MXPA06001668A - Treatment for acne vulgaris and method of use - Google Patents
Treatment for acne vulgaris and method of useInfo
- Publication number
- MXPA06001668A MXPA06001668A MXPA/A/2006/001668A MXPA06001668A MXPA06001668A MX PA06001668 A MXPA06001668 A MX PA06001668A MX PA06001668 A MXPA06001668 A MX PA06001668A MX PA06001668 A MXPA06001668 A MX PA06001668A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- ethoxylate
- common acne
- composition
- exchanged
- Prior art date
Links
- 206010000496 acne Diseases 0.000 title claims abstract description 41
- 238000011282 treatment Methods 0.000 title claims abstract description 39
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title claims abstract description 17
- 239000000203 mixture Substances 0.000 claims abstract description 35
- -1 polyethylene Polymers 0.000 claims abstract description 13
- 239000004698 Polyethylene Substances 0.000 claims abstract description 10
- 229920000573 polyethylene Polymers 0.000 claims abstract description 10
- 108700004121 sarkosyl Proteins 0.000 claims abstract description 10
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims abstract description 10
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 8
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000004166 Lanolin Substances 0.000 claims abstract description 6
- 229940039717 lanolin Drugs 0.000 claims abstract description 6
- 235000019388 lanolin Nutrition 0.000 claims abstract description 6
- 239000006260 foam Substances 0.000 claims abstract description 5
- 239000003381 stabilizer Substances 0.000 claims abstract description 5
- 238000005520 cutting process Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims 1
- 239000004872 foam stabilizing agent Substances 0.000 claims 1
- 239000012749 thinning agent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 5
- 230000000699 topical effect Effects 0.000 abstract description 3
- 239000011324 bead Substances 0.000 abstract 1
- 238000005201 scrubbing Methods 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 6
- 125000000524 functional group Chemical group 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 206010033733 Papule Diseases 0.000 description 4
- 230000002757 inflammatory effect Effects 0.000 description 4
- 230000003902 lesion Effects 0.000 description 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 206010054107 Nodule Diseases 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000012459 cleaning agent Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000003860 topical agent Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- IEORSVTYLWZQJQ-UHFFFAOYSA-N 2-(2-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=CC=C1OCCO IEORSVTYLWZQJQ-UHFFFAOYSA-N 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241001635598 Enicostema Species 0.000 description 1
- 206010027626 Milia Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000007720 emulsion polymerization reaction Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000004130 lipolysis Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 229920000847 nonoxynol Polymers 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Abstract
A treatment for Acne Vulgaris is provided for in a topical treatment. According to the invention, a method is provided for applying composition substances to the infected area, working the composition into the infected area, and removing the composition from the infected area. The composition comprises at least one ethoxylate in combination with Sodium Lauroyl Sarcosinate. Alternatively, the ethoxylate can be exchanged for a methoxylate or a propoxylate. An inert scrubbing agent, such as polyethylene beads, can also be included. Acetylated lanolin alcohol, sodium Lauroyl Sarcosinate, EDTA, a foam stabilizer, and water can also be added to the composition to assist performance.
Description
TREATMENT FOR COMMON ACNE AND METHOD OF USE
FIELD OF THE INVENTION
The present invention relates to a composition that includes surfactants for the treatment of common acne. The methods of use are also included. BACKGROUND OF THE INVENTION Acne vulgaris (or "acne") is a disorder of the sebaceous glands. This is characterized by lesions that are either non-inflammatory or inflammatory papules and nodules. Noninflammatory papules may be open, commonly referred to as "blackheads," or closed, commonly referred to as "whiteheads." As a group, non-inflammatory papules are called comedones. Closed comedones can lead to inflammatory nodules, papules and pustules. The severe fields of common acne can lead to scars characterized by dimples. It is believed that common acne results from the partial rupture of a partially inflamed follicle. The follicle then spills its components, which results in the development of a perifollicular inflammatory process. In general, fresh lesions are sterile, but later gram-positive diphtheroids are present. Ref .: 170255 Many times the skin will have a greasy appearance to them; this is probably due, at least in part, to the release of fatty acids during P-induced lipolysis. Acnes. Acne can be a serious problem. This usually manifests during adolescence and resolves spontaneously in late adolescence or around twenty years of age; although for some, this can be a long-term problem. Mild to moderate acne is most often treated with topical agents. More severe cases are treated with incisions and drained lesions, light therapy with ultraviolet and systemic antibiotics. The prior art is replete with compositions for use in the treatment of acne. Topical agents, such as benzoyl peroxide, are thought to decrease bacteria and are frequently used in the treatment of acne. These treatments are found in many forms, lotions, agents, pads, etc. and they are generally available at the counter. Retinol in various forms has been most recently proposed by various inventors. There are also many soaps used in the treatment of acne. A major drawback of most of the prior art is that they often do not penetrate sufficiently and leave the skin dry. OBJECTIVES OF THE INVENTION An objective of the present invention is to provide a treatment that helps alleviate the local signs and symptoms caused by common acne. A further objective of the present invention is to provide a method of using the treatment of the present invention. Yet another objective of the present invention is to provide a treatment that includes at least a first nonylphenyl ethoxylate and sodium lauroyl sarcosinate to which a second non-indole ethoxylate, acetylated lanolin alcohol, EDTA, a foam stabilizer, water and granules can be added. of inert polyethylene, without altering the effectiveness of the treatment. Yet another objective of the present invention is to provide a treatment that is safe to use. Yet another objective of the present invention is to provide such a treatment that is topical, that can be acquired at the counter, and that is economical. BRIEF DESCRIPTION OF THE INVENTION The above objectives of the invention are provided for a topical treatment for common acne. According to the invention, a method is provided for applying a composition of substances to the infected area, dispersing the composition in the infected area, and removing the composition from the infected area. The composition comprises at least one ethoxylate in combination with sodium lauroyl sarcosinate (or "SLS"). An inert cleaning agent can also be included in the formula, such as polyethylene spheres. Acetylated lanolin alcohol, a second ethoxylate, EDTA, a foam stabilizer and water can also be added to the composition without affecting performance. Other formulas that maintain polarity similar to that of the formula of the invention will also work. To maintain similar polarity, it is necessary that the compound has similar characteristics, such as carbon chains, carbon chains, nitrogen-to-carbon bond, aromatic ring (s), oxylate groups, and appropriate functional groups at the ends of the individual molecules. The ideal substitute chemical products could have all the characteristics mentioned above, but it is not necessary that they have each of those as listed. For example, if the functional groups at the ends of the individual molecules are exchanged for other functional groups that retain the ability to undergo polymerization, in the emulsion, then the effectiveness of the compound is also retained. Yet another example is changing the ethoxylate to a methoxylate or propoxylate. These formulations could retain a similar polarity but they would be different compounds with different characteristics. Another example would be to exchange the nitrogen with triple bond with a double bond or perhaps nitrogen with 4 carbons bound to it. DETAILED DESCRIPTION OF THE INVENTION Chemical analysis and research have revealed that two of the component parts of the composition of the invention are primarily involved in its effectiveness as a treatment for acne: an ethoxylate and sodium lauroyl sarcosinate ("SLS") . The ethoxylate is preferably a nonylphenol ethoxylate. The inventor has also found, however, that other formulas that maintain polarity similar to that of the formula of the invention will also work. To maintain similar polarity, it is necessary that the compound has similar characteristics, such as carbon chains, carbonyl groups, nitrogen bonded to carbon, to one or more aromatic rings, oxylate groups, and appropriate functional groups at the ends of the individual molecules. The individual substitute chemical products would have all the characteristics mentioned above, but it is not necessary to have each of those as listed. For example, if the functional groups at the ends of the individual molecules are exchanged for other functional groups that retain the ability to undergo an emulsion polymerization, then the effectiveness of the compound is also retained. Another example is changing the ethoxylate to a methoxylate or propoxylate. These formulations could also retain a similar polarity but they would be different compounds with different characteristics. Another example would be exchanging the nitrogen with triple bond with a double bond or perhaps nitrogen with four carbons linked to it. The inventor has also discovered that the addition
• an inert cleaning agent improves the action of the composition of the invention. The spheres must be large enough to be effective but not so large as to cause abrasions. The inventor suggests that the spheres are in the range of 5 to 50 micrometers, with an average size that is about 25 micrometers or 50 mesh. To make the composition of the invention, an exact ratio of the ethoxylate to the SLS is not critical. The only requirement is that the ethoxylate reacts completely with the SLS, creating a polymer. This will vary with the ethoxylate used, but the inventor has determined that a proportion of the ethoxylate-to-SLS of 1.5: 2 is preferable. The amount by weight of the polyethylene spheres can vary according to the desired sandy texture. The inventor has found that an ethoxylate: SLS: polyethylene formula of 40:20:40 is preferred, but that formulas of other concentrations are useful. Thus, for purposes of production, formulas having SLS in the range of 10 to 20% by weight, ethoxylate in the range of 20 to 40% by weight, and polyethylene spheres of 20 to 50% by weight are reasonable. . But again, the formula is not restricted to these intervals, whose intervals are presented for exemplary purposes only. Also, a cutting agent that does not react chemically with the composition can be added. The cutting agent makes the entire composition flow more easily, thereby making more packaging options impossible, such as tubes. The cutting agent must be added only in sufficient quantity to promote flow, but not to affect the action of the composition. In use, a sufficient amount of the composition is used to cover the affected area the composition is applied to an affected area and rubbed over the area by a cleaning action. After sufficient time has elapsed to ensure that the affected area has been adequately exposed to the composition, such that the area feels clean, approximately ten to thirty seconds for the typical person, the area is cleaned by rinsing. It is noted that in relation to this date, the best known method for carrying out the aforementioned invention is that which is clear from the present description of the invention
Claims (32)
1. A treatment for common acne, characterized in that it comprises sodium lauroyl sarcosinate and a nonylphenyl ethoxylate in combination.
2. The treatment for common acne according to claim 1, characterized in that it includes a second nonylphenyl ethoxylate.
3. The treatment for common acne according to claim 1, characterized in that it also comprises acetylated lanolin alcohol.
4. The treatment for common acne according to claim 1, characterized in that it also includes polyethylene granules.
5. The treatment for common acne according to claim 1, characterized in that it also includes water.
6. The treatment for common acne according to claim 1, characterized in that it also includes ethylenediaminetetraacetic acid.
7. The treatment for common acne according to claim 1, further characterized in that it includes a foam stabilizing agent.
8. The treatment for common acne according to claim 1, characterized in that it also includes a cutting agent.
9. The cutting agent according to claim 8, characterized in that it is selected from the group of solutions based on water and oil-based solutions.
10. The treatment for common acne according to claim 1, characterized in that the ethoxylate is exchanged for a methoxylate.
11. The treatment for common acne according to claim 1, characterized in that the ethoxylate is exchanged for a propoxylate.
12. A treatment for common acne, characterized in that it comprises an ethoxylate, sodium lauroyl sarcosinate, and a cleansing medium.
13. The treatment for common acne according to claim 12, characterized in that the cleaning medium is polyethylene spheres.
14. The treatment for common acne according to claim 12, characterized in that it also includes a cutting agent.
15. The treatment for common acne according to claim 12, characterized in that the ethoxylate is exchanged for a methoxylate.
16. The treatment for common acne according to claim 12, characterized in that the ethoxylate is exchanged for a propoxylate.
17. A treatment for common acne, characterized in that it comprises: a first ethoxylate, a second ethoxylate, acetylated lanolin alcohol, sodium lauroyl sarcosinate, EDTA, a foam stabilizer, water, and inert polyethylene granules.
18. The treatment for common acne according to claim 17, characterized in that the first ethoxylate is exchanged for un-methoxylate.
19. The treatment for common acne according to claim 17, characterized in that the first ethoxylate is exchanged for a propoxylate.
20. A treatment for common acne, characterized in that it comprises an ethoxylate, sodium lauroyl sarcosinate and EDTA.
21. The treatment for common acne according to claim 20, characterized in that the ethoxylate is exchanged for a methoxylate.
22. The treatment for common acne according to claim 20, characterized in that the ethoxylate is exchanged for a propoxylate.
23. A treatment method for common acne, characterized in that it comprises the steps of: preparing a composition comprising an ethoxylate and sodium lauroyl sarcosinate; apply the composition to an infected area; allowing the composition to remain on the infected area a sufficient amount of time for the composition of interest to elicit an effect; and remove the composition of the infected area.
24. The method of compliance with the claim 23, characterized in that the preparation of the composition also includes adding a second ethoxylate.
25. The method according to claim 23, characterized in that the preparation of the composition further includes adding acetylated lanolin alcohol.
26. The method according to claim 23, characterized in that the preparation of the composition further includes the addition of acetylated polyethylene granules.
27. The method of compliance with the claim 23, characterized in that the preparation of the composition also includes the addition of water.
28. The method according to claim 23, characterized in that the preparation of the composition also includes EDTA.
29. The method according to claim 23, characterized in that the preparation of the composition also includes a foam stabilizer.
30. The method according to claim 23, characterized in that it also includes the step of adding a thinning agent to the composition.
31. The method according to claim 23, characterized in that the ethoxylate is exchanged for a methoxylate.
32. The method of compliance with the claim 23, characterized in that the ethoxylate is exchanged for a propoxylate.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06001668A true MXPA06001668A (en) | 2007-04-10 |
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