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MXPA03010121A - Terapia de combinacion que utiliza anticuerpos anti-receptor de factor de crecimiento epidermico y agentes anti-hormonales. - Google Patents

Terapia de combinacion que utiliza anticuerpos anti-receptor de factor de crecimiento epidermico y agentes anti-hormonales.

Info

Publication number
MXPA03010121A
MXPA03010121A MXPA03010121A MXPA03010121A MXPA03010121A MX PA03010121 A MXPA03010121 A MX PA03010121A MX PA03010121 A MXPA03010121 A MX PA03010121A MX PA03010121 A MXPA03010121 A MX PA03010121A MX PA03010121 A MXPA03010121 A MX PA03010121A
Authority
MX
Mexico
Prior art keywords
combination therapy
hormonal agents
egfr antibodies
agents
tumors
Prior art date
Application number
MXPA03010121A
Other languages
English (en)
Inventor
Oliver Rosen
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MXPA03010121A publication Critical patent/MXPA03010121A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion se refiere a una terapia de combinacion para el tratamiento de tumores y metastasis tumorales, preferiblemente tumores de mama y de prostata, que consiste en la administracion de anticuerpos anti-EGFR (Her1) y agentes anti-hormonales, opcionalmente junto con un agente citotoxico y/o quimioterapeutico. El metodo y las composiciones farmaceuticas que comprenden esos agentes pueden dar por resultado una potenciacion sinergistica del efecto de inhibicion de proliferacion de celulas tumorales de cada agente terapeutico individual, lo que da un tratamiento mas efectivo que el encontrado al administrar un componente individual solo.
MXPA03010121A 2001-05-08 2002-04-22 Terapia de combinacion que utiliza anticuerpos anti-receptor de factor de crecimiento epidermico y agentes anti-hormonales. MXPA03010121A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01111049 2001-05-08
PCT/EP2002/004404 WO2002089842A1 (en) 2001-05-08 2002-04-22 Combination therapy using anti-egfr antibodies and anti-hormonal agents

Publications (1)

Publication Number Publication Date
MXPA03010121A true MXPA03010121A (es) 2004-03-10

Family

ID=8177348

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03010121A MXPA03010121A (es) 2001-05-08 2002-04-22 Terapia de combinacion que utiliza anticuerpos anti-receptor de factor de crecimiento epidermico y agentes anti-hormonales.

Country Status (16)

Country Link
US (2) US20040131611A1 (es)
EP (1) EP1385546A1 (es)
JP (1) JP2004528368A (es)
KR (1) KR20040029975A (es)
CN (1) CN1507355A (es)
AU (1) AU2002315306B2 (es)
BR (1) BR0209147A (es)
CA (1) CA2449166A1 (es)
CZ (1) CZ20033226A3 (es)
HU (1) HUP0303976A3 (es)
MX (1) MXPA03010121A (es)
PL (1) PL363322A1 (es)
RU (1) RU2003134180A (es)
SK (1) SK14632003A3 (es)
WO (1) WO2002089842A1 (es)
ZA (1) ZA200309437B (es)

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Also Published As

Publication number Publication date
KR20040029975A (ko) 2004-04-08
CN1507355A (zh) 2004-06-23
SK14632003A3 (sk) 2004-03-02
RU2003134180A (ru) 2005-02-10
EP1385546A1 (en) 2004-02-04
HUP0303976A2 (hu) 2004-03-01
PL363322A1 (en) 2004-11-15
US20070202101A1 (en) 2007-08-30
WO2002089842A1 (en) 2002-11-14
BR0209147A (pt) 2004-06-08
CA2449166A1 (en) 2002-11-14
JP2004528368A (ja) 2004-09-16
ZA200309437B (en) 2005-03-04
AU2002315306B2 (en) 2007-05-17
CZ20033226A3 (en) 2004-07-14
HUP0303976A3 (en) 2006-11-28
US20040131611A1 (en) 2004-07-08

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