US5334618A
(en)
*
|
1991-04-04 |
1994-08-02 |
The Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
US5506231A
(en)
*
|
1989-03-31 |
1996-04-09 |
The Children's Medical Center Corporation |
Treatment of aids dementia, myelopathy and blindness
|
WO1992017168A1
(en)
*
|
1991-04-04 |
1992-10-15 |
The Children's Medical Center Corporation |
Method of preventing nmda receptor-mediated neuronal damage
|
US5614560A
(en)
*
|
1991-04-04 |
1997-03-25 |
Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
US5455279A
(en)
*
|
1991-04-19 |
1995-10-03 |
The Children's Medical Center Corporation |
Regimen method of mediating neuronal damage using nitroglycerine
|
DE4225730C2
(de)
*
|
1992-08-04 |
2003-04-30 |
Merz Pharma Gmbh & Co Kgaa |
Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung
|
DE19510189A1
(de)
*
|
1995-03-21 |
1996-09-26 |
Hartmut Dr Goebel |
Verwendung von Amantadin
|
DE19528388A1
(de)
*
|
1995-08-02 |
1997-02-06 |
Hans Peter Prof Dr Med Zenner |
Verwendung von Adamantan-Derivaten zur Behandlung von Erkrankungen des Innenohrs
|
US6057373A
(en)
*
|
1997-05-22 |
2000-05-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists
|
US5866585A
(en)
*
|
1997-05-22 |
1999-02-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia using NMDA receptor antagonists
|
US5952389A
(en)
*
|
1998-01-13 |
1999-09-14 |
Synchroneuron |
Methods of treating tardive dyskinesia and other movement disorders
|
US6294583B1
(en)
*
|
1998-01-13 |
2001-09-25 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders
|
GB9802225D0
(en)
*
|
1998-02-02 |
1998-04-01 |
Cerebrus Ltd |
Chemical compounds
|
US6444702B1
(en)
*
|
2000-02-22 |
2002-09-03 |
Neuromolecular, Inc. |
Aminoadamantane derivatives as therapeutic agents
|
US20040122090A1
(en)
*
|
2001-12-07 |
2004-06-24 |
Lipton Stuart A. |
Methods for treating neuropsychiatric disorders with nmda receptor antagonists
|
US7795468B2
(en)
*
|
2001-01-19 |
2010-09-14 |
Chevron U.S.A. Inc. |
Functionalized higher diamondoids
|
WO2003020257A2
(de)
|
2001-08-29 |
2003-03-13 |
Eucro European Contract Research Gmbh & Co. Kg |
VERWENDUNG VON β-ADRENOZEPTOR-AGONISTEN ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN
|
DE10142176A1
(de)
*
|
2001-08-29 |
2003-03-27 |
Eucro Europe Contract Res Gmbh |
Verwendung einer Kombination aus ß-adrenergen Agonisten und NDMA-Antagonisten
|
US20040248984A1
(en)
*
|
2001-08-29 |
2004-12-09 |
Josef Krieglstein |
Use of $g(b)-adrenoceptor agonists for the treatment of neurodegenerative diseases
|
GB0202161D0
(en)
*
|
2002-01-30 |
2002-03-20 |
Vernalis Res Ltd |
Chemical compounds V
|
EP1523309A2
(en)
*
|
2002-07-19 |
2005-04-20 |
Khalid Iqbal |
Nmda receptor antagonists and their use in inhibiting abnormal hyperphosphorylation of microtubule associated protein tau
|
US20040087658A1
(en)
|
2002-10-24 |
2004-05-06 |
Hans-Joerg Moebius |
Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors
|
RS20050851A
(sr)
*
|
2003-05-27 |
2008-04-04 |
Forest Laboratories Inc., |
Kombinacija antagonista nmda receptora i selektivnog inhibitora ponovnog preuzimanja serotonina za lečenje depresije i drugih poremećaja raspoloženja
|
CN100345819C
(zh)
*
|
2003-07-01 |
2007-10-31 |
北京德众万全药物技术开发有限公司 |
一种取代的金刚烷胺类化合物或其盐的制备方法
|
ITTO20030668A1
(it)
*
|
2003-09-02 |
2005-03-03 |
Rotta Res Lab S P A O Ra Rottapharm |
Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione.
|
CN1240668C
(zh)
*
|
2003-09-10 |
2006-02-08 |
上海医药工业研究院 |
一种新的盐酸美金刚制备方法
|
ATE411015T1
(de)
*
|
2003-10-22 |
2008-10-15 |
Merz Pharma Gmbh & Co Kgaa |
Verwendung von 1-aminocyclohexan-derivaten zur modifizierung der abscheidung von fibrillogenen as peptiden in amyloidpathien
|
AR046314A1
(es)
|
2003-11-05 |
2005-11-30 |
Merz Pharma Gmbh & Co Kgaa |
Composiciones que comprenden ciclohexilaminas y aminoadamantanos
|
UY28650A1
(es)
*
|
2003-12-05 |
2005-02-28 |
Forest Laboratories |
Memantina para la prevencion o disminucion de la conducta suicida y para el tratamiento de la depresion mayor asociada con esta conducta
|
CA2551689A1
(en)
*
|
2004-01-05 |
2005-07-28 |
Merz Pharma Gmbh & Co. Kgaa |
Memantine for the treatment of mild and mild-to-moderate alzheimer's disease
|
KR20060124731A
(ko)
*
|
2004-01-29 |
2006-12-05 |
뉴로몰레큘라 파마슈티칼스, 인코포레이티드 |
중추신경계-관련 질환 치료용 nmda 수용체 길항제 및mao-억제제 또는 gadph-억제제의 배합물
|
US7456224B2
(en)
*
|
2004-04-05 |
2008-11-25 |
Forest Laboratories Holdings, Ltd. |
Method for treating autism
|
EA011290B1
(ru)
*
|
2004-06-17 |
2009-02-27 |
Мерц Фарма Гмбх Унд Ко. Кгаа |
Препаративные формы пероральных лекарственных форм мемантина с немедленным высвобождением
|
US20060002999A1
(en)
*
|
2004-06-17 |
2006-01-05 |
Forest Laboratories, Inc. |
Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
|
EP1781261A1
(en)
*
|
2004-06-17 |
2007-05-09 |
Forest Laboratories, Inc. |
Modified release formulation of memantine
|
TW200616608A
(en)
*
|
2004-07-09 |
2006-06-01 |
Forest Laboratories |
Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients
|
TW200621677A
(en)
*
|
2004-09-21 |
2006-07-01 |
Astellas Pharma Inc |
Cyclic amine derivative or salt thereof
|
MX2007003267A
(es)
*
|
2004-09-23 |
2007-05-23 |
Merz Pharma Gmbh & Co Kgaa |
Memantina para el tratamiento de trastornos de conducta en la infancia.
|
CN100351225C
(zh)
*
|
2004-10-28 |
2007-11-28 |
中国医学科学院医药生物技术研究所 |
一组金刚烷胺类衍生物及其合成方法和作为神经元损伤保护剂的应用
|
AU2005309601A1
(en)
|
2004-11-23 |
2006-06-01 |
Neuromolecular Pharmaceuticals, Inc. |
Composition comprising a sustained release coating or matrix and an NMDA receptor antagonist, method for administration such NMDA antagonist to a subject
|
US7619007B2
(en)
|
2004-11-23 |
2009-11-17 |
Adamas Pharmaceuticals, Inc. |
Method and composition for administering an NMDA receptor antagonist to a subject
|
EP2623099A1
(en)
|
2004-11-24 |
2013-08-07 |
Neuromolecular Pharmaceuticals, Inc |
Composition and method for treating neurological disease
|
US20060205822A1
(en)
*
|
2004-12-22 |
2006-09-14 |
Forest Laboratories, Inc. |
1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
|
MX2007007301A
(es)
*
|
2005-01-11 |
2008-02-11 |
Teva Pharm Fine Chemicals Srl |
Polimorfos de clorhidrato de memantina.
|
WO2006121560A2
(en)
|
2005-04-06 |
2006-11-16 |
Adamas Pharmaceuticals, Inc. |
Methods and compositions for treatment of cns disorders
|
ITMI20050833A1
(it)
|
2005-05-10 |
2006-11-11 |
A M S A S P A Anonima Materie Sintetiche Affini |
Nuovo procedimento per la sintesi di aminoadamantani
|
EP1879849A1
(en)
*
|
2005-05-11 |
2008-01-23 |
Dr. Reddy's Laboratories, Inc. |
Process for preparing memantine
|
AU2006259619A1
(en)
*
|
2005-06-16 |
2006-12-28 |
Forest Laboratories, Inc. |
Modified and immediate release memantine bead formulation
|
CA2612338C
(en)
|
2005-06-17 |
2015-02-03 |
Apogee Biotechnology Corporation |
Sphingosine kinase inhibitors
|
US20070099947A1
(en)
*
|
2005-11-03 |
2007-05-03 |
Alkermes, Inc. |
Methods and compositions for the treatment of brain reward system disorders by combination therapy
|
SI1820792T1
(sl)
|
2006-02-21 |
2012-04-30 |
Hexal Ag |
Postopek za pripravo adamantanaminov
|
DE102006009279A1
(de)
*
|
2006-03-01 |
2007-09-06 |
Justus-Liebig-Universität Giessen |
Verfahren zur Herstellung von 1-Formamido-3,5-dimethyladamantan
|
DE102006009278B4
(de)
*
|
2006-03-01 |
2010-06-02 |
Justus-Liebig-Universität Giessen |
Verfahren zur direkten Formamidierung oder Acetamidierung von Admantan und Admantanderivaten sowie deren Verwendung zur Herstellung von Aminoadmantanen
|
EP1999100A1
(en)
|
2006-03-27 |
2008-12-10 |
Teva Pharmaceutical Fine Chemicals S.R.L. |
Process for preparing memantine hydrochloride substantially free of impurities
|
US20090291976A1
(en)
*
|
2006-06-27 |
2009-11-26 |
Peter Andrew Ferchmin |
Neuronal circuit-dependent neuroprotection by interaction between nicotinic receptors
|
US20080008743A1
(en)
*
|
2006-07-06 |
2008-01-10 |
Forest Laboratories Holdings Limited |
Orally Dissolving Formulations of Memantine
|
US8013018B2
(en)
|
2006-07-18 |
2011-09-06 |
Astellas Pharma Inc. |
Aminoindane derivative or salt thereof
|
AR063680A1
(es)
|
2006-08-04 |
2009-02-11 |
Merz Pharma Gmbh & Co Kgaa |
Derivados de pirazolo[1, 5-a]pirimidina, metodos e intermediario para su preparacion, composiciones farmaceuticas que los comprenden y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mediadas por la modulacion de mglur5.
|
WO2008062472A2
(en)
*
|
2006-10-24 |
2008-05-29 |
Cadila Healthcare Limited |
Process for the preparation of memantine
|
BRPI0718437A2
(pt)
|
2006-10-27 |
2013-11-19 |
Medivation Neurology Inc |
Métodos e terapias de combinação para tratar a doença de alzheimer usando, entre outros, dimebon e dolepezil
|
WO2008063847A2
(en)
*
|
2006-11-03 |
2008-05-29 |
Forest Laboratories Holdings Limited |
Method for treating autism
|
GB0623897D0
(en)
*
|
2006-11-30 |
2007-01-10 |
Pliva Istrazivanje I Razvoj D |
Pharmaceutical composition of memantine
|
US20080182908A1
(en)
*
|
2007-01-25 |
2008-07-31 |
Vinita Umashankar Vyas |
Pharmaceutical compositions comprising memantine
|
EP2090576A1
(en)
|
2008-02-01 |
2009-08-19 |
Merz Pharma GmbH & Co.KGaA |
6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators
|
EP2085398A1
(en)
|
2008-02-01 |
2009-08-05 |
Merz Pharma GmbH & Co. KGaA |
Pyrazolopyrimidines, a process for their preparation and their use as medicine
|
CA2718056A1
(en)
*
|
2008-03-13 |
2009-09-17 |
The Regents Of The University Of California |
Use of epicatechin and derivatives and salts thereof for cardiac protection of ischemic myocardium and to ameliorate adverse cardiac remodeling
|
ES2507085T3
(es)
*
|
2008-03-20 |
2014-10-14 |
Merz Pharma Gmbh & Co. Kgaa |
Proceso para la fabricación de Memantina y producto intermedio
|
EP2103597A1
(en)
|
2008-03-20 |
2009-09-23 |
Merz Pharma GmbH & Co.KGaA |
Process for the manufacture of memantine and intermediate product
|
KR100998525B1
(ko)
|
2008-03-28 |
2010-12-07 |
나노다이아몬드 주식회사 |
아밀로이드 올리고머 독성 억제제로서의 아다만탄 유도체
|
US20090247644A1
(en)
*
|
2008-03-28 |
2009-10-01 |
Forest Laboratories Holdings Limited |
Memantine formulations
|
WO2009128058A1
(en)
|
2008-04-18 |
2009-10-22 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al |
Psycho-pharmaceuticals
|
EP2111858A1
(en)
|
2008-04-25 |
2009-10-28 |
EPFL Ecole Polytechnique Fédérale de Lausanne |
Novel treatment for alzheimer's disease
|
US20090275597A1
(en)
*
|
2008-05-02 |
2009-11-05 |
Forest Laboratories Holdings Limited |
Methods of treating cns disorders
|
EP2138173A1
(en)
|
2008-06-26 |
2009-12-30 |
Merz Pharma GmbH & Co.KGaA |
Pharmaceutical compositions comprising aminoadamantane derivatives
|
UA105182C2
(ru)
|
2008-07-03 |
2014-04-25 |
Ньюрексон, Інк. |
Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
|
WO2010112221A1
(en)
|
2009-04-03 |
2010-10-07 |
Synthon B.V. |
Pharmaceutical compositions comprising memantine
|
JP5778148B2
(ja)
|
2009-08-04 |
2015-09-16 |
メルク パテント ゲーエムベーハー |
多環式炭水化物を含む電子デバイス
|
TW201116532A
(en)
|
2009-08-05 |
2011-05-16 |
Merz Pharma Gmbh & Co Kgaa |
Metabotropic glutamate receptor modulators
|
CA2782556C
(en)
|
2009-12-02 |
2018-03-27 |
Adamas Pharmaceuticals, Inc. |
Amantadine compositions and methods of use
|
WO2011071995A2
(en)
|
2009-12-08 |
2011-06-16 |
Case Western Reserve University |
Compounds and methods of treating ocular disorders
|
WO2011127235A1
(en)
|
2010-04-07 |
2011-10-13 |
Eisai Inc. |
Combination therapy for the treatment of dementia
|
JP5562716B2
(ja)
*
|
2010-05-12 |
2014-07-30 |
花王株式会社 |
電位依存性カチオンチャネル抑制剤
|
PL2578212T3
(pl)
|
2010-05-24 |
2017-01-31 |
Farmalider Sa |
Związek hamujący aktywację enzymu Erk 1/2 do zastosowania w leczeniu chorób neurodegeneracyjnych
|
FR2962335B1
(fr)
|
2010-07-12 |
2013-01-18 |
Cll Pharma |
Utilisation du nonapeptide pat dans le traitement et la prevention des maladies neurodegeneratives
|
WO2012048871A1
(en)
|
2010-10-12 |
2012-04-19 |
Merz Pharma Gmbh & Co. Kgaa |
Memantine for improving cognitive performance in subjects
|
WO2012052451A1
(en)
|
2010-10-18 |
2012-04-26 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
JP5848768B2
(ja)
|
2010-10-29 |
2016-01-27 |
ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドRamot At Tel Aviv University Ltd. |
インドール誘導体及びその製造方法
|
NO3034079T3
(nl)
|
2010-11-15 |
2018-06-09 |
|
|
AR084515A1
(es)
|
2010-12-22 |
2013-05-22 |
Merz Pharma Gmbh & Co Kgaa |
Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras
|
AR084516A1
(es)
|
2010-12-22 |
2013-05-22 |
Merz Pharma Gmbh & Co Kgaa |
Moduladores de receptores de glutamato metabotropicos
|
US20140004189A1
(en)
|
2011-01-25 |
2014-01-02 |
Cadila Healthcare Limited |
Modified release pharmaceutical compositions memantine
|
CN102241678B
(zh)
|
2011-04-26 |
2014-10-29 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
WO2012152854A1
(en)
|
2011-05-12 |
2012-11-15 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
WO2012172093A1
(en)
|
2011-06-17 |
2012-12-20 |
Merz Pharma Gmbh & Co. Kgaa |
Dihydroindolizine derivate as metabotropic glutamate receptor modulators
|
EP2650284A1
(en)
|
2012-04-10 |
2013-10-16 |
Merz Pharma GmbH & Co. KGaA |
Heterocyclic derivatives as metabotropic glutamate receptor modulators
|
EP2836213B1
(en)
|
2012-04-14 |
2018-07-04 |
Intra-Cellular Therapies, Inc. |
Fused gamma carbolines
|
RU2488388C1
(ru)
|
2012-05-24 |
2013-07-27 |
Ооо "Валента Интеллект" |
Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств
|
WO2014015047A1
(en)
|
2012-07-17 |
2014-01-23 |
The General Hospital Corporation |
Compositions and methods to treat neurodegenerative diseases
|
UA107653U
(uk)
|
2012-10-01 |
2016-06-24 |
Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" |
Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів
|
US10154971B2
(en)
|
2013-06-17 |
2018-12-18 |
Adamas Pharma, Llc |
Methods of administering amantadine
|
CA2934553C
(en)
|
2013-12-20 |
2023-10-31 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
US20150216849A1
(en)
|
2014-02-04 |
2015-08-06 |
Forest Laboratories Holdings Ltd. |
Donepezil compositions and methods of treating alzheimers disease
|
IL234638A0
(en)
|
2014-09-14 |
2014-12-02 |
Yeda Res & Dev |
NMDA receptor antagonists for the treatment of Gaucher disease
|
US10815242B2
(en)
|
2015-06-19 |
2020-10-27 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
US10583171B2
(en)
|
2015-11-30 |
2020-03-10 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
NMDAR antagonists for the treatment of diseases associated with angiogenesis
|
KR20180127315A
(ko)
|
2015-12-30 |
2018-11-28 |
코리움 인터네셔널, 인크. |
장기 경피 투여를 위한 시스템 및 방법
|
JP7174632B2
(ja)
|
2016-06-23 |
2022-11-17 |
コリウム, インコーポレイテッド |
親水性ドメインおよび疎水性ドメインならびに処置剤との接着剤マトリックス
|
CA3031944A1
(en)
|
2016-07-27 |
2018-02-01 |
Corium International, Inc. |
Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
|
WO2018022816A1
(en)
|
2016-07-27 |
2018-02-01 |
Corium International, Inc. |
Sodium bicarbonate in situ conversion driven transdermal delivery of amine drug
|
KR102508993B1
(ko)
|
2016-07-27 |
2023-03-10 |
코리움, 인크. |
메만틴 경피 송달 시스템
|
US20180170941A1
(en)
|
2016-12-19 |
2018-06-21 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
US11505555B2
(en)
|
2016-12-19 |
2022-11-22 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
US10369187B2
(en)
|
2017-02-09 |
2019-08-06 |
Vanderbilt University |
Peptide regulators of JNK family kinases
|
WO2019018185A1
(en)
|
2017-07-15 |
2019-01-24 |
Arisan Therapeutics Inc. |
ENANTIOMERICALLY PURE ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTIONS
|
AU2018392686A1
(en)
|
2017-12-20 |
2020-07-09 |
Corium Pharma Solutions, Inc. |
Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
|
BR112020026062B1
(pt)
|
2018-06-19 |
2023-04-04 |
Agenebio, Inc |
Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson
|
WO2020240505A1
(en)
|
2019-05-31 |
2020-12-03 |
TECNIMEDE - Sociedade Técnico-medicinal, SA |
Immediate release fixed-dose combination of memantine and donepezil
|
EP4005565A1
(en)
|
2020-11-30 |
2022-06-01 |
Merz Pharmaceuticals GmbH |
Novel uses of adamantane derivatives
|
WO2023154014A1
(en)
|
2022-02-08 |
2023-08-17 |
Sahin Fikret |
Nmdar antagonists prevent ageing and aging-associated conditions and diseases through increasing 20s proteasome activity
|
US20240132513A1
(en)
|
2022-08-19 |
2024-04-25 |
Agenebio, Inc. |
Benzazepine derivatives, compositions, and methods for treating cognitive impairment
|