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Application filed by Targacept IncfiledCriticalTargacept Inc
Priority to MYPI20070724priorityCriticalpatent/MY152146A/en
Publication of MY152146ApublicationCriticalpatent/MY152146A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PATIENTS SUSCEPTIBLE TO OR SUFFERING FROM CONDITIONS AND DISORDERS, SUCH AS CENTRAL NERVOUS SYSTEM DISORDERS, ARE TREATED BY ADMINISTERING TO A PATIENT IN NEED THEREOF COMPOSITIONS THAT ARE HYDROXYBENZOATE SALTS OF E-METANICOTINE-TYPE COMPOUNDS. THE FORMATION OF HYDROXYBENZOATE SALTS OF THE E-METANICOTINE COMPOUNDS IS ALSO USEFUL IN PURIFYING THE E-METANICOTINE COMPOUNDS, AS THE HYDROXYBENZOATE SALTS TEND TO CRYSTALLIZE OUT, LEAVING IMPURITIES SUCH AS Z-METANICOTINE COMPOUNDS, AND COMPOUNDS WHERE THE DOUBLE BOND HAS MIGRATED, IN SOLUTION. IF DESIRED, THE HYDROXYBENZOATE SALTS CAN BE CONVERTED TO EITHER THE FREE BASE (THE E-METANICOTINE) OR TO ANOTHER PHARMACEUTICALLY ACCEPTABLE SALT FORM.
MYPI200707242007-05-102007-05-10Hydroxybenzoate salts of metanicotine compounds
MY152146A
(en)
Piperidine sulfonamide derivatives, process for their preparation, medicaments containing them and use thereof for the preparation of medicaments for therapy