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NL2036752B1 - Sputum sample pretreatment device for pathogenic microorganism testing - Google Patents

Sputum sample pretreatment device for pathogenic microorganism testing Download PDF

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Publication number
NL2036752B1
NL2036752B1 NL2036752A NL2036752A NL2036752B1 NL 2036752 B1 NL2036752 B1 NL 2036752B1 NL 2036752 A NL2036752 A NL 2036752A NL 2036752 A NL2036752 A NL 2036752A NL 2036752 B1 NL2036752 B1 NL 2036752B1
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Netherlands
Prior art keywords
rod
sputum
gear
block
proximity switch
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NL2036752A
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Dutch (nl)
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NL2036752A (en
Inventor
Wang Yaning
Zhang Zhongfa
Deng Yunfeng
Zhang Zhenjin
Wang Junling
Wang Yan
Tian Peng
Original Assignee
Shandong Public Health Clinical Center
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Publication of NL2036752A publication Critical patent/NL2036752A/en
Application granted granted Critical
Publication of NL2036752B1 publication Critical patent/NL2036752B1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2866—Grinding or homogeneising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G01N2001/386—Other diluting or mixing processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G01N2035/00554—Mixing by a special element, e.g. stirrer using ultrasound
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0482—Transmission
    • G01N2035/0487—Helix or lead screw

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The present invention discloses a sputum sample pretreatment device for pathogenic microorganism testing, and relates to the technical field of pathogenic microorganism testing. The device includes a housing, where a bottom plate is arranged on a bottom wall of an inner 5 cavity of the housing, lifting motor units and an ultrasonic unit are arranged on the bottom plate, the lifting motor units are connected to a positioning plate, a proximity switch unit is arranged on the positioning plate, the proximity switch unit is electrically connected to the ultrasonic unit, a placement block is arranged on the ultrasonic unit, the placement block is provided with a sputum cup accommodating cavity, a clamping mechanism is arranged on an outer side of the 10 sputum cup accommodating cavity, and the clamping mechanism is connected to the lifting motor units through a connecting rod. In the present invention, through the ultrasonic unit, ultrasonic waves are generated, and sputum is homogenized quickly and effectively, thereby improving the detection efficiency of pathogenic microorganism testing and reducing the cost of pretreatment. 15 [FIG. 2] l3

Description

SPUTUM SAMPLE PRETREATMENT DEVICE FOR PATHOGENIC
MICROORGANISM TESTING
TECHNICAL FIELD
[01] The present invention relates to the technical field of pathogenic microorganism testing, and particularly relates to a sputum sample pretreatment device for pathogenic microorganism testing.
BACKGROUND ART
[02] Clinical pathogenic microorganism detection methods generally include smear staining microscopy and isolated culture. As a main type of samples for pathogenic detection of respiratory diseases, sputum samples have complex components. Under pathological conditions, respiratory mucosa and pulmonary alveoli are usually congested and edematous after stimulation, which is accompanied by serous exudation, increased mucus secretion, and increased exudates of various cells, fibrin and the like. Therefore, sputum samples are relatively viscous. However, pathogenic microorganisms or conditionally pathogenic microorganisms are usually encased in the viscous sputum, which is not conducive to the pathogenic detection of clinical microorganisms. Pretreatment of sputum can improve the detection efficiency of pathogenic microorganism testing.
[03] The pre-treatment of sputum in the prior art is performed usually by adding a digestive reagent to the sputum, including various proteases, which is effective to liquefy the sputum, but there exists a problem of high cost of reagents. A Chinese invention patent with the publication
No.CN113188867A discloses a sputum sample pretreatment device for medical examination.
The device comprises a housing, a plurality of sputum cup placement seats, an accommodating cavity for accommodating a sputum cup in each sputum cup accommodating seat, an injector configured for injecting composite enzymatic hydrolysate into the sputum cup so as to pre-treat a sputum sample in the sputum cup, and a sampler which penetrates through the bottom of the sputum cup and is configured for exporting the pre-treated sputum sample into a bacterial culture mechanism pre-filled with a culture solution for culture and propagation. In use, the protein in the sputum sample should be enzymatically hydrolyzed in advance to remove the viscous state of the sputum sample. The bacteria contained in the sputum sample can flow into the bacterial culture mechanism together with the sputum sample that turns into liquid, and proliferate in the culture solution, thus making it easier to detect trace amounts of pathogenic bacteria. This device essentially uses the digestive reagent to remove the viscous state of the 1 sputum sample, and has the deficiency of high pre-treatment cost.
[04] In addition, in the prior art, the sputum cup is usually placed in the accommodating cavity configured, but there exist the problems including instability after placement and applicability to only a single-sized sputum cup.
SUMMARY
[05] An objective of the present invention is mainly to provide a sputum sample pretreatment device for pathogenic microorganism testing, so as to solve the problems in the prior art.
[06] In order to solve the technical problems, the present invention adopts the following technical solution:
[07] a sputum sample pretreatment device for pathogenic microorganism testing, including a housing, where a bottom plate is arranged on a bottom wall of an inner cavity of the housing, lifting motor units and an ultrasonic unit are arranged on the bottom plate, the lifting motor units are connected to a positioning plate, a proximity switch unit is arranged on the positioning plate, the proximity switch unit is electrically connected to the ultrasonic unit, a placement block is arranged on the ultrasonic unit, the placement block is provided with a sputum cup accommodating cavity, a clamping mechanism is arranged on an outer side of the sputum cup accommodating cavity, and the clamping mechanism is connected to the lifting motor units through a connecting rod.
[08] Further, the proximity switch unit includes a proximity switch body, a spring box and a spring, where the spring box is fixedly arranged at the bottom of the positioning plate, the spring is arranged inside the spring box, the bottom of the proximity switch body penetrates through a limiting hole on the positioning plate and extends to the inside of the spring box, the bottom of the proximity switch body is fixedly connected to the spring, a sliding block is slidably connected inside the spring box, the bottom of the spring is connected to the top of the sliding block, a through hole is formed at the bottom of the spring box, the through hole 1s configured for the passage of the sputum cup, and the proximity switch body is electrically connected to the ultrasonic unit.
[09] Further, an outer side of the proximity switch body is sleeved with a protective case, and the protective case is connected to the limiting hole on the positioning plate through threads.
[10] Further, the lifting motor unit includes a driving motor, a screw rod and a guide rod, where the driving motor is fixedly arranged on the bottom plate, one end of the screw rod is connected to an output end of the driving motor, the other end of the same is rotatably connected 2 to a top wall of the inner cavity of the housing, the positioning plate is connected to the screw rod through a first threaded block, a second threaded block is also connected to the screw rod through threads, the second threaded block is located below the positioning plate, a side portion of the second threaded block is connected to the clamping mechanism through a connecting rod, one end of the guide rod is fixedly connected to the bottom plate, the other end of the same sequentially penetrates through the second threaded block and the positioning plate and is fixedly connected to the top wall of the inner cavity of the housing, and the second threaded block and the positioning plate are both slidably connected to the guide rod.
[11] Further, the clamping mechanism includes a driving rod, a first gear, a second gear, a first rack and a second rack, where a groove is formed at the top of the placement block, the driving rod is slidably arranged on a bottom wall of the groove, a first positioning column and a second positioning column are arranged on the bottom wall of the groove, the first positioning column and the second positioning column are respectively located on both sides of the driving rod, the first gear is rotatably connected to the first positioning column, the second gear is rotatably connected to the second positioning column, both sides of the driving rod are respectively connected to the first gear and the second gear through a rotating rod, the first rack is in mesh connection with the first gear, the second rack is in mesh connection with the second gear, a sliding rail is further arranged on the bottom wall of the groove, bottom portions of the first rack and the second rack are both slidably connected to the sliding rail, and a clamping plate is arranged on one side of the first rack and the second rack away from the driving rod respectively.
[12] Further, the rotating rod includes a first rotating rod and a second rotating rod, where one ends of the first rotating rod and the second rotating rod are respectively connected to lugs on both sides of the driving rod through a rotating shaft, the other end of the first rotating rod is connected to the lug of the first gear through a rotating shaft, and the other end of the second rotating rod is connected to the lug of the second gear through a rotating shaft.
[13] Further, the connecting rod includes a first connecting rod and a second connecting rod, where the driving rod is away from one side of the rotating rod, extends to an outer side of the placement block and is fixedly connected to one end of the first connecting rod, the other end of the first connecting rod is hinged to one end of the second connecting rod, and the other end of the second connecting rod is hinged to a side wall of the second threaded block.
[14] Further, the ultrasonic unit includes oscillators and an ultrasonic probe, where the bottom of the oscillator is connected to the bottom plate through a fixed block, the top of the oscillator is connected to the ultrasonic probe through a connecting block, and the placement 3 block is arranged at the top of the ultrasonic probe.
[15] Compared with the prior art, the present invention has the following beneficial effects:
[16] ultrasonic waves are generated through the ultrasonic unit, sputum is homogenized quickly and effectively, and pathogenic or conditionally pathogenic microorganisms encased in the sputum are released and homogeneously suspended in a post-treatment sputum sample, thereby improving the detection efficiency of pathogenic microorganism testing; compared to the method of using a digestive reagent to remove the viscous state of the sputum sample, this method reduces the cost of pretreatment; and
[17] the clamping mechanism arranged on an outer side of the sputum cup accommodating cavity enables clamping and fixing of the sputum cup, which not only can be used to clamp different sizes of sputum cups, but also makes it more stable.
BRIEF DESCRIPTION OF THE DRAWINGS
[18] FIG. lis a schematic diagram of an external structure of the present invention.
[19] FIG. 2 is a schematic diagram of an internal structure of the present invention.
[20] FIG. 3 is a top view of a clamping mechanism and a placement block of the present invention.
[21] FIG.4 is a schematic diagram of a structure of a placement block of the present invention.
[22] FIG. 5 is a schematic diagram of an internal structure of a proximity switch unit of the present invention.
[23] FIG. 6 is a schematic diagram of a structure of an ultrasonic unit of the present invention.
[24] FIG. 7 is a schematic diagram of a structure of a fixed block of the present invention.
[25] FIG. 8 is a schematic diagram of a structure of an oscillator fixing bolt of the present invention.
[26] FIG. 9 is a schematic diagram of a structure of an ultrasonic probe connecting bolt of the present invention.
[27] In the figures, 1-housing, 11-bottom plate, 2-ultrasonic unit, 21-fixed block, 211- positioning hole, 221-first oscillator, 222-second oscillator, 223-third oscillator, 224-fourth oscillator, 23-oscillator fixing bolt, 24-connecting block, 25-ultrasonic probe connecting bolt, 26-ultrasonic probe, 3-touch screen, 4-power interface, 5-proximity switch unit, S1-spring box, 52-spring, 53-positioning plate, 54-limiting switch body, 55-sliding block, 56-protective case, 6-lifting motor unit, 61-driving motor, 62-screw rod, 63-guide rod, 64-second threaded block, 4
65-fixture block, 7-placement block, 71-sputum cup accommodating cavity, 72-sputum cup, 73-groove, 74-first positioning column, 75-second positioning column, 76-sliding rail, 77- limiting groove, 8-clamping mechanism, 81-driving rod, 82-first gear, 83-second gear, 84-first rack, 85-second rack, 86-clamping plate, 87-first rotating rod, 88-second rotating rod, 9-first connecting rod, and 10-second connecting rod.
DETAILED DESCRIPTION OF THE EMBODIMENTS
[28] The technical solution of the present disclosure will be further described below with reference to the accompanying drawings and the embodiments.
[29] With reference to FIGs. 1-9, the present invention provides a sputum sample pretreatment device for pathogenic microorganism testing. The device includes a housing 1, where a bottom plate 11 is arranged on a bottom wall of an inner cavity of the housing 1, lifting motor units 6 and an ultrasonic unit 2 are arranged on the bottom plate 11, the lifting motor units 6 are connected to a positioning plate 53, a proximity switch unit 5 is arranged on the positioning plate 53, the proximity switch unit 5 is electrically connected to the ultrasonic unit 2, a placement block 7 is arranged on the ultrasonic unit 2, the placement block 7 is provided with a sputum cup accommodating cavity 71, a clamping mechanism 8 is arranged on an outer side of the sputum cup accommodating cavity 71, and the clamping mechanism 8 is connected to the lifting motor units 6 through a connecting rod.
[30] In this embodiment, the proximity switch unit 5 includes a proximity switch body 54, a spring box 51 and a spring 52, where the spring box 51 is fixedly arranged at the bottom of the positioning plate 53, the spring 52 is arranged inside the spring box 51, the bottom of the proximity switch body 54 penetrates through a limiting hole on the positioning plate 53 and extends to the inside of the spring box 51, the bottom of the proximity switch body 54 is fixedly connected to the spring, a sliding block 55 is slidably connected inside the spring box 51, the bottom of the spring is connected to the top of the sliding block 55, a through hole is formed at the bottom of the spring box 51, the through hole is configured for the passage of the sputum cup, and the proximity switch body 54 is electrically connected to the ultrasonic unit 2.
[31] Preferably, the proximity switch unit 5 adopts a pressure proximity switch. In use, the sputum cup containing a sputum sample is placed in a sputum cup accommodating cavity 71, power is turned on through a power interface, the lifting motor units 6 are turned on to drive the proximity switch unit 5 to move downwards, moving downwards is continued after contacting the sputum cup, and in this case, the sputum cup penetrates through the through hole at the bottom of the spring box 51 and contacts the sliding block 55, so that the sliding block 5
55 moves upwards. When the sliding block 55 moves upwards, the spring is compressed, when the spring is compressed to a certain extent, the pressure proximity switch is communicated with a circuit through a contact junction, and the proximity switch body 54 is communicated with the ultrasonic unit, so that the ultrasonic unit is turned on and generates ultrasonic waves, sputum is homogenized quickly and effectively, and pathogenic or conditionally pathogenic microorganisms encased in the sputum are released and homogeneously suspended in a post- treatment sputum sample, thereby improving the detection efficiency of pathogenic microorganism testing.
[32] Preferably, an outer side of the proximity switch body 54 is sleeved with a protective case 56, and the protective case 56 is connected to the limiting hole on the positioning plate 53 through threads.
[33] In this embodiment, the lifting motor unit 6 includes a driving motor 61, a screw rod 62 and a guide rod 63, where the driving motor 61 is fixedly arranged on the bottom plate 11, one end of the screw rod 62 is connected to an output end of the driving motor 61, the other end of the same is rotatably connected to a top wall of the inner cavity of the housing 1, the positioning plate 53 is connected to the screw rod 62 through a first threaded block, a second threaded block 64 is also connected to the screw rod 62 through threads, the second threaded block 64 is located below the positioning plate 53, a side portion of the second threaded block 64 is connected to the clamping mechanism 8 through a connecting rod, one end of the guide rod 63 is fixedly connected to the bottom plate 11, the other end of the same sequentially penetrates through the second threaded block 64 and the positioning plate 53 and is fixedly connected to the top wall of the inner cavity of the housing 1, and the second threaded block 64 and the positioning plate 53 are both slidably connected to the guide rod 63. Specifically, an initial distance between the second threaded block 64 and the positioning plate 53 can be adjusted as needed, and when the driving motor 61 works after the adjustment is completed, the screw rod 62 is driven to rotate, so that the positioning plate 53 and the second threaded block 64 synchronously move up and down linearly on the screw rod.
[34] Preferably, the number of the lifting motor units 6 is two, and they are located on both sides of the ultrasonic unit 2.
[35] In this embodiment, the clamping mechanism 8 includes a driving rod 81, a first gear 82, a second gear 83, a first rack 84 and a second rack 85, where a groove 73 is formed at the top of the placement block 7, the driving rod 81 is slidably arranged on a bottom wall of the groove 73, a first positioning column 74 and a second positioning column 75 are arranged on the bottom wall of the groove 73, the first positioning column 74 and the second positioning 6 column 75 are respectively located on both sides of the driving rod 81, the first gear 82 is rotatably connected to the first positioning column 74, the second gear 83 is rotatably connected to the second positioning column 75, both sides of the driving rod 81 are respectively connected to the first gear 82 and the second gear 83 through a rotating rod, the first rack 84 is in mesh connection with the first gear 82, the second rack 85 is in mesh connection with the second gear 83, a sliding rail 76 is further arranged on the bottom wall of the groove 73, bottom portions of the first rack 84 and the second rack 85 are both slidably connected to the sliding rail 76, and a clamping plate 86 is arranged on one side of the first rack 84 and the second rack 85 away from the driving rod 81 respectively.
[36] During operation, when the second threaded block 64 is in descending motion, the driving rod 81 is pulled by a connecting rod to move towards one side close to the second threaded block 64, in this case, the driving rod 81 drives the first gear 82 and the second gear 83 to rotate through the rotating rod, and rotation of the first gear 82 and the second gear 83 simultaneously drives the first rack 84 and the second rack 85 that mesh with them to move towards each other, so that the two clamping plates 86 approach each other, and finally the sputum cup inside the sputum cup accommodating cavity 71 is clamped. Combination of the clamping plate 86 and the sputum cup accommodating cavity 71 makes the sputum cup more stable after placement and is suitable for different sizes of sputum cups.
[37] Preferably, a limiting groove 77 for limiting the driving rod 81 is formed at the top of the placement block 7. The configuration of the limiting groove 77 makes the driving rod 81 more stable during movement.
[38] Preferably, the rotating rod includes a first rotating rod 87 and a second rotating rod 88, where one ends of the first rotating rod 87 and the second rotating rod 88 are respectively connected to lugs on both sides of the driving rod 81 through a rotating shaft, the other end of the first rotating rod 87 is connected to the lug of the first gear 82 through a rotating shaft, and the other end of the second rotating rod 88 is connected to the lug of the second gear 83 through a rotating shaft.
[39] Preferably, the connecting rod includes a first connecting rod 9 and a second connecting rod 10, where the driving rod 81 is away from one side of the rotating rod, extends to an outer side of the placement block 7 and is fixedly connected to one end of the first connecting rod 9, the other end of the first connecting rod 9 is hinged to one end of the second connecting rod 10, and the other end of the second connecting rod 10 is hinged to a side wall of the second threaded block 64.
[40] Preferably, a side wall of the second threaded block 64 is clamped with a fixture block 7
65, and one end portion of the first connecting rod 9 is hinged with the fixture block 65.
[41] In this embodiment, an outer surface of the housing 1 is provided with a touch screen 3, a side portion of the same is provided with a power interface 4, and an openable door is provided on one side of the housing 1 away from the power interface 4.
[42] In this embodiment, the ultrasonic unit includes oscillators and an ultrasonic probe 26, where the bottom of the oscillator is connected to the bottom plate 11 through a fixed block 21, the top of the oscillator is connected to the ultrasonic probe 26 through a connecting block 24, and the placement block 7 is arranged at the top of the ultrasonic probe 26. Preferably, a positioning hole 211 is formed on the fixed block 21 for an oscillator fixing bolt 23 to pass through, the oscillator fixing bolt 23 connects the oscillators to the fixed block 21, and a bolt hole is formed at the bottom of the fixed block 21 for connection to the bottom plate 11 through a bolt; and a bolt hole is formed at the bottom of the ultrasonic probe 26, and the ultrasonic probe 26 is connected to the connecting block 24 through an ultrasonic probe connecting bolt 25.
[43] In this embodiment, there are a plurality of oscillators. Preferably, the number of oscillators is four, and the oscillators include a first oscillator 221, a second oscillator 222, a third oscillator 223 and a fourth oscillator 224 that are sequentially configured from top to bottom.
[44] Working principle:
[45] The door on the side portion of the housing 1 is opened, the sputum cup containing a sputum sample is placed in the sputum cup accommodating cavity 71, power is turned on through the power interface 4, and then the door is closed. When it is necessary to pretreat the sputum sample in the sputum cup, the driving motor 61 is turned on to drive the screw rod 62 to rotate, so that the positioning plate 53 and the second threaded block 64 are synchronously in descending motion on the screw rod, the positioning plate 53 drives the proximity switch unit 5 to move downwards, moving downwards is continued after contacting the sputum cup, and in this case, the sputum cup penetrates through the through hole at the bottom of the spring box 51 and contacts the sliding block 55,so that the sliding block 55 moves upwards. When the sliding block 55 moves upwards, the spring is compressed, when the spring is compressed to a certain extent, the pressure proximity switch is communicated with a circuit through a contact junction, and the proximity switch body 54 is communicated with the ultrasonic unit, so that the ultrasonic unit is turned on. At the same time, the second threaded block 64 drives the second connecting rod 10 to tilt downward during the descending process, and the second connecting rod 10 generates an outward pulling force on the driving rod 81 through the first 8 connecting rod 9, so that the driving rod 81 moves towards one side close to the second threaded block 64, during the horizontal movement of the driving rod 81, the first gear 82 and the second gear 83 are driven to rotate through the first rotating rod 87 and the second rotating rod 88 respectively, rotation of the first gear 82 and the second gear 83 simultaneously drives the first rack 84 and the second rack 85 that mesh with them to move towards each other, so that the two clamping plates 86 approach each other, and finally the sputum cup is clamped. After the pre-treatment of the sputum sample is completed, the driving motor reversely rotates and drives the positioning plate 53 and the second threaded block 64 to synchronously move up on the screw rod, so that the two clamping plates 86 moves away from each other and release the
IO sputum cup, the spring is not compressed, the circuit is disconnected, the ultrasonic unit is turned off, then the door is opened, and the sputum cup is taken out.
[46] In this embodiment, the clamping mechanism is used to clamp the side portion of the sputum cup, the proximity switch unit not only is capable to control the opening and closing of the ultrasonic unit, but also is capable to apply downward pressure on the sputum cup, and multidimensional clamping makes the sputum cup more stable after placement.
[47] The foregoing descriptions are merely preferred embodiments of the present invention, but are not intended to limit the technical scope of the present invention. Therefore, any minor alteration, equivalent change and modification which are made to the above embodiments in accordance with the technical essence of the present invention all fall within the scope of protection of the technical solution of the present invention. 9

Claims (8)

ConclusiesConclusions 1. Een sputummonster voorbehandelingsapparaat voor pathogene micro-organisme testen, omvattend een behuizing, waarin een bodemplaat is aangebracht op een bodemwand van een binnenholte van de behuizing, hefmotor eenheden en een ultrasone eenheid zijn aangebracht op de bodemplaat, de hefinotor eenheden zijn verbonden met een positioneringsplaat, een nabijheidsschakelaar eenheid is aangebracht op de positioneringsplaat, de nabijheidsschakelaar eenheid is elektrisch verbonden met de ultrasone eenheid, een plaatsingsblok is aangebracht op de ultrasone eenheid, het plaatsingsblok is voorzien van een sputumbeker opvangholte, een klemmechanisme is aangebracht aan een buitenzijde van de sputumbeker opvangholte, en het klemmechanisme is verbonden met de hefmotor eenheden via een verbindingsstang.1. A sputum sample pretreatment apparatus for pathogenic microorganism testing, comprising a housing, wherein a bottom plate is provided on a bottom wall of an inner cavity of the housing, lifting motor units and an ultrasonic unit are provided on the bottom plate, the lifting motor units are connected to a positioning plate, a proximity switch unit is provided on the positioning plate, the proximity switch unit is electrically connected to the ultrasonic unit, a positioning block is provided on the ultrasonic unit, the positioning block is provided with a sputum cup collecting cavity, a clamping mechanism is provided on an outer side of the sputum cup collecting cavity, and the clamping mechanism is connected to the lifting motor units via a connecting rod. 2. Het sputummonster voorbehandelingsapparaat voor pathogene micro-organisme testen volgens claim 1, waarbij de nabijheidsschakelaar eenheid een nabijheidsschakelaar lichaam, een veerdoos en een veer omvat, waarbij de veerdoos vast is aangebracht aan de onderkant van de positioneringsplaat, de veer is aangebracht in de veerdoos, de onderkant van het nabijheidsschakelaar lichaam steekt door een begrenzingsgat op de positioneringsplaat en strekt zich uit tot in de veerdoos, de onderkant van het nabijheidsschakelaar lichaam is vast verbonden met de veer, een schuifblok is schuifbaar verbonden in de veerdoos, de onderkant van de veer is verbonden met de bovenkant van het schuifblok, een doorgaand gat is gevormd aan de onderkant van de veerdoos, het doorgaande gat is bedoeld voor de doorgang van de sputumbeker, en het nabijheidsschakelaar lichaam is elektrisch verbonden met de ultrasone eenheid.2. The sputum sample pretreatment apparatus for pathogenic microorganism testing according to claim 1, wherein the proximity switch unit comprises a proximity switch body, a spring box and a spring, the spring box being fixedly mounted on the bottom of the positioning plate, the spring being mounted in the spring box, the bottom of the proximity switch body protruding through a limiting hole on the positioning plate and extending into the spring box, the bottom of the proximity switch body being fixedly connected to the spring, a slide block being slidably connected in the spring box, the bottom of the spring being connected to the top of the slide block, a through hole being formed at the bottom of the spring box, the through hole being for the passage of the sputum cup, and the proximity switch body being electrically connected to the ultrasonic unit. 3. Het sputummonster voorbehandelingsapparaat voor pathogene micro-organisme testen volgens claim 2, waarbij een buitenzijde van het nabijheidsschakelaar lichaam is voorzien van een beschermhoes, en de beschermhoes is verbonden met het begrenzingsgat op de positioneringsplaat door middel van schroefdraad.3. The sputum sample pretreatment device for pathogenic microorganism testing according to claim 2, wherein an outer side of the proximity switch body is provided with a protective cover, and the protective cover is connected to the limiting hole on the positioning plate by means of a screw thread. 4. Het sputummonster voorbehandelingsapparaat voor pathogene micro-organisme testen volgens claim 1, waarbij de hefmotor eenheid een aandrijfmotor, een schroefstang en een geleidestang omvat, waarbij de aandrijfmotor vast is aangebracht op de bodemplaat, één uiteinde van de schroefstang is verbonden met een uitgangseinde van de aandrijfmotor, het andere uiteinde daarvan is draaibaar verbonden met een bovenwand van de binnenholte van de 10 behuizing, de positioneringsplaat is verbonden met de schroefstang door middel van een eerste schroefdraadblok, een tweede schroefdraadblok is ook verbonden met de schroefstang door middel van schroefdraad, het tweede schroefdraadblok bevindt zich onder de positioneringsplaat, een zijgedeelte van het tweede schroefdraadblok is verbonden met het klemmechanisme door middel van een verbindingsstang, één uiteinde van de geleidestang is vast verbonden met de bodemplaat, het andere uiteinde daarvan steekt achtereenvolgens door het tweede schroefdraadblok en de positioneringsplaat en is vast verbonden met de bovenwand van de binnenholte van de behuizing, en het tweede schroefdraadblok en de positioneringsplaat zijn beide schuifbaar verbonden met de geleidestang.4. The sputum sample pretreatment apparatus for pathogenic microorganism testing according to claim 1, wherein the lifting motor unit comprises a drive motor, a screw rod and a guide rod, the drive motor is fixedly mounted on the base plate, one end of the screw rod is connected to an output end of the drive motor, the other end thereof is rotatably connected to an upper wall of the inner cavity of the housing, the positioning plate is connected to the screw rod by means of a first threaded block, a second threaded block is also connected to the screw rod by means of a thread, the second threaded block is located below the positioning plate, a side portion of the second threaded block is connected to the clamping mechanism by means of a connecting rod, one end of the guide rod is fixedly connected to the base plate, the other end thereof successively passes through the second threaded block and the positioning plate and is fixedly connected to the upper wall of the inner cavity of the housing, and the second threaded block and the positioning plate are both slidably connected to the guide rod. 5. Het sputummonster voorbehandelingsapparaat voor pathogene micro-organisme testen volgens claim 4, waarbij het klemmechanisme een aandrijfstang, een eerste tandwiel, een tweede tandwiel, een eerste rek en een tweede rek omvat, waarbij een groef is gevormd aan de bovenkant van het plaatsingsblok, de aandrijfstang 1s schuifbaar aangebracht op een bodemwand van de groef, een eerste positioneringskolom en een tweede positioneringskolom zijn aangebracht op de bodemwand van de groef, de eerste positioneringskolom en de tweede positioneringskolom bevinden zich respectievelijk aan beide zijden van de aandrijfstang, het eerste tandwiel 1s draaibaar verbonden met de eerste positioneringskolom, het tweede tandwiel is draaibaar verbonden met de tweede positioneringskolom, beide zijden van de aandrijfstang zijn respectievelijk verbonden met het eerste tandwiel en het tweede tandwiel door middel van een draaistang, het eerste rek is in mesh verbinding met het eerste tandwiel, het tweede rek is in mesh verbinding met het tweede tandwiel, een schuifrail is verder aangebracht op de bodemwand van de groef, onderste delen van het eerste rek en het tweede rek zijn beide schuifbaar verbonden met de schuifrail, en een klemplaat is aangebracht aan één zijde van het eerste rek en het tweede rek weg van de aandrijfstang respectievelijk.5. The sputum sample pretreatment apparatus for pathogenic microorganism testing according to claim 4, wherein the clamping mechanism comprises a drive rod, a first gear, a second gear, a first rack and a second rack, a groove being formed at the top of the positioning block, the drive rod 1s slidably disposed on a bottom wall of the groove, a first positioning column and a second positioning column are disposed on the bottom wall of the groove, the first positioning column and the second positioning column are respectively located on both sides of the drive rod, the first gear 1s rotatably connected to the first positioning column, the second gear is rotatably connected to the second positioning column, both sides of the drive rod are respectively connected to the first gear and the second gear by means of a pivot rod, the first rack is in mesh connection with the first gear, the second rack is in mesh connection with the second gear, a slide rail is further provided on the bottom wall of the groove, lower parts of the first rack and the second rack are both slidably connected to the slide rail, and a clamp plate is provided on one side of the first rack and the second rack away from the drive rod respectively. 6. Het sputummonster voorbehandelingsapparaat voor pathogene micro-organisme testen volgens claim 5, waarbij de draaistang een eerste draaistang en een tweede draaistang omvat, waarbij één uiteinde van de eerste draaistang en de tweede draaistang respectievelijk is verbonden met lugs aan beide zijden van de aandrijfstang door middel van een draaiende as, het andere uiteinde van de eerste draaistang is verbonden met de lug van het eerste tandwiel door middel van een draaiende as, en het andere uiteinde van de tweede draaistang is verbonden met de lug van het tweede tandwiel door middel van een draaiende as. 116. The sputum sample pretreatment device for pathogenic microorganism testing according to claim 5, wherein the rotating rod comprises a first rotating rod and a second rotating rod, one end of the first rotating rod and the second rotating rod being respectively connected to lugs on both sides of the drive rod by means of a rotating shaft, the other end of the first rotating rod being connected to the lug of the first gear by means of a rotating shaft, and the other end of the second rotating rod being connected to the lug of the second gear by means of a rotating shaft. 11 7. Het sputummonster voorbehandelingsapparaat voor pathogene micro-organisme testen volgens claim 5, waarbij de verbindingsstang een eerste verbindingsstang en een tweede verbindingsstang omvat, waarbij de aandrijfstang zich uitstrekt vanaf één zijde van de draaistang, zich uitstrekt naar een buitenzijde van het plaatsingsblok en vast is verbonden met één uiteinde van de eerste verbindingsstang, het andere uiteinde van de eerste verbindingsstang is scharnierend verbonden met één uiteinde van de tweede verbindingsstang, en het andere uiteinde van de tweede verbindingsstang 1s scharnierend verbonden met een zijwand van het tweede schroefdraadblok.7. The sputum sample pretreatment device for pathogenic microorganism testing according to claim 5, wherein the connecting rod comprises a first connecting rod and a second connecting rod, the drive rod extending from one side of the pivot rod, extending to an outer side of the placement block and being fixedly connected to one end of the first connecting rod, the other end of the first connecting rod being hingedly connected to one end of the second connecting rod, and the other end of the second connecting rod being hingedly connected to a side wall of the second threaded block. 8. Het sputummonster voorbehandelingsapparaat voor pathogene micro-organisme testen volgens claim 1, waarbij de ultrasone eenheid oscillatoren en een ultrasone sonde omvat, waarbij de onderkant van de oscillator is verbonden met de bodemplaat door middel van een vast blok, de bovenkant van de oscillator 1s verbonden met de ultrasone sonde door middel van een verbindingsblok, en het plaatsingsblok is aangebracht aan de bovenkant van de ultrasone sonde. 128. The sputum sample pretreatment apparatus for pathogenic microorganism testing according to claim 1, wherein the ultrasonic unit comprises oscillators and an ultrasonic probe, the bottom of the oscillator is connected to the bottom plate by a fixed block, the top of the oscillator is connected to the ultrasonic probe by a connecting block, and the placement block is provided at the top of the ultrasonic probe. 12
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FR2791697B1 (en) * 1999-04-01 2003-02-28 Biomerieux Sa APPARATUS AND METHOD FOR ULTRASOUND LYSIS OF BIOLOGICAL CELLS
GB2425974A (en) * 2005-05-09 2006-11-15 Orion Diagnostica Oy Sonication of a medium
CN105102110B (en) * 2013-03-15 2018-01-26 默克专利股份公司 Equipment for performing sonication
EP3215260B1 (en) * 2014-11-03 2020-01-15 Tangen Biosciences Inc. Apparatus and method for cell, spore, or virus capture and disruption
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