MXPA03008681A - (oxo-pirazol[1,5]pirimidin-2-il)alquil-carboxamidas. - Google Patents
(oxo-pirazol[1,5]pirimidin-2-il)alquil-carboxamidas.Info
- Publication number
- MXPA03008681A MXPA03008681A MXPA03008681A MXPA03008681A MXPA03008681A MX PA03008681 A MXPA03008681 A MX PA03008681A MX PA03008681 A MXPA03008681 A MX PA03008681A MX PA03008681 A MXPA03008681 A MX PA03008681A MX PA03008681 A MXPA03008681 A MX PA03008681A
- Authority
- MX
- Mexico
- Prior art keywords
- carboxamides
- pyrazolo
- pyrimidin
- oxo
- alkyl
- Prior art date
Links
- 125000005431 alkyl carboxamide group Chemical group 0.000 title 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 title 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 2
- 108091008681 GABAA receptors Proteins 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invencion se refiere a compuestos de la formula: (I), y las sales de los mismos farmaceuticamente aceptables, en donde las variables R1, R2, A, R4, R5, R6, R6', n y W, son como se definen en este documento. Se proporcionan estos compuestos que se enlazan al sitio benzodiazepina de los receptores GABAA, y por lo tanto, pueden ser usados para modular en enlace ligando a los receptores GABAA in vivo o in vitro y son particularmente empleados en el tratamiento de una variedad de trastornos del sistema nervioso central (SNC) en humanos, animales de compania domesticados y de ganado.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27914701P | 2001-03-27 | 2001-03-27 | |
| PCT/US2002/009339 WO2002076987A1 (en) | 2001-03-27 | 2002-03-27 | (oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03008681A true MXPA03008681A (es) | 2004-04-02 |
Family
ID=23067823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03008681A MXPA03008681A (es) | 2001-03-27 | 2002-03-27 | (oxo-pirazol[1,5]pirimidin-2-il)alquil-carboxamidas. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6703393B2 (es) |
| EP (1) | EP1392692B1 (es) |
| JP (1) | JP2004525937A (es) |
| AT (1) | ATE345344T1 (es) |
| BR (1) | BR0208241A (es) |
| CA (1) | CA2441926A1 (es) |
| DE (1) | DE60216083T2 (es) |
| ES (1) | ES2276936T3 (es) |
| MX (1) | MXPA03008681A (es) |
| WO (1) | WO2002076987A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0303910D0 (en) * | 2003-02-20 | 2003-03-26 | Merck Sharp & Dohme | Therapeutic agents |
| US20050245517A1 (en) * | 2004-04-29 | 2005-11-03 | Phil Skolnick | 2-pyridinyl[7-(substituted-pyridin-4-yl) pyrazolo[1,5-a]pyrimidin-3-yl]methanones |
| US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
| SI2074123T1 (sl) * | 2006-10-16 | 2013-03-29 | Bionomics Limited | Nove anksiolitične spojine |
| EP2681198A4 (en) | 2011-03-02 | 2014-09-03 | Bionomics Ltd | NEW LITTLE MOLECULES AS THERAPIES |
| US9133188B2 (en) | 2011-05-12 | 2015-09-15 | Bionomics Limited | Methods for preparing naphthyridines |
| EP2674434A1 (en) * | 2012-06-11 | 2013-12-18 | Ares Trading S.A. | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
| WO2013091773A1 (en) * | 2011-12-22 | 2013-06-27 | Merck Patent Gmbh | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| JP2018076234A (ja) * | 2015-03-16 | 2018-05-17 | 大正製薬株式会社 | ピラゾロ［１，５−ａ］ピリミジン化合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2157285B (en) * | 1984-04-11 | 1987-10-28 | Erba Farmitalia | 1h, 7h-pyrazolo1, 5-a pyrimidine-7-one derivatives and process for their preparation |
| US4950585A (en) * | 1987-08-18 | 1990-08-21 | Konica Corporation | Coupler for photographic use |
| WO1992018504A1 (fr) * | 1991-04-22 | 1992-10-29 | Otsuka Pharmaceutical Factory, Inc. | DERIVE DE PYRAZOLO[1,5-a]PYRIMIDINE ET AGENT ANTI-INFLAMMATOIRECONTENANT CE DERIVE |
| EP0795555A4 (en) * | 1995-09-28 | 1998-01-07 | Otsuka Pharma Co Ltd | ANALGESICS |
| US5723608A (en) | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
| US6380210B1 (en) | 1999-04-02 | 2002-04-30 | Neurogen Corporation | Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
| US6271241B1 (en) | 1999-04-02 | 2001-08-07 | Neurogen Corporation | Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors |
| US6358949B1 (en) | 1999-04-02 | 2002-03-19 | Neurogen Corporation | Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors |
| AU2001236471A1 (en) | 2000-01-18 | 2001-07-31 | Neurogen Corporation | Imidazopyridines and related azacyclic derivatives as selective modulators of bradykinin b2 receptors |
| AU2001264932A1 (en) | 2000-05-26 | 2001-12-11 | Neurogen Corporation | Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands |
| AU2001270297A1 (en) | 2000-06-30 | 2002-01-14 | Neurogen Corporation | 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands |
| CA2419966A1 (en) | 2000-09-06 | 2002-03-14 | Neurogen Corporation | Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor |
| CA2419958A1 (en) | 2000-09-06 | 2002-03-14 | Neurogen Corporation | Substituted fused pyrroleimines and pyrazoleimines |
| EP1506196B1 (en) * | 2001-11-01 | 2012-01-18 | Icagen, Inc. | Pyrazolopyrimidines as sodium channel inhibitors |
-
2002
- 2002-03-27 JP JP2002576245A patent/JP2004525937A/ja active Pending
- 2002-03-27 ES ES02728576T patent/ES2276936T3/es not_active Expired - Lifetime
- 2002-03-27 CA CA002441926A patent/CA2441926A1/en not_active Abandoned
- 2002-03-27 MX MXPA03008681A patent/MXPA03008681A/es active IP Right Grant
- 2002-03-27 WO PCT/US2002/009339 patent/WO2002076987A1/en active IP Right Grant
- 2002-03-27 EP EP02728576A patent/EP1392692B1/en not_active Expired - Lifetime
- 2002-03-27 US US10/107,790 patent/US6703393B2/en not_active Expired - Fee Related
- 2002-03-27 BR BR0208241-1A patent/BR0208241A/pt not_active IP Right Cessation
- 2002-03-27 DE DE60216083T patent/DE60216083T2/de not_active Expired - Fee Related
- 2002-03-27 AT AT02728576T patent/ATE345344T1/de not_active IP Right Cessation
-
2004
- 2004-03-09 US US10/796,509 patent/US7008947B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20040176397A1 (en) | 2004-09-09 |
| EP1392692B1 (en) | 2006-11-15 |
| US20030109536A1 (en) | 2003-06-12 |
| US6703393B2 (en) | 2004-03-09 |
| US7008947B2 (en) | 2006-03-07 |
| ES2276936T3 (es) | 2007-07-01 |
| JP2004525937A (ja) | 2004-08-26 |
| ATE345344T1 (de) | 2006-12-15 |
| EP1392692A1 (en) | 2004-03-03 |
| DE60216083D1 (de) | 2006-12-28 |
| CA2441926A1 (en) | 2002-10-03 |
| DE60216083T2 (de) | 2007-06-28 |
| WO2002076987A1 (en) | 2002-10-03 |
| BR0208241A (pt) | 2004-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |