[go: up one dir, main page]

MY119473A - Novel counterparts of camptothecin, their application as medicine and pharmaceutical compositions containing them - Google Patents

Novel counterparts of camptothecin, their application as medicine and pharmaceutical compositions containing them

Info

Publication number
MY119473A
MY119473A MYPI97006088A MYPI9706088A MY119473A MY 119473 A MY119473 A MY 119473A MY PI97006088 A MYPI97006088 A MY PI97006088A MY PI9706088 A MYPI9706088 A MY PI9706088A MY 119473 A MY119473 A MY 119473A
Authority
MY
Malaysia
Prior art keywords
pharmaceutical compositions
camptothecin
counterparts
medicine
novel
Prior art date
Application number
MYPI97006088A
Inventor
Bigg Dennis
Lavergne Olivier
Pla Rodas Francesc
Pommier Jacques
Ulibarri Gerard
Original Assignee
Ipsen Pharma Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Pharma Sas filed Critical Ipsen Pharma Sas
Publication of MY119473A publication Critical patent/MY119473A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

THE INVENTION CONCERNS NEW CAMPTOTHECIN ANALOGUES AND ESPECIALLY PRODUCTS CORRESPONDING TO THE FOLLOWING FORMULAE: -5-ETHYL-9,10-DIFLUORO-4,5-DIHYDRO-5-HYDROXY-12-(4-METHYLPIPERIDINOMETHYL)-1H-OXEPINO [3',4’:6, 7]INDOLIZINO[1,2-B] QUINOLINE-3,15( 4H,13H)-DIONE; -5-ETHYL-12-DIETHYLAMINOMETHYL-9-FLUORO-4,5-DIHYDRO-5-HYDROXY-L0-METHYL-LHOXEPINO[ 3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,15( 4H,13H)-DIONE; -5-ETHYL-9-FLUORO-4,5-DIHYDRO-5-HYDROXY-10-METHYL-12-(4-METHYLPIPERIDINOMETHYL)-1HOXEPINO[ 3',4':6,7]INDOLIZINO[1 ,2-B] QUINOLINE-3,15(4H, 13H)-DIONE; THEIR USE AS MEDICINES, THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE PREPARATION OF ANTI-TUMORAL, ANTI-VIRAL AND ANTI-PARASITIC MEDICINES.
MYPI97006088A 1996-12-20 1997-12-17 Novel counterparts of camptothecin, their application as medicine and pharmaceutical compositions containing them MY119473A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615774A FR2757514B1 (en) 1996-12-20 1996-12-20 NOVEL CAMPTOTHECIN ANALOGS, PREPARATION METHODS, USE THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
MY119473A true MY119473A (en) 2005-05-31

Family

ID=9498938

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI97006088A MY119473A (en) 1996-12-20 1997-12-17 Novel counterparts of camptothecin, their application as medicine and pharmaceutical compositions containing them

Country Status (26)

Country Link
EP (1) EP0946567B1 (en)
JP (2) JP3576175B2 (en)
KR (1) KR100516874B1 (en)
CN (1) CN1097056C (en)
AR (1) AR008543A1 (en)
AT (1) ATE248177T1 (en)
AU (1) AU734485B2 (en)
BR (1) BR9714170A (en)
CA (1) CA2275351C (en)
CZ (1) CZ299795B6 (en)
DE (1) DE69724453T2 (en)
DK (1) DK0946567T3 (en)
ES (1) ES2206761T3 (en)
FR (1) FR2757514B1 (en)
HK (1) HK1024695A1 (en)
HU (1) HUP9904210A3 (en)
MX (1) MXPA99005776A (en)
MY (1) MY119473A (en)
NO (1) NO326464B1 (en)
NZ (1) NZ335939A (en)
PL (1) PL188181B1 (en)
PT (1) PT946567E (en)
RU (1) RU2194051C2 (en)
UA (1) UA57758C2 (en)
WO (1) WO1998028305A1 (en)
ZA (1) ZA9711129B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (en) 1999-02-26 2004-09-10 Sod Conseils Rech Applic NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS AND PROCESSES FOR THEIR PREPARATION
US6291676B1 (en) * 1999-03-03 2001-09-18 University Of Kentucky Research Foundation Water-soluble derivatives of camptothecin/homocamptothecin
US6207832B1 (en) * 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
AU3455100A (en) * 1999-05-28 2000-12-18 Nippon Chemiphar Co. Ltd. Process for the preparation of 2-halo-3-(3-quinolyl)propionic acid derivatives
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
AU2003225642A1 (en) * 2002-03-01 2003-09-16 Fluorous Techonologies Inc Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
ITRM20040288A1 (en) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti USE OF 7-T-BUTOXYIMINOMETHYL CAMPTOTECIN FOR THE PREPARATION OF A MEDICATION FOR THE TREATMENT OF UTERUS NEOPLASIES.
JP2008513437A (en) * 2004-09-21 2008-05-01 ソシエテ ド コンセイユ ド ルシェルシェ エ ダアップリカーション シャンティフィック（エス．セー．エール．アー．エス．） Novel process for the production of useful intermediates
CN102746314B (en) * 2011-04-18 2016-07-06 华东师范大学 Containing stablizing the camptothecine compounds of 7 yuan of lactonic rings, preparation method and purposes
WO2023232145A1 (en) * 2022-06-02 2023-12-07 华东师范大学 Small molecule of homocamptothecins and use thereof
WO2024230752A1 (en) * 2023-05-08 2024-11-14 甘李药业股份有限公司 Camptothecin derivative, linker, ligand-drug conjugate and medical use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011376A1 (en) * 1992-07-23 1994-05-26 Sloan-Kettering Institute For Cancer Research Camptothecin analogues and methods of preparation thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000876A1 (en) * 1995-06-21 1997-01-09 Societe De Conseils De Recherches Et D'applications Scientifiques (Scras) Novel camptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011376A1 (en) * 1992-07-23 1994-05-26 Sloan-Kettering Institute For Cancer Research Camptothecin analogues and methods of preparation thereof

Also Published As

Publication number Publication date
CA2275351C (en) 2008-10-14
WO1998028305A1 (en) 1998-07-02
CN1241191A (en) 2000-01-12
DE69724453D1 (en) 2003-10-02
PL188181B1 (en) 2004-12-31
ES2206761T3 (en) 2004-05-16
CA2275351A1 (en) 1998-07-02
ZA9711129B (en) 1999-05-03
PL334125A1 (en) 2000-02-14
AU734485B2 (en) 2001-06-14
KR100516874B1 (en) 2005-09-26
DK0946567T3 (en) 2003-12-22
JP2001505922A (en) 2001-05-08
UA57758C2 (en) 2003-07-15
BR9714170A (en) 2000-02-29
HUP9904210A3 (en) 2000-09-28
JP2004115535A (en) 2004-04-15
CZ299795B6 (en) 2008-11-26
HUP9904210A2 (en) 2000-05-28
EP0946567A1 (en) 1999-10-06
AU5326598A (en) 1998-07-17
PT946567E (en) 2004-01-30
FR2757514A1 (en) 1998-06-26
AR008543A1 (en) 2000-01-19
NO992998D0 (en) 1999-06-18
ATE248177T1 (en) 2003-09-15
DE69724453T2 (en) 2004-06-09
EP0946567B1 (en) 2003-08-27
KR20000069608A (en) 2000-11-25
CN1097056C (en) 2002-12-25
JP3576175B2 (en) 2004-10-13
MXPA99005776A (en) 2004-08-31
RU2194051C2 (en) 2002-12-10
NO992998L (en) 1999-08-18
NZ335939A (en) 2000-04-28
HK1024695A1 (en) 2000-10-20
CZ220599A3 (en) 1999-09-15
FR2757514B1 (en) 1999-02-12
NO326464B1 (en) 2008-12-08

Similar Documents

Publication Publication Date Title
EP0275005A3 (en) Complex compounds of bioflavonoids with phospholipids, their preparation and use, and pharmaceutical and cosmetic compositions containing them
JO1502B1 (en) Novel pharmacological compounds
IL105727A (en) 7-(2-mercapto-acetamido)-octahydro-6-oxopyrido[2,1-a][2]-benzazepine derivatives analogs thereof their preparation and pharmaceutical enkephalinase-inhibiting compositions containing them
CS653586A3 (en) Pharmaceutical containing 7-isopropoxyisoflavone
NZ516347A (en) Indanyl-substituted benzenecarboxamides, process for their preparation, their use as a medicament and pharmaceutical formulations containing them
BG103417A (en) Condensed pyrimidine bicyclic derivatives
IL132763A0 (en) Novel compounds
MY117585A (en) New tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them.
HUP0204143A3 (en) Tricyclic 1-benzylpyrazole-3-carboxylic acid derivatives, preparation of the compounds, their use and pharmaceutical compositions containing them
PT86186A (en) Process for the preparation of benzimidazol derivatives and of pharmaceutical compositions containing the same
MY119473A (en) Novel counterparts of camptothecin, their application as medicine and pharmaceutical compositions containing them
MY122042A (en) Pro-drugs and counterparts of camptothecin, their application as medicines
FI945807A0 (en) 2,5-Dioxo-2,5-dihydro-1H-benz [b] azepines as NMDA receptor antagonists
HUP9900987A3 (en) Camptothecin derivatives process for their preparation, use thereof as antitumor agents and pharmaceutical compositions containing them
CA2078869A1 (en) Pharmaceutical compositions containing ipriflavone, process for the preparation thereof and relative therapeutic use
BG106893A (en) NOVEL SUBSTITUTED PYRAZOLO[4,3-e]DIAZEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE AS MEDICINAL PRODUCTS AND PROCESSES FOR PREPARING THEM
US5378844B1 (en) 8-(1-aminocycloalkyl)-1,3-dialkylxanthine derivatives preparation process and antidepressant nootropic and psychostimulant composition thereof
HU9800395D0 (en) Sulfonamide-substituted anellated compounds of seven ring, their use as medicines and pharmaceutical compositions containing them
MY103593A (en) Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
IL106289A0 (en) Phospholipid derivatives, their preparation and pharmaceutical compositions containing them
IL105867A0 (en) Derivatives of substituted imidazo benzoxazin-1-one,their preparation and pharmaceutical compositions containing them
KR960033455A (en) Anticancer composition
AU605822C (en) Tricyclic benzimidazoles, processes for the preparation thereof and pharmaceutical compositions containing them
JO1531B1 (en) Novel pharmacological compounds
AU6975891A (en) Pharmaceutical compositions for the treatment of drug dependence