NO130344B - - Google Patents

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Info

Publication number: NO130344B
Authority: NO; Norway
Prior art keywords: solution; mucoprotein; water; approx; added
Prior art date: 1968-12-26

Application number

NO05106/69A

Other languages

English (en)

Norwegian (no)

Inventor

Y Kobayashi

H Kabeno

T Honda

Original Assignee

Nissui Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1968-12-26

Filing date

1969-12-23

Publication date

1974-08-19

1969-12-23 Application filed by Nissui Pharm Co Ltd filed Critical Nissui Pharm Co Ltd

1974-08-19 Publication of NO130344B publication Critical patent/NO130344B/no

Links

239000000243 solution Substances 0.000 claims description 45
102000001621 Mucoproteins Human genes 0.000 claims description 32
108010093825 Mucoproteins Proteins 0.000 claims description 32
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 18
238000000034 method Methods 0.000 claims description 18
239000002244 precipitate Substances 0.000 claims description 16
102000004142 Trypsin Human genes 0.000 claims description 12
108090000631 Trypsin Proteins 0.000 claims description 12
239000012588 trypsin Substances 0.000 claims description 12
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
239000007864 aqueous solution Substances 0.000 claims description 11
239000012528 membrane Substances 0.000 claims description 10
239000005711 Benzoic acid Substances 0.000 claims description 9
235000010233 benzoic acid Nutrition 0.000 claims description 9
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 8
210000002784 stomach Anatomy 0.000 claims description 8
229920002307 Dextran Polymers 0.000 claims description 7
241000124008 Mammalia Species 0.000 claims description 6
239000002253 acid Substances 0.000 claims description 6
229910052921 ammonium sulfate Inorganic materials 0.000 claims description 6
235000011130 ammonium sulphate Nutrition 0.000 claims description 6
210000004877 mucosa Anatomy 0.000 claims description 6
102000004169 proteins and genes Human genes 0.000 claims description 6
108090000623 proteins and genes Proteins 0.000 claims description 6
230000000694 effects Effects 0.000 claims description 5
150000002402 hexoses Chemical class 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 5
210000000813 small intestine Anatomy 0.000 claims description 5
230000000767 anti-ulcer Effects 0.000 claims description 4
238000000502 dialysis Methods 0.000 claims description 4
238000011085 pressure filtration Methods 0.000 claims description 4
125000005233 alkylalcohol group Chemical group 0.000 claims description 3
238000000605 extraction Methods 0.000 claims description 3
210000003097 mucus Anatomy 0.000 claims description 3
230000003248 secreting effect Effects 0.000 claims description 3
239000011248 coating agent Substances 0.000 claims description 2
238000000576 coating method Methods 0.000 claims description 2
150000001875 compounds Chemical class 0.000 claims description 2
239000012535 impurity Substances 0.000 claims description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 16
239000007788 liquid Substances 0.000 description 15
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
239000000047 product Substances 0.000 description 12
239000012043 crude product Substances 0.000 description 11
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
239000003795 chemical substances by application Substances 0.000 description 9
210000004379 membrane Anatomy 0.000 description 9
239000007787 solid Substances 0.000 description 7
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
239000000706 filtrate Substances 0.000 description 6
238000004108 freeze drying Methods 0.000 description 6
239000000126 substance Substances 0.000 description 6
239000001166 ammonium sulphate Substances 0.000 description 5
239000000203 mixture Substances 0.000 description 5
210000004400 mucous membrane Anatomy 0.000 description 5
239000008213 purified water Substances 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
238000000926 separation method Methods 0.000 description 5
238000003756 stirring Methods 0.000 description 5
208000025865 Ulcer Diseases 0.000 description 4
210000004051 gastric juice Anatomy 0.000 description 4
210000001156 gastric mucosa Anatomy 0.000 description 4
210000001035 gastrointestinal tract Anatomy 0.000 description 4
239000005556 hormone Substances 0.000 description 4
229940088597 hormone Drugs 0.000 description 4
239000000843 powder Substances 0.000 description 4
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
241000283153 Cetacea Species 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
239000013543 active substance Substances 0.000 description 3
238000009835 boiling Methods 0.000 description 3
239000003344 environmental pollutant Substances 0.000 description 3
230000002496 gastric effect Effects 0.000 description 3
210000004907 gland Anatomy 0.000 description 3
231100000719 pollutant Toxicity 0.000 description 3
231100000397 ulcer Toxicity 0.000 description 3
DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
206010002091 Anaesthesia Diseases 0.000 description 2
229920000298 Cellophane Polymers 0.000 description 2
GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 2
108010015899 Glycopeptides Proteins 0.000 description 2
102000002068 Glycopeptides Human genes 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
239000004677 Nylon Substances 0.000 description 2
241000700159 Rattus Species 0.000 description 2
241000282887 Suidae Species 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
230000037005 anaesthesia Effects 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
239000004744 fabric Substances 0.000 description 2
238000001914 filtration Methods 0.000 description 2
238000002350 laparotomy Methods 0.000 description 2
239000013541 low molecular weight contaminant Substances 0.000 description 2
229920001778 nylon Polymers 0.000 description 2
KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
JVIPLYCGEZUBIO-UHFFFAOYSA-N 2-(4-fluorophenyl)-1,3-dioxoisoindole-5-carboxylic acid Chemical compound O=C1C2=CC(C(=O)O)=CC=C2C(=O)N1C1=CC=C(F)C=C1 JVIPLYCGEZUBIO-UHFFFAOYSA-N 0.000 description 1
241000283707 Capra Species 0.000 description 1
229920001425 Diethylaminoethyl cellulose Polymers 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
PQMWYJDJHJQZDE-UHFFFAOYSA-M Methantheline bromide Chemical compound [Br-].C1=CC=C2C(C(=O)OCC[N+](C)(CC)CC)C3=CC=CC=C3OC2=C1 PQMWYJDJHJQZDE-UHFFFAOYSA-M 0.000 description 1
241001494479 Pecora Species 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
241000283222 Physeter catodon Species 0.000 description 1
239000004365 Protease Substances 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
229960002028 atropine sulfate Drugs 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
235000008504 concentrate Nutrition 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
238000010411 cooking Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
238000001035 drying Methods 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
108010062619 enterogastrone Proteins 0.000 description 1
230000029142 excretion Effects 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
210000004347 intestinal mucosa Anatomy 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
235000014666 liquid concentrate Nutrition 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
210000002787 omasum Anatomy 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
239000002994 raw material Substances 0.000 description 1
210000004767 rumen Anatomy 0.000 description 1
239000012488 sample solution Substances 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
230000007017 scission Effects 0.000 description 1
230000028327 secretion Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
239000011343 solid material Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000000967 suction filtration Methods 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000036269 ulceration Effects 0.000 description 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
210000003462 vein Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Cell Biology (AREA)
Virology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Developmental Biology & Embryology (AREA)
Immunology (AREA)
Nutrition Science (AREA)
Zoology (AREA)
Physiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO05106/69A 1968-12-26 1969-12-23 NO130344B (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP9577468		1968-12-26
JP6157569		1969-08-04

Publications (1)

Publication Number	Publication Date
NO130344B true NO130344B (fr)	1974-08-19

Family

ID=26402621

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO05106/69A NO130344B (fr)	1968-12-26	1969-12-23

Country Status (6)

Country	Link
CH (1)	CH503054A (fr)
DE (1)	DE1963816A1 (fr)
DK (1)	DK126024B (fr)
FR (1)	FR2027116B1 (fr)
GB (1)	GB1279820A (fr)
NO (1)	NO130344B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU176089A (sh) *	1989-09-12	1992-09-07	Sikirić, Predrag	Postupak za pripremu supstancije bpc i supstancija bpc
AU6901191A (en) *	1990-09-11	1992-03-30	Marko Duvnjak	Pharmacologically active substance bpc, the process for its preparation and its use in the therapy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR3626M (fr) *	1963-11-13	1965-10-18	Lucien Nouvel	Médicament pour affections intestinales.

1969
- 1969-11-21 GB GB57172/69A patent/GB1279820A/en not_active Expired
- 1969-12-16 FR FR6943426A patent/FR2027116B1/fr not_active Expired
- 1969-12-17 CH CH1876469A patent/CH503054A/fr not_active IP Right Cessation
- 1969-12-19 DE DE19691963816 patent/DE1963816A1/de active Pending
- 1969-12-23 NO NO05106/69A patent/NO130344B/no unknown
- 1969-12-23 DK DK682969AA patent/DK126024B/da unknown

Also Published As

Publication number	Publication date
DK126024B (da)	1973-06-04
GB1279820A (en)	1972-06-28
FR2027116B1 (fr)	1974-08-30
CH503054A (fr)	1971-02-15
DE1963816A1 (de)	1970-07-23
FR2027116A1 (fr)	1970-09-25

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