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MXPA05008088A - Proceso mejorado para preparar benzhidril tioacetamida. - Google Patents

Proceso mejorado para preparar benzhidril tioacetamida.

Info

Publication number
MXPA05008088A
MXPA05008088A MXPA05008088A MXPA05008088A MXPA05008088A MX PA05008088 A MXPA05008088 A MX PA05008088A MX PA05008088 A MXPA05008088 A MX PA05008088A MX PA05008088 A MXPA05008088 A MX PA05008088A MX PA05008088 A MXPA05008088 A MX PA05008088A
Authority
MX
Mexico
Prior art keywords
benzhydrylthioacetamide
preparing
reaction
haloacetamide
modafinil
Prior art date
Application number
MXPA05008088A
Other languages
English (en)
Inventor
Liang Sidney
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of MXPA05008088A publication Critical patent/MXPA05008088A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invencion se dirige a un proceso mejorado para preparar el modafinilo, en donde la benzhidriltioacetamida se prepara con alto rendimiento y pureza mediante la reaccion de una haloacetamida con el producto de reaccion de tiourea y benzhidrol en una solucion acuosa. La reaccion que emplea la haloacetamida se conduce en un solvente que comprende agua y un solvente organico, tal como dimetilformamida que tiene disuelto en el mismo una sal basica, tal como carbonato de potasio, la benzhidriltioacetamida resultante se puede oxidar para proporcionar el modafinilo farmaceutico.
MXPA05008088A 2003-02-24 2004-02-23 Proceso mejorado para preparar benzhidril tioacetamida. MXPA05008088A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44962903P 2003-02-24 2003-02-24
PCT/US2004/005265 WO2004075841A2 (en) 2003-02-24 2004-02-23 Process for preparing benzhydrylthioacetamide

Publications (1)

Publication Number Publication Date
MXPA05008088A true MXPA05008088A (es) 2005-09-21

Family

ID=32927542

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05008088A MXPA05008088A (es) 2003-02-24 2004-02-23 Proceso mejorado para preparar benzhidril tioacetamida.

Country Status (7)

Country Link
US (1) US7244865B2 (es)
EP (1) EP1603867A2 (es)
JP (1) JP2006518754A (es)
CN (1) CN1753867A (es)
CA (1) CA2511992A1 (es)
MX (1) MXPA05008088A (es)
WO (1) WO2004075841A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1787980E (pt) 2000-07-27 2010-03-18 Teva Pharma Modafinil cristalino e puro e processo para a sua preparação
CN1753867A (zh) 2003-02-24 2006-03-29 马林克罗特公司 制备二苯甲基硫代乙酰胺的方法
ES2314464T3 (es) * 2003-10-23 2009-03-16 Mallinckrodt Inc. Procedimiento mejorado para preparar bencihidriltioacetamida.
CN101326159A (zh) * 2005-12-09 2008-12-17 马林克罗特公司 制备莫达非尼及其类似物的方法
MX2007012605A (es) * 2006-02-21 2008-01-11 Teva Pharma Formas cristalinas novedosas de armodafinil y preparacion de ellas.
WO2007103221A2 (en) * 2006-03-01 2007-09-13 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of armodafinil
US7960586B2 (en) * 2007-08-16 2011-06-14 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
CN104672118A (zh) * 2014-12-12 2015-06-03 上海泓海荣通医药技术有限公司 一种莫达非尼多晶体的合成方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1520812A (en) * 1975-10-02 1978-08-09 Lafon Labor Benzhydrylsulphinyl derivatives
US4127722A (en) * 1975-10-02 1978-11-28 Laboratoire L. Lafon Benzhydrylsulphinyl derivatives
CH607923A5 (es) * 1976-02-05 1978-12-15 Ardizio P
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2528038B2 (fr) 1982-06-04 1985-08-09 Lafon Labor Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
FR2528041A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique
DK62184D0 (da) * 1984-02-10 1984-02-10 Benzon As Alfred Diffusionsovertrukket polydepotpraeparat
US4713246A (en) 1984-03-19 1987-12-15 Bristol-Myers Company Etoposide oral dosage form
IT1187751B (it) * 1985-10-15 1987-12-23 Eurand Spa Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute
FR2593809B1 (fr) 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
FR2611709B1 (fr) 1987-02-26 1989-06-09 Lafon Labor 2-(benzhydrylsulfonyl)acetamide, son procede de preparation et son application en therapeutique
DE3720493A1 (de) * 1987-06-20 1989-01-26 Nattermann A & Cie Arzneizubereitungen mit mikronisierten ebselen-kristallen
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
US4952574A (en) * 1988-09-26 1990-08-28 Riker Laboratories, Inc. Antiarrhythmic substituted N-(2-piperidylmethyl)benzamides
JP2642486B2 (ja) * 1989-08-04 1997-08-20 田辺製薬株式会社 難溶性薬物の超微粒子化法
FR2663225B1 (fr) * 1990-06-14 1994-11-04 Lafon Labor Nouvelle utilisation du modafinil.
FR2684875B1 (fr) * 1991-12-13 1995-05-24 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique.
FR2702968B1 (fr) 1993-03-23 1995-06-23 Lafon Labor Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation .
EP0618191A1 (en) * 1993-04-02 1994-10-05 AMERSHAM INTERNATIONAL plc Metal chelating compounds
FR2707637B1 (fr) * 1993-06-30 1995-10-06 Lafon Labor Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique.
US6670358B2 (en) * 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
US6492396B2 (en) * 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
PT1787980E (pt) * 2000-07-27 2010-03-18 Teva Pharma Modafinil cristalino e puro e processo para a sua preparação
EP1330244B1 (en) 2000-10-11 2008-12-17 Cephalon, Inc. Compositions comprising modafinil compounds
IL143106A (en) * 2001-05-13 2005-11-20 Chemagis Ltd Process for the preparation of diphenylmethylthioacetamide
CN1193987C (zh) 2002-01-18 2005-03-23 北京瑞康医药技术有限公司 巯基乙酰胺的一种制备方法
US6875893B2 (en) * 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
US6992219B2 (en) * 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
ITMI20022390A1 (it) * 2002-11-12 2004-05-13 Procos Spa Processo per la sintesi del modafinil.
CN1753867A (zh) 2003-02-24 2006-03-29 马林克罗特公司 制备二苯甲基硫代乙酰胺的方法

Also Published As

Publication number Publication date
US7244865B2 (en) 2007-07-17
WO2004075841A2 (en) 2004-09-10
US20060160903A1 (en) 2006-07-20
JP2006518754A (ja) 2006-08-17
CA2511992A1 (en) 2004-09-10
WO2004075841A3 (en) 2005-04-07
EP1603867A2 (en) 2005-12-14
CN1753867A (zh) 2006-03-29

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