|
JPS5896097A
(ja)
*
|
1981-12-01 |
1983-06-07 |
Taisho Pharmaceut Co Ltd |
エリスロマイシンｂ誘導体
|
|
JPS5896098A
(ja)
*
|
1981-12-03 |
1983-06-07 |
Taisho Pharmaceut Co Ltd |
エリスロマイシンａ誘導体
|
|
JPS60120895A
(ja)
*
|
1983-12-02 |
1985-06-28 |
Taisho Pharmaceut Co Ltd |
６−０−メチル−２′−０，ν−ビス（ベンジルオキシカルボニル）−ν−デメチルエリスロマイシンａの製法
|
|
JPS60214796A
(ja)
*
|
1984-04-06 |
1985-10-28 |
Taisho Pharmaceut Co Ltd |
６−０−メチルエリスロマイシン類の製法
|
|
IL75908A0
(en)
*
|
1984-08-31 |
1985-12-31 |
Abbott Lab |
Macrolide alkylation process
|
|
JPS61103890A
(ja)
*
|
1984-10-26 |
1986-05-22 |
Taisho Pharmaceut Co Ltd |
６−０−メチルエリスロマイシンａ誘導体
|
|
EP0201166B1
(en)
|
1985-03-12 |
1990-02-07 |
Beecham Group Plc |
Erythromycin derivatives
|
|
GB8506380D0
(en)
*
|
1985-03-12 |
1985-04-11 |
Beecham Group Plc |
Chemical compounds
|
|
US4670549A
(en)
*
|
1985-03-18 |
1987-06-02 |
Taisho Pharmaceutical Co., Ltd. |
Method for selective methylation of erythromycin a derivatives
|
|
JPS61229895A
(ja)
*
|
1985-04-03 |
1986-10-14 |
Nippon Zeon Co Ltd |
保護化デス−ｎ−メチルエリスロマイシン誘導体
|
|
US5175150A
(en)
*
|
1985-08-31 |
1992-12-29 |
Kitasato, Kenkyusho |
Erythromycin derivative
|
|
US4640910A
(en)
*
|
1985-11-12 |
1987-02-03 |
Abbott Laboratories |
Erythromycin A silylated compounds and method of use
|
|
US4672056A
(en)
*
|
1985-11-12 |
1987-06-09 |
Abbott Laboratories |
Erythromycin A derivatives and method of use
|
|
US4874748A
(en)
*
|
1986-03-24 |
1989-10-17 |
Abbott Laboratories |
Cloning vectors for streptomyces and use thereof in macrolide antibiotic production
|
|
US5149639A
(en)
*
|
1986-03-24 |
1992-09-22 |
Abbott Laboratories |
Biologically pure cultures of streptomyces and use thereof in macrolide antibiotic production
|
|
US4833236A
(en)
*
|
1986-05-02 |
1989-05-23 |
Taisho Pharmaceutical Co., Ltd. |
Erythromycin derivatives
|
|
JPH0633312B2
(ja)
*
|
1986-05-02 |
1994-05-02 |
大正製薬株式会社 |
１４−ハイドロキシエリスロマイシン誘導体およびその製造方法
|
|
US4740502A
(en)
*
|
1986-06-20 |
1988-04-26 |
Abbott Laboratories |
Semisynthetic erythromycin antibiotics
|
|
EP0260938B1
(en)
|
1986-09-18 |
1992-12-09 |
Taisho Pharmaceutical Co. Ltd |
Erythromycin a derivatives and method for preparing the same
|
|
US5302705A
(en)
*
|
1989-10-07 |
1994-04-12 |
Taisho Pharmaceutical Co., Ltd. |
6-O-methylerythromycin a oxime derivatives
|
|
US5141926A
(en)
*
|
1990-04-18 |
1992-08-25 |
Abbott Laboratories |
Erythromycin derivatives
|
|
HRP930014A2
(en)
*
|
1993-01-08 |
1994-08-31 |
Pliva Pharm & Chem Works |
9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
|
|
KR970702725A
(ko)
*
|
1994-04-26 |
1997-06-10 |
노부히로 나리따 |
비소세포 폐암 치료용 의약 조성물(Medicinal Composition as a Remedy for Nonsmall Cell Lung Cancer)
|
|
US5498424A
(en)
*
|
1994-11-30 |
1996-03-12 |
Klein; Ira |
Method of treating obesity
|
|
US5747466A
(en)
*
|
1995-11-08 |
1998-05-05 |
Abbott Laboratories |
3-deoxy-3-descladinose derivatives of erythromycins A and B
|
|
US5872229A
(en)
|
1995-11-21 |
1999-02-16 |
Abbott Laboratories |
Process for 6-O-alkylation of erythromycin derivatives
|
|
US5756473A
(en)
*
|
1995-11-21 |
1998-05-26 |
Abbott Laboratories |
6-O-methyl erythromycin D and process for making
|
|
PT915899E
(pt)
|
1996-07-29 |
2004-11-30 |
Abbott Lab |
Preparacao da forma cristalina ii da eritromicina
|
|
US5844105A
(en)
*
|
1996-07-29 |
1998-12-01 |
Abbott Laboratories |
Preparation of crystal form II of clarithromycin
|
|
US5858986A
(en)
|
1996-07-29 |
1999-01-12 |
Abbott Laboratories |
Crystal form I of clarithromycin
|
|
US5804565A
(en)
*
|
1996-09-24 |
1998-09-08 |
Taisho Pharmaceutical Co., Ltd. |
Erythromycin A derivatives
|
|
HUP0000198A3
(en)
|
1996-11-27 |
2000-09-28 |
Taisho Pharmaceutical Co Ltd |
Erythromycin a derivatives
|
|
US5945405A
(en)
*
|
1997-01-17 |
1999-08-31 |
Abbott Laboratories |
Crystal form O of clarithromycin
|
|
US5864023A
(en)
*
|
1997-02-13 |
1999-01-26 |
Abbott Laboratories |
3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
|
|
WO1998040392A1
(fr)
*
|
1997-03-10 |
1998-09-17 |
Taisho Pharmaceutical Co., Ltd. |
Derives d'erythromycine a
|
|
US6140479A
(en)
*
|
1997-03-24 |
2000-10-31 |
Taisho Pharmaceuticals Co., Ltd. |
Erythromycin a derivatives
|
|
US5929219A
(en)
*
|
1997-09-10 |
1999-07-27 |
Abbott Laboratories |
9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
|
|
US6174865B1
(en)
|
1997-09-25 |
2001-01-16 |
Ira Klein |
Method of treating hypertriglyceridemia with an erythromycin compound
|
|
US5780604A
(en)
*
|
1997-09-26 |
1998-07-14 |
Abbott Laboratories |
11,12-cyclic phosphite or phosphate derivatives of erythromycin and related macrolides
|
|
US6169168B1
(en)
|
1997-10-29 |
2001-01-02 |
Taisho Pharmaceuticals Co., Ltd. |
Erythromycin A derivatives
|
|
US5852180A
(en)
*
|
1997-11-17 |
1998-12-22 |
Abbott Laboratories |
Chemical synthesis of 6-O-alkyl erythromycin A
|
|
IL135792A0
(en)
*
|
1997-12-01 |
2001-05-20 |
Abbott Lab |
6-o-alkyl derivatives of erythronolide b
|
|
US5892008A
(en)
*
|
1997-12-16 |
1999-04-06 |
Abbott Laboratories |
Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
|
|
AP1060A
(en)
*
|
1998-01-02 |
2002-04-23 |
Pfizer Prod Inc |
Novel erythromycin derivatives.
|
|
HRP980189B1
(en)
*
|
1998-04-06 |
2004-04-30 |
Pliva Pharm & Chem Works |
Novel 15-membered lactams ketolides
|
|
SI20150A
(sl)
*
|
1999-02-19 |
2000-08-31 |
Lek, Tovarna Farmacevtskih In |
Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina
|
|
CZ20013733A3
(cs)
*
|
1999-05-24 |
2002-11-13 |
Pfizer Products Inc. |
Deriváty 13-methylerythromycinu
|
|
US6420535B1
(en)
|
1999-06-07 |
2002-07-16 |
Abbott Laboratories |
6-O-carbamate ketolide derivatives
|
|
US6417366B2
(en)
|
1999-06-24 |
2002-07-09 |
Abbott Laboratories |
Preparation of quinoline-substituted carbonate and carbamate derivatives
|
|
US6437106B1
(en)
|
1999-06-24 |
2002-08-20 |
Abbott Laboratories |
Process for preparing 6-o-substituted erythromycin derivatives
|
|
GB9915745D0
(en)
*
|
1999-07-06 |
1999-09-08 |
Biochemie Sa |
Organic compounds
|
|
US6569836B2
(en)
|
1999-12-02 |
2003-05-27 |
Abbott Laboratories |
6-O-alkyl-2-nor-2-substituted ketolide derivatives
|
|
US6627743B1
(en)
|
1999-12-03 |
2003-09-30 |
Abbott Laboratories |
6-O-methylerythromycin A crystal form III
|
|
KR20020070991A
(ko)
*
|
1999-12-16 |
2002-09-11 |
테바 파마슈티컬 인더스트리즈 리미티드 |
클라리트로마이신 다형체 및 신규의 다형체 ⅳ의 제조 방법
|
|
KR20020071012A
(ko)
*
|
2000-01-11 |
2002-09-11 |
테바 파마슈티컬 인더스트리즈 리미티드 |
클래리스로마이신 다형체의 제조 방법
|
|
US6544555B2
(en)
|
2000-02-24 |
2003-04-08 |
Advancis Pharmaceutical Corp. |
Antibiotic product, use and formulation thereof
|
|
US6565882B2
(en)
|
2000-02-24 |
2003-05-20 |
Advancis Pharmaceutical Corp |
Antibiotic composition with inhibitor
|
|
US6946446B2
(en)
|
2000-02-24 |
2005-09-20 |
Abbott Laboratories |
Anti-infective agents useful against multidrug-resistant strains of bacteria
|
|
KR20030047873A
(ko)
*
|
2000-02-29 |
2003-06-18 |
테바 파마슈티컬 인더스트리즈 리미티드 |
클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
|
|
US6605707B1
(en)
|
2000-03-23 |
2003-08-12 |
Abbott Laboratories |
Process for the preparation of 6-O-propargyl erythromycin derivatives
|
|
NZ521368A
(en)
*
|
2000-03-28 |
2004-05-28 |
Biochemie Ges M |
Granulated particles of an active compound, with a film-forming coating resulting in the masked taste of said active compound
|
|
PT1283821E
(pt)
*
|
2000-05-15 |
2004-06-30 |
Ranbaxy Lab Ltd |
Metodo rentavel para metilacao selectiva de derivados de eritromicina a
|
|
ATE306491T1
(de)
*
|
2000-08-23 |
2005-10-15 |
Wockhardt Ltd |
Verfahren zur herstellung von wasserfreiem azithromycin
|
|
US20020068078A1
(en)
|
2000-10-13 |
2002-06-06 |
Rudnic Edward M. |
Antifungal product, use and formulation thereof
|
|
US6541014B2
(en)
|
2000-10-13 |
2003-04-01 |
Advancis Pharmaceutical Corp. |
Antiviral product, use and formulation thereof
|
|
US6455680B1
(en)
|
2000-12-21 |
2002-09-24 |
Abbott Laboratories |
Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
|
|
US20020197314A1
(en)
*
|
2001-02-23 |
2002-12-26 |
Rudnic Edward M. |
Anti-fungal composition
|
|
TWI246515B
(en)
|
2001-05-30 |
2006-01-01 |
Abbott Lab |
An arylation method for the functionalization of O-allyl erythromycin derivatives
|
|
US20050053657A1
(en)
*
|
2001-08-29 |
2005-03-10 |
Ashok Rampal |
Controlled release formulation of clarithromycin or tinidazol
|
|
US20030091627A1
(en)
*
|
2001-10-31 |
2003-05-15 |
Vinay Sharma |
Rate-controlled delivery of macrolides
|
|
AU2003211923A1
(en)
*
|
2002-02-13 |
2003-09-04 |
Taisho Pharmaceutical Co., Ltd. |
Process for producing erythromycin a derivative
|
|
JP4625637B2
(ja)
|
2002-02-22 |
2011-02-02 |
シャイア エルエルシー |
活性物質送達系及び活性物質を保護し投与する方法
|
|
US20050163857A1
(en)
*
|
2002-04-03 |
2005-07-28 |
Ashok Rampal |
Clarithromycin formulations having improved bioavailability
|
|
US6843854B2
(en)
|
2002-05-31 |
2005-01-18 |
Purdue Research Foundation |
Method and apparatus for separating a component from a mixture
|
|
CA2529817C
(en)
*
|
2003-03-10 |
2013-02-12 |
Optimer Pharmaceuticals, Inc. |
Novel antibacterial agents
|
|
US7435805B2
(en)
|
2003-05-30 |
2008-10-14 |
Glaxpsmithkline Istrazivacki |
O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
|
|
EP1636160A4
(en)
*
|
2003-06-23 |
2006-09-27 |
Auspex Pharmaceuticals |
NEW THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER, METABOLISM AND SKIN DISEASES
|
|
CA2533178C
(en)
|
2003-07-21 |
2014-03-11 |
Advancis Pharmaceutical Corporation |
Antibiotic product, use and formulation thereof
|
|
WO2005009364A2
(en)
|
2003-07-21 |
2005-02-03 |
Advancis Pharmaceutical Corporation |
Antibiotic product, use and formulation thereof
|
|
JP2006528190A
(ja)
|
2003-07-21 |
2006-12-14 |
アドバンシス ファーマスーティカル コーポレイション |
抗生物質製剤、その使用法及び作成方法
|
|
US8758820B2
(en)
|
2003-08-11 |
2014-06-24 |
Shionogi Inc. |
Robust pellet
|
|
US8062672B2
(en)
|
2003-08-12 |
2011-11-22 |
Shionogi Inc. |
Antibiotic product, use and formulation thereof
|
|
CA2535780A1
(en)
|
2003-08-29 |
2005-03-17 |
Advancis Pharmaceuticals Corporation |
Antibiotic product, use and formulation thereof
|
|
US8460710B2
(en)
|
2003-09-15 |
2013-06-11 |
Shionogi, Inc. |
Antibiotic product, use and formulation thereof
|
|
AU2003263482A1
(en)
*
|
2003-09-25 |
2005-04-14 |
Ranbaxy Laboratories Limited |
3'-n-substituted-3-o-substituted erythronolide a derivatives
|
|
WO2006014427A1
(en)
|
2004-07-02 |
2006-02-09 |
Advancis Pharmaceutical Corporation |
Tablet for pulsed delivery
|
|
US20060111560A1
(en)
*
|
2004-11-01 |
2006-05-25 |
Glenmark Pharmaceuticals Limited |
Process for the preparation of crystalline form II of clarithromycin
|
|
UA85937C2
(uk)
|
2004-12-21 |
2009-03-10 |
Пфайзер Продактс Інк. |
Макроліди
|
|
US7582611B2
(en)
|
2005-05-24 |
2009-09-01 |
Pfizer Inc. |
Motilide compounds
|
|
US20060293261A1
(en)
*
|
2005-06-24 |
2006-12-28 |
Taisho Pharmaceutical Co., Ltd. |
Clarithromycin or a salt thereof for the treatment or prevention of pulmonary disorders caused by the destruction of pulmonary alveoli
|
|
US20070015719A1
(en)
*
|
2005-07-07 |
2007-01-18 |
Elan Pharma International Limited |
Nanoparticulate clarithromycin formulations
|
|
US8357394B2
(en)
|
2005-12-08 |
2013-01-22 |
Shionogi Inc. |
Compositions and methods for improved efficacy of penicillin-type antibiotics
|
|
US8778924B2
(en)
|
2006-12-04 |
2014-07-15 |
Shionogi Inc. |
Modified release amoxicillin products
|
|
US8299052B2
(en)
*
|
2006-05-05 |
2012-10-30 |
Shionogi Inc. |
Pharmaceutical compositions and methods for improved bacterial eradication
|
|
US20070281894A1
(en)
*
|
2006-06-05 |
2007-12-06 |
Auspex Pharmaceuticals, Inc. |
Preparation and utility of substituted erythromycin analogs
|
|
KR20090042971A
(ko)
|
2006-08-24 |
2009-05-04 |
욱크하르트 리서치 센터 |
항미생물 활성을 갖는 신규한 마크로라이드 및 케토라이드
|
|
WO2009023191A2
(en)
*
|
2007-08-09 |
2009-02-19 |
Teva Pharmaceutical Industries Ltd. |
An improved process for the preparation of clarithromycin
|
|
US20090069255A1
(en)
*
|
2007-09-11 |
2009-03-12 |
Protia, Llc |
Deuterium-enriched clarithromycin
|
|
CN101917850B
(zh)
*
|
2007-10-25 |
2016-01-13 |
森普拉制药公司 |
大环内酯类抗菌剂的制备方法
|
|
CN102223794B
(zh)
|
2008-10-24 |
2017-12-22 |
森普拉制药公司 |
使用含三唑的大环内酯治疗抗性疾病的方法
|
|
CN101875678B
(zh)
*
|
2009-04-30 |
2012-06-27 |
浙江华义医药有限公司 |
一种制备克拉霉素的方法
|
|
US9937194B1
(en)
|
2009-06-12 |
2018-04-10 |
Cempra Pharmaceuticals, Inc. |
Compounds and methods for treating inflammatory diseases
|
|
JP5914335B2
(ja)
|
2009-09-10 |
2016-05-11 |
センプラ ファーマシューティカルズ，インコーポレイテッド |
マラリア、結核、及びｍａｃ病の治療方法
|
|
BR112012023950A2
(pt)
|
2010-03-22 |
2016-07-05 |
Cempra Pharmaceuticals Inc |
formas cristalinas de um macrolídeo, e usos dos mesmos
|
|
CN102250180B
(zh)
*
|
2010-05-18 |
2015-07-22 |
上海医药工业研究院 |
2’,4”-o-二(三甲基硅基)-红霉素a衍生物和克拉霉素制备方法
|
|
CN102250173B
(zh)
*
|
2010-05-18 |
2015-07-08 |
上海医药工业研究院 |
一种6-o-甲基红霉素a衍生物和克拉霉素的制备方法
|
|
ES2636948T3
(es)
|
2010-05-20 |
2017-10-10 |
Cempra Pharmaceuticals, Inc. |
Procesos para preparar macrólidos y cetólidos e intermediarios para los mismos
|
|
EP2613630A4
(en)
|
2010-09-10 |
2014-01-15 |
Cempra Pharmaceuticals Inc |
FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES
|
|
RU2601550C2
(ru)
|
2010-12-09 |
2016-11-10 |
Вокхардт Лимитед |
Кетолидные соединения
|
|
CN103619849B
(zh)
|
2011-03-01 |
2016-05-25 |
沃克哈特有限公司 |
酮内酯中间体的制备方法
|
|
KR101795838B1
(ko)
|
2011-03-22 |
2017-11-08 |
욱크하르트 리미티드 |
케톨리드 화합물의 제조 방법
|
|
RU2658050C2
(ru)
|
2012-03-27 |
2018-06-19 |
Семпра Фармасьютикалз, Инк. |
Парентеральные составы для введения макролидных антибиотиков
|
|
EP2671571A1
(en)
|
2012-06-05 |
2013-12-11 |
Sanovel Ilac Sanayi ve Ticaret A.S. |
Controlled-release formulations of clarithromycin
|
|
CA2894992A1
(en)
|
2012-12-24 |
2014-07-03 |
Ramot At Tel-Aviv University Ltd. |
Agents for treating genetic diseases resulting from nonsense mutations, and methods for identifying the same
|
|
WO2014152326A1
(en)
|
2013-03-14 |
2014-09-25 |
Cempra Pharmaceuticals, Inc. |
Methods for treating respiratory diseases and formulations therefor
|
|
RU2015138797A
(ru)
|
2013-03-15 |
2017-04-24 |
Семпра Фармасьютикалс, Инк. |
Конвергентные способы получения макролидных антибактериальных агентов
|
|
CN105801642B
(zh)
*
|
2016-03-11 |
2019-03-26 |
北京理工大学 |
一种制备6,11-双-o-甲基红霉素a的方法
|