(C)C1=CCCCC1 UYXAWHWODHRRMR-UHFFFAOYSA-N 0.000 description 1
- 229960002456 hexobarbital Drugs 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702027890 DE2027890C3 (de) | 1970-06-06 | 1970-06-06 | 8-AIkoxy oder -Benzyloxy-3-methyl-lO- methylen-2,9-dioxatricyclo-(43,l,03,7 )-decan-4-one und 8-AIkoxy oder 8-Benzyloxy-3,10-dimethyl-2,9dioxatricyclo- (43,1,O" )-decan-4-one |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO132801B true NO132801B (de) | 1975-09-29 |
| NO132801C NO132801C (de) | 1976-01-07 |
Family
ID=5773229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO210171A NO132801C (de) | 1970-06-06 | 1971-06-04 |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5417759B1 (de) |
| AT (1) | AT306047B (de) |
| CH (1) | CH550786A (de) |
| CS (1) | CS178095B2 (de) |
| DE (1) | DE2027890C3 (de) |
| FI (1) | FI52981C (de) |
| GB (1) | GB1290828A (de) |
| NL (1) | NL173524C (de) |
| NO (1) | NO132801C (de) |
| PL (1) | PL92385B1 (de) |
| SE (1) | SE376001B (de) |
| SU (1) | SU665794A3 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI56533C (fi) * | 1973-02-08 | 1980-02-11 | Kali Chemie Pharma Gmbh | Saett att framstaella nya 4alfa-karbamyloxi-8-alkoxi-10-metylen-3-metyl-2,9-dioxatricyklo(4,3,1,03,7)-dekaner |
| DE2607106C2 (de) | 1976-02-21 | 1986-01-16 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 2,9-Dioxatricyclo[4,3,1,0↑3↑↑,↑↑7↑]decane und Verfahren zu deren Herstellung |
| DE2730988A1 (de) | 1977-07-08 | 1979-01-25 | Kali Chemie Pharma Gmbh | 3-azidomethyl-2,9-dioxatricyclo eckige klammer auf 4,3,1,0 hoch 3,7 eckige klammer zu decane und verfahren zu deren herstellung |
| US4237055A (en) * | 1979-06-18 | 1980-12-02 | Ortho Pharmaceutical Corporation | Synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid |
| EP2200992B1 (de) * | 2007-10-03 | 2014-02-26 | Eisai R&D Management Co., Ltd. | Zwischenprodukte und verfahren zur synthese von halichondrin-b-analoga |
-
1970
- 1970-06-06 DE DE19702027890 patent/DE2027890C3/de not_active Expired
- 1970-12-07 CS CS12170A patent/CS178095B2/cs unknown
- 1970-12-07 PL PL18268770A patent/PL92385B1/pl unknown
-
1971
- 1971-04-20 CH CH574471A patent/CH550786A/de not_active IP Right Cessation
- 1971-04-27 SE SE543071A patent/SE376001B/xx unknown
- 1971-05-05 NL NL7106155A patent/NL173524C/xx not_active IP Right Cessation
- 1971-05-19 FI FI138571A patent/FI52981C/fi active
- 1971-05-26 GB GB1290828D patent/GB1290828A/en not_active Expired
- 1971-06-04 AT AT488571A patent/AT306047B/de not_active IP Right Cessation
- 1971-06-04 NO NO210171A patent/NO132801C/no unknown
- 1971-06-07 JP JP4009971A patent/JPS5417759B1/ja active Pending
-
1975
- 1975-03-21 SU SU752116608A patent/SU665794A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| GB1290828A (de) | 1972-09-27 |
| CS178095B2 (de) | 1977-08-31 |
| AT306047B (de) | 1973-03-26 |
| SE376001B (de) | 1975-05-05 |
| FI52981C (de) | 1978-01-10 |
| NL7106155A (de) | 1971-12-08 |
| DE2027890B2 (de) | 1978-06-08 |
| DE2027890C3 (de) | 1979-02-01 |
| SU665794A3 (ru) | 1979-05-30 |
| FI52981B (de) | 1977-09-30 |
| NL173524B (nl) | 1983-09-01 |
| NO132801C (de) | 1976-01-07 |
| PL92385B1 (de) | 1977-04-30 |
| DE2027890A1 (de) | 1971-12-16 |
| NL173524C (nl) | 1984-02-01 |
| JPS5417759B1 (de) | 1979-07-02 |
| CH550786A (de) | 1974-06-28 |
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