MXPA00005236A - Skin protection composition - Google Patents

Abstract

The invention relates to cationic compounds and triester compounds to be used for preparation of compositions, which preferably can be in the form of lotions, creams, powders, oils, foams and the like, and be applied to the skin to prevent or reduce or treat skin rash or diaper rash resulting from lypolytic dermatitis. The compositions of the invention can also be applied to diapers, incontinent-pads, wipes and the like. The invention also relates to the use of such a composition to prevent or reduce such a skin rash and a process for reducing the enzyme activity enzymes which are deactivated when the pH is reduced, such as lipase enzymes present on external skin.

Description

COMPOSITION FOR SKIN PROTECTION The invention relates to cationic compounds and triester compounds which will be used in the preparation of compositions, which may be in the form of lotions, creams, powders, oils, foams and the like, and applied to the skin to prevent or reduce or treating the skin rash or rash by diaper resulting from lipolytic dermatitis. The compositions can also be applied to diapers, incontinence pads, cleaning towels and the like. The invention also relates to the use of such a composition to prevent or reduce such a skin rash and to a process for reducing enzymes with enzymatic activity which are deactivated when the pH is reduced, such as the lipase enzymes present in the outer skin. .

BACKGROUND The skin rash caused by dermatitis, often referred to as a diaper rash, has always been a problem encountered by users of disposable absorbent articles, such as diapers, incontinence articles, sanitary napkins, training pants, etc. Therefore, one of the greatest needs of users is a solution for this type of skin rash problem. The main factor influencing the development of the skin rash is the contact of the skin with the wet exudations of the body, directly or for example contained in the absorbent article. Especially when the water content is high, the skin rash can easily occur.

Manufacturers of diapers and skin care products have developed several products in the past decades that help reduce the outbreak of the diaper rash (or skin rash). The central point of this has been to reduce the exposure of the skin to body exudations. This is done for example by introducing the diapers with absorbent or more absorbent materials. The amount of water that is in contact with the skin is thus reduced. Other products that are developed to treat the skin rash problem reduce the exposure of the skin with certain ingredients of the body exudations. An example of such ingredients are bacteria that can infect the skin and thus start or aggravate the skin rash. For example, lotions that have been developed can form a barrier between the skin and body exudations. Also, the compositions can be applied to the skin or to the absorbent article. European patent EP 0191128 discloses a preparation comprising 8-hydroxy quinoline sulfate for the treatment of skin irritation. However, it remains one of the most widely heard complaints among users of absorbent articles such as diapers, the persistence of the skin rash or diaper, despite the numerous products on the market that can be applied to prevent irritation. the skin or diaper. It has been discovered that another factor can also generate or aggravate the skin rash, namely the presence in the body exudations of several enzymes, especially the enzymes of lipase and protease. European patent EP 0117632-B refers to disposable articles comprising lipase inhibiting agents, preferably zinc-containing components, and a carrier material. The use of glycerol triacetate is also mentioned. U.S. Patent No. 3,961,486 teaches the use of adipic acid to reduce the activity of the lipase enzyme and to reduce the skin rash. When the skin is exposed to lipase enzymes, the lipids of the skin can be affected by these enzymes. In addition, protease enzymes present in the body's exudate on the skin can affect the proteins (or peptides) of the skin. The protective function or barrier of the upper layer of the skin (the Strateum Corneum) will thus be diminished. This can affect the health of the skin and / or facilitate skin infection. This can thus lead to skin rash or diaper rash. It has been found that the triester compounds similar to skin lipids in particular, they can function as enzyme substrates, which, when acting on a hydrolyzing esterase enzyme, such as lipase enzymes, will be hydrolyzed resulting in the release of the free acids. First, the presence of these acids will reduce the pH of the area where the esters are applied topically. This will increase the inactivation of all or most of the enzymes present in this area, in the exudates of the body, such as lipase enzymes, protease enzymes. Secondarily, the lipase or esterase enzymes are "deactivated", because instead of hydrolyzing the esters, such as lipids, of the skin, these hydrolyse the alternative substrate, the triester compounds of the invention. It is known that bile salts are present in body exudations. These bile salts are known to emulsify the lipase enzymes in the body, which ensure that the lipase enzymes are capable of working at the lipid / water interface. It has been found that these bile salts have an emulsifying function once they leave the body, in the exudates of the body. These help the lipase enzyme that is present in body exudation by attacking the lipids in the outer layer of the skin, exposed to the exudation of the body. The inventors have found that these bile salts can be inactive (and thereby the lipase can be deactivated) when the salts react with specific cationic compounds. They have found that compositions comprising cationic components can be applied directly to the skin. This can be done by introducing the composition into cream, lotion, foam, oil, cosmetic powder. Alternatively, the composition can be applied to an absorbent article, such as a diaper, which can be applied to the skin. Surprisingly, it has been found that the use of a combination of cationic compounds and the triester compounds has an improved and prolonged effect on skin rash or lipolytic dermatitis. Unexpectedly, it has been found that the inhibition or inactivation of lipase enzymes by inactivating the bile salts by the cationic compounds does not make the triester compounds less useful as enzyme substrates. Primarily, it has been found that cationic compounds provide an immediate effect, i.e., the inhibition or inactivation of lipase enzymes, which can be reduced over time, while the effect of the triester compounds is relatively delayed but long duration. In this way, the combination of two compounds provides an effective, immediate and long-lasting reduction or prevention of skin / diaper rash, which results from dermatitis caused by enzymes present in body exudates on the skin. .

BRIEF DESCRIPTION OF THE INVENTION The invention relates to the use of a compound (a) and a compound (b) for the preparation of a composition for the prevention or treatment of lipolytic dermatitis of the external skin, wherein (a) and (b) are: (a) a triester compound of the formula: wherein R ^ R2 and R3 are independently an alkyl or alkenyl or hydroxyalkyl group with 1 to 22 carbon atoms, and R, R5, R6, R and Rs are independently selected from the group consisting of alkyl, alkenyl or hydroxyalkyl groups of linear or branched C, hydroxy, chlorine, bromine, amine or hydrogen; and (b) a cationic compound of the formula: R ^ R - N - Rl Rn M "(ll) or an amphoteric compound and preferably an acid source, the amphoteric compound having its electrical point the formula: - wherein R1 f R2, R3 and R are independently selected from the group consisting of linear or branched alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl or acyl groups, or two or more groups of R ^ R2, R3 and R4 together form one or more ring structures; R5, R6 and A are independently selected from the group consisting of linear or branched alkylene, alkenylene, (poly) alkoxylene, hydroxyalkylene, arylalkylene or amidoalkylene groups of C, -C22; R7 and R8 are independently an alkyl group of CtC l alkenyl, alkoxy, or a hydroxy group or hydrogen; R9 and R10 are independently selected from the group consisting of linear or branched alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl or acyl groups, or two or more groups of R ^ R9, and R10 form jointly one or more ring structures; BH is a proton donor group; x is from 2 to 4; and M "is a counter ion.

The invention also provides a disposable absorbent article, preferably a cleaning diaper or towel, which contains a composition comprising the cationic compound and the ester compound described above, preferably at a level such that the compounds are each present at a level of 0.01% to 10% by weight of the article, preferably comprised in the upper sheet of the diaper. The invention also provides compositions introduced in a cosmetic cream, lotion, gel, oil, ointment or powder or the like, for topical application to the outer skin.

DETAILED DESCRIPTION OF THE INVENTION The cationic compounds and the ester compounds are used for the preparation of compositions for the prevention, reduction and treatment of lipolytic dermatitis of the skin (external). Herein the treatment or reduction means the reduction of lipolytic dermatitis or skin rash, the rash by the diaper, which is caused by the lipase enzymes present in the skin, or at least the stabilization of the skin. Dermatitis or the skin rash that is caused by these enzymes. The composition of the invention can be applied to the skin that is in contact with at least the lipase enzymes. Such compositions can be comprised in a cream, lotion, oil, ointment, foam, powder or gel, which can be applied topically to the skin. Alternatively, the compositions of the invention can be applied to an absorbent article, which can be brought into contact with the skin which is in contact with the lipase enzymes. Such articles are preferably disposable such as diapers, incontinence pads, training pants, sanitary napkins, feminine hygiene garments, dry or wet cleaning towels. By the term "topical application" or "topically applied", as used herein, it is understood that it is directly placed or dispersed in the epidermal tissue, specifically in the outer skin. The amount of the composition comprising the ester compounds of the invention will vary according to the particular location of the condition being treated., the severity of the condition being treated, the expected duration of the treatment, any specific sensitivity for any composition by itself, or the concentration of the specific ester compounds for the user, the condition of the user, concurrent therapies that are administered, other conditions present in the user. For the present invention it is preferred that a minimum inhibitory concentration of the compositions containing the ester and cationic compounds of the invention be applied topically, to act as a deactivator or inhibitor of the lipase in the area in need of treatment of the lipolytic dermatitis or the area where the prevention of enzymatic dermatitis is desired in such a way that it is available to inhibit the activity of the present lipase. This area (or "affected area," as it is used here) means the area of the skin that presently exhibits any level of skin rash or enzymatic dermatitis, or the area that will be in prolonged contact with body exudates. which contain the enzymes, in particular the lipase enzyme. This also includes the area immediately approaching the area described. This is the area in which the treatment, reduction, and / or prevention is desired.

Lipolytic Dermatitis This invention relates to compositions comprising the triester compounds and the cationic compounds described above or the absorbent (disposable) articles incorporating the compositions for the treatment of dermatitis, in particular diaper rash or diaper rash caused by the lipase enzymes present in body exudates (thus lipolytic dermatitis), and other conditions that are associated with prolonged contact of the skin with body exudations and / or the use of an absorbent article, or in particular a diaper. Lipase, lipase enzymes or lipolytic enzymes is the trivial or common term used to represent a group of enzymes that belong to esterases. Its general activity is to hydrolyze the fats present in the form of ester (such as glycerin found in human skin), and accordingly generate fatty acids and glycerol. Because this group of enzymes is very widely distributed in plants, molds, batteries, milk, and milk products, as well as in almost all animal tissues, and because human lipase enzymes are also present in pancreatic exudations, they are usually present in the body exudations. The activity of lipase enzymes contributes to almost all the skin rash, or in particular to the diaper rash, causing irritation by the degenerative digestive action of these enzymes on the skin per se and by breaking down the skin components ( lipids), compromise the barrier property of the skin in the affected area. This breakdown of the integrity of the skin allows other components of the body exudates (urine and feces in particular), which may not, by themselves, be irritating, migrate through the exposed skin. At this point normally the harmful components can then become irritants.

Compositions Trister Compound The present invention provides tri-ester compounds, as defined above in formulas (I) and cationic compounds as defined in formulas (II), (III) and (IV), for use in the preparation of compositions that can be used for the treatment, prevention or reduction of the skin rash or particularly of the diaper rash, which sprouts or aggravates by the enzymes, in particular the enzymes of esterase, lipase enzymes and protease, being of this the result of enzymatic dermatitis. The composition preferably comprises the triester compounds at a level of from 0.01% to 90%, more preferably from 0.5% to 60%, more preferably from 2% to 25% by weight of the composition. It should be understood that for the purposes of this invention, the Ri-R8 groups of the formulation (I) and the Ri-R10 groups of the formulas (II), (III) and (IV) above can be substituted by any suitable substituent group. . Preferred triester compounds have one or more, preferably all of R4, R5, R6 and R7 of said compound being hydrogen. Preferably, the triester compounds have at least one, preferably all of R ^ R2 and R3 being CfC4 alkyl groups. It may be highly preferred that the triester compound be glycerol triacetate.

Cationic Compounds In formulas (II), (lll) and (IV) above, Ri, R2 R3 and R9 are independently preferably alkenyl or Ci-Cs alkoxy, more preferably Ci-C, more preferably alkyl group, more preferably group methyl or ethyl.

Preferably, R4, R5 and R10 are independently alkenyl or C8-C18 alkoxy, more preferably alkenyl or C12-C16 alkoxy, more preferably alkyl or arylalkyl groups, whereby it may be preferred that one of the substituents of R4, R5 and R9 is the benzyl group. Alternatively, it may be preferred that the cationic compounds comprise at least: an R? R2 and R3 or R9 which is a poly-alkoxy group. In this way, preferably R ^ R2 and R3 or R9 are independently polyalkoxy groups comprising C2-C6 alkoxy units, preferably C2-C3, and having an alkoxylation number of 2 to 50, preferably 5 to 18. Then, preferably R3 , R4 and R10 are independently alkenyl or alkoxy of C ^ Cs, more preferably CrC4, more preferably alkyl groups, most preferably the methyl or ethyl groups. A, R5 and R6 are, independently, preferably C2-C6-alkenylene or more preferably alkylene groups, more preferably methylene or ethylene. Preferred compounds can be benzalkonium chloride or Merquat 2200 (trade name, which is N-N-N-dimethyl-N-2-Propenyl-1-ammonium 2-Propenamide chloride polymer). Preferred cationic compounds of the above formulas comprise one or more substituted groups R ^ R2, R3, R4 or Rio and / or a substituted group R5 and / or a substituted group R6, by means of which the substituent is selected from the group consisting of in derivatives of silicone, glucose, fructose and sucrose. The preferred one can be Glucquat 125 (trade name, which is lauryl dimentyl glucet-10-hydroxy-diammonium chloride). Preferred cationic compounds of formula (III) above are betaine or sulfo betaine preferably having R ^ and R9 which are a methyl group.

The composition preferably comprises the cationic compounds at a level of from 0.01% to 90%, more preferably from 0.5% to 60%, more preferably from 2% to 25% by weight of the composition.

Lotions, creams, oils, ointments, foams, gels, powders and the like The compositions according to the invention can be cosmetic compositions, preferably in the form of lotions, creams, oils, foams, ointments, powders, gels. These may comprise any of the ingredients commonly used in the art for such compositions. It will be understood that the ingredients of the above compositions will depend on the character of the composition, thus the lotions will generally comprise additional ingredients than the powders. In the creams, lotions, gels, oils and cosmetic powders comprising the composition of the invention preferably an acid source is present, preferably in such a way that it is able to reduce the pH of the skin to lower it to a pH of 8, more preferably below a pH of 7, more preferably below 6, or even more preferably below pH 5. A wide variety of optional ingredients may be added such as non-occlusive moisturizers, humectants, gelling agents, neutralizing agents, perfumes, coloring agents, a the skin compositions of the present. It may be preferred that the cream, lotion, gel, oil, ointment or powder are substantially free of nonionic and / or anionic surfactants and / or phosphoric acid esters and / or enzymes.

Additional ingredients The composition of the invention may comprise additional ingredients. What ingredient is present and at what level depends on the nature of the composition and the use of it. A further highly preferred component to be used in the preparation of the compositions or for use in the compositions of the present invention are certain additional ester compounds. A highly preferred additional ester compound for use, or preparation of the compositions of the invention is of the formula: O O for the preparation of a composition for the prevention or treatment of enzymatic dermatitis, wherein R ^ and each R2 independently are in the acyl group with 2 to 22 carbon atoms, or an alkyl, alkenyl, hydroxyalkyl group with 1 to 24 carbon atoms of hydrogen, by means of which at least one of R- and R2 is said acyl group, R3, R4, R5, R6, R7, R8 and R9 are independently an alkyl, alkenyl, arylalkyl, hydroxyalkyl group , alkoxy of 1 to 24 carbon atoms, hydroxy group or hydrogen; Rio and R 11 are independently an alkyl, alkenyl, arylalkyl, hydroxyalkyl, alkoxy group of 2 to 24 carbon atoms, hydroxy group or hydrogen; A and B are independently an alkylene, alkenylene, linear or branched C-i-Cß hydroxyalkylene group; the values of x are independent of 0 to 15; the values of y are independent of 0 to 1, with the proviso that when X = 2 and y = 0, at least R2 is an alkyl, alkenyl, arylalkyl, hydroxyalkyl group with 1 to 24 carbon atoms or hydrogen. It should be understood that for the purposes of this invention, the R-to Rn groups of the formulas (V) and (VI) above may be substituted by any suitable substituent group. Preferred are the above-defined ester components, wherein the component is of the formulas (V) or (VI) wherein x is 1 or 2, and is 0; R- and R2 are an acid group of C2-C16, R-io and one or more R-n are a C2-C16 alkyl group; R3, R4, R5, R6 > R7 and R8 are hydrogen. It is highly preferred that the additional ester compound is a mono or diester of the formula (VI), more preferably a mono or diester of citric acid or tartaric acid (or salts thereof), or a triester of citric acid. Additional ester compounds are preferably present in the compositions of the invention at a level of from 0.01% to 20%, more preferably from 0.05% to 10%, more preferably from 0.1% to 5% by weight of the composition.

Process Also included in the invention is a process for reducing the enzymatic activity of the enzymes present in the outer skin, by which the process comprises the steps of topically applying a composition according to the invention to the outer skin. In this way, the acids are formed (at the site), preferably capable of reducing the initial pH to below 7.9, more preferably below 7.5 or even 7.3. It may be preferred that an additional source of acidity be present, capable of reducing the pH below 7.3, preferably below 6 or even 5. The composition used in the process or process is preferably such that in the first 15 minutes after the application of the compound or the composition in the affected area, the activity of the lipase enzyme is reduced by 35%, preferably by 25%, more preferably to less than 20% of the initial lipase activity in this area. Preferably the composition used in the process or the process is such that 60 minutes after the application of the composition in affected area, the activity of the lipase enzyme is still less than 45%, preferably 35%, more preferably less than 30%. % of the initial lipase activity in this area. This process can also be done by applying an absorbent article comprising the composition present at an appropriate level, on the skin.

Absorbent Articles The compositions of the invention, comprising the triester compounds and the cationic compound, may be comprised in an absorbent article, preferably a disposable absorbent article. A particularly preferred absorbent article for the same is a cleaning towel or a diaper. The diaper preferably comprises the composition in the upper sheet of the diaper. As used herein, the term "absorbent articles" refers to devices that absorb and contain body exudates, and, more specifically, refers to devices that are positioned against or approximate to the body of the wearer to absorb and absorb. contain the various exudations discharged from the body. The term "disposable" is used herein to describe absorbent articles that do not intend to be washed or otherwise restored or reused as an absorbent article (for example, they are intended to be discharged after a single use and, preferably, to to be recycled, compounded or otherwise disposed in an environmentally compatible manner The structure of the disposable absorbent article is not critical in the practice of the present invention.The composition is normally incorporated into the absorbent article or the particular diaper in an amount which will provide the required treatment or reduction or prevention of lipolytic dermatitis preferably after frequent use The disposable absorbent article preferably contains the cationic compounds and the triester compounds in a composition present at a level of 0.01% to 30%, more preferably from 0.01% to 10%, more preferably from 0.5% to 5% in pes or of the article An absorbent article generally comprises an absorbent core (which may consist of sub-structures); a fluid permeable upper sheet; a waterproof back sheet of fluids; - additional features such as closure or elasticity elements. As used herein, the term "diaper" refers to an absorbent article generally worn by infants and incontinent persons that is worn close to the wearer's lower torso. It should be understood, however, that the present invention is also applicable to other absorbent articles such as incontinent shorts, incontinent underwear, diaper and vapor holders, feminine hygiene garments, and the like. A preferred cleaning towel for the object of the present invention comprises an absorbent fibrous material or core in which the composition can be freely incorporated. A highly preferred disposable cleaning towel for the purpose of this invention comprises an absorbent fibrous material and a waterproof fecal backing material; said backing which is superimposed or coextensive with a face of said absorbent fibrous material; said backing material, more preferably is a backing-web material and more preferably having a thickness greater than that of said absorbent material by providing marginal side portions extending beyond said absorbent material, said marginal portions being folded around and in the upper part of the edges of said absorbent material. The compositions of the agent of the invention can be freely incorporated into the structure of the cleaning towel by various methods that will readily be apparent to those skilled in the art. For example, the compositions may be present in aqueous or volatile carriers such as water, ethanol, or the like, or creams, lotions, oils, ointments, gels, or powders, and applied to the absorbent material upon spraying, immersion, pressing, bathing or otherwise contacting the absorbent material of the cleaning towel with the lipase inhibiting agent and its carrier. A skin cleansing agent, preferably an oleaginous cleansing agent, can optionally be freely incorporated into the absorbent material as well. The compositions of the present invention are preferably incorporated in the diaper, preferably in the structure of the absorbent core or more preferably in the structure of the topsheet. The composition can be incorporated into the diaper structure by various methods that will be readily apparent to those skilled in the art. For example, the composition may be, optionally after the aqueous or volatile carrier such as water, ethanol, or the core side of the backsheet has been dispersed, by spraying, immersion, pressing, soaking or otherwise contacting the selected structural element of the diaper with the composition and optionally its carrier, which is called in the present impregnation. The diaper preferably comprises a liquid permeable top sheet, a liquid impermeable back sheet bonded with the top sheet, an absorbent core positioned between the top sheet and the back sheet. While the topsheet, and the absorbent core can be assembled in a variety of well-known configurations, the preferred diaper configurations are generally described in US Patent 3,850,003 entitled "Contractable side portions for disposable diapers" which was filed by Kenneth B Buell on January 14, 1975; and Patent Application Serial No. 07 / 715,152, allowed, "Absorbent Article with Elastic and Dynamic Waist Device Having a Predisposed Elastic Flexural Hinge", Kenneth B. Buell et, to the filed June 13, 1991. backsheet is positioned adjacent to the garment surface of the absorbent core and is preferably attached thereto by joining means such as those well known in the art. For example, the backsheet can be secured to the absorbent core by a uniform continuous layer of adhesive, a designed layer of adhesive, or a formation of separate lines, spirals, or spots of adhesive. The adhesives that have been found satisfactory have been manufactured by H. B. Fuller Company of St. Paul, Minnesota and marked as HL-1258. The attachment means will preferably comprise an open-web network of adhesive filaments as disclosed in U.S. Patent 4,573,986 entitled "Disposable Waste-Container Garment," which was filed by Minetola et al. On March 4, 1986, more preferably several filament lines of adhesives rotated in a spiral design as illustrated by the apparatus and methods shown in US Patent 3,911,173 filed by Sprague, Jr. on October 7, 1975; U.S. Patent 4,785,996 filed by Ziecker, and others on November 22, 1978, and US Patent 4,842,666 filed by Werenicz on June 27, 1989. Alternatively, the joining means may comprise heat bonding, or any other joining means or combinations of these joining means such and as sun known in the art. The absorbent article may further comprise elastification or closure characteristics well known in the art and - for example - described in E 0254476 (Germany). The topsheet is placed adjacent to the body surface of the absorbent core and is preferably bonded thereto and to the backsheet by joining means such as those known in the art. As used herein, the term "attached" encompasses configurations by means of which one element is directly secured to the other element by fixing the element directly to the other element, and the configurations by which the element is indirectly secured. to another element when fixing the element to indeterminate member (s) that in turn are fixed to the other element. Generally, the top sheet is satisfactory, soft to the touch, and does not irritate the user's skin. In addition, the superior sheet is permeable to liquid allowing liquids (eg urine) to quickly penetrate through its thickness. An appropriate top sheet can be manufactured from a wide range of materials, such as porous foams; the reticulated foams; open plastic films; or woven or non-woven nets of natural fibers (for example wood or cotton fibers), synthetic fibers (for example polyester or polypropylene fibers), a combination of natural and synthetic fibers. There are a number of manufacturing techniques that can be used to manufacture the top sheet. For example, the topsheet may be a non-woven web of spunbonded, carded, wet-laid, melt-blown, hydroentangled fibers, combinations of the above mentioned, or the like. Preferably the top sheet comprises a means for adjusting the hydrophilic capacity of the material. The absorbent cores comprise essentially all of the absorbent parts of the absorbent article other than the topsheet, which contributes to fluid absorbency or fluid handling. The absorbent cores should generally be compressible, capable of shaping, non-irritating to the wearer's skin, and capable of absorbing and retaining liquids such as urine and other certain exudations from the body. The absorbent core can be made from a variety of materials. Preferred materials are fibrous materials, which can form a fibrous web, fibers of natural or synthetic occurrence or optionally thermoplastic fibers. In addition, polymeric curing agents are present. Also preferred are hydrogel-forming polymers or superabsorbent polymers. The various cores, upper sheet materials and back sheets can be arranged in any manner known in the art, as described in Weisman et al. (EP 0 202 125) or Germany et al. (EP 0 254476). The present invention also encompasses a process for making a diaper comprising the composition of the invention whereby the topsheet is impregnated with the composition before it is incorporated into the diaper.

Claims (17)

1. The use of a compound (a) and a compound (b) for the preparation of a composition for the prevention or treatment of lipolytic dermatitis of the external skin, wherein (a) and (b) are: (a) a compound of the formula: R O) wherein R1t R2 and R3 are independently an alkyl or alkenyl or hydroxyalkyl group with 1 to 22 carbon atoms, and R, R5, R6, R7 and R8 are independently selected from the group consisting of alkyl, alkenyl or hydroxyalkyl groups of C? -C10 linear or branched, hydroxy, chloro, bromo, amine or hydrogen; and (b) a cationic compound of the formula: R4 - N- Rl R, M "(ll) (Hl) or an amphoteric compound and preferably an acid source, the amphoteric compound having its isoelectric point the formula: wherein R ^ R2, R3 and R are independently selected from the group consisting of linear or branched alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl or acyl groups of linear or branched, or two or more groups of R ^ R2, R3 and R4 together form one or more ring structures; R5, R6 and A are independently selected from the group consisting of linear or branched alkylene, alkenylene, (poly) alkoxylene, hydroxyalkylene, arylalkylene or amidoalkylene groups of d-C22; R7 and R8 are independently an alkyl group of C C, alkenyl, alkoxy, or a hydroxy group or hydrogen; R9 and R10 are independently selected from the group consisting of linear or branched alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl or acyl groups, or two or more groups of R1 t R9, and R10 form jointly one or more ring structures; BH is a proton donor group; x is from 2 to 4; and M "is a counter ion

2. The use of a compound (a) and (b) for the preparation of a composition according to claim 1, wherein the composition is for the prevention or treatment of the diaper rash.

3. The use of a compound (a) and (b) for the preparation of a composition according to claim 1 or 2, wherein the compound (a) has R, Rs, Re, R7 and Rs being hydrogen.

4. The use of a compound (a) and (b) for the preparation of a composition according to any of claims 1 to 3, wherein the compound (a) has R ^ R2 and R3 independently being an alkyl group of C? -C4.

5. The use of a compound (a) and (b) for the preparation of a composition according to claim 4, wherein the compound (a) is glycerol triacete.

6. The use of a compound (a) and (b) for the preparation of a composition according to any of the preceding claims, wherein the cationic compound (b) comprises one or more groups R ^ R2, R3, R4 R9 or R10 substituted and / or a substituted R5 group and / or a substituted R6 group, whereby the substituent is selected from the group consisting of silicone, glucose, fructose and sucrose derivatives.

7. The use of a compound (a) and (b) for the preparation of a composition according to any of the preceding claims, wherein the cationic compound (b) comprises at least one Ri, R2, R3, and R9 being C8 alkyl, alkenyl or alkoxy groups, preferably C4 alkyl, most preferably methyl or ethyl groups.

8. The use of a compound (a) and (b) for the preparation of a composition according to any of the preceding claims, wherein the cationic compound (b) comprises at least one R ^ R2, R3, and R9 being a poly-alkoxy group.

9. The use of a compound (a) and (b) for the preparation of a composition according to any of the preceding claims, wherein the cationic compound (b) is of the formula (IV), being a betaine compound or composed of sulfo betaine.

10. The use of 0.5% to 60% by weight (of the composition) of the compounds (a) and (b) for the preparation of a composition according to any of claims 1 to 8.

11. A disposable absorbent article in the shape of a damp cleaning towel, a cleaning towel, a diaper or a catamenial article to be used on or applied to the outer skin containing the composition according to any preceding claim.

12. A disposable absorbent article according to claim 11 in the form of a diaper comprising the composition, whereby the compound (a) and the compound (b) of the composition are present at a level of 0.01% to 10% in weight of the diaper.

13. A disposable absorbent article according to claim 12, by means of which the diaper comprises a top sheet containing the composition. A method for making a diaper according to claim 13, wherein the topsheet is impregnated with the composition prior to incorporation into the diaper. 15. A composition according to any of claims 1 to 10 in the form of a cosmetic cream, lotion, gel, ointment or powder, for topical application to the outer skin or to a disposable absorbent article. 16. A process for reducing the activity of the lipolytic enzyme of the lipase enzymes present on the outer skin comprising the step of (topically) applying a composition according to any of claims 1 to 10 to the outer skin. 17. A process for reducing the activity of the lipolytic enzyme of the lipase enzymes present on the outer skin comprising the step of (topically) applying a composition or an absorbent article comprising the composition according to any of the preceding claims to the external skin.