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MXPA04004658A - Tumor specific monoclonal antibodies. - Google Patents

Tumor specific monoclonal antibodies.

Info

Publication number
MXPA04004658A
MXPA04004658A MXPA04004658A MXPA04004658A MXPA04004658A MX PA04004658 A MXPA04004658 A MX PA04004658A MX PA04004658 A MXPA04004658 A MX PA04004658A MX PA04004658 A MXPA04004658 A MX PA04004658A MX PA04004658 A MXPA04004658 A MX PA04004658A
Authority
MX
Mexico
Prior art keywords
monoclonal antibodies
tumor
human monoclonal
specific
monoclonal antibody
Prior art date
Application number
MXPA04004658A
Other languages
Spanish (es)
Inventor
D Watkins Jeffry
Original Assignee
Applied Molecular Evolution
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Molecular Evolution filed Critical Applied Molecular Evolution
Publication of MXPA04004658A publication Critical patent/MXPA04004658A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides tumor-specific human monoclonal antibodies and functional fragments. Also provided are nucleic acids encoding tumor-specific human monoclonal antibodies and functional fragments. A method for reducing neoplastic cell proliferation is also provided. The method consists of administering an effective amount of a tumor-specific human monoclonal antibody or functional fragment. Also provided is a method of detecting a neoplastic cell in a sample. The method consists of contacting a cell with a tumor-specific monoclonal antibody or functional fragment and detecting the specific binding of the human monoclonal antibody or functional fragment to the sample.
MXPA04004658A 2001-11-19 2002-11-19 Tumor specific monoclonal antibodies. MXPA04004658A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98990101A 2001-11-19 2001-11-19
PCT/US2002/037134 WO2003044036A1 (en) 2001-11-19 2002-11-19 Tumor specific monoclonal antibodies

Publications (1)

Publication Number Publication Date
MXPA04004658A true MXPA04004658A (en) 2004-08-13

Family

ID=25535569

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04004658A MXPA04004658A (en) 2001-11-19 2002-11-19 Tumor specific monoclonal antibodies.

Country Status (8)

Country Link
EP (1) EP1446416A4 (en)
JP (1) JP2005517388A (en)
CN (1) CN1615315A (en)
AU (1) AU2002365978A1 (en)
BR (1) BR0214288A (en)
CA (1) CA2467020A1 (en)
MX (1) MXPA04004658A (en)
WO (1) WO2003044036A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2164869A2 (en) * 2007-05-31 2010-03-24 Merck Sharp & Dohme Corp. Antigen-binding proteins targeting s. aureus orf0657n
CA2836468C (en) 2011-05-17 2021-05-04 The Rockefeller University Human immunodeficiency virus neutralizing antibodies and methods of use thereof
CA3097369A1 (en) 2018-04-17 2019-10-24 Celldex Therapeutics, Inc. Anti-cd27 and anti-pd-l1 antibodies and bispecific constructs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281335B1 (en) * 1993-10-08 2001-08-28 Coulter Corporation Hybridoma and anti-KC-4 humanized monoclonal antibody
JP4436457B2 (en) * 1995-08-18 2010-03-24 モルフォシス アイピー ゲーエムベーハー Protein / (poly) peptide library
ES2312177T3 (en) * 1996-05-22 2009-02-16 Viventia Biotech Inc. FRAGMENTS OF UNION TO ANTIGENS THAT SPECIFICALLY DETECT CANCER CELLS, NUCLEOTIDES THAT CODIFY FRAGMENTS AND THE USE OF THE SAME FOR THE PROFILAXIS AND CANCER DETECTION.
US6303323B1 (en) * 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
US6787638B1 (en) * 1998-12-02 2004-09-07 Applied Molecular Evolution, Inc. Tumor specific human monoclonal antibodies and methods of use
IT1307864B1 (en) * 1999-04-20 2001-11-19 Istituto Naz Per La Ricerca Su DIAGNOSTIC METHOD FOR THE RECOGNITION OF HUMAN NEOPLASIA THROUGH THE DETERMINATION OF THE CTN-C ISOFORM OF TN-C, FRAGMENTS OF

Also Published As

Publication number Publication date
JP2005517388A (en) 2005-06-16
EP1446416A1 (en) 2004-08-18
WO2003044036A1 (en) 2003-05-30
EP1446416A4 (en) 2005-11-30
CN1615315A (en) 2005-05-11
AU2002365978A1 (en) 2003-06-10
CA2467020A1 (en) 2003-05-30
BR0214288A (en) 2004-11-09

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal