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MY193807A - T-cell receptor and uses thereof - Google Patents

T-cell receptor and uses thereof

Info

Publication number
MY193807A
MY193807A MYPI2018701841A MYPI2018701841A MY193807A MY 193807 A MY193807 A MY 193807A MY PI2018701841 A MYPI2018701841 A MY PI2018701841A MY PI2018701841 A MYPI2018701841 A MY PI2018701841A MY 193807 A MY193807 A MY 193807A
Authority
MY
Malaysia
Prior art keywords
cell receptor
seq
amino acid
acid sequence
set forth
Prior art date
Application number
MYPI2018701841A
Inventor
Steven P Lee
Original Assignee
Cancer Research Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Tech Ltd filed Critical Cancer Research Tech Ltd
Publication of MY193807A publication Critical patent/MY193807A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to a T-cell receptor comprising: a) an alpha chain comprising an amino acid sequence as set forth in SEQ ID No.1 or a functional equivalent thereof; and/or b) a beta chain comprising an amino acid sequence as set forth in SEQ ID No.2 or a functional equivalent thereof; as well as uses thereof including in the treatment of an EBV+ tumour. Figure 1.
MYPI2018701841A 2015-11-16 2016-11-15 T-cell receptor and uses thereof MY193807A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1520191.6A GB201520191D0 (en) 2015-11-16 2015-11-16 T-cell receptor and uses thereof
PCT/GB2016/053566 WO2017085471A1 (en) 2015-11-16 2016-11-15 T-cell receptor and uses thereof

Publications (1)

Publication Number Publication Date
MY193807A true MY193807A (en) 2022-10-27

Family

ID=55132860

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2018701841A MY193807A (en) 2015-11-16 2016-11-15 T-cell receptor and uses thereof

Country Status (6)

Country Link
CN (1) CN108602875B (en)
GB (1) GB201520191D0 (en)
HK (1) HK1258886A1 (en)
MY (1) MY193807A (en)
SG (1) SG11201803942QA (en)
WO (1) WO2017085471A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210380657A1 (en) * 2018-10-25 2021-12-09 The Council Of The Queensland Institute Of Medical Research T-Cell Receptors and Uses Thereof
US12139523B2 (en) 2018-11-27 2024-11-12 Duke University Anti-LMP2 TCR-T cell therapy for the treatment of EBV-associated cancers
CN113423724B (en) * 2018-12-27 2023-11-24 深圳华大生命科学研究院 EBV epitope high affinity T cell receptor
CN111848781A (en) * 2019-04-25 2020-10-30 天津亨佳生物科技发展有限公司 Specific T cell receptor aiming at EGFR L858R gene mutation and application thereof
CN113621070A (en) * 2020-05-06 2021-11-09 华夏英泰（北京）生物技术有限公司 T cell antigen receptor, polymer compound thereof, preparation method and application thereof
CN112940108B (en) * 2021-03-19 2022-10-14 河南省肿瘤医院 T cell receptor for identifying EBV antigen and application of T cell receptor
WO2023092452A1 (en) * 2021-11-26 2023-06-01 上海吉倍生物技术有限公司 T cell receptor for identifying ebv lmp2 antigen and use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361539A (en) 1980-05-05 1982-11-30 Instrumentation Laboratory Inc. Analysis system
US6750325B1 (en) 1989-12-21 2004-06-15 Celltech R&D Limited CD3 specific recombinant antibody
GB9021679D0 (en) 1990-10-05 1990-11-21 Gorman Scott David Antibody preparation
US5968509A (en) 1990-10-05 1999-10-19 Btp International Limited Antibodies with binding affinity for the CD3 antigen
GB9206422D0 (en) 1992-03-24 1992-05-06 Bolt Sarah L Antibody preparation
CA2523716C (en) 2003-05-31 2014-11-25 Micromet Ag Human anti-human cd3 binding molecules
EP1765873A4 (en) 2004-07-01 2009-07-01 Waratah Pharmaceuticals Inc Methods and compositions using cd3 agonists
JP5292550B2 (en) * 2007-03-23 2013-09-18 静岡県 T cell receptor β chain gene and α chain gene
CN101182531B (en) * 2007-11-09 2010-06-02 暨南大学 Recombinant plasmid related to EBV-specific TCR gene and method for constructing anti-EBV-specific CTL
GB0917090D0 (en) * 2009-09-29 2009-11-11 Ucl Biomedica Plc T-cell receptor
WO2012038055A1 (en) * 2010-09-20 2012-03-29 Unicell Gmbh Antigen-specific t cell receptors and t cell epitopes
GB201314404D0 (en) * 2013-08-12 2013-09-25 Immunocore Ltd T Cell Receptors

Also Published As

Publication number Publication date
CN108602875A (en) 2018-09-28
CN108602875B (en) 2022-08-12
WO2017085471A1 (en) 2017-05-26
SG11201803942QA (en) 2018-06-28
GB201520191D0 (en) 2015-12-30
HK1258886A1 (en) 2019-11-22

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