MX9707214A - Derivados de acido hidroxamico que contiene lactama, composiciones que contienen los mismos y el uso de los mismos. - Google Patents
Derivados de acido hidroxamico que contiene lactama, composiciones que contienen los mismos y el uso de los mismos.Info
- Publication number
- MX9707214A MX9707214A MX9707214A MX9707214A MX9707214A MX 9707214 A MX9707214 A MX 9707214A MX 9707214 A MX9707214 A MX 9707214A MX 9707214 A MX9707214 A MX 9707214A MX 9707214 A MX9707214 A MX 9707214A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- carbocycle
- heterocycle
- compounds
- hydrogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invencion se refiere a compuestos que exhiben actividad inhibidora contra las metaloproteasas se matriz ("MMPs"); ya que se conoce que las MMPs desempeñan un papel en la degradacion de tejido, los compuestos de la presente invencion pueden ser utiles para prevenir o tratar enfermedades asociadas con exceso de actividad de MMP; en particular, los compuestos tienen una estructura de conformidad con la formula (I), en donde (A) (1) (a) R1 es hidrogeno; alquilo; heteroalquilo; un anillo heterocíclico; un anillo carbocíclico; alcoxi; carbociclo-alquilo; heterociclo-alquilo; carbociclo-heteroalquilo; o heterociclo-heteroalquilo; y (b) R2 es hidrogeno, hidroxi; alquilo; alquenilo; alquinilo; heteroalquilo; un anillo heterocíclico; un anillo carbocíclico; carbociclo-alquilo; heterociclo-alquilo; o -OR, en donde R es alquilo, alquenilo o carbociclo-alquilo; o (2) R1 y R2 juntos forman un anillo de cicloalquilo de 3 a 8 átomos de anillo; (B) R3 es hidrogeno; alquilo; o carbociclo-alquilo; (C) R4 es (1) alquilo; (2) carbociclo-alquilo; (3) -X-C(=Y)-Z-R5 o X-CH2-Z-R5 o -X-CH2-Z-R5, en donde (a) X es una union covalente o alquilo; (b) Y es O, S o NH; (c) Z es O, S o NH; y (d) R5 es hidrogeno; alquilo; alquenilo; carbociclo-alquilo; o arilo; o (4) -S=2-R6, en donde R6 es alquilo, carbociclo-alquilo, heterociclo-alquilo, o arilo; y (D) Q es [-C(R7)2-]-n, en donde (I) n es el entero 2, 3 o 4; y (2) cada R7 es independientemente hidrogeno o alquilo de modo que el heterociclo que contiene Q está saturado; o la porcion de R7 en dos átomos de carbono adyacentes es una union covalente de modo que el heterociclo que contiene Q de la formula (I) es insaturado; o una sal farmacéuticamente aceptable, o alcoxiamida biohidrolizable, aciloxiamida o imida de los mismos; la invencion se refiere también a composiciones farmacéuticas que comprenden estos compuestos, y al uso de dichos compuestos y composiciones en la preparacion de composiciones farmacéuticas para prevenir o tratar enfermedades asociadas con la actividad de MMP no deseada.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US407389 | 1995-03-21 | ||
| US08/407,839 US5672598A (en) | 1995-03-21 | 1995-03-21 | Lactam-containing hydroxamic acids |
| US08407839 | 1995-03-21 | ||
| PCT/US1996/003726 WO1996029313A1 (en) | 1995-03-21 | 1996-03-19 | Lactam-containing hydroxamic acid derivatives, their preparation and their use as inhibitors of matrix metalloprotease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9707214A true MX9707214A (es) | 1997-11-29 |
| MXPA97007214A MXPA97007214A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| IL117527A0 (en) | 1996-07-23 |
| AU711889B2 (en) | 1999-10-21 |
| CA2216129C (en) | 2002-08-20 |
| BR9607772A (pt) | 1998-07-07 |
| CZ295197A3 (cs) | 1998-05-13 |
| HUP9800813A3 (en) | 1998-09-28 |
| AU5255896A (en) | 1996-10-08 |
| AR002718A1 (es) | 1998-04-29 |
| DE69629670D1 (de) | 2003-10-02 |
| HUP9800813A2 (hu) | 1998-07-28 |
| WO1996029313A1 (en) | 1996-09-26 |
| EP0815084B1 (en) | 2003-08-27 |
| ATE248150T1 (de) | 2003-09-15 |
| JPH11502523A (ja) | 1999-03-02 |
| CA2216129A1 (en) | 1996-09-26 |
| NZ304689A (en) | 1999-05-28 |
| NO974335L (no) | 1997-11-21 |
| ZA962253B (en) | 1996-09-30 |
| US5672598A (en) | 1997-09-30 |
| EP0815084A1 (en) | 1998-01-07 |
| KR19980703151A (ko) | 1998-10-15 |
| NO974335D0 (no) | 1997-09-19 |
| DE69629670T2 (de) | 2004-06-17 |
| IL117527A (en) | 1999-12-22 |
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