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MXPA03004300A - Microangulos basados en principio activo y metodo para su fabricacion. - Google Patents

Microangulos basados en principio activo y metodo para su fabricacion.

Info

Publication number
MXPA03004300A
MXPA03004300A MXPA03004300A MXPA03004300A MXPA03004300A MX PA03004300 A MXPA03004300 A MX PA03004300A MX PA03004300 A MXPA03004300 A MX PA03004300A MX PA03004300 A MXPA03004300 A MX PA03004300A MX PA03004300 A MXPA03004300 A MX PA03004300A
Authority
MX
Mexico
Prior art keywords
active principle
making same
core
microgranules
coated
Prior art date
Application number
MXPA03004300A
Other languages
English (en)
Inventor
Gerard Cousin
Original Assignee
Ethypharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Sa filed Critical Ethypharm Sa
Publication of MXPA03004300A publication Critical patent/MXPA03004300A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micromachines (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion se refiere a un microgranulo que consiste de un nucleo recubierto con al menos una capa de recubrimiento, el nucleo recubierto comprende al menos un principio activo. La invencion esta caracterizada porque el nucleo y la capa de recubrimiento contienen cada uno entre 80 y 95% en peso de principio activo, el complemento hasta 100% consiste de al menos un agente aglutinante, y el nucleo recubierto tiene una forma sustancialmente esferica. La invencion tambien se refiere al metodo para la fabricacion de tales microgranulos.
MXPA03004300A 2000-11-16 2001-11-15 Microangulos basados en principio activo y metodo para su fabricacion. MXPA03004300A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0014803A FR2816507B1 (fr) 2000-11-16 2000-11-16 Microgranules a base de principe actif, procede de fabrication et compositons pharmaceutiques integrant lesdits microgranules
PCT/FR2001/003584 WO2002039981A1 (fr) 2000-11-16 2001-11-15 Microgranules a base de principe actif et leur procede de fabrication

Publications (1)

Publication Number Publication Date
MXPA03004300A true MXPA03004300A (es) 2004-09-10

Family

ID=8856551

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03004300A MXPA03004300A (es) 2000-11-16 2001-11-15 Microangulos basados en principio activo y metodo para su fabricacion.

Country Status (15)

Country Link
US (1) US7829122B2 (es)
EP (1) EP1333812B1 (es)
JP (1) JP4234427B2 (es)
CN (1) CN1222277C (es)
AT (1) ATE387187T1 (es)
AU (2) AU2307402A (es)
CA (1) CA2427899C (es)
DE (1) DE60133028T2 (es)
DK (1) DK1333812T3 (es)
ES (1) ES2300384T3 (es)
FR (1) FR2816507B1 (es)
HK (1) HK1063017A1 (es)
MX (1) MXPA03004300A (es)
PT (1) PT1333812E (es)
WO (1) WO2002039981A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796840B1 (fr) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques Comprimes faiblement doses et procede de preparation
ATE346590T1 (de) * 2001-07-26 2006-12-15 Ethypharm Sa Umgehüllte allylamine oder benzylamine enthaltende granulate, verfahren zur herstellung und in der mundhöhle dispergierbare tabletten enthaltend die umgehüllten granulate
FR2831820B1 (fr) * 2001-11-05 2004-08-20 Ethypharm Sa Comprime orodispersible presentant une grande homogeneite et son procede de preparation
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
FR2850576B1 (fr) * 2003-02-05 2007-03-23 Ethypharm Sa Composition comprenant un melange de principes actifs, et procede de preparation
AU2004261143B2 (en) * 2003-07-25 2009-11-05 Allergan Pharmaceuticals International Limited A doxycycline metal complex in a solid dosage form
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
LT2486942T (lt) 2004-11-24 2019-01-25 Meda Pharmaceuticals Inc. Kompozicijos, apimančios azelastiną ir jų panaudojimo būdai
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
CA2595481C (en) * 2005-01-21 2014-05-13 Warner Chilcott Company, Inc. A tetracycline metal complex in a solid dosage form
CN101912360A (zh) * 2010-07-13 2010-12-15 山东达因海洋生物制药股份有限公司 布洛芬混悬液及其制备方法
ES2673286T3 (es) 2011-02-11 2018-06-21 Zx Pharma, Llc Formulaciones multiparticuladas de L-mentol y métodos relacionados
US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
DE102012007671A1 (de) 2012-04-16 2013-10-17 Acino Pharma Ag Pellets mit hohem Wirkstoffgehalt
FR2999432B1 (fr) 2012-12-17 2014-12-12 Ethypharm Sa Comprimes orodispersibles obtenus par compression moulage
ES2706152T3 (es) 2013-04-23 2019-03-27 Zx Pharma Llc Composición entérica de múltiples partículas revestida con subrevestimiento proteico
KR102019645B1 (ko) * 2019-02-21 2019-09-09 한국화학연구원 염기성오염물질 제거용 비드 및 이의 제조방법
CN111184694A (zh) * 2020-01-19 2020-05-22 广东青云山药业有限公司 一种口腔速溶颗粒的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558768A (en) * 1969-12-19 1971-01-26 Sterling Drug Inc Sustained release pharmaceutical compositions
IT1115596B (it) 1978-03-13 1986-02-03 Bayer Italia Spa Metodo per la preparazione di microgranuli gastoresistenti ed enterosolubili di sostanze farmaceutiche,in particolare di sostanze proteiche e microgranuli preparati con detto metodo
US4248858A (en) * 1979-08-09 1981-02-03 American Home Products Corporation Sustained release pharmaceutical compositions
IT1180507B (it) * 1984-06-29 1987-09-23 Roberto Valducci Procedimento per la preparazione di etofibrato o sostanze di pari o simili caratteristiche, in microgunuli-ritardo e prodotto ottenuto con tale procedimento
JPS63188621A (ja) * 1987-01-30 1988-08-04 Taisho Pharmaceut Co Ltd 矯味経口製剤
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US4853229A (en) * 1987-10-26 1989-08-01 Alza Corporation Method for adminstering tiny pills
US5344657A (en) * 1988-04-27 1994-09-06 Elf Sanofi Microbeads of diltiazem, a process for their manufacture and a substained-release pharmaceutical composition containing them
JP3078859B2 (ja) 1990-02-23 2000-08-21 武田薬品工業株式会社 安定な放出制御性製剤用コーティング剤
SE9003296L (sv) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
EP0744941B1 (en) 1994-02-16 2003-06-04 Abbott Laboratories Process for preparing fine particle pharmaceutical formulations
US5837292A (en) * 1996-07-03 1998-11-17 Yamanouchi Europe B.V. Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug

Also Published As

Publication number Publication date
FR2816507B1 (fr) 2003-02-28
CA2427899A1 (fr) 2002-05-23
ATE387187T1 (de) 2008-03-15
US7829122B2 (en) 2010-11-09
PT1333812E (pt) 2008-03-17
HK1063017A1 (en) 2004-12-10
DK1333812T3 (da) 2008-03-31
CN1481235A (zh) 2004-03-10
DE60133028D1 (de) 2008-04-10
JP2004517064A (ja) 2004-06-10
ES2300384T3 (es) 2008-06-16
EP1333812A1 (fr) 2003-08-13
US20040101568A1 (en) 2004-05-27
JP4234427B2 (ja) 2009-03-04
FR2816507A1 (fr) 2002-05-17
CN1222277C (zh) 2005-10-12
AU2002223074B2 (en) 2005-03-10
CA2427899C (fr) 2011-05-10
DE60133028T2 (de) 2009-03-12
WO2002039981A1 (fr) 2002-05-23
AU2307402A (en) 2002-05-27
EP1333812B1 (fr) 2008-02-27

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