NL185279C - Werkwijze ter bereiding van een farmaceutisch preparaat met analgetische werking en werkwijze ter bereiding van een gesubstitueerd n-(4-piperidinyl)-n-fenylamide of -carbamaat. - Google Patents

Werkwijze ter bereiding van een farmaceutisch preparaat met analgetische werking en werkwijze ter bereiding van een gesubstitueerd n-(4-piperidinyl)-n-fenylamide of -carbamaat.

Info

Publication number: NL185279C
Authority: NL; Netherlands
Prior art keywords: preparing; piperidinyl; phenylamide; carbamate; substituted
Prior art date: 1975-03-14

Application number

NLAANVRAGE7602612,A

Other languages

English (en)

Other versions

NL7602612A (nl

NL185279B (nl

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-03-14

Filing date

1976-03-12

Publication date

1990-03-01

1976-03-12 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1976-09-16 Publication of NL7602612A publication Critical patent/NL7602612A/nl

1989-10-02 Publication of NL185279B publication Critical patent/NL185279B/nl

1990-03-01 Application granted granted Critical

1990-03-01 Publication of NL185279C publication Critical patent/NL185279C/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

NLAANVRAGE7602612,A 1975-03-14 1976-03-12 Werkwijze ter bereiding van een farmaceutisch preparaat met analgetische werking en werkwijze ter bereiding van een gesubstitueerd n-(4-piperidinyl)-n-fenylamide of -carbamaat. NL185279C (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US55851175A	1975-03-14	1975-03-14
US05/648,685 US3998834A (en)	1975-03-14	1976-01-13	N-(4-piperidinyl)-n-phenylamides and -carbamates

Publications (3)

Publication Number	Publication Date
NL7602612A NL7602612A (nl)	1976-09-16
NL185279B NL185279B (nl)	1989-10-02
NL185279C true NL185279C (nl)	1990-03-01

Family

ID=27071767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NLAANVRAGE7602612,A NL185279C (nl)	1975-03-14	1976-03-12	Werkwijze ter bereiding van een farmaceutisch preparaat met analgetische werking en werkwijze ter bereiding van een gesubstitueerd n-(4-piperidinyl)-n-fenylamide of -carbamaat.

Country Status (28)

Country	Link
US (1)	US3998834A (nl)
JP (1)	JPS5946217B2 (nl)
AT (1)	AT359493B (nl)
AU (1)	AU503632B2 (nl)
BG (1)	BG28259A3 (nl)
CA (1)	CA1080232A (nl)
CH (1)	CH629486A5 (nl)
CZ (1)	CZ278060B6 (nl)
DE (1)	DE2610228A1 (nl)
DK (1)	DK148960C (nl)
ES (1)	ES446034A1 (nl)
FI (1)	FI61481C (nl)
FR (1)	FR2303546A1 (nl)
GB (1)	GB1538938A (nl)
HU (1)	HU172963B (nl)
IE (1)	IE42512B1 (nl)
IL (1)	IL49204A (nl)
IT (1)	IT1057988B (nl)
LU (1)	LU74511A1 (nl)
NL (1)	NL185279C (nl)
NO (1)	NO146162C (nl)
NZ (1)	NZ180096A (nl)
PH (1)	PH12746A (nl)
PL (1)	PL102474B1 (nl)
PT (1)	PT64898B (nl)
SE (1)	SE426486B (nl)
SU (1)	SU1227109A3 (nl)
YU (1)	YU39960B (nl)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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US4179569A (en) *	1975-03-14	1979-12-18	Janssen Pharmaceutica N.V.	N-(4-piperidinyl)-N-phenylamides
US4208418A (en) *	1975-09-23	1980-06-17	Janssen Pharmaceutica N.V.	N-Aryl-N-(1-alkyl-4-piperidinyl)arylacetamides
US4225606A (en) *	1975-09-23	1980-09-30	Janssen Pharmaceutica N.V.	N-Aryl-N-(1-L-4-piperidinyl)arylacetamides
FR2389622B1 (nl) *	1977-05-05	1982-05-21	Janssen Pharmaceutica Nv
US4167574A (en) *	1978-03-13	1979-09-11	Janssen Pharmaceutica, N.V.	N-phenyl-N-(4-piperidinyl)amides
US4584303A (en) *	1984-04-09	1986-04-22	The Boc Group, Inc.	N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
FR2608602A1 (fr) *	1986-12-23	1988-06-24	Cerm Cent Europ Rech Mauvernay	Nouvelles 3-piperidineamines ou 3-azepineamines substituees, leur preparation et leurs applications en therapeutique
US4791121A (en) *	1987-11-02	1988-12-13	The Boc Group, Inc.	4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5013742A (en) *	1987-11-02	1991-05-07	Boc, Inc.	4-phenyl-4-N-(phenyl) amido piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4957929A (en) *	1987-11-02	1990-09-18	Boc, Inc.	4-phenyl-4-[N-(phenyl)amido]piperidine compounds and pharmaceutical compositions employing such compounds
US4849521A (en) *	1987-11-02	1989-07-18	Boc, Inc.	Stereoselective preparation of 3-substituted-4-piperidine compounds and derivatives
US4921864A (en) *	1987-11-02	1990-05-01	Boc, Inc.	4-Phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
USRE33495E (en) *	1987-11-02	1990-12-18	Boc, Inc.	Stereoselective preparation of 3-substituted-4-anilino-piperidine compounds and derivatives
US4791120A (en) *	1987-12-31	1988-12-13	The Boc Group, Inc.	4-heteropentacyclic-4-[N-(phenyl)amino] piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4801615A (en) *	1987-12-31	1989-01-31	The Boc Group, Inc.	4-heterohexacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5019583A (en) *	1989-02-15	1991-05-28	Glaxo Inc.	N-phenyl-N-(4-piperidinyl)amides useful as analgesics
USRE34201E (en) *	1989-04-20	1993-03-23	Anaquest, Inc.	N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
US5145967A (en) *	1989-04-20	1992-09-08	Anaquest, Inc.	Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof
US5053411A (en) *	1989-04-20	1991-10-01	Anaquest, Inc.	N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
US4994471A (en) *	1989-05-12	1991-02-19	Boc, Inc.	N-aryl-N-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US5100903A (en) *	1989-05-12	1992-03-31	Anaquest, Inc.	N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US4939161A (en) *	1989-05-12	1990-07-03	Boc, Inc.	Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides
US5126455A (en) *	1989-12-13	1992-06-30	Glaxo Inc.	Preparation of substituted alkali metal piperidine-4-carboxylates
US5039804A (en) *	1989-12-13	1991-08-13	Glaxo Inc.	Preparation of substituted alkali metal piperidine-4-carboxylates
US5130321A (en) *	1990-12-18	1992-07-14	Glaxo Inc.	Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides
US5214148A (en) *	1990-12-18	1993-05-25	Glaxo Inc.	Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides
FR2676054B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
GB9316863D0 (en) *	1993-08-13	1993-09-29	Glaxo Group Ltd	Chemical process
US5489689A (en) *	1993-09-30	1996-02-06	Mallinckrodt Chemical, Inc.	Preparation of piperidine derivatives
US6541021B1 (en)	1999-03-18	2003-04-01	Durect Corporation	Devices and methods for pain management
US6835194B2 (en) *	1999-03-18	2004-12-28	Durect Corporation	Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
WO2000061557A1 (fr) *	1999-04-09	2000-10-19	Mochida Pharmaceutical Co., Ltd.	Derives de 4-hydroxypiperidine ayant un effet anti-arythmique
US6677332B1 (en)	1999-05-25	2004-01-13	Sepracor, Inc.	Heterocyclic analgesic compounds and methods of use thereof
US6635661B2 (en)	2000-05-25	2003-10-21	Sepracor Inc.	Heterocyclic analgesic compounds and methods of use thereof
US7361666B2 (en) *	1999-05-25	2008-04-22	Sepracor, Inc.	Heterocyclic analgesic compounds and methods of use thereof
AU2427201A (en) *	1999-12-06	2001-06-12	Mallinckrodt, Inc.	New methods for the syntheses of alfentanil, sufentanil and remifentanil
US7074803B2 (en) *	2001-03-02	2006-07-11	Durect Corporation	Opioid formulations
US20040102476A1 (en) *	2002-11-25	2004-05-27	Chan Tai Wah	High concentration formulations of opioids and opioid derivatives
EP1795526A4 (en) *	2004-09-14	2010-10-13	Nippon Chemiphar Co	N-SUBSTITUTED N- (4-PIPERIDINYL) AMIDE DERIVATIVE
JP2008088057A (ja) *	2005-03-23	2008-04-17	Nippon Chemiphar Co Ltd	Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体
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US20080009782A1 (en) *	2006-06-28	2008-01-10	Alza Corporation	Methods and Devices for Transdermal Electrotransport Delivery of Lofentanil and Carfentanil
WO2008005423A1 (en) *	2006-07-03	2008-01-10	Cambrex Charles City, Inc.	Improved method of making sufentanil
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US8299258B2 (en) *	2008-11-04	2012-10-30	Cambrex Charles City	Method of making piperidine derivatives
ES2664801T3 (es)	2010-09-17	2018-04-23	Mallinckrodt Llc	Proceso mejorado para la preparación de un precursor de sufentanilo base
EP2455377B1 (de)	2010-11-11	2014-07-09	hameln rds gmbh	Synthese von Fentanyl Analoga
EP2646107A2 (en)	2010-12-01	2013-10-09	Spinal Modulation Inc.	Agent delivery systems for selective neuromodulation
SG10201913593WA (en) *	2013-03-13	2020-02-27	Harvard College	Stapled and stitched polypeptides and uses thereof
US10752588B2 (en)	2014-12-19	2020-08-25	The Broad Institute, Inc.	Dopamine D2 receptor ligands
WO2016100940A1 (en)	2014-12-19	2016-06-23	The Broad Institute, Inc.	Dopamine d2 receptor ligands
ES2806631T3 (es)	2015-05-27	2021-02-18	SpecGx LLC	Preparación de citrato de sufentanilo y base de sufentanilo
CN106854203B (zh) *	2015-12-08	2020-12-01	江苏恩华药业股份有限公司	枸橼酸舒芬太尼的新晶型及其制备方法
PL3199523T3 (pl)	2016-01-29	2019-03-29	Bioka s. r.o.	Nowa procedura do produkcji n-fenylo-n-(4- piperydynylo) pochodnych amidowych, jakimi jest na przykład remifentanyl i karfentanyl
CN108503579B (zh) *	2018-03-28	2021-03-26	南京医科大学	芬太尼类似物及其应用
CN113214140B (zh) *	2020-02-03	2022-09-09	江苏谛奇医药科技有限公司	哌啶酰胺类衍生物、其药物组合物及其应用
BR112023002031A2 (pt)	2020-08-14	2023-03-07	Novartis Ag	Derivados de espiropiperidinila substituídos por heteroarila e usos farmacêuticos dos mesmos
CN114262320A (zh) *	2021-12-28	2022-04-01	宜昌人福药业有限责任公司	一种利用连续流微通道反应器制备苯胺基哌啶类药物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
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US3171838A (en) *	1961-10-10	1965-03-02	Res Lab Dr C Janssen N V	Aroylalkyl and hydroxyaralkyl derivatives of 4-(n-arylalkanamido)-piperidines and related compounds
NL284196A (nl) *	1961-10-10

1976
- 1976-01-13 US US05/648,685 patent/US3998834A/en not_active Expired - Lifetime
- 1976-02-23 NO NO760591A patent/NO146162C/no unknown
- 1976-02-24 NZ NZ180096A patent/NZ180096A/xx unknown
- 1976-02-27 SE SE7602740A patent/SE426486B/xx active Protection Beyond IP Right Term
- 1976-02-27 CA CA246,697A patent/CA1080232A/en not_active Expired
- 1976-03-09 LU LU74511A patent/LU74511A1/xx unknown
- 1976-03-10 FR FR7606870A patent/FR2303546A1/fr active Granted
- 1976-03-10 GB GB9593/76A patent/GB1538938A/en not_active Expired
- 1976-03-11 DE DE19762610228 patent/DE2610228A1/de active Granted
- 1976-03-11 HU HU76JA00000751A patent/HU172963B/hu unknown
- 1976-03-12 FI FI760646A patent/FI61481C/fi not_active IP Right Cessation
- 1976-03-12 SU SU762332950A patent/SU1227109A3/ru active
- 1976-03-12 BG BG032601A patent/BG28259A3/xx unknown
- 1976-03-12 CH CH310476A patent/CH629486A5/de not_active IP Right Cessation
- 1976-03-12 ES ES446034A patent/ES446034A1/es not_active Expired
- 1976-03-12 PL PL1976187910A patent/PL102474B1/pl unknown
- 1976-03-12 JP JP51026226A patent/JPS5946217B2/ja not_active Expired
- 1976-03-12 NL NLAANVRAGE7602612,A patent/NL185279C/nl not_active IP Right Cessation
- 1976-03-12 PT PT64898A patent/PT64898B/pt unknown
- 1976-03-12 CZ CS761632A patent/CZ278060B6/cs unknown
- 1976-03-12 PH PH18204A patent/PH12746A/en unknown
- 1976-03-12 IL IL49204A patent/IL49204A/xx unknown
- 1976-03-12 DK DK110376A patent/DK148960C/da not_active IP Right Cessation
- 1976-03-12 IT IT48556/76A patent/IT1057988B/it active
- 1976-03-12 AT AT184676A patent/AT359493B/de not_active IP Right Cessation
- 1976-03-12 IE IE527/76A patent/IE42512B1/en not_active IP Right Cessation
- 1976-03-12 YU YU652/76A patent/YU39960B/xx unknown
- 1976-03-15 AU AU12006/76A patent/AU503632B2/en not_active Expired

Also Published As

Publication number	Publication date
FR2303546B1 (nl)	1980-11-28
CZ278060B6 (en)	1993-08-11
IE42512B1 (en)	1980-08-27
IL49204A (en)	1979-11-30
NO760591L (nl)	1976-09-15
DK148960C (da)	1986-06-23
HU172963B (hu)	1979-01-28
FI61481B (fi)	1982-04-30
NZ180096A (en)	1978-06-02
CA1080232A (en)	1980-06-24
FR2303546A1 (fr)	1976-10-08
BG28259A3 (en)	1980-03-25
AT359493B (de)	1980-11-10
NO146162B (no)	1982-05-03
SE426486B (sv)	1983-01-24
DK110376A (da)	1976-09-15
JPS5946217B2 (ja)	1984-11-10
CZ163276A3 (en)	1993-03-17
NL7602612A (nl)	1976-09-16
PT64898B (en)	1977-08-18
LU74511A1 (nl)	1976-09-01
SU1227109A3 (ru)	1986-04-23
IL49204A0 (en)	1976-05-31
PH12746A (en)	1979-08-09
AU1200676A (en)	1977-09-22
YU39960B (en)	1985-06-30
PT64898A (en)	1976-04-01
CH629486A5 (de)	1982-04-30
IE42512L (en)	1976-09-14
US3998834A (en)	1976-12-21
YU65276A (en)	1982-08-31
FI61481C (fi)	1982-08-10
DK148960B (da)	1985-12-02
ATA184676A (de)	1980-04-15
FI760646A (nl)	1976-09-15
ES446034A1 (es)	1977-10-16
NL185279B (nl)	1989-10-02
AU503632B2 (en)	1979-09-13
DE2610228C2 (nl)	1990-04-05
DE2610228A1 (de)	1976-09-30
JPS51115478A (en)	1976-10-12
IT1057988B (it)	1982-03-30
GB1538938A (en)	1979-01-24
SE7602740L (sv)	1976-09-15
NO146162C (no)	1982-08-11
PL102474B1 (pl)	1979-03-31

Publication	Publication Date	Title
NL185279C (nl)	1990-03-01	Werkwijze ter bereiding van een farmaceutisch preparaat met analgetische werking en werkwijze ter bereiding van een gesubstitueerd n-(4-piperidinyl)-n-fenylamide of -carbamaat.
IT1062037B (it)	1983-06-25	Procedimento per la produzione di poliammine
NL179974B (nl)	1986-07-16	Werkwijze ter bereiding respectievelijk vervaardiging van een farmaceutisch preparaat met beta-adrenergisch stimulerende werking en werkwijze ter bereiding van daarbij bruikbare fenylethylaminederivaten.
ES462287A1 (es)	1978-12-01	Procedimiento para resolver acidos ciclopropangoicarboxili- cos sustituidos racemicos.
BG33006A3 (en)	1982-11-15	Method for obtaining of n- (perfluoracil)- n- phosphonomethyl- glycine compounds
BG25072A3 (bg)	1978-07-12	Метод за получаване на n-(1-бензилпиролидинил-2-алкил) субституирани бензамиди
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