NL176459B - Farmaceutisch preparaat met remmende werking op aldose-reductase, alsmede tricyclisch, gecondenseerd heterocyclisch imide. - Google Patents

Farmaceutisch preparaat met remmende werking op aldose-reductase, alsmede tricyclisch, gecondenseerd heterocyclisch imide.

Info

Publication number: NL176459B
Authority: NL; Netherlands
Prior art keywords: pharmaceutical preparation; aldose reductase; condensed heterocyclic; tricyclic condensed; heterocyclic imide
Prior art date: 1978-01-18

Application number

NLAANVRAGE7900354,A

Other languages

English (en)

Other versions

NL7900354A (nl

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-01-18

Filing date

1979-01-17

Publication date

1984-11-16

1979-01-17 Application filed by Pfizer filed Critical Pfizer

1979-07-20 Publication of NL7900354A publication Critical patent/NL7900354A/nl

1984-11-16 Publication of NL176459B publication Critical patent/NL176459B/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NLAANVRAGE7900354,A 1978-01-18 1979-01-17 Farmaceutisch preparaat met remmende werking op aldose-reductase, alsmede tricyclisch, gecondenseerd heterocyclisch imide. NL176459B (nl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/870,542 US4127665A (en)	1978-01-18	1978-01-18	Thienohydantoin derivatives

Publications (2)

Publication Number	Publication Date
NL7900354A NL7900354A (nl)	1979-07-20
NL176459B true NL176459B (nl)	1984-11-16

Family

ID=25355609

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NLAANVRAGE7900354,A NL176459B (nl)	1978-01-18	1979-01-17	Farmaceutisch preparaat met remmende werking op aldose-reductase, alsmede tricyclisch, gecondenseerd heterocyclisch imide.

Country Status (11)

Country	Link
US (1)	US4127665A (nl)
JP (1)	JPS54109975A (nl)
BE (1)	BE873500A (nl)
DE (1)	DE2901477C2 (nl)
DK (1)	DK151260C (nl)
FR (1)	FR2415112A1 (nl)
GB (1)	GB2012759B (nl)
IE (1)	IE47726B1 (nl)
IT (1)	IT1110007B (nl)
LU (1)	LU80795A1 (nl)
NL (1)	NL176459B (nl)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4147797A (en) *	1978-08-11	1979-04-03	Pfizer Inc.	Spiro-furanohydantoin derivatives
US4181728A (en) *	1978-11-16	1980-01-01	Pfizer Inc.	Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) *	1979-03-21	1980-01-01	Pfizer Inc.	Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4210667A (en) *	1979-04-19	1980-07-01	Pfizer Inc.	Pharmaceutical preparations containing coumarin carboxylic acid derivatives
IE50332B1 (en) *	1979-11-13	1986-04-02	Ici Ltd	1'-substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones,processes for their manufacture and pharmaceutical compositions thereof
DE3261684D1 (en) *	1981-05-12	1985-02-07	Ici Plc	Pyrrole derivatives
US4438272A (en)	1982-04-15	1984-03-20	Alcon Laboratories, Inc.	Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
US4436745A (en)	1982-04-15	1984-03-13	Alcon Laboratories, Inc.	Method of inhibiting aldose reductase activity
US4464385A (en) *	1982-04-15	1984-08-07	Alcon Laboratories, Inc.	Treatment of diabetic complications with hydantoins
US4540700A (en) *	1982-04-15	1985-09-10	Alcon Laboratories, Inc.	Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4537892A (en) *	1983-09-14	1985-08-27	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US5153211A (en) *	1983-09-14	1992-10-06	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US5070100A (en) *	1983-09-14	1991-12-03	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives
US4864028A (en) *	1983-09-14	1989-09-05	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives
US4680306A (en) *	1984-07-20	1987-07-14	Pfizer Inc.	Sprio-imidazolones for treatment of diabetes complications
US4966911A (en) *	1984-11-20	1990-10-30	Washington Research Foundation	Immunoregulatory agents
US5340829A (en) *	1984-11-20	1994-08-23	Washington Research Foundation	Immunoregulatory agents
JP2708507B2 (ja) *	1988-04-07	1998-02-04	株式会社三和化学研究所	（ｄ）‐６‐フルオロ‐２，３‐ジヒドロ‐２’，５’‐ジオキソ‐スピロ［４Ｈ‐１‐ベンゾピラン‐４，４’‐イミダゾリジン］‐２‐カルボキサミド誘導体、これらの製法及び用途
EP0536119A4 (en) *	1989-02-10	1993-08-04	Washington Research Foundation	Immunoregulatory agents
CN111560025A (zh)	2009-12-04	2020-08-21	桑诺维恩药品公司	多环化合物及其使用方法
EA201990400A1 (ru)	2016-07-29	2019-07-31	Суновион Фармасьютикалз, Инк.	Соединения и композиции и их применение
SG10202100751YA (en)	2016-07-29	2021-03-30	Sunovion Pharmaceuticals Inc	Compounds and compositions and uses thereof
IL268694B2 (en)	2017-02-16	2023-10-01	Sunovion Pharmaceuticals Inc	Treatment of schizophrenia
SG11202000669VA (en)	2017-08-02	2020-02-27	Sunovion Pharmaceuticals Inc	Isochroman compounds and uses thereof
CN112135827B (zh)	2018-02-16	2024-01-12	赛诺维信制药公司	盐、晶型及其制备方法
CA3130849A1 (en)	2019-03-14	2020-09-17	Sunovion Pharmaceuticals Inc.	Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
JP2023523569A (ja)	2020-04-14	2023-06-06	サノビオンファーマシューティカルズインク	神経学的および精神障害の治療方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB796069A (en) *	1955-12-23	1958-06-04	Ici Ltd	Substituted hydantoins
DE1135915B (de) *	1961-06-29	1962-09-06	Asta Werke Ag Chem Fab	Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
CA1088945A (en) *	1976-10-18	1980-11-04	Pfizer Limited	Hydantoin derivatives as therapeutic agents

1978
- 1978-01-18 US US05/870,542 patent/US4127665A/en not_active Expired - Lifetime
1979
- 1979-01-16 BE BE0/192915A patent/BE873500A/xx not_active IP Right Cessation
- 1979-01-16 LU LU80795A patent/LU80795A1/xx unknown
- 1979-01-16 DE DE2901477A patent/DE2901477C2/de not_active Expired
- 1979-01-17 FR FR7901155A patent/FR2415112A1/fr active Granted
- 1979-01-17 GB GB791692A patent/GB2012759B/en not_active Expired
- 1979-01-17 IT IT19369/79A patent/IT1110007B/it active
- 1979-01-17 JP JP444379A patent/JPS54109975A/ja active Granted
- 1979-01-17 DK DK019579A patent/DK151260C/da not_active IP Right Cessation
- 1979-01-17 NL NLAANVRAGE7900354,A patent/NL176459B/nl not_active IP Right Cessation
- 1979-01-30 IE IE88/79A patent/IE47726B1/en unknown

Also Published As

Publication number	Publication date
JPS612067B2 (nl)	1986-01-22
JPS54109975A (en)	1979-08-29
DK151260B (da)	1987-11-16
IT1110007B (it)	1985-12-23
IE47726B1 (en)	1984-05-30
DK151260C (da)	1988-05-09
US4127665A (en)	1978-11-28
NL7900354A (nl)	1979-07-20
BE873500A (fr)	1979-07-16
FR2415112B1 (nl)	1983-01-14
IT7919369A0 (it)	1979-01-17
GB2012759A (en)	1979-08-01
DE2901477C2 (de)	1982-06-09
FR2415112A1 (fr)	1979-08-17
GB2012759B (en)	1982-05-26
DK19579A (da)	1979-07-19
DE2901477A1 (de)	1979-07-19
IE790088L (en)	1979-07-18
LU80795A1 (fr)	1979-09-07

Publication	Publication Date	Title
NL176459B (nl)	1984-11-16	Farmaceutisch preparaat met remmende werking op aldose-reductase, alsmede tricyclisch, gecondenseerd heterocyclisch imide.
NL980035I2 (nl)	1999-03-01	Benzimidazolen, de bereiding daarvan en deze verbindingen bevattende geneesmiddelen.
FI872862A (fi)	1988-01-29	Foerfarande foer modifiering av substratmaterial foer anvaendning i roekningsartiklar och produkt framstaelld daermed.
NL930029I2 (nl)	1993-12-01	Enzymederivaten en bereiding daarvan.
NL7605499A (nl)	1976-12-07	Heupgewrichtsprotese.
IT7924811A0 (it)	1979-07-31	Acidi 2-pirrolidincarbossilici 5-sostituiti, antiipertensivi.
NL175016C (nl)	1984-09-17	Veldhakselaar.
NL7805814A (nl)	1979-08-15	Spiro-aminederivaten, de bereiding ervan, alsmede der- gelijke derivaten bevattende farmacologische prepara- ten.
NL190519B (nl)	1993-11-01	4-gesubstitueerde fenylazijnzuurverbindingen, alsmede farmaceutische preparaten.
NO790689L (no)	1979-09-04	Gjenstand med aapen ring.
NL7900104A (nl)	1979-07-09	Axiale borging.
IT7927614A0 (it)	1979-11-27	1,2,4,5-tetra-alchil-4-arilpiperidi ne e relative formulazioni farmaceutiche.
NL7902333A (nl)	1979-10-09	3-acetoxy-9beta,11beta-epoxy-trienen en -dienen en de bereiding van de overeenkomstige 6alpha-halogeen-1,4- -dieen-3-onen en 6alpha-halogeen-4-een-3-onen.
NL7903769A (nl)	1979-11-19	Di-o-n-alkylglycerolderivaten en farmaceutische preparaten daarvan.
NL7902726A (nl)	1979-10-15	Sulfonato-organosilanolverbindingen en preparaten, welke deze bevatten.
NO793590L (no)	1980-05-16	Fremgangsmaate til fremstilling av klordioksyd, alkalilut og eventuelt klor.
IT7925387A0 (it)	1979-08-30	2-amminoetil-1-fenil-indoline, loro preparazione e loro applicazione come medicamenti.
ATE8256T1 (de)	1984-07-15	Phenyliminomethyl-3-pyridin-derivate, ihre herstellung und verwendung.
ATE4563T1 (de)	1983-09-15	Sicherheitsanordnung.
ES244212Y (es)	1980-09-01	Llavero y recipiente combinados.
NL7903973A (nl)	1979-11-27	1,2,4-triazolidinonen-3 en thionen-3.
NO152971C (no)	1985-12-27	Analogifremgangsmaate for fremstilling av n-(1-metyl-2-pyrrolidinyl-metyl)-2,3-dimetoksy-5-metylsulfamoyl-benzamid og derivater derav.
NL190120C (nl)	1993-11-01	2,3-dihydro-4h-1-benzopyran-4-on-0-carbamoyloximen alsmede farmaceutisch preparaat daarvan.
IT7923000A0 (it)	1979-05-25	Arilalchil-e arilossialchil-fosfonati e loro preparazione.
IT8020503A0 (it)	1980-03-11	Derivati della 1,1'-bifenil-2-ilalchilammina ad azione farmaceutica.

Legal Events

Date	Code	Title
1979-08-10	A1A	A request for search or an international-type search has been filed
1980-07-25	BB	A search report has been drawn up
1980-10-27	BC	A request for examination has been filed
1985-01-01	A85	Still pending on 85-01-01
1992-09-16	V1	Lapsed because of non-payment of the annual fee