[go: up one dir, main page]

MX9704440A - Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses. - Google Patents

Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses.

Info

Publication number
MX9704440A
MX9704440A MX9704440A MX9704440A MX9704440A MX 9704440 A MX9704440 A MX 9704440A MX 9704440 A MX9704440 A MX 9704440A MX 9704440 A MX9704440 A MX 9704440A MX 9704440 A MX9704440 A MX 9704440A
Authority
MX
Mexico
Prior art keywords
reversal
induction
reagent
promoter
treatment
Prior art date
Application number
MX9704440A
Other languages
Spanish (es)
Inventor
Leonid Beigelman
Daniel T Stinchcomb
Thale Jarvis
Kenneth Draper
Pamela Pavco
James Mcswiggen
John Gustofson
Nassim Usman
Francine Wincott
Original Assignee
Ribozyme Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/363,254 external-priority patent/US5891684A/en
Priority claimed from US08/363,253 external-priority patent/US5891683A/en
Priority claimed from US08/390,850 external-priority patent/US5612215A/en
Priority claimed from US08/426,124 external-priority patent/US5716824A/en
Priority claimed from US08/432,874 external-priority patent/US5627053A/en
Priority claimed from US08/512,861 external-priority patent/US6146886A/en
Priority claimed from US08/541,365 external-priority patent/US5672501A/en
Application filed by Ribozyme Pharm Inc filed Critical Ribozyme Pharm Inc
Priority claimed from PCT/US1995/015516 external-priority patent/WO1996018736A2/en
Publication of MX9704440A publication Critical patent/MX9704440A/en

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An enzymatic nucleic acid molecule which cleaves RNA associated with development or maintenance of an arthritic condition, induction of graft tolerance or reversal of an immune response. In particular, the ribozyme sequences are directed to an mRNA encoding B7-1, B7-2, B7-3, CD40 and/or stromelysin. Also provided are ribozymes where the uracil in positions 4 and/or 7 are substituted, as well as methods for the synthesis of 2'-alkylnucleotides, 2'-O-alkylthioalkyl, or 2'-alkylthioalkylnucleotides. The application further describes a method for diprotection of RNA with aqueous ethylamine, a method for synthesis of a basic ribonucleoside mimetics, and transcription units comprising an RNA polymerase II promoter, a U6 small nuclear promoter, or an adenovirus VA1 promoter system.
MX9704440A 1994-12-13 1995-11-22 Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses. MX9704440A (en)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US35492094A 1994-12-13 1994-12-13
US08/363,254 US5891684A (en) 1992-10-15 1994-12-23 Base-modified enzymatic nucleic acid
US08/363,253 US5891683A (en) 1993-09-02 1994-12-23 Non-nucleotide containing enzymatic nucleic acid
US08/390,850 US5612215A (en) 1992-12-07 1995-02-17 Stromelysin targeted ribozymes
US08/426,124 US5716824A (en) 1995-04-20 1995-04-20 2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
US08/432,874 US5627053A (en) 1994-03-29 1995-05-02 2'deoxy-2'-alkylnucleotide containing nucleic acid
US43450995A 1995-05-04 1995-05-04
US97495P 1995-07-07 1995-07-07
US95195P 1995-07-07 1995-07-07
US08/512,861 US6146886A (en) 1994-08-19 1995-08-07 RNA polymerase III-based expression of therapeutic RNAs
US08/541,365 US5672501A (en) 1994-12-23 1995-10-05 Base-modified enzymatic nucleic acid
PCT/US1995/015516 WO1996018736A2 (en) 1994-12-13 1995-11-22 Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses

Publications (1)

Publication Number Publication Date
MX9704440A true MX9704440A (en) 1997-10-31

Family

ID=56289668

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704440A MX9704440A (en) 1994-12-13 1995-11-22 Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses.

Country Status (2)

Country Link
EP (1) EP0799313A2 (en)
MX (1) MX9704440A (en)

Also Published As

Publication number Publication date
EP0799313A2 (en) 1997-10-08

Similar Documents

Publication Publication Date Title
WO1996018736A3 (en) Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses
BR9808154A (en) Nucleic acid molecules encoding enzymes having fructosyl polymerase activity
DE60037938D1 (en) ANTISENSE THERAPY FOR TRPM-2
MX9605716A (en) Methods and compositions for treatment of restenosis and cancer using ribozymes.
GR3024597T3 (en) 7-deazapurine modified oligonucleotides
WO2001089583A3 (en) Glutamic acid decarboxylase (gad)_delivery system for treating neurodegenerative diseases
EP0654077A4 (en) Method and reagent for treatment of animal diseases.
DE69736598D1 (en) Ribonucleic acid RNA preparation and its use
PT1053313E (en) OLIGONUCLEOTIDOS '' ANTISENSE '' OPTIMIZED COMPLEMENTARY SEQUENCES OF DNA METHYLTRANSFERASE
BR0015114A (en) Nucleic acid and amino acid sequences, nucleic acid construction, vector, microorganism, l-pantolactone hydrolase, and process for preparing d-pantolactone
HK1013103A1 (en) Method of cleaving specific strands of rna
ES8504458A1 (en) Preparation of DNA sequences and DNA recombinant molecules coding for the cholera toxine units A and B, the products obtained and compositions containing the unit(s) obtained.
WO1997026270A3 (en) Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
WO2001025488A3 (en) Method for enrichment of natural antisense messenger rna
WO1994025612A3 (en) Nucleotide sequences for the control of the expression of dna sequences in a cellular host
ES2193144T3 (en) DNA COMPOUNDS THAT INCLUDE SEQUENCES CODING MANURONANE C-5-EPIMERASE.
WO1995013380A3 (en) Method and reagent for treatment of arthritic conditions
WO1996018733A3 (en) Ribozyme-mediated inactivation of leukemia-associated rna
MX9704440A (en) Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses.
AU6724794A (en) GRB3-3 gene, its variants and their uses
EP1118667A4 (en) Novel enzyme compositions, process for producing the same and utilization of the same
ZA200101737B (en) Nucleic acid molecules which code for enzymes with fructosyltransferase activity and use thereof.
NZ330290A (en) Purified proteins, recombinant DNA sequences and processes for producing caffeine free beverages
GB9028107D0 (en) System for isolating and producing new genes,gene products and dna sequences
ZA99236B (en) Orotidine-5'-phosphate decarboxylase gene, gene construct comprising this gene and its use.