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MX9803316A - Process for the preparation of a growth hormone secretagogue. - Google Patents

Process for the preparation of a growth hormone secretagogue.

Info

Publication number
MX9803316A
MX9803316A MX9803316A MX9803316A MX9803316A MX 9803316 A MX9803316 A MX 9803316A MX 9803316 A MX9803316 A MX 9803316A MX 9803316 A MX9803316 A MX 9803316A MX 9803316 A MX9803316 A MX 9803316A
Authority
MX
Mexico
Prior art keywords
growth hormone
preparation
stimulation
compound
hormone secretagogue
Prior art date
Application number
MX9803316A
Other languages
Spanish (es)
Other versions
MXPA98003316A (en
Inventor
Peter G Houghton
Ioannis Houpis
Audrey Molina
Joseph E Lynch
Ralph P Volante
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602949.1A external-priority patent/GB9602949D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX9803316A publication Critical patent/MX9803316A/en
Publication of MXPA98003316A publication Critical patent/MXPA98003316A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention is directed to a novel process for the preparation of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonyl-spiro[3H-indole-3,4' -piperdin]-1'-yl)carbonyl]-2-(phenylmethyl-oxy)ethyl]-2-amin o-2-methyl-propanamide, and salts thereof, which has structure (1) and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound may be used to treat conditions which require the stimulation of growth hormone production or secretion such as in humans with a deficiency of natural growth hormone or in animals used for food or wool production where the stimulation of growth hormone will result in a larger, more productive animal.
MXPA/A/1998/003316A 1995-10-27 1998-04-27 Procedure for preparing a secretagogo de hormona de crecimie MXPA98003316A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US589895P 1995-10-27 1995-10-27
US005898 1995-10-27
GBGB9602949.1A GB9602949D0 (en) 1996-02-13 1996-02-13 Process for the preparation of a growth hormone secretagogue
GB9602949.1 1996-02-13

Publications (2)

Publication Number Publication Date
MX9803316A true MX9803316A (en) 1998-09-30
MXPA98003316A MXPA98003316A (en) 1998-11-16

Family

ID=

Also Published As

Publication number Publication date
KR19990067097A (en) 1999-08-16
WO1997015573A1 (en) 1997-05-01
AU7468596A (en) 1997-05-15
CZ128298A3 (en) 1998-07-15
HUP9902095A2 (en) 1999-10-28
AR004124A1 (en) 1998-09-30
JPH11513984A (en) 1999-11-30
HUP9902095A3 (en) 2001-05-28
HRP960494A2 (en) 1998-04-30
PL326428A1 (en) 1998-09-14
SK51198A3 (en) 1998-11-04
CA2235511A1 (en) 1997-05-01
YU56596A (en) 1999-09-27
EP0863900A1 (en) 1998-09-16
BR9610887A (en) 1999-07-13

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