MXPA98005216A - Pla repellent - Google Patents

Abstract

This invention provides a pest repellent of the type that is not only applied directly to the skin but is capable of preventing damage from harmful insects, especially blood suckers such as mosquitoes and flies, by inhibiting them from entering the interior of the room. The pest repellent is characterized because it contains hyssop oil as an active ingredient.

Description

RQpgjgntg dt? pl »gfta The present invention relates to a pest repellent.

So far, to protect human and animal bodies from blood sucking insects such as mosquitoes and flies, pest repellents such as N, N-diethyl-m-toluamide (hereinafter referred to as "DEET") have been used by applying them directly to the skin of humans and animals. However, a satisfactory plague repellent effect of DEET has not been obtained by atomizing the compound inside a house or containing the compound in an appropriate vehicle or by placing it inside a house, next to the direct application box To the skin.

The object of the present invention is to provide a pest repellent that can be effectively used not only in direct application to the skin but also in various other ways of use including atomization inside a house or on a piece of furniture.

As a review of the studies aimed at solving a pest repellent that can respond to the above objective, the present inventors found that the oil REF: 27748 hyssop is useful as an active ingredient of pest repellents and responds to the present invention.

Thus, the present invention relates to a pest repellent using hyssop oil as an active ingredient, and to a pest repellent method using hyssop oil. A pest can be effectively repelled according to the present method.

The hyssop oil used in the present invention is an essential oil of a hyssop plant (HVSSODUS officinalis L.) obtainable for steam distillation of dried or green hyssop herbs. Hyssop oil is commercially available from, for example, Takasago Koryo KK and Hasegawa Koryo KK, and commercially available swab oil can be used as is.

Pests against which the repellent of the present invention is effective include harmful invertebrates, for example, arthropods such as insects, arachnids, crustaceans, chilopoda, and molluscs such as snails and slugs. Examples of insects include harmful insects of the order of Diptera, for example, anopheles, aedos such as Aedes aesypti and Aedes albopictus. culexos such as Culex pjpiens and Culex tritaeniorhynchus. midge, stable fly, sand fly, biting water fly, housefly, vinegar and moth flies; of the order of Dictióptera such as German cockroach, coffee roach cockroach, American cockroach, brown cockroach and oriental cockroach, of the order of Coleoptera such as rice weevil, adzuki bean weevil, red flour beetle, black carpet beetle, various beetles of the carpet, wood sprayer beetle and Paederus fuscipes; of the order of Hymenoptera such as ants, apterous wasps and betilid wasps; of the order of Sifonaotera such as Pulex; of the order of Anoplura such as Pediculus humanus and Phthirus pubis; and of the order of Isoptera such as Reticulitermes speratus and Coototermes formosanus. Examples of arachnids include house dust mites such as common grain mites, Dermatophasoides farinae and Queiletid mites, Ornithonysus bacoti, Ixodides such as Boophilus microplus and spider3. Examples of crustaceans include Oniscoidea such as dirty tick and wood louse. Examples of chilopoda include centipedes and millipedes. Examples of diplópodos include caterpillar. The pest repellent of the present invention can also be applied to plants to inhibit the behavior of the sap sucker of the aphids, whereby the propagation of the host of infectious virus in plant disease is avoided. Therefore, the pest repellent of the present invention can be used for the purpose of protecting plants.

In the present invention, the swab oil could be used directly to repel the pests, but usually a vehicle is added to the swab oil to form a liquid formulation (such as an aerosol), cream or the like, or the swab oil is impregnated in a synthetic resin to form a resin mold. Also, the swab oil could be impregnated in an unglazed paper, clothing or pottery, or it could be formulated in a gel-like formulation, and subsequently used.

As the vehicle used in formulations in liquid form, for example, water, can be used; alcohols such as methanol, ethanol, glycerin and polyethylene glycol; ethers such as tetrahydrofuran and dioxane; aliphatic hydrocarbons such as hexane, kerosene, paraffin and petroleum benzine; and esters such as ethyl acetate.

In liquid formulations, it is possible to combine commonly used adjuvants or auxiliary agents such as emulsifying or dispersing agent, diffusing agent, moisturizing agent, suspending agent, preservative, blowing agent and film-forming agent. Examples of emulsifying or dispersing agents used in the present invention include soaps, ethers of polyoxyethylene fatty acid alcohols such as polyoxyethylene oleyl ether, alkylaryl polyoxyethylene ethers such as polyoxyethylene nonylphenyl ether, esters of polyoxyethylene fatty acids, fatty acid glyceride. esters of sorbitan fatty acids, sulfur esters of higher alcohols, and alkylaryl sulfonates such as sodium dodecylbenzenesulfonate; examples of the diffusion and humidifying agents include glycerin and polyethylene glycol; examples of the suspending agents include casein, gelatin, alginic acid, carboxymethyl cellulose, gum arabic, hydroxypropyl cellulose and bentonite; examples of preservatives include methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, and butyl p-hydroxybenzoate; examples of the impellents include dimethyl ether, chlorofluorocarbons and carbon dioxide; and examples of film-forming agents include nitrocellulose derivatives, acetyl cellulose, acetylbutyl cellulose, vinyl resins such as vinyl acetate resin and polyvinyl alcohol.

The vehicles used in the preparation of cream formulations include hydrocarbons such as liquid paraffin, petrolatum and paraffin; silicones such as dimethylsiloxane, colloidal silica and bentonite; monohydric alcohols such as ethanol, stearyl alcohol, lauryl alcohol and cetyl alcohol; polyhydric alcohols such as polyethylene glycol, ethylene glycol and glycerin; carboxylic acids such as lauric acid and stearic acid; and esters such as wax and lanolin. In cream formulations, adjuvants or auxiliary agents may be combined as used in liquid formulations.

The synthetic resins used to form the resin molds include polyethylene; Polypropylene; ethylene copolymers and monomers having polar groups, such as ethylene vinyl acetate copolymer, ethylene methyl acrylate (or methacrylate) copolymer, ethylene ethyl acrylate copolymer and ethylene vinyl acetate (or methacrylate) acrylate copolymer ); and synthetic resins containing chlorine such as polyvinyl chloride and polyvinylidene chloride. Of these substances, the ethylene vinyl acetate copolymer or the ethylene methyl methacrylate copolymer is preferred in view of the thermoforming properties (low temperature processability), and the absorbent properties of hyssop oil, diffusibility and stability.

Impregnation of the swab oil in the synthetic resin can be effected by having the swab oil impregnated directly into the synthetic base resin or after dissolving the swab oil in an appropriate solvent such as acetone, or mixing the swab oil and a synthetic resin in a state of fusion. In the latter case, a process could be employed in which the master granules are prepared by first mixing the hyssop oil at a high concentration and a synthetic resin at a high concentration in a melting state, and these master granules, either directly or then they are diluted with the synthetic base resin by containing a predetermined amount of the swab oil, they are molded into a desired product such as film, sheet, mesh, etc., by a method usually used for molding thermoplastic resins, such as molding injection, inflation, spinning, etc. It is also possible to apply multilayer molding, composite spinning or other molding method according to the purpose of use of the molded product, such as controlling the retention time of the plague repelling effect.

The content of the active ingredient of hyssop oil in the formulations is variable depending on the form of the formulation, method of application and other factors, but in the case of liquid or cream formulations, the content of the swab oil is usually of 0.1 to 50% weight, preferably 1 to 20% weight. In the case of resin molds, the hyssop oil content is usually 1 to 40% by weight, preferably 5 to 30% by weight.

When the content of the swab oil in the resin mold is less than 1% by weight, the pest repellent effect of the product is not excellent, and when the oil content exceeds 40% by weight, not preferably the swab oil could spill over to the mold surface to make it viscous.

In the pest repellent of the present invention, it is possible to combine other types of pest repellent, synergist, antioxidant, UV absorber, insecticide and other suitable additives such as dye and pigment.

As other types of pest repellents that can be combined in the formulations of the present invention, there may be exemplified, for example, carano-3,4-diol, DEET, p-menthane-3,8-diol, 2, 3, 4, 5-bis (? 2-butylene) tetrahydrofurfural, di-n-butyl succinate, 2-hydroxyoctyl sulfide, and (N-carbo-sec-butyloxy) -2- (2'-hydroxyethyl) -piperidine. As synergists, for example, N- (2-ethylhexyl) -8, 9, 10-trinorborna-5-en-2,3-dicarboxyimide (MGK-264) can be used. As antioxidants, for example, butylhydroxyanisole, dibutylhydroxytoluene, tocopherol, α-oryzanol and the like can be used. As an insecticide, there may be used, for example, Empentrin, Transfluthrin Praetrin Aletrin, Pyrethrin, Tetramethrin, Phenothrin, Cyphenothrin, Permethrin, Cypermethrin, Fenvalerate, Deltamethrin, Tralometrine, Tefuramethrin, Etofenprox, Silafluofen, Furamethrin, Imiprotrin, Teralethrin, Metoxadiazone, Propuxur, Fenitrothione , Dichlorovos and the like.

In the present invention, hyssop oil or its formulations could be applied, by appropriate means such as spraying, spraying, coating, solidification, to a pertinent location in the accessible pest area where the repellent effect of the swab oil or its formulation is desired to be demonstrated (such as walls, floors, furniture, curtains, window protectors, etc., of the rooms of a house, kitchen, store, etc.), or to the boundary between said area and the surface and the exterior or appropriate nearby places (such as doors and windows of the rooms of a house, kitchen, store, etc.). This is why it is possible to maintain blood-sucking insects as well as other pests such as food plague and harassing plague that enter the rooms of the house, kitchen, store and other places where you want to repel them. The quantity of swab oil or its formulations to be applied is variable depending on the application pest, form of the formulation, type of pest to be repelled, etc., but could be, for example, 0.1 to 100 g / m calculated as oil of hyssop It is also possible to provide the pest repellent effect using the plant body (green or dry grass) of the same swab (Hyssopus officialis L.) or a pot in which the swab is planted. That is, the plague can be repelled from a place by placing the swab or its pot there. The amount of swabs to be placed could be a sufficient amount to repel the pest and is variable due to the degree of its growth. For example, when using swabs that grow approximately 30 cm in height, they are used in a ratio of 0.05 to 20 plants / m3. The pest repellent effect can also be obtained by wearing a wrist band, hat, clothing, socks or similar treated with hyssop oil or by applying hyssop oil or its formulations (aerosol, cream, etc.) directly to the skin.

By virtue of this, the present invention will be described in greater detail by showing the formulation examples and the test examples, but the present invention is not limited to these examples.

First, the formulation examples are shown. In the following descriptions, all "parts" are by weight.

Example d Formulation 1 parts of hyssop oil was dissolved in ethanol to make the total amount of 35 parts, and the solution was filled into an aerosol container. A valve was then placed in the container and 65 parts of dimethyl ether was filled into the container by means of the valve under pressure to obtain an aerosol.

Formulation Example 2 parts of stearic acid, 2 parts of cetyl alcohol, one part of lanolin, 2 parts of liquid paraffin and 62 parts of water were added to 10 parts of hyssop oil, and melted and mixed under heating, and then 13 parts of glycerin heated was poured into the mixture and stirred well to obtain a cream formulation.

Formulation Example 3 parts of hyssop oil and 70 parts of an ethylene-methyl methacrylate copolymer (Acryft H202 produced by Sumitomo Chemical Co., Ltd.) were kneaded by an airtight pressure kneader for approximately 15 minutes and pelleted to prepare master granules and 200 parts of the ethylene methyl methacrylate copolymer used as matrix resin were kneaded again by said sealed pressure kneader for 15 minutes, then fed to an extruder and hot cut while being extruded to obtain granules having a content of hyssop oil of 10% weight. These granules were extruded in a T-die to obtain a 1 mm thick sheet.

Preparation example 4 A 25% w / v solution of hyssop oil was prepared.

One ml of this solution was applied to 20 cm x 2.5 cm of filter paper and dry air, and this filter paper was made into a ring shape to obtain a wrist band pest repellent.

Formulation Example 5 parts of hyssop oil, 2 parts of carano-3,4-diol and 0.2 parts of Aletrin were dissolved in isopropanol to have the total amount of 25 parts, and the solution is filled into an aerosol container. In addition, 30 parts of deionized water are added. A valve was then placed in the container and filled with 45 parts of dimethyl ether in the container by means of the valve under pressure to obtain an aerosol.

Then, the usefulness of swab oil to repel pests is demonstrated by the following test examples.

Test Example 1 A lower side part of a plastic tray (diameter of the base: 10 cm, diameter of the top opening: 12 cm, height: 7 cm, capacity: approximately 650 ml) was cut to form a square entrance of mosquitoes of 2 cm . In the center of the bucket was placed a heater with two steps arrangement (Kiribai New Hand Warmer, 24 hour type, 13.5 x 10 cm) as a decoy for mosquitoes. A 9 cm diameter filter paper was treated with 1 ml of the test substance solution diluted with acetone to a predetermined concentration, and then the acetone was air dried, the filter paper was annealed to the inside of the tray cover with a double-sided adhesive tape. This cover was fitted over the cuvette, allowing the test substance to volatilize and diffuse into the cuvette for one minute.

In a cage made of nylon gauze (50 cm x 50 cm x 50 cm) retaining approximately 600 mosquitoes (Aedes aesypti) from one to 2 weeks of age after emergence (sexual rate = ca. 1: 1), 2 of the cuvettes were placed supplied at the corners through the cage, each of the buckets was positioned about 10 cm removed from the corner of the cage, to attract mosquitoes. In the remaining corner abstaining positions, the two untreated cuvettes were placed (the cuvettes were treated with only 1 ml of acetone instead of one ml of solution of the test substance diluted with acetone to a predetermined concentration). To minimize the influence of the test substance on the untreated cuvettes, each cuvette was positioned such that its mosquito entry was opposite the corner of the cage. 10 minutes after adjusting the cuvettes in the positions of the cage, each cuvette was removed from the cage and the number of female insects attracted inside the cuvette was counted. Based on the result obtained, the inhibition rate of insect input was calculated by the following equation: Rate of inhibition of insect entry (%) =. { (number of insects attracted in the untreated section - number of insects attracted in the treated section) / number of insects attracted in the treated section} x 100 The test was carried out in a system of two replicas. The result is shown in Table 1. The result obtained after performing the similar test in DEET, a commercially available active ingredient compound, is also shown in Table 1.

Table 1 Test Example 2 The same test as in Test Example 1 was performed on mosquitoes (Culex oipiens pallens) that were 5 to 7 days old after emerging. Since these species of mosquitoes are nocturnal in their habitat, the attraction was continued throughout the night and the observation was made in the morning of the following day. Also, to prevent the mosquitoes once they have entered the buckets from escaping, a sticky trap was attached to the inside surface of each bucket. Results are shown in table 2.

Table 2 Test Example 3 The same test as in Test Example 1 was performed on house flies (Musca domestica). However, a mixture of powdered milk and sugar 1: 1 (by weight was used as a decoy instead of a heater array.) The results are shown in Table 3.

Table 3 Test Example 4 The same test as in Example, of Test 1 was performed on Meaacelia spiracularis using a growth medium (a mixture of powdered feed for animals, wheat and water 1: 7: 14 (by weight)) as a decoy instead of the heater arrangement. High cages of 50 cm x 25 cm x 30 cm were used. A cuvette treated with the test substance and an untreated cuvette were placed in each cage, and observation was made 30 minutes after adjustment. The test was performed in a system of two replicas. The results are shown in Table 4.

Table 4 Test Example 5 The same test as in Test Example 4 was performed on Clogmia albipunctata. However, the cage was placed in the dark and the solution was made two hours after the adjustment of the cuvettes in the cage. The results are shown in Table 5.

Table 5 Test Example 6 A lower end of a 4.5 cm x 4.5 cm x 4.5 cm carton was cut to form an insect entrance of 0.5 cm x 4.5 cm. A filter paper (2 cm x 2 cm) impregnated with a diluted solution of acetone of the test substance was placed in the cardboard box, and a piece of 1 cm x 1 cm of wool muslin was spread on the filter paper. This cardboard box was placed in a corner of a cage made of nylon gauze (20 cm x 20 cm x 30 cm), and a cardboard box containing an untreated filter paper with hyssop oil and having woolen muslin spread over it was placed in a diagonally opposite corner of the cage.

Approximately 60 female adults of Tineola bisselliella from one to 2 days of age after emergence were released into the cage, and the number of insects that entered the cardboard boxes was counted. The test was performed in a system of two replicas. The results are shown in Table 6.

Table 6 Test Example 7 The predetermined part of a forearm of the experimenter was covered with a glove and a support so that only a portion of 10 cm wide is exposed above the wrist. The wrist band made in the Formulation Example 4 was placed on the wrist side of the exposed portion, and the experimenter's arm was inserted in a 50 cm x 50 cm x 50 cm nylon cage in which 10 female adults of Aedes aesvpti were released. The time that elapsed until the first and second aedes took the bloodsucking action on the exposed skin of the experimenter was counted. The wrist band was fixed to the skin with adhesive tape so it would not move. The same test was performed on a case where a wrist band was placed without treating with hyssop oil. The experiment was carried out in a system of 3 replicas. The results are shown in Table 7.

Table 7 [Effect of the Invention] The present invention provides an effective pest repellent and a pest repellent method.

It is noted that in relation to this date, the best method known by the applicant to carry out the aforementioned invention, is the conventional one for the manufacture of the objects to which it relates.

Having described the invention as above, the content of the following is claimed as property.

Claims (7)

1. A pest repellent, characterized in that it contains hyssop oil as an active ingredient.

2. The repellent according to claim 1, characterized in that it is used to repel insects.

3. A method to repel pest, characterized in that it uses hyssop oil.

4. A method for repelling pest, characterized in that a repellently effective amount of hyssop oil is applied to a place where it is desired to repel the pest.

5. A method for repelling pest, characterized in that a repellently effective amount of swab oil is applied to the skin.

6. A method to repel pest, characterized in that it uses swab.

7. Use of hyssop oil, characterized in that it is used as a pest repellent.