MXPA04004982A - Derivados de benzotiazol. - Google Patents
Derivados de benzotiazol.Info
- Publication number
- MXPA04004982A MXPA04004982A MXPA04004982A MXPA04004982A MXPA04004982A MX PA04004982 A MXPA04004982 A MX PA04004982A MX PA04004982 A MXPA04004982 A MX PA04004982A MX PA04004982 A MXPA04004982 A MX PA04004982A MX PA04004982 A MXPA04004982 A MX PA04004982A
- Authority
- MX
- Mexico
- Prior art keywords
- optionally substituted
- lower alkyl
- phenyl
- thiophenyl
- pyridinyl
- Prior art date
Links
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 101150051188 Adora2a gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
La invencion se refiere a compuestos de formula general (I) en donde R es Hidrogeno, -(CH2)n,-fenilo, opcionalmente sustituido por halogeno,alquilo inferior, alcoxilo inferior, trifluorometilo o- N(R??)-C(O)-alquilo inferior, -(CH2)n-piridinilo, opcionalmente sustituido por alquilo inferior,-(CH2)n-C3-6-cicloalquilo, opcionalmente sustituido por hidroxilo,-(CH2)n -N(R??)-C3 -6-cicloalquilo, -(CH2)n-benzo ?1, 3?-dioxilo, -(CH??2)n -tiofenilo, opcionalmente sustituido por alquilo inferior,-(CR??2)n-tiazolilo, opcionalmente sustituido por alquilo inferior, -(CH2)n- C(O)-tiofenilo, opcionalmente sustituido por halogeno, -(CH2)n -furanilo, opcionalmente sustituido por alquilo inferior, -(CH2)n -C(O)-(CH2) n-tiofenilo, -(CHR??)n -benzofuran-2 -ilo, -(CH2)n -benzo? b?tiofenilo, opcionalmente sustituido por alquilo inferior, -(CH2)n-N(R??) -C(O) -fenilo, opcionalmente sustituido por halogeno o alcoxilo inferior, -(CH2) n-C(O) -fenilo, opcionalmente sustituido por alcoxilo inferior, -(CH2)n -C(O)-2, 3-dihidro -benzo ?1, 4?dioxin- 6-ilo, -(CH2)n -N(R??) -C(O)-piridinilo, -(CH2)n- tetrahidrofuranilo, -CH-bi -fenilo, -CH(fenil) -piridinilo, -(CH2)n -1-oxo-1, 3-dihidro-isoindol -2-ilo, -(CH2)n-1, 3-dioxo-1, 3-dihidro -isoindol-2 -ilo, -(CH2)n-CH (fenil)-tetrahidropiranilo, -(CH2)n-1 -oxo-1, 2, 3, 4-tetrahidro-isoquinolin. 3.il o -(CH2)n-S-?1, 3, 4?tiazol-2 -ilo, opcionalmente sustituido por amino; R?? es hidrogeno o alquilo inferior, independientemente uno del otro en el caso de R??2; y n es o, 1, 2, 3 o 4; y las sales de adicion acida farmaceuticamente aceptables de los mismos. Los compuestos de formula I tienen una buena afinidad por el receptor A2A y estos son por lo tanto utiles en el tratamiento de enfermedades, relacionadas con este receptor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01127442 | 2001-11-27 | ||
| PCT/EP2002/012907 WO2003045385A1 (en) | 2001-11-27 | 2002-11-18 | Benzothiazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04004982A true MXPA04004982A (es) | 2004-08-11 |
Family
ID=8179277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04004982A MXPA04004982A (es) | 2001-11-27 | 2002-11-18 | Derivados de benzotiazol. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6596718B1 (es) |
| EP (1) | EP1450796B1 (es) |
| JP (1) | JP4216193B2 (es) |
| KR (1) | KR100613197B1 (es) |
| CN (1) | CN1325052C (es) |
| AR (1) | AR037418A1 (es) |
| AT (1) | ATE391505T1 (es) |
| AU (1) | AU2002352045B2 (es) |
| BR (1) | BR0214455A (es) |
| CA (1) | CA2467825A1 (es) |
| DE (1) | DE60226063T2 (es) |
| ES (1) | ES2303558T3 (es) |
| GT (1) | GT200200240A (es) |
| MX (1) | MXPA04004982A (es) |
| PA (1) | PA8558201A1 (es) |
| PE (1) | PE20030735A1 (es) |
| PL (1) | PL370978A1 (es) |
| RU (1) | RU2293083C2 (es) |
| TW (1) | TW200408391A (es) |
| UY (1) | UY27551A1 (es) |
| WO (1) | WO2003045385A1 (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6678828B1 (en) * | 2002-07-22 | 2004-01-13 | Vormetric, Inc. | Secure network file access control system |
| RU2351597C2 (ru) * | 2003-05-19 | 2009-04-10 | Ф.Хоффманн-Ля Рош Аг | Производные бензотиазола в качестве лигандов аденозиновых рецепторов |
| JP4795022B2 (ja) * | 2003-09-30 | 2011-10-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環化合物を含有する新規な抗真菌剤 |
| JP4842829B2 (ja) | 2003-10-31 | 2011-12-21 | 武田薬品工業株式会社 | 含窒素縮合複素環化合物 |
| CA2553084A1 (en) * | 2004-01-28 | 2005-08-11 | Kissei Pharmaceutical Co., Ltd. | Novel benzofuran derivative, medicinal composition containing the same, and uses of these |
| WO2005096098A2 (en) * | 2004-03-30 | 2005-10-13 | Carl Zeiss Smt Ag | Projection objective, projection exposure apparatus and reflective reticle for microlithography |
| AU2005263499B2 (en) * | 2004-07-22 | 2010-11-25 | F. Hoffmann-La Roche Ag | Substituted benzothiazoles |
| JPWO2006016548A1 (ja) * | 2004-08-09 | 2008-05-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環化合物を含有する新規な抗マラリア剤 |
| JP4874958B2 (ja) | 2005-03-30 | 2012-02-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピリジン誘導体を含有する抗真菌剤 |
| JPWO2006115134A1 (ja) * | 2005-04-22 | 2008-12-18 | キッセイ薬品工業株式会社 | 新規なベンゾフラン誘導体、それを含有する医薬組成物およびそれらの用途 |
| TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| JP2009544616A (ja) * | 2006-07-21 | 2009-12-17 | 武田薬品工業株式会社 | アミド化合物 |
| US8183264B2 (en) * | 2006-09-21 | 2012-05-22 | Eisai R&D Managment Co., Ltd. | Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same |
| RU2009119394A (ru) | 2006-12-07 | 2011-01-20 | Ф. Хоффманн-Ля Рош Аг (Ch) | Производные спиро-пиперидина в качестве антагонистов рецептора v1a |
| KR101122969B1 (ko) | 2006-12-22 | 2012-03-22 | 에프. 호프만-라 로슈 아게 | 스피로-피페리딘 유도체 |
| US8084609B2 (en) | 2006-12-22 | 2011-12-27 | Hoffman-La Roche Inc. | Spiropiperidine derivatives |
| EP2143723A4 (en) * | 2007-04-27 | 2011-05-18 | Eisai R&D Man Co Ltd | SALT OF A PYRIDINE DERIVATIVE SUBSTITUTED BY HETEROCYCLE OR CRYSTALS OF THE SAME |
| TW200841879A (en) | 2007-04-27 | 2008-11-01 | Eisai R&D Man Co Ltd | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| US8188119B2 (en) * | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
| AU2012272895B2 (en) | 2011-06-24 | 2015-01-22 | Amgen Inc. | TRPM8 antagonists and their use in treatments |
| WO2012177896A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| WO2013042137A1 (en) * | 2011-09-19 | 2013-03-28 | Aurigene Discovery Technologies Limited | Bicyclic heterocycles as irak4 inhibitors |
| US8940742B2 (en) * | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3964507A1 (en) | 2013-10-04 | 2022-03-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9775844B2 (en) | 2014-03-19 | 2017-10-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
| HK1261923A1 (zh) | 2015-09-14 | 2020-01-10 | Twelve Therapeutics, Inc. | 异喹啉酮衍生物的固体形式、其制备方法、包含其的组合物及其使用方法 |
| US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
| US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MA46856A (fr) * | 2016-11-18 | 2019-09-25 | Merck Sharp & Dohme | Dérivés d'indazole utiles en tant qu'inhibiteurs de la diacylglycéride o-acyltransférase 2 |
| JP7233809B2 (ja) | 2018-09-04 | 2023-03-07 | エフ． ホフマン－ラ ロシュ アーゲー | 自己免疫疾患の処置のためのベンゾチアゾール化合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8717068D0 (en) * | 1987-07-20 | 1987-08-26 | Fujisawa Pharmaceutical Co | Nitric ester derivative |
| PT1303272E (pt) * | 2000-06-21 | 2008-04-14 | Hoffmann La Roche | Derivados de benzotiazole |
-
2002
- 2002-11-18 AT AT02787718T patent/ATE391505T1/de active
- 2002-11-18 RU RU2004119438/04A patent/RU2293083C2/ru not_active IP Right Cessation
- 2002-11-18 JP JP2003546887A patent/JP4216193B2/ja not_active Expired - Fee Related
- 2002-11-18 MX MXPA04004982A patent/MXPA04004982A/es active IP Right Grant
- 2002-11-18 AU AU2002352045A patent/AU2002352045B2/en not_active Ceased
- 2002-11-18 PL PL02370978A patent/PL370978A1/xx not_active Application Discontinuation
- 2002-11-18 BR BR0214455-7A patent/BR0214455A/pt not_active IP Right Cessation
- 2002-11-18 KR KR1020047007929A patent/KR100613197B1/ko not_active Expired - Fee Related
- 2002-11-18 WO PCT/EP2002/012907 patent/WO2003045385A1/en active IP Right Grant
- 2002-11-18 CA CA002467825A patent/CA2467825A1/en not_active Abandoned
- 2002-11-18 EP EP02787718A patent/EP1450796B1/en not_active Expired - Lifetime
- 2002-11-18 US US10/298,347 patent/US6596718B1/en not_active Expired - Fee Related
- 2002-11-18 CN CNB028236041A patent/CN1325052C/zh not_active Expired - Fee Related
- 2002-11-18 ES ES02787718T patent/ES2303558T3/es not_active Expired - Lifetime
- 2002-11-18 DE DE60226063T patent/DE60226063T2/de not_active Expired - Lifetime
- 2002-11-22 PA PA20028558201A patent/PA8558201A1/es unknown
- 2002-11-22 TW TW091134083A patent/TW200408391A/zh unknown
- 2002-11-22 GT GT200200240A patent/GT200200240A/es unknown
- 2002-11-25 AR ARP020104516A patent/AR037418A1/es unknown
- 2002-11-25 PE PE2002001132A patent/PE20030735A1/es not_active Application Discontinuation
- 2002-11-26 UY UY27551A patent/UY27551A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1731999A (zh) | 2006-02-08 |
| JP4216193B2 (ja) | 2009-01-28 |
| RU2293083C2 (ru) | 2007-02-10 |
| RU2004119438A (ru) | 2006-01-10 |
| DE60226063D1 (en) | 2008-05-21 |
| AU2002352045B2 (en) | 2006-08-17 |
| PL370978A1 (en) | 2005-06-13 |
| EP1450796B1 (en) | 2008-04-09 |
| KR100613197B1 (ko) | 2006-08-21 |
| US6596718B1 (en) | 2003-07-22 |
| CN1325052C (zh) | 2007-07-11 |
| WO2003045385A1 (en) | 2003-06-05 |
| EP1450796A1 (en) | 2004-09-01 |
| AR037418A1 (es) | 2004-11-10 |
| UY27551A1 (es) | 2003-06-30 |
| JP2005526007A (ja) | 2005-09-02 |
| AU2002352045A1 (en) | 2003-06-10 |
| DE60226063T2 (de) | 2009-05-20 |
| PA8558201A1 (es) | 2003-09-05 |
| GT200200240A (es) | 2003-07-30 |
| ATE391505T1 (de) | 2008-04-15 |
| ES2303558T3 (es) | 2008-08-16 |
| BR0214455A (pt) | 2004-11-03 |
| TW200408391A (en) | 2004-06-01 |
| PE20030735A1 (es) | 2003-08-29 |
| KR20040062968A (ko) | 2004-07-09 |
| CA2467825A1 (en) | 2003-06-05 |
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