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MX9709913A - Metaloconstrucciones determinadas estructuralmente y aplicaciones. - Google Patents

Metaloconstrucciones determinadas estructuralmente y aplicaciones.

Info

Publication number
MX9709913A
MX9709913A MX9709913A MX9709913A MX9709913A MX 9709913 A MX9709913 A MX 9709913A MX 9709913 A MX9709913 A MX 9709913A MX 9709913 A MX9709913 A MX 9709913A MX 9709913 A MX9709913 A MX 9709913A
Authority
MX
Mexico
Prior art keywords
metal ion
secondary structure
complexing
construct
amino acids
Prior art date
Application number
MX9709913A
Other languages
English (en)
Inventor
Shubh D Sharma
Original Assignee
Rhomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/476,652 external-priority patent/US5891418A/en
Application filed by Rhomed Inc filed Critical Rhomed Inc
Publication of MX9709913A publication Critical patent/MX9709913A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/086—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being alphaMSH, alpha melanocyte stimulating hormone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/16—Libraries containing metal-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Structural Engineering (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Laminated Bodies (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)

Abstract

Se provee una metaloconstruccion, que puede ser un péptido, para usarse como un agente biologico, terapéutico, radioterapéutico, o de formacion de imágenes diagnosticas, y para usarse en métodos de química de colecciones o combinatoria; la construccion tiene una estructura secundaria global restringida conformacionalmente obtenida por formacion de complejo con un ion de metal; las construcciones de péptido son de la formula general: R1-X-R2, en donde X es una pluralidad de aminoácidos e incluye un esqueleto formador de complejo para formar complejo con iones de metal, de modo que substancialmente todas las valencias del ion de metal están ocupadas por formacion de complejo del ion de metal con X, dando como resultado una estructura secundaria regional específica que forma parte de la estructura secundaria global; y en donde R1 y R2 incluyen cada uno de 0 a aproximadamente 20 aminoácidos, los aminoácidos se seleccionan de modo que por formacion de complejo del ion de metal con X, por lo menos una porcion de R1 o bien de R2 o de ambos tienen una estructura que forma el resto de la estructura secundaria global restringida conformacionalmente; toda la estructura secundaria global o una porcion de ella; que puede ser sicnologica o regnilogica, puede formar un ligando o imitar un dominio de funcion biologico conocido; la construccion tiene una afinidad substancialmente mayor por su blanco por marcado con un ion de metal.
MX9709913A 1995-06-07 1997-12-08 Metaloconstrucciones determinadas estructuralmente y aplicaciones. MX9709913A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/476,652 US5891418A (en) 1995-06-07 1995-06-07 Peptide-metal ion pharmaceutical constructs and applications
US08/660,697 US6027711A (en) 1995-06-07 1996-06-05 Structurally determined metallo-constructs and applications

Publications (1)

Publication Number Publication Date
MX9709913A true MX9709913A (es) 1998-08-30

Family

ID=27045238

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9709913A MX9709913A (es) 1995-06-07 1997-12-08 Metaloconstrucciones determinadas estructuralmente y aplicaciones.

Country Status (10)

Country Link
US (2) US6027711A (es)
EP (1) EP0831939A4 (es)
JP (2) JP2001518055A (es)
KR (2) KR19990022735A (es)
AU (1) AU719556B2 (es)
BR (1) BR9609400A (es)
CA (1) CA2221146A1 (es)
IL (1) IL122392A (es)
MX (1) MX9709913A (es)
WO (1) WO1996040293A1 (es)

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GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
WO1999033863A1 (en) * 1997-12-24 1999-07-08 Resolution Pharmaceuticals Inc. Peptide chelators that predominately form a single stereoisomeric species upon coordination to a metal center
US6334996B1 (en) 1997-12-24 2002-01-01 Resolution Pharmaceuticals Inc. Chelators that predominantely form a single stereoisomeric species upon coordination to a metal center
US20020155576A1 (en) * 1998-02-10 2002-10-24 Mills Stanley L. Metal-chelated nucleic acid binding peptides for in vivo detection and therapy of disease
AU760257B2 (en) * 1998-12-14 2003-05-08 Palatin Technologies, Inc. Metallopeptide combinatorial libraries and applications
JP2002537274A (ja) * 1999-02-17 2002-11-05 ブラッコ インターナショナル ベスローテン フエンノートシャップ 固定化した標識配合物および方法
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US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
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Also Published As

Publication number Publication date
US6027711A (en) 2000-02-22
IL122392A (en) 2002-11-10
JP2007056029A (ja) 2007-03-08
WO1996040293A1 (en) 1996-12-19
JP2001518055A (ja) 2001-10-09
US20060040324A1 (en) 2006-02-23
AU6330096A (en) 1996-12-30
KR20050062639A (ko) 2005-06-23
BR9609400A (pt) 1999-12-14
EP0831939A1 (en) 1998-04-01
IL122392A0 (en) 1998-06-15
KR19990022735A (ko) 1999-03-25
AU719556B2 (en) 2000-05-11
EP0831939A4 (en) 2004-11-24
CA2221146A1 (en) 1996-12-19

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