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NI201100035A - Agentes antifúngicos. - Google Patents

Agentes antifúngicos.

Info

Publication number
NI201100035A
NI201100035A NI201100035A NI201100035A NI201100035A NI 201100035 A NI201100035 A NI 201100035A NI 201100035 A NI201100035 A NI 201100035A NI 201100035 A NI201100035 A NI 201100035A NI 201100035 A NI201100035 A NI 201100035A
Authority
NI
Nicaragua
Prior art keywords
compounds
prodrugs
hydrates
antifungal agents
compositions
Prior art date
Application number
NI201100035A
Other languages
English (en)
Inventor
L Greenlee Mark
Apgar James
Meng Dongfang
Wilkening Robert
James Wildonger Kenneth
L Parker Dann Jr
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NI201100035(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NI201100035A publication Critical patent/NI201100035A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen novedosos derivados de enfumafungina, junto con sus sales, hidratos y prodrogas farmacéuticamente aceptables. También se describen composiciones que comprenden dichos compuestos, métodos para preparar dichos compuestos y métodos para usar dichos compuestos como agentes antifúngicos y/o inhibidores de (1,3)-Beta-D-glucan sintasa. Los compuestos descriptos, sus sales, hidratos y prodrogas farmacéuticamente aceptables, así como las composiciones que comprenden dichas sales, hidratos y prodrogas, son útiles para tratar y/o prevenir infecciones fúngicas y enfermedades y afecciones asociadas.
NI201100035A 2008-08-12 2011-02-10 Agentes antifúngicos. NI201100035A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13610608P 2008-08-12 2008-08-12

Publications (1)

Publication Number Publication Date
NI201100035A true NI201100035A (es) 2011-09-20

Family

ID=41669132

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201100035A NI201100035A (es) 2008-08-12 2011-02-10 Agentes antifúngicos.

Country Status (30)

Country Link
EP (1) EP2326172B1 (es)
KR (1) KR101686075B1 (es)
AR (1) AR073037A1 (es)
BR (1) BRPI0912074B1 (es)
CL (1) CL2011000292A1 (es)
CO (1) CO6351686A2 (es)
CR (1) CR20110075A (es)
DK (1) DK2326172T3 (es)
DO (1) DOP2011000053A (es)
EA (1) EA018337B1 (es)
ES (1) ES2526652T3 (es)
GT (1) GT201100039A (es)
HN (1) HN2011000404A (es)
HR (1) HRP20150009T1 (es)
IL (2) IL210975A (es)
MA (1) MA32628B1 (es)
MX (1) MX2011001656A (es)
MY (1) MY156955A (es)
NI (1) NI201100035A (es)
NZ (1) NZ590914A (es)
PE (1) PE20110676A1 (es)
PL (1) PL2326172T3 (es)
PT (1) PT2326172E (es)
RS (1) RS53731B1 (es)
SI (1) SI2326172T1 (es)
SV (1) SV2011003839A (es)
TW (1) TWI439458B (es)
UA (1) UA105639C2 (es)
WO (1) WO2010019203A1 (es)
ZA (1) ZA201100788B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3247711T3 (pl) 2015-01-19 2022-06-27 Scynexis, Inc. Nowoczesne sole i polimorfy scy-078
JP7263313B2 (ja) 2017-04-10 2023-04-24 サイネクシス，インコーポレーテッド 併用される抗真菌剤
RS63746B1 (sr) * 2017-08-04 2022-12-30 Scynexis Inc Antifungalni agensi sa pojačanom aktivnošću u kiseloj ph
JP7562542B2 (ja) * 2019-01-30 2024-10-07 サイネクシス，インコーポレーテッド 真菌性骨－関節感染症を治療するためのトリテルペノイド系抗真菌薬
CN113905733A (zh) * 2019-05-16 2022-01-07 西尼克斯公司 用于消除耳念珠菌移生的如依贝瑞芬赫普的抗真菌剂
WO2021239992A1 (en) 2020-05-29 2021-12-02 Centre National De La Recherche Scientifique Antifungal prodrugs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
JP3834062B2 (ja) * 1996-01-31 2006-10-18 メルク エンド カンパニー インコーポレーテッド 抗真菌剤
CN1705657A (zh) * 2002-04-17 2005-12-07 兰贝克赛实验室有限公司 作为抗真菌剂的吡咯衍生物
CN101454010B (zh) * 2006-04-03 2012-06-20 默克夏普和道赫莫公司 抗真菌剂

Also Published As

Publication number Publication date
MA32628B1 (fr) 2011-09-01
DK2326172T3 (da) 2015-01-26
HRP20150009T1 (hr) 2015-02-27
HK1158017A1 (en) 2012-07-13
EA018337B1 (ru) 2013-07-30
AR073037A1 (es) 2010-10-06
UA105639C2 (uk) 2014-06-10
RS53731B1 (en) 2015-06-30
TW201011004A (en) 2010-03-16
EP2326172B1 (en) 2014-10-22
KR20110045054A (ko) 2011-05-03
IL210975A (en) 2015-10-29
MY156955A (en) 2016-04-15
BRPI0912074B1 (pt) 2021-08-03
KR101686075B1 (ko) 2016-12-13
HN2011000404A (es) 2013-09-23
ZA201100788B (en) 2012-05-01
PE20110676A1 (es) 2011-09-23
CL2011000292A1 (es) 2011-11-04
WO2010019203A1 (en) 2010-02-18
EA201100350A1 (ru) 2011-08-30
TWI439458B (zh) 2014-06-01
DOP2011000053A (es) 2011-04-30
PL2326172T3 (pl) 2015-03-31
EP2326172A1 (en) 2011-06-01
BRPI0912074A2 (pt) 2018-10-02
CR20110075A (es) 2011-06-03
EP2326172A4 (en) 2012-06-06
MX2011001656A (es) 2011-05-25
SI2326172T1 (sl) 2015-02-27
SV2011003839A (es) 2011-07-06
IL210975A0 (en) 2011-04-28
IL242031A0 (en) 2015-11-30
PT2326172E (pt) 2015-02-04
GT201100039A (es) 2013-08-21
ES2526652T3 (es) 2015-01-14
NZ590914A (en) 2011-11-25
WO2010019203A8 (en) 2011-03-17
CO6351686A2 (es) 2011-12-20

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