MXPA00005091A - Turmeric as an anti-irritant in compositions containing hydroxy acids or retinoids - Google Patents

Abstract

Compositions containing hydroxy acids and/or retinoids and further containing turmeric extract as an anti-irritant/anti-sting agent.

Description

Ib CÚRCUMA LIKE AN ANT I - IRRITANT IN COMPOSITIONS CONTAINING H I DROXI -ÁCI DOS OR RETINOIDES FIELD OF THE INVENTION The present invention relates to the use of turmeric in a composition and method for reducing or eliminating skin irritation or itching induced by hydroxy-acids or retinoids.

BACKGROUND OF THE INVENTION It has been proven that hydroxy acids (HA) and retinoids provide cosmetic benefits, such as improvement in the appearance of photodamaged or aged skin naturally, skin lightening, treatment of age spots, etc. Unfortunately, its use at high concentrations can sometimes be associated with skin irritation, for example, redness of the skin and a spicy sensation in the application. Irritation can be improve by decreasing the amount of an active ingredient in a composition or by reducing the penetration of the active compound through the skin. A serious disadvantage of both approaches is that effectiveness deteriorates. Irritation related to HA can be reduced by increasing the pH of the composition, but this method produces a reduced efficiency, due to a penetration. decreased HA through the skin. It is desirable to reduce or eliminate the irritation potential of the HAs and / or retinoids as long as their efficacy is maintained. Turmeric is a powdery rhizome of the Cúcuta l on ga Linn plant. The biological activities of turmeric have been generally attributed to the curcumin, or component of the turmeric extract. The curcumin has been reported to have anti-inflammatory and anti-oxidant activity. See Huang et al., "Inhibitory Effects of Curcumin on Tumorigenesis in Mice", Journal of Cellular Biochemistry Supplement 27: 26-34 (1997), Mukundan et al., "Effect of turmeric and curcumin on BP-DNA adducts", Carciogenesis, Vol. 14, No. 3, pp. 493-496 (1993) and Huang et al., "Inhibitory Effects of Curcumin on in Vitro Lipoxygenase and Cyclooxynase Activities in Mouse Epidermis", Cancer Research 51, 813-819 (1991). U.S. Patent No. 5,053,222 (Takasu et al.) Discloses a hair cosmetic composition for the treatment of dandruff, which may contain a variety of optional ingredients, including certain alpha-hydroxy acids, vitamin A and turmeric. The Patent of -. United States 5,152,983 (Nambudiry et al.) discloses sunscreen compositions, which comprise a 1,3-diketone, which may be curcumin. The 1,3-diketone is present in the composition of Nambudiry at 0.01 to 15%. In contrast, the curcumin content in the compositions of the present invention, even if up to 20% of the turmeric extract is used, is at most 0.0002%, that is, the orders of magnitude below the minimum amount in the patent of Nambudiry. If turmeric extract was used at levels sufficient to provide a curcumin amount of the Nambudiry patent, an unacceptable yellow color would be expected. The technique discussed above does not teach any composition containing turmeric extract at a level currently claimed in combination with the HA and / or retinoids. The technique does not seem to teach the use of turmeric or curcumin extract to reduce the irritation or itching associated with the use of HAs and / or retinoids. More importantly, the technique does not describe the critical ability to use turmeric extract instead of curcumin to reduce skin irritation. On the contrary, the literature seems to match the activities of turmeric extract and curcumin.

BRIEF DESCRIPTION OF THE INVENTION The present invention includes, in part, a composition comprising a cosmetic benefit ingredient selected from a group consisting of hydroxy acids ("HA") and certain retinoids which additionally contain turmeric extract. The invention also includes a method for reducing irritation or itching induced by topical application of a composition containing HA or retinoids, the method comprises topically applying turmeric extract. According to the inventive method, the turmeric extract may be co-present with the HA and / or retinoids in the same composition, or the turmeric extract may be applied in a separate composition. In accordance with the present invention by virtue of the topical application of the turmeric extract, irritation or itching induced by topical application of HA and / or retinoids is reduced or eliminated. It has been found as part of the invention that not all known anti-irritants improve the irritation induced by HA / retinoids.

DETAILED DESCRIPTION OF THE INVENTION Except in the operation and comparative examples, or where otherwise explicitly indicated, all numbers in this description indicating material quantities or reaction conditions, physical properties of materials and / or use are they will understand as modified by the word "approximately". All amounts are by weight of the composition unless otherwise specified. The turmeric extract is an essential ingredient of the inventive compositions and is employed in accordance with the present invention, to reduce or eliminate skin irritation induced by hydroxy acids and / or retinoids. The amount of turmeric extract in the inventive compositions generally varies from 0.01% to 20% by weight of the composition, preferably from 0.1% to 10%, most preferably from 1% to 5%. Hydroxy acids improve proliferation and increase the biosynthesis of ceramide in keratinocytes, increase epidermal thickness, and increase the peeling of normal skin that results in a younger looking, smoother skin. The hydroxy acid may be chosen from alpha-hydroxy acids, beta-hydroxy acids (eg, salicylic acid), other hydroxycarboxylic acids (eg, hydroxy-carboxylic acid, hydroxy-dicarboxylic acid, hydroxy-tricarboxylic acid) and mixtures thereof or combination of their stereoisomers (DL, or L). Preferably, the hydroxy acid is chosen from the alpha-hydroxy acids having the general structure (1): OH (i) MCHCOOH where M is hydrogen or a straight or branched saturated or unsaturated hydrocarbon chain containing from 1 to 27 carbon atoms. Still more preferably, the hydroxy acid is chosen from lactic acid, 2-hydroxy-octanoic acid, hydroxy lauric acid, acid. glycolic, and mixtures thereof. When stereoisomers exist, the L-isomer is preferred. It is to be understood that depending on the pH of the composition, the hydroxy acid may be present as a salt, for example, ammonium or potassium or sodium salt. Although the inventive compositions can have any pH in the general range of 2.0 to , the inventive compositions are particularly useful when they are at a pH (especially if they contain a hydroxy acid) more preferably at a pH of 2 to 4, because these compositions are particularly irritating. Retinoids improve the proliferation of keratinocytes in vitro, increase the epidermal thickness and increase the synthesis of collagen by dermal fibroblasts. This results in protection from sun damage and smoothing of wrinkled skin. The term "retinoid" as used herein includes retinoic acid, retinol, retinal and retinyl esters of 2 to 5 carbon atoms, because these are the most irritating. Included in the term "retinoic acid" is in 13-cis -retinoic acid and -. trans-retinoic acid. The term "retinol" includes the following isomers of retinol: t rans-ret inol, 13-cis-retinol, 11-cis-retinol, 9-cis-retinol, 3,4-didehydro-retinol. Preferred isomers are trans-retinol, 13-cis-retinol, 3,4-didehydro-retinol, 9-cis-retinol. The most preferred is trans-ret inol, due to its wide commercial availability. The retinyl ester is an ester of retinol. The term "retinol" has been previously defined. Retinyl esters suitable for use in the present invention are esters of 2 to 5 carbon atoms of retinol, preferably esters of 2 and 3 carbon atoms, and more preferably ester of 2 carbon atoms because it is most commonly available. The retinyl esters included in the invention are also known as: retinyl acetate, retinyl propionate, retinyl butyrate, and retinyl pentanolate. A particular advantage of the inventive compositions is that larger amounts of hydroxy acids or retinoids can be employed without causing skin irritation. Preferably, the amount of the hydroxy acid component present. in the composition according to the invention is from 0.01 to 20%, more preferably from 0.1 to 12% and more preferably from 4 to 12% by weight. A retinoid may be present in the inventive compositions in an amount of 33 to 330,000 IU per gram of the composition, preferably 330 to 16,500 IU, more preferably 1,650 to 6,600 IU. Again, a higher amount of a retinoid may be employed in the inventive compositions without causing skin irritation due to the co-presence of the turmeric extract. The most preferred inventive compositions containing anti-irritant turmeric extract have retinol and / or retinyl acetate and / or glycolic acid and / or lactic acid because these ingredients have been found to cause irritation, yet they were found to be particularly effective in the distribution of cosmetic benefits. The skin treatment composition of the invention also includes a cosmetically acceptable vehicle or carrier that is inert, usually an ingredient present in the highest amounts, and functioning to distribute active or performance ingredients. Vehicles other than water may include liquid or solid emollients, solvents, humectants, thickeners and powders. An especially preferred non-aqueous carrier is a polydimethylsiloxane and / or a polydimethephenyl-silicon. The silicones of this invention can be those with viscosities that vary anywhere from about 10 to 10,000,000 centistokes at 25 ° C. Especially suitable are low and high viscosity silicone blends. These silicones are available from the General Electric Company under the trademarks Vicasil, SE and SF and from the Dow Corning Company under the Series 200 and 550. The amounts of silicone that can be used in the compositions of this invention vary anywhere from 5. to 95%, preferably 25 to 90% by weight of the composition. The amount of vehicle can vary from about 2 to about 99% by weight, preferably from about 50 to about 99%, most preferably from about 80 to 99%, the weight of the total composition. According to the present invention, the vehicle is preferably at least 60% by weight of water, by weight of the vehicle. The inventive compositions are preferably oil-water emulsions, in order to improve the dermal distribution of hydroxy acids (See, Sah A., "An in vitro study of the effect of formulation and product structure on the delivery of alpha. - hydroxy acid (Lactic acid) to skin ", MS Thesis, Department of Pharmaceutical Sciences of the College of Pharmacy, University of Cincinnati, OH, July 1996). This improved distribution is often accompanied by increased irritation / itching, making the use of turmeric extract in these emulsions particularly critical. In preferred oil-in-water emulsions according to the present invention, the water comprises at least 50% by weight of the inventive emulsion, more preferably from 50 to 70%, by weight of the composition.

Optional Skin Benefit Materials and Cosmetic Attachments The various types of active ingredients can be presented to the cosmetic compositions in the present invention. "Active" products are defined as skin benefit agents other than emollients and other ingredients that improve only the physical characteristics of the composition.While not limited to this category, general examples include anti-wrinkle compounds and sunscreens and tanning agents Sunscreens include those materials commonly employed to block ultraviolet light Illustrative compounds are titanium dioxide, PABA derivatives, cinnamate and salicylate For example, octyl methoxycinnamate and 2-hydroxy can be used. 4-methoxy-benzophenone (also known as oxybenzone) Octyl methoxycinnamate and 2-hydroxy-4-methoxy-benzophenone are commercially available under the trademarks Parsol MCX and Benzophenone-3, respectively The exact amount of sunscreen used in emulsions can vary depending on the degree of protection desired from UV radiation Another category of functional ingredients within the cosmetic preparations of the present invention are thickeners. A thickener will usually be present in quantities, -. anywhere, from 0.1 to 20% by weight, preferably from about 0.5% to 10% by weight of the composition. Exemplary thickeners are crosslinked polyacrylate materials available under the trademark Carbopol from B: F: Goodrich Company. Gums such as xanthan gum, carragahen, gelatin, karaya, pectin and acacia can be used. Under certain circumstances, the thickening function can be achieved by a material that also serves as a silicone or emollient. For example, silicone gum in excess of 10 centiestokes and esters such as glycerol stearate have a dual functionality. Powders can be incorporated in the cosmetic composition of the invention. These powders include gypsum, talc, fuller's earth, kaolin, starch, smectite clays, chemically modified aluminum magnesium silicate, organically modified montmorillonite clay, hydrous aluminum silicate, fumed silica, aluminum octenyl succinate and starch, and mixtures thereof.

Other minor adjuncts may also be incorporated into the cosmetic compositions. These ingredients may include coloring agents, opacifiers and perfumes. The amounts of these other component materials can vary anywhere from 0.001% to 20% by weight of the composition.

Use of the Composition The composition according to the invention is proposed primarily as a product for topical application to human skin, especially as an agent for conditioning and smoothing the skin, and for preventing or reducing the appearance of the skin. wrinkled or aged. In use, a small amount of the composition, for example from 1 to 100 ml, is applied to exposed areas of the skin, of a suitable container or applicator, and if necessary, then it is spread over and / or rubbed on the skin using your hands or fingers or a suitable device. According to the present inventive method, the skin irritation induced by the active ingredient is reduced or eliminated by topical application of the turmeric extract. The turmeric extract may be co-present with the active product, or the skin may be applied separately from the active ingredient.

Product Form and Packaging The topical composition of the skin treatment of the invention can be formulated as a lotion, a fluid cream, a cream or a gel. The composition can be packed in a suitable container to adapt its viscosity and use proposed by the consumer. For example, you can pack a lotion or fluid cream in a bottle, or in a rolling ball applicator, or a capsule or a propeller-driven aerosol device or a container equipped with a pump suitable for operation with the fingers. When the composition is a cream, it can be stored simply in a non-deformable bottle or tightening container, such as a tube or jar with lid. The invention therefore also provides a closed container containing a cosmetically acceptable composition as defined herein. The turmeric extract can be packaged separately in the composition containing the HA and / or retinoids. The following specific examples further illustrate the invention, but the invention is not limited thereto. The turmeric extract used in the examples was obtained from C.V. Alam Sari, Indonesia, under the trademark Extract of Curcuma / Extract Temugirin. It contained 0.0009% curcumino.

EXAMPLE 1 This example investigated the anti-irritant capacity of turmeric and curcumin using an "in vitro" test.The cytokine interlucin-1 (IL-1) is known to have pro-inflammatory effects on the skin.Ill-1 causes release of the pros taglandin E2 (PGE2) which, in turn, may be responsible for skin irritation.A compound that can inhibit the release of PGE2 caused by 1L-1 can be expected to have anti-irritant properties.In addition, it has been reported that agents such as hydroxy acids can elicit IL-1 release in the skin This example examined the ability of the test compounds to inhibit the induction of PGE2 by the cytokine IL-1.

The dermal, human, neonatal fibroblasts (obtained from Clonetics Corp., San Diego, CA, passage 5-9) were seeded at a density of 7500 cells per well in plates treated with 96-well tissue culture ( Corning-Costar, Corning, NY). The medium used was Dulbecco's Modified Eagle Medium (DMEM), high glucose content (Life Technologies, Gaithersburg, MD) supplemented with 2 mM L-glutamine, 10% fetal bovine serum, and antibiotic and anti-mycotic solutions ( all also from Life Technologies). After 48 hours, each well was rinsed twice with 200 μl of serum-free DMEM and the cells were dosed with 200 μl in DMEM + L-glutamine containing 1L-1 to lng / ml or 1L-1 plus the compound of test (turmeric or curcumin extract). Curcumin was purchased from Sigma. After six hours, the cells were examined microscopically for qualitative availability, and the medium was collected and frozen until analysis. Each treatment was run in quadruple. The immunoassay was performed using the commercial PGE2 kit (Amersham, Buckinghamshire, England). The PGE2 specific antibody was pre-coated in a set of microtiter wells. The essay is based on the competition •. between unlabeled PGE2 (normal or sample) and a fixed amount of PGE2 labeled with peroxidase for a limited amount of PGE2- specific antibody bound to the well. Standards of 0, 1, 2, 4, 8, 16 and 32 pg / well or 50 μl / half well were applied with 50 μl / well of phosphate buffer of 0.1 M pH 7.5 for 3 hours at 4 ° C. At the end of this incubation, 50 μl / well of horseradish peroxidase-conjugated PGE2 was added to all wells and the plate was incubated for 1 hour at 4 ° C. The plates were washed 4 times with 300 μl / well of 0.01 M phosphate buffer, pH 7.5 containing 0.5% Tween 20. 150 μl / well of 3, 3 ', 5, 5' -tet ramet ilbenzidine / hydrogen peroxide in 20% dimethylformamide were added and the plate was incubated exactly 30 minutes at room temperature. The reaction was stopped by adding 100 μl / well of 1 M sulfuric acid. The Spectramax 340 microplate spectrophotometer (Molecular Devises, Sunnyvale, CT) was used to quantify the color in the wells by reading the absorbance at 450 nm. A normal curve was plotted and the amount of PGE2 in the samples was extrapolated from the curve. The anti-irritant potential of the test compounds is assessed by the ability of the compound to inhibit PGE2 induced by IL-1. The higher the percent inhibition, the more effective it is anti-irritant. The statistical significance was determined using a student's t-test. The results were obtained in summary in Table 1.

Table 1 * Significantly different from IL-la, p < 0.05, Student's t-test ** Increase in PEG2 (increase in irradiation) The results in Table 1 show that both curcumin and turmeric extract exhibit -. anti-irritant activity in this test, but the following analysis shows that the activity of turmeric extract is not due to curcumin: the turmeric extract used in the previous experiments was an ethanolic extract at 0.36% by weight of turmeric. It has been reported that the curcumin content of the turmeric collected is from 0.1% to 0.24% (curcumin content of turmeric grown in Korea, Chi et al. Saengyay Hakhoechi (1983) 14 (2) 67-69). Assuming a curcumin content of 0.25%, the curcumin concentration of turmeric used here was 0.0009%. When used at 0.001% in the test (experiment 1), this would have contained only 0.9 x 10 ~ 6% curcumin. Experiment 3 indicates that a concentration of 0.002% curcumin is required to give an activity compared to 0.001% turmeric, therefore, it is evident that the turmeric activity is not due to its curcumin content.

EXAMPLE 2 Subjects were tested according to the irritation test method, described below.

• Irritation test method Patch test of four exposures. The objective was to compare the level of irritation produced by various test materials after repeated applications of patches. The test materials were kept in contact with the skin under occlusive conditions. The upper outer glass of the panelists was designated as the application area. A bandage-type bandage (Scanpor® tape) was used to retain the patches (Hill TopR 25 mm camera equipped with an 18 mm diameter disc of a Webril® pad in place). Both upper arms of the panelist were used. The patches were applied in a balanced random order. The patches were applied on Monday at 9:00 o'clock in the morning and were removed at 9:00 o'clock on Tuesday morning (24 hours exposure). A new set of patches was applied at 3:00 o'clock on the afternoon of Tuesday and it was removed on Wednesday morning at 9:00 o'clock (18 hours exposure). A third set of patches was applied at 3:00 o'clock on the afternoon of Wednesday and it was removed at 9:00 o'clock on the morning of Thursday (18 hours of • -exposition). A final set of patches was applied at 3:00 o'clock on Thursday afternoon and was removed at 9:00 o'clock on Friday morning (18 hours exposure). Each time the patches were removed, the sites were rinsed with hot water and patted dry. The test sites were then marked with a skin-marking, surgical pen to expose the location for graduation and subsequent patch applications. The test sites were valued at 3:00 p.m. on Tuesday, Wednesday, Thursday and Friday of the study, before the re-placement of the patches. Skin irritation such as moderate redness, dryness and / or itching of the test site is expected. Swelling of the test sites is possible. If any test has moderate redness or any swelling in the evaluation, it is the particular test site should not be re-treated with patch. The test sites in each arm were visually classified by two examiners trained under consistent lighting. The test sites were classified in order of severity. The examiner who classifies the answers in the first period of continuous evaluation, classifying the sites every day throughout the study. In the classification of the reactions, the site with the most severe response was given the lowest score. The site with the second most severe response was given the second lowest score etc. There was no forced classification. If two or more sites have no answer or have the same answer (there is no difference between the sites), an average of the classifications was assigned. If a site has been discontinued, due to the degree of irritation the site retained the classification received at the time the dosage was discontinued.

Statistical Analysis The classification results of patch treatments were statistically compared by nonparametric statistical methods. The test materials containing the anti-irritants were compared to the corresponding control containing only the hydroxy acid and / or retinoid, using the Friedman classification sum. The treatments were compared to formula 2 at each evaluation point using Friedman's analysis with the panelist acting as a block (ie analysis, each panelist was tested with each test treatment.) The p-value of <0.1 considered statistically significant EMULSION BASIC FORMULA (continuation) Additional ingredients in the following examples were added instead of water. The compositions containing the ingredients as indicated in Tables 2 and 2A were tested using the irritation test method. Twenty subjects were tested for test in Table 2 and 17 for the test in Table 2A. The results that were obtained are summarized in Tables 2 and 2A. The greater the sum of the classifications, the less severe the irritation.

TABLE 2 Irritation Test Results * Significantly less irritating than composition # 2.

TABLE 2A Irritation Test Results a: Ethanol was tested since the turmeric extract was. in ethanol. b: Significantly less irritating than compositions 5 and 6 can be seen from the results in - Table 2 that after four exposures, 8% glycolic acid with 0.075% retinol (composition # 2) was significantly more irritating than base formula # 1. 1% of Sambucus (# 4) or 3% Black Currant Seed Oil (# 3) did not significantly reduce the irritation.

Sambucus and black currant seed oil are known as anti-irritants. However, no agent was effective in reducing the irritation induced by the alpha-hydroxy acids / retinol. In contrast, as demonstrated by the results in Table 2A, the turmeric extract (composition # 7) significantly reduced the irritation reduced by composition 5 (containing 8% glycolic acid) and composition 6 (containing 8% of glycolic and ethanol, the most appropriate control for this experiment).

COMPARATIVE EXAMPLE 3 Compositions 1, 2 and 11-14 containing ingredients as indicated in Table 3 were tested using the irritation test method described in Example 2. 17 subjects were tested. The results that were obtained are summarized in Table 3. The greater the sum of the classifications, the lower the irritation.

TABLE 3 Irritation Test Results a Statistically less irritating than composition # 2 * An anti-irritant from Centerchem (containing water, butylene glycol, kola seed extracts, guarana extract, and extra mate). ** An anti-irritant from Penederm, Inc. (name CFTA PPG-12 / SMDI).

It can be seen from the results in Table 3 that none of the known anti-irritants tested were able to significantly reduce the irritation reduced by composition # 2 (containing 8% glycolic acid and 0.075% retinol .

EXAMPLE 4 A typical oil-in-water emulsion within the scope of the invention is as follows: Chemical Name% by Weight Propylene Glycol 1.0 Glycerin 1.0 Hydroxyethylcellulose 0.5 Aluminum silicate and 0.5 mg Imidazolidinyl urea 0.5 Tetrasodium EDTA 0.05 Petrolatum 2.0 Isopropyl Palmitate 5.0 Dimethicone 0.5 Cholesterol 0.5 Cetyl Alcohol 0.5 Isostearic Acid 3.0 (continued) Chemical Name% by weight Retinyl Palmitate 0.1 Stearate peg-40 1.0 Stearate peg-100 1.0 Sorbitan stearate 1.0 Turmeric extract 0.5 Glycolic acid 7.0 Ammonium hydroxide at pH 4.0 Water DI cs for 100 EXAMPLE 5 Another oil-in-water emulsion typical within the scope of the invention is as follows: Chemical name% by weight Propylene glycol 1,. 0 Hydroxyethylcellulose 0. . 5 Aluminum silicate and 0. . 5 Magnesium Imidazolidinyl urea 0.2 Petrolatum 2.0 Isopropyl Palmitate 5.0 Dimethicone 0.5 Cholesterol 0.5 (continued) Chemical Name% by weight Cetyl Alcohol 3.0 Isoestearic Acid 1.5 Glycerol Stearate 1.5 Peg-40 Stearate 1.0 Peg-100 Stearate 1.0 Sorbitan Stearate 1.0 Alcohol cetílico 0.5 Turmeric extract 2.0 Glycolic acid 10.0 Ammonium hydroxide at pH 3.tí Water DI cs for 100% EXAMPLE 6 A typical water-in-oil dispersion within the scope of the invention is as follows: Chemical name% by weight Neopentanoate 20.0 isostearyl Glycerides 6.0 caprylic / caprice pectin Cetyl Octanoate 17.0 (continued) Chemical name by weight polyglyceryl dioleate-6 15.0 Cyclomethicone 20.0 Glyceryl isostearate 0.5 Isoestearic acid 0.5 Ceramide III 0.1 Ppg-5- cetet-20 3.0 L-lactic acid / 6.0 potassium lactate Hydroxycaprilic acid 0.1 Water DI 1.3 Turmeric extract 0.5 EXAMPLE 7 The following oil-in-water emulsion within the scope of the invention is prepared: Chemical name by weight Glycerin 1.0 Tetrasodium EDTA 0.1 Cetyl alcohol 1.0 Stearyl alcohol 1.0 Mineral oil 5.0 Dimethicone 1.0 (continued) Chemical name% by weight Cyclomethicone 0.5 Dimeticonol 0.2 Polyquaternium-37 2.0 Esteareth-21 1.0 Esteareth-2 0.5 Salicylic acid 2.0 Turmeric extract 0.5 Triethanolamine at pH 3.0 Water DI cs for 100% EXAMPLE 8 The following oil-in-water emulsion within the scope of the invention is prepared: Chemical Name% by weight Xanthan gum 0.2 Disodium EDTA 0.1 Sodium PCA 0.5 Diazodinyl urea 0.3 Titanium dioxide 1.0 Stearic acid 3.0 Cyclomethicone 0.3 Cetyl alcohol 0.5 (continued) Chemical name% by weight Glyceryl stearate 0.5 Peg-100 stearate 0.5 Esteareth- 2 0.2 Lecithin 0.5 Tocoperol 0.2 Octyc Motoxicinamate 6.0 Turmeric Extract 0.5 Glycolic Acid 3.0 Malic Acid 2.0 Lactic Acid 2.0 Green Tea Extract 1.0 Triethanolamine at pH 3.8 Water DI cs for 100% EXAMPLE 8 The following oil-in-water emulsion within the scope of the invention is prepared: Chemical name% by weight Trans-retinoic acid 0.05 Light mineral oil 10.0 Stearoxitrimethylsilane and 5.0 stearyl alcohol (continued) Chemical name% by weight Dimethicone 2.0 Stearyl stearate 10.0 Quaternium-15 3.0 Dodecylglycol copolymer 1.0 peg-22 Turmeric extract 0.1 Sorbitol 0.5 Methylparaben 0.2 EDTA disodium 0.1 Hydroxytoluene butylated 0.1 Water DI cs for 100 EXAMPLE 10 The following oil-in-water emulsion within the scope of the invention is prepared: Chemical Name Weight% Squalane 20.0 Macadamia Oil 5.0 Pentaerythritol Tetraoctanoate 15.0 Petrolatum 5.0 Glyceryl Stearate 3.0 Tocopherol Acetate 0.5 (continued) Chemical Name% by Weight Butylated Hydroxytoluene 0.05 Methylparaben 0.15 Propylparaben 0.15 Retinol 0.1 Turmeric Extract 0.25 Sodium Citrate 1.0 Ascorbic acid 1.0 Butylene glycol 2.0 Glycerol 2.0 Benton clay 0.2 Disodium EDTA 0.05 Water DI cs for 100 It should be understood that the specific forms of the invention illustrated herein and described propose to be representative only. The changes, including but not limited to those suggested in this specification, can be made in the illustrated modalities, without departing from the clear teachings of the description. Accordingly, reference should be made to the following appended claims in the determination of the full scope of the invention.

Claims (6)

1. CLAIMS 1. A cosmetic skin care composition having reduced irritation and itching, comprising: (i) a cosmetic benefit ingredient selected from the group consisting of a hydroxy-acid, retinol, retinoic acid, retinal, ester retinyl of 2 to 5 carbon atoms and mixtures thereof; (ü) turmeric extract in an amount of about 0.01 to about 20% by weight; and (iii) a cosmetically acceptable vehicle. The composition according to claim 1, wherein the cosmetic benefit ingredient is a hydroxy acid, which is present in an amount of about 0.01 to about 20% by weight of the composition. 3. The composition according to claim 2, wherein the amount of the hydroxy acid is from about 0.1 to about 12% by weight of the composition. 4. The composition according to claim 1, wherein the cosmetic benefit ingredient is a retinol or a retinyl ester, which is present in an amount of about 33 to about 330,000 IU per gram of the composition. The composition according to claim 1, wherein the cosmetic benefit ingredient is selected from the group consisting of retinol, glycolic acid, lactic acid, and mixtures thereof. 6. A cosmetic method for reducing itching or irritation induced by topical application of a composition containing a hydroxy acid or a retinoid, the method comprising topically applying the turmeric extract.