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MXPA05013349A - Derivados de 2-amino-pirimidina como inhibidores de quinasa raf. - Google Patents

Derivados de 2-amino-pirimidina como inhibidores de quinasa raf.

Info

Publication number
MXPA05013349A
MXPA05013349A MXPA05013349A MXPA05013349A MXPA05013349A MX PA05013349 A MXPA05013349 A MX PA05013349A MX PA05013349 A MXPA05013349 A MX PA05013349A MX PA05013349 A MXPA05013349 A MX PA05013349A MX PA05013349 A MXPA05013349 A MX PA05013349A
Authority
MX
Mexico
Prior art keywords
raf kinase
kinase inhibitors
aminopyrimidine derivatives
compounds
phenyl radical
Prior art date
Application number
MXPA05013349A
Other languages
English (en)
Inventor
Michael Lloyd Sabio
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MXPA05013349A publication Critical patent/MXPA05013349A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta solicitud da a conocer compuestos que inhiben la quinasa Raf, que tienen la formula (I) (ver formula (I)): en donde R1 es un radical de fenilo o un radical de heterorarilo; y R2 es un radical de fenilo; o un N-oxido o una sal farmaceuticamente aceptable de los mismos. Los compuestos son utiles para el tratamiento de enfermedades proliferativas, tales como cancer.
MXPA05013349A 2003-06-13 2004-06-11 Derivados de 2-amino-pirimidina como inhibidores de quinasa raf. MXPA05013349A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47870903P 2003-06-13 2003-06-13
PCT/EP2004/006317 WO2004110452A1 (en) 2003-06-13 2004-06-11 2-aminopyrimidine derivatives as raf kinase inhibitors

Publications (1)

Publication Number Publication Date
MXPA05013349A true MXPA05013349A (es) 2006-03-09

Family

ID=33551850

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013349A MXPA05013349A (es) 2003-06-13 2004-06-11 Derivados de 2-amino-pirimidina como inhibidores de quinasa raf.

Country Status (14)

Country Link
US (1) US20060293340A1 (es)
EP (1) EP1635835B1 (es)
JP (1) JP2006527230A (es)
CN (1) CN1805748B (es)
AT (1) ATE454152T1 (es)
AU (1) AU2004246800B2 (es)
BR (1) BRPI0411365A (es)
CA (1) CA2529090A1 (es)
DE (1) DE602004024988D1 (es)
ES (1) ES2338557T3 (es)
MX (1) MXPA05013349A (es)
PL (1) PL1635835T3 (es)
PT (1) PT1635835E (es)
WO (1) WO2004110452A1 (es)

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US7939541B2 (en) * 2004-09-09 2011-05-10 Natco Pharma Limited Intermediates and a process employing the intermediates for the preparation of (3-trifluoromethylsulfonyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
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US20080207658A1 (en) * 2005-02-25 2008-08-28 Manley Paul W Pharmaceutical Combination of Bcr-Abl and Raf Inhibitors
KR100674813B1 (ko) * 2005-08-05 2007-01-29 일양약품주식회사 Ｎ-페닐-2-피리미딘-아민 유도체 및 그의 제조방법
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WO2008153959A1 (en) * 2007-06-07 2008-12-18 Intra-Cellular Therapies, Inc. Novel heterocycle compounds and uses thereof
WO2008153974A1 (en) 2007-06-07 2008-12-18 Intra-Cellular Therapies, Inc. Novel heterocycle compounds and uses thereof
JP5511680B2 (ja) 2007-12-19 2014-06-04 キャンサー・リサーチ・テクノロジー・リミテッド ピリド［２，３−ｂ］ピラジン−８−置換化合物及びその使用
TW200940539A (en) * 2008-02-29 2009-10-01 Array Biopharma Inc RAF inhibitor compounds and methods of use thereof
MX2010009410A (es) * 2008-02-29 2010-11-30 Array Biopharma Inc Compuestos del inhibidor de raf y métodos de uso de los mismos.
JP2011513332A (ja) * 2008-02-29 2011-04-28 アレイ バイオファーマ、インコーポレイテッド 癌の治療のためのｒａｆ阻害剤としてのｎ−（６−アミノピリジン−３−イル）−３−（スルホンアミド）ベンズアミド誘導体
US20110003809A1 (en) * 2008-02-29 2011-01-06 Array Biopharma Inc. Imidazo [4,5-b] pyridine derivatives used as raf inhibitors
US8067422B2 (en) 2008-03-04 2011-11-29 Natco Pharma Limited Crystal form of phenylamino pyrimidine derivatives
US8513242B2 (en) 2008-12-12 2013-08-20 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
WO2010100127A1 (en) 2009-03-04 2010-09-10 Novartis Ag Disubstituted imidazole derivatives as modulators of raf kinase
WO2011016861A2 (en) 2009-08-05 2011-02-10 Intra-Cellular Therapies, Inc. Novel regulatory proteins and inhibitors
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PL2531502T3 (pl) 2010-02-01 2014-08-29 Cancer Research Tech Ltd 1-(5-tert-Butylo-2-fenylo-2H-pirazol-3-ilo)-3-[2-fluoro-4-(1-metylo-2-okso-2,3-dihydro-1H-imidazo[4,5-b]pirydyn-7-yloksy)-fenylo]-mocznik i związki pokrewne oraz ich zastosowanie w terapii
US20110281893A1 (en) * 2010-05-11 2011-11-17 Krisani Biosciences (P) Ltd Compound, synthesis, composition and uses thereof
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Also Published As

Publication number Publication date
PL1635835T3 (pl) 2010-06-30
DE602004024988D1 (de) 2010-02-25
AU2004246800B2 (en) 2008-12-04
CA2529090A1 (en) 2004-12-23
CN1805748B (zh) 2010-05-26
ATE454152T1 (de) 2010-01-15
EP1635835A1 (en) 2006-03-22
ES2338557T3 (es) 2010-05-10
WO2004110452A1 (en) 2004-12-23
BRPI0411365A (pt) 2006-07-25
JP2006527230A (ja) 2006-11-30
AU2004246800A1 (en) 2004-12-23
CN1805748A (zh) 2006-07-19
US20060293340A1 (en) 2006-12-28
EP1635835B1 (en) 2010-01-06
PT1635835E (pt) 2010-03-17

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