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MX9708378A - Compuestos y metodos para impedir la trombogenesis. - Google Patents

Compuestos y metodos para impedir la trombogenesis.

Info

Publication number
MX9708378A
MX9708378A MX9708378A MX9708378A MX9708378A MX 9708378 A MX9708378 A MX 9708378A MX 9708378 A MX9708378 A MX 9708378A MX 9708378 A MX9708378 A MX 9708378A MX 9708378 A MX9708378 A MX 9708378A
Authority
MX
Mexico
Prior art keywords
methods
clot
compositions
thrombus
thrombosis
Prior art date
Application number
MX9708378A
Other languages
English (en)
Other versions
MXPA97008378A (es
Inventor
Jeffrey L Weitz
Jack Hirsh
Edward Young
Original Assignee
Hamilton Civic Hospital Res De
Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamilton Civic Hospital Res De, Inc filed Critical Hamilton Civic Hospital Res De
Publication of MX9708378A publication Critical patent/MX9708378A/es
Publication of MXPA97008378A publication Critical patent/MXPA97008378A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion provee composiciones y métodos para inactivar trobina unida a fibrina en un trombo o coágulo, esto por la capacidad de la trombina unida al coágulo para promover catalíticamente además el crecimiento es sustancialmente disminuido o eliminado. Las composiciones y métodos de la presente invencion son particularmente util en la prevencion de trombosis en el aparato bypass del circuito cardiaco y en pacientes bajo diálisis renal, y para tratamiento de pacientes que sufren de o tienen un riesgo de sufrir trombos relacionados con condiciones cardiovasculares, tales como angina inestable, infarto al miocardio agudo (ataque al corazon), accidente cerebrovascular (embolia), embolia pulmonar, trombosis venal, trombosis arterial, etc.
MXPA/A/1997/008378A 1995-03-31 1997-10-30 Compuestos y metodos para impedir la trombogenesis MXPA97008378A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41233295A 1995-03-31 1995-03-31
US412332 1995-03-31

Publications (2)

Publication Number Publication Date
MX9708378A true MX9708378A (es) 1998-10-31
MXPA97008378A MXPA97008378A (es) 1999-01-11

Family

ID=

Also Published As

Publication number Publication date
CA2217054C (en) 2009-02-17
AU5140096A (en) 1996-10-16
WO1996029973A3 (en) 1996-12-19
CA2217054A1 (en) 1996-10-03
CN1186502A (zh) 1998-07-01
US5744457A (en) 1998-04-28
WO1996029973A2 (en) 1996-10-03
NO974500D0 (no) 1997-09-29
JP2007204500A (ja) 2007-08-16
KR19980703628A (ko) 1998-12-05
JPH11506420A (ja) 1999-06-08
NO974500L (no) 1997-11-28

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal