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MY135359A - New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof - Google Patents

New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof

Info

Publication number
MY135359A
MY135359A MYPI20040880A MYPI20040880A MY135359A MY 135359 A MY135359 A MY 135359A MY PI20040880 A MYPI20040880 A MY PI20040880A MY PI20040880 A MYPI20040880 A MY PI20040880A MY 135359 A MY135359 A MY 135359A
Authority
MY
Malaysia
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
new process
Prior art date
Application number
MYPI20040880A
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MY135359A publication Critical patent/MY135359A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCESS FOR THE SYNTHESIS OF PERINDOPRIL OF FORMULA (I): AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.
MYPI20040880A 2003-03-12 2004-03-12 New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof MY135359A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290605A EP1321471B1 (en) 2003-03-12 2003-03-12 Method for synthesis of perindopril and its pharmaceutically acceptable salts

Publications (1)

Publication Number Publication Date
MY135359A true MY135359A (en) 2008-03-31

Family

ID=8185877

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20040880A MY135359A (en) 2003-03-12 2004-03-12 New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof

Country Status (10)

Country Link
EP (1) EP1321471B1 (en)
AR (1) AR043567A1 (en)
AT (1) ATE294814T1 (en)
DE (1) DE60300581T2 (en)
DK (1) DK1321471T3 (en)
ES (1) ES2240919T3 (en)
MY (1) MY135359A (en)
PT (1) PT1321471E (en)
SI (1) SI1321471T1 (en)
WO (1) WO2004083238A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1367061B1 (en) * 2003-06-30 2006-01-04 Les Laboratoires Servier Method for synthesis of perindopril and its pharmaceutically acceptable salts
PT1362864E (en) 2003-06-30 2007-07-23 Servier Lab Method for synthesis of perindopril and its pharmaceutically acceptable salts
SI1367062T1 (en) * 2003-07-31 2006-12-31 Servier Lab Method for synthesis of perindopril and its pharmaceutically acceptable salts
DE60302287T2 (en) 2003-08-29 2006-08-10 Les Laboratoires Servier Process for the synthesis of perindopril and its pharmaceutically acceptable salts
DK1380590T3 (en) 2003-08-29 2007-01-08 Servier Lab New method for synthesis of perindopril and pharmaceutically acceptable salts thereof
BRPI0614622A2 (en) * 2005-08-12 2011-04-12 Lek Pharmaceuticals Process for the preparation of perindopril erbumin
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
FR2807431B1 (en) * 2000-04-06 2002-07-19 Adir NOVEL PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
FR2827860B1 (en) * 2001-07-24 2004-12-10 Servier Lab NOVEL PROCESS FOR SYNTHESIS OF ACID DERIVATIVES (2S, 3AS, 7AS) -1 - [(S) -ALANYL] -OCTAHYDRO-1H-INDOLE-2-CARBOXYLINE AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL

Also Published As

Publication number Publication date
DE60300581D1 (en) 2005-06-09
EP1321471A1 (en) 2003-06-25
SI1321471T1 (en) 2005-08-31
ES2240919T3 (en) 2005-10-16
DE60300581T2 (en) 2006-01-19
AR043567A1 (en) 2005-08-03
WO2004083238A1 (en) 2004-09-30
DK1321471T3 (en) 2005-08-29
PT1321471E (en) 2005-07-29
EP1321471B1 (en) 2005-05-04
ATE294814T1 (en) 2005-05-15

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