[go: up one dir, main page]

MXPA05009682A - Metodos de radiofluorinacion de vectores biologicamente activos. - Google Patents

Metodos de radiofluorinacion de vectores biologicamente activos.

Info

Publication number
MXPA05009682A
MXPA05009682A MXPA05009682A MXPA05009682A MXPA05009682A MX PA05009682 A MXPA05009682 A MX PA05009682A MX PA05009682 A MXPA05009682 A MX PA05009682A MX PA05009682 A MXPA05009682 A MX PA05009682A MX PA05009682 A MXPA05009682 A MX PA05009682A
Authority
MX
Mexico
Prior art keywords
radiofluorination
methods
biologically active
active vectors
vectors
Prior art date
Application number
MXPA05009682A
Other languages
English (en)
Inventor
Matthias Eberhard Glaser
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health As filed Critical Amersham Health As
Publication of MXPA05009682A publication Critical patent/MXPA05009682A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/04—Preparation of hydrazides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/02—Preparation of hydrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/14—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/66—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C07C41/56—Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/55—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion se refiere a conjugados de las formulas (V) o (VI): en donde X es -CO-NH, -NH-, -O-, -NHCONH-, o -NHCSNH-; su uso como radiofarmaceuticos, procesos para su preparacion, e intermedios sinteticos utilizados en tales procesos.
MXPA05009682A 2003-03-13 2004-03-12 Metodos de radiofluorinacion de vectores biologicamente activos. MXPA05009682A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0305704.9A GB0305704D0 (en) 2003-03-13 2003-03-13 Radiofluorination methods
PCT/GB2004/001052 WO2004080492A1 (en) 2003-03-13 2004-03-12 Methods of radiofluorination of biologically active vectors

Publications (1)

Publication Number Publication Date
MXPA05009682A true MXPA05009682A (es) 2006-01-27

Family

ID=9954659

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05009682A MXPA05009682A (es) 2003-03-13 2004-03-12 Metodos de radiofluorinacion de vectores biologicamente activos.

Country Status (19)

Country Link
US (1) US8197793B2 (es)
EP (1) EP1601384B1 (es)
JP (1) JP4855924B2 (es)
KR (1) KR101066684B1 (es)
CN (1) CN100586485C (es)
AT (1) ATE481987T1 (es)
AU (1) AU2004218879B2 (es)
BR (1) BRPI0408236B1 (es)
CA (1) CA2518889C (es)
DE (1) DE602004029237D1 (es)
ES (1) ES2352731T3 (es)
GB (1) GB0305704D0 (es)
IL (1) IL170339A (es)
MX (1) MXPA05009682A (es)
NO (1) NO333174B1 (es)
PL (1) PL1601384T3 (es)
RU (2) RU2363704C2 (es)
WO (1) WO2004080492A1 (es)
ZA (1) ZA200507849B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0210886B8 (pt) 2001-07-10 2021-05-25 Amersham Health As composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal
GB0420344D0 (en) * 2004-09-14 2004-10-13 Amersham Plc Diagnostic compounds
GB0420365D0 (en) * 2004-09-14 2004-10-13 Hammersmith Imanet Ltd Radiolabelled insulin
US7842279B2 (en) * 2005-08-31 2010-11-30 Immunomedics, Inc. F-18 peptides for pre targeted positron emission tomography imaging
WO2007148089A2 (en) * 2006-06-21 2007-12-27 Hammersmith Imanet Limited Radiolabelling methods
BRPI0716554A2 (pt) 2006-09-08 2013-09-24 Bayer Schering Pharma Ag compostos de mÉtodos para agentes rotulados de 18f
CA2664700A1 (en) * 2006-10-02 2008-04-10 Bayer Schering Pharma Aktiengesellschaft Silicon derivatives for pet imaging
US7902332B2 (en) 2006-11-30 2011-03-08 General Electric Company Fluorine-labeled compounds
KR20090097868A (ko) * 2006-12-11 2009-09-16 지이 헬스케어 에이에스 방사선 표지된 펩티드 기재 화합물 및 그의 용도
US8247534B2 (en) 2006-12-13 2012-08-21 Ge Healthcare As Synthesis of radiofluorinated peptide using microwave activation technology
US8241606B2 (en) * 2006-12-18 2012-08-14 Ge Healthcare As Synthesis of a radiofluorinated peptide using photolabile protecting groups
JP4989241B2 (ja) * 2007-01-29 2012-08-01 静岡県公立大学法人 ［１８ｆ］標識化合物及びその製造方法、並びに［１８ｆ］標識リポソーム及び［１８ｆ］標識リポソーム製剤の製造方法
CA2679514A1 (en) * 2007-03-01 2008-09-04 Bayer Schering Pharma Aktiengesellschaft 18f fluoro-benzoyl labelled biologically active compounds as diagnostic imaging agents as well as benzotriazol-1-yloxy-benzoyl, 2,5-dioxo-pyrrolidin-1-yloxy-benzoyl and trimethylammonio-benzoyl precursers
US8466151B2 (en) 2007-12-26 2013-06-18 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
WO2009108484A1 (en) * 2008-02-28 2009-09-03 Ge Healthcare Limited Synthesis of a peg-6 moiety from commercial low-cost chemicals
CA2999321A1 (en) 2008-07-17 2010-01-21 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
GB0819293D0 (en) * 2008-10-21 2008-11-26 Hammersmith Imanet Ltd Radiofluorination
GB0819280D0 (en) * 2008-10-21 2008-11-26 Gen Electric Imgaing and radiotherapy methods
US20120165650A1 (en) 2010-12-22 2012-06-28 General Electric Company Her2 binders
GB0901483D0 (en) * 2009-01-29 2009-03-11 Ge Healthcare Ltd Radioiodination method
GB0905438D0 (en) 2009-03-30 2009-05-13 Ge Healthcare Ltd Radiolabelling reagents and methods
GB0905515D0 (en) * 2009-03-31 2009-05-13 Ge Healthcare Ltd Radiolabelling methods
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
US20120229804A1 (en) 2009-12-21 2012-09-13 Medi-Physics, Inc. Borosilicate glassware and silica based qma's in 18f nucleophilic substitution: influence of aluminum, boron and silicon on the reactivity of the 18f- ion
WO2011087823A1 (en) * 2009-12-22 2011-07-21 Ge Healthcare Limited Aldehydes for in vivo imaging of aldh in cancer stem cells
EP2552915B1 (en) 2010-04-01 2017-07-19 Critical Outcome Technologies Inc. Compounds for the treatment of hiv
GB201013808D0 (en) * 2010-08-18 2010-09-29 Ge Healthcare Ltd Peptide radiotracer compositions
GB201020314D0 (en) * 2010-12-01 2011-01-12 Ge Healthcare Ltd Apoptosis pet imaging agents
EP3395373B1 (en) * 2010-12-01 2022-10-19 GE Healthcare Limited Method for labelling a biological targeting molecule via conjugation with a radioisotope suitable for pet or spect imaging
CA2820387A1 (en) 2010-12-09 2012-06-14 Ge Healthcare Limited Radiotracer compositions
KR20130132941A (ko) 2010-12-21 2013-12-05 지이 헬쓰케어 리미티드 옥심 라이게이션의 방사성안정화에서의 아닐린의 용도
KR20130132939A (ko) 2010-12-22 2013-12-05 지이 헬쓰케어 리미티드 １８ｆ - 함유 유기실리콘 화합물로 표지된 ｈｅｒ２ 결합 펩티드
MX2013007371A (es) 2010-12-22 2014-05-27 Affibody Ab Peptidos de enlace her2 radiomarcados.
WO2013048832A1 (en) 2011-09-29 2013-04-04 Ge Healthcare Limited 18 f - labelled 6 - ( 2 - fluoroethoxy) - 2 - naphthaldehyde for detecting cancer stem cells
WO2013048811A1 (en) 2011-09-30 2013-04-04 Ge Healthcare Limited Imaging and radiotherapy methods for tumour stem cells
GB201205703D0 (en) 2012-03-30 2012-05-16 Ge Healthcare Ltd Synthon composition
GB201221266D0 (en) 2012-11-27 2013-01-09 Ge Healthcare Ltd Aldehyde compositions
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
MA40415A (fr) 2014-09-03 2016-03-10 Immunogen Inc Conjugués comprenant des agents de liaison cellulaire et des agents cytotoxiques
AU2015356971B2 (en) 2014-12-04 2021-09-09 Ge Healthcare Limited Method of removing acetaldehyde from radioactive pharmaceuticals
WO2020205544A1 (en) * 2019-03-29 2020-10-08 Cary Douglas D Use of ketone bodies medical imaging and diagnostics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE353864T1 (de) * 1997-09-03 2007-03-15 Immunomedics Inc Fluorierung von proteinen und peptiden für positronemissionstomographie
RU2165266C1 (ru) * 2000-06-28 2001-04-20 Центральный научно-исследовательский рентгенорадиологический институт Способ получения [2-18f]-2-дезоксиглюкозы
GB0206750D0 (en) * 2002-03-22 2002-05-01 Amersham Plc Radiofluorination methods

Also Published As

Publication number Publication date
ZA200507849B (en) 2007-09-26
US20100068139A1 (en) 2010-03-18
NO20054185D0 (no) 2005-09-09
EP1601384B1 (en) 2010-09-22
GB0305704D0 (en) 2003-04-16
CA2518889C (en) 2015-11-03
ATE481987T1 (de) 2010-10-15
RU2005126984A (ru) 2006-06-27
KR101066684B1 (ko) 2011-09-21
NO333174B1 (no) 2013-03-25
EP1601384A1 (en) 2005-12-07
RU2363704C2 (ru) 2009-08-10
BRPI0408236A (pt) 2006-03-01
AU2004218879A1 (en) 2004-09-23
US8197793B2 (en) 2012-06-12
CA2518889A1 (en) 2004-09-23
PL1601384T3 (pl) 2011-03-31
KR20060002819A (ko) 2006-01-09
CN100586485C (zh) 2010-02-03
HK1087928A1 (zh) 2006-10-27
AU2004218879B2 (en) 2009-10-01
RU2009112412A (ru) 2010-10-20
IL170339A (en) 2012-02-29
NO20054185L (no) 2005-11-10
DE602004029237D1 (de) 2010-11-04
CN1758925A (zh) 2006-04-12
ES2352731T3 (es) 2011-02-22
WO2004080492A1 (en) 2004-09-23
JP2006523658A (ja) 2006-10-19
BRPI0408236B1 (pt) 2016-09-20
JP4855924B2 (ja) 2012-01-18

Similar Documents

Publication Publication Date Title
MXPA05009682A (es) Metodos de radiofluorinacion de vectores biologicamente activos.
HUS2000011I1 (hu) A 2,4-pirimidin-diamin vegyületek elõgyógyszerei és alkalmazásuk
AU2002319814A1 (en) Substituted 1h-dihydropyrazoles, their preparation and use
TNSN05254A1 (en) Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics
TNSN07235A1 (en) Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
TW200505875A (en) Novel compounds
TW200508214A (en) Novel compounds
HRP20010738B1 (en) N-cyanomethyl amides as protease inhibitors
TW200716529A (en) New compounds II
AU2003228770A8 (en) Substituted pyrazolopyrimidines
SI1791571T1 (sl) Radiofluorirani peptidi
TW200736227A (en) New compounds III
IL160171A0 (en) Depsipeptide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
TW200604197A (en) New compounds
DE502008001158D1 (en) Benzimidazolderivate
TWI319399B (en) Biguanide and dihydrotriazine derivatives
TW200603746A (en) Iron sulfate based phosphate adsorbent
MY134026A (en) ?-carboline derivatives and its pharmaceutical use against depression and anxiety
SE0303280D0 (sv) Novel compounds
MXPA04001419A (es) Isoxazolopiridinonas y su uso en el tratamiento de enfermedad de parkinson.
DE60201074D1 (en) Pyrazolopyridinderivate
MXPA04005151A (es) Compuestos terapeuticos.
SG146640A1 (en) Isolated photoprotein mtclytin, and use thereof
TW200716530A (en) New compounds I
TW200504075A (en) Imidazopyridine intermediates

Legal Events

Date Code Title Description
HC Change of company name or juridical status
FG Grant or registration