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NL180381C - METHOD FOR PREPARING A 2- (4-ISOBUTYLPHENYL) PROPIONIC ACID ESTER CONTAINING MEDICINAL PRODUCT AND METHOD FOR PREPARING THE MEDICINAL COMPOUNDS - Google Patents

METHOD FOR PREPARING A 2- (4-ISOBUTYLPHENYL) PROPIONIC ACID ESTER CONTAINING MEDICINAL PRODUCT AND METHOD FOR PREPARING THE MEDICINAL COMPOUNDS

Info

Publication number
NL180381C
NL180381C NLAANVRAGE7614308,A NL7614308A NL180381C NL 180381 C NL180381 C NL 180381C NL 7614308 A NL7614308 A NL 7614308A NL 180381 C NL180381 C NL 180381C
Authority
NL
Netherlands
Prior art keywords
preparing
isobutylphenyl
acid ester
propionic acid
medicinal
Prior art date
Application number
NLAANVRAGE7614308,A
Other languages
Dutch (nl)
Other versions
NL7614308A (en
NL180381B (en
Original Assignee
Hisamitsu Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co filed Critical Hisamitsu Pharmaceutical Co
Publication of NL7614308A publication Critical patent/NL7614308A/en
Publication of NL180381B publication Critical patent/NL180381B/en
Application granted granted Critical
Publication of NL180381C publication Critical patent/NL180381C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
NLAANVRAGE7614308,A 1975-12-24 1976-12-23 METHOD FOR PREPARING A 2- (4-ISOBUTYLPHENYL) PROPIONIC ACID ESTER CONTAINING MEDICINAL PRODUCT AND METHOD FOR PREPARING THE MEDICINAL COMPOUNDS NL180381C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50156799A JPS5826744B2 (en) 1975-12-24 1975-12-24 Shinkinapropionsan Ester Yudou Tino Seizou

Publications (3)

Publication Number Publication Date
NL7614308A NL7614308A (en) 1977-06-28
NL180381B NL180381B (en) 1986-09-16
NL180381C true NL180381C (en) 1987-02-16

Family

ID=15635562

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7614308,A NL180381C (en) 1975-12-24 1976-12-23 METHOD FOR PREPARING A 2- (4-ISOBUTYLPHENYL) PROPIONIC ACID ESTER CONTAINING MEDICINAL PRODUCT AND METHOD FOR PREPARING THE MEDICINAL COMPOUNDS

Country Status (9)

Country Link
JP (1) JPS5826744B2 (en)
AU (1) AU507661B2 (en)
CA (1) CA1076134A (en)
CH (1) CH617919A5 (en)
DE (1) DE2658610C2 (en)
FR (1) FR2336126A1 (en)
GB (1) GB1573322A (en)
NL (1) NL180381C (en)
SE (1) SE433492B (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5517358A (en) * 1978-07-24 1980-02-06 Teikoku Seiyaku Kk Butyl propionate derivative, its preparation, and antiphlogistic and analgesic comprising it
JPS54144336A (en) * 1978-07-24 1979-11-10 Teikoku Seiyaku Kk Propionic acid propylester derivative*its manufacture and antiiinflammatory and sedative agent containing it
JPS5587770A (en) * 1978-12-27 1980-07-02 Hisamitsu Pharmaceut Co Inc Preparation of 2-(p-isobutylphenyl)propionic acid 2-pyridinemethyl ester
JPS57203035A (en) * 1981-06-05 1982-12-13 Taisho Pharmaceut Co Ltd Carboxylic acid ester
DE3225290A1 (en) * 1982-07-07 1984-01-12 Merck Patent Gmbh RING CONNECTIONS
YU43408B (en) * 1985-04-26 1989-06-30 Lek Tovarna Farmacevtskih Process for preparation of 2-(4-isobuthylphenyl)-prophiohydroxamic acid
JPH0635378B2 (en) * 1985-06-27 1994-05-11 ポ−ラ化成工業株式会社 Cosmetics
ES2004447A6 (en) * 1987-07-06 1989-01-01 Sune Coma Nuria New 2-(P-isobutylphenyl)-propionic acid ester and process for the preparation thereof.
DE3811118C1 (en) * 1988-03-31 1989-10-12 Merckle Gmbh, 7902 Blaubeuren, De
IT1217589B (en) * 1988-05-13 1990-03-30 Pulitzer Italiana ANTI-INFLAMMATORY AGENT FOR THERAPY OF PROSTATIC HYPERTROPHY, ITS PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
JPH0639449B2 (en) * 1989-04-10 1994-05-25 エーザイ株式会社 Polyprenyl compound, method for producing the same, and medicament containing the same
US6525214B1 (en) 1991-05-13 2003-02-25 Bernard John Armitage Therapeutic agent
US6399618B1 (en) * 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
CN103948571A (en) * 2006-07-18 2014-07-30 天津昕晨泰飞尔医药科技有限公司 Water-soluble ibuprofen prodrug with high skin penetration rate and positive charge
CN101506161B (en) * 2006-08-15 2013-11-13 于崇曦 Positively charged water-soluble prodrugs of aryl and heteroaryl propionic acids with fast skin penetration rate
MX377501B (en) 2007-06-04 2025-03-10 Techfields Inc NSAIAS PRODRUGS WITH SKIN AND MEMBRANES WITH VERY HIGH PENETRATION RATES AND NEW MEDICINAL USES.
EP2773378B1 (en) 2011-10-31 2016-08-10 Larsen, Claus Selch Prodrugs of non-steroid anti-inflammatory agents (nsaids)
US9557087B2 (en) 2012-12-13 2017-01-31 Whirlpool Corporation Clear ice making apparatus having an oscillation frequency and angle
US9500398B2 (en) 2012-12-13 2016-11-22 Whirlpool Corporation Twist harvest ice geometry
US9470448B2 (en) 2012-12-13 2016-10-18 Whirlpool Corporation Apparatus to warm plastic side of mold
US9273891B2 (en) 2012-12-13 2016-03-01 Whirlpool Corporation Rotational ice maker
CN105461731B (en) * 2014-08-07 2017-05-24 富力 Phillygenin ibuprofen ester, preparation and applications thereof
WO2016065269A2 (en) 2014-10-23 2016-04-28 Whirlpool Corporation Method and apparatus for increasing rate of ice production in an automatic ice maker
JP6153264B2 (en) * 2015-01-05 2017-06-28 テックフィールズ インコーポレイテッド NSAIA prodrug with very fast skin and membrane permeation rate and novel pharmaceutical use thereof
CN109134261A (en) * 2017-06-15 2019-01-04 北京蓝丹医药科技有限公司 A kind of loxoprofen derivative
CN109134262A (en) * 2017-06-15 2019-01-04 北京蓝丹医药科技有限公司 A kind of loxoprofen derivative
US10907874B2 (en) 2018-10-22 2021-02-02 Whirlpool Corporation Ice maker downspout

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents

Also Published As

Publication number Publication date
CH617919A5 (en) 1980-06-30
DE2658610A1 (en) 1977-07-07
GB1573322A (en) 1980-08-20
NL7614308A (en) 1977-06-28
SE433492B (en) 1984-05-28
CA1076134A (en) 1980-04-22
DE2658610C2 (en) 1982-12-23
FR2336126B1 (en) 1979-03-09
FR2336126A1 (en) 1977-07-22
SE7613651L (en) 1977-06-25
NL180381B (en) 1986-09-16
JPS5278848A (en) 1977-07-02
JPS5826744B2 (en) 1983-06-04
AU507661B2 (en) 1980-02-21
AU2087876A (en) 1978-06-29

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Legal Events

Date Code Title Description
BC A request for examination has been filed
A85 Still pending on 85-01-01
SNR Assignments of patents or rights arising from examined patent applications

Owner name: AB NYNAES PETROLEUM

V4 Lapsed because of reaching the maximum lifetime of a patent

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