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MX9703093A - N-arilo y n-heteroarilo-1,2-diaminociclobuten-3, 4-dionas con actividades relajantes del musculo liso. - Google Patents

N-arilo y n-heteroarilo-1,2-diaminociclobuten-3, 4-dionas con actividades relajantes del musculo liso.

Info

Publication number
MX9703093A
MX9703093A MX9703093A MX9703093A MX9703093A MX 9703093 A MX9703093 A MX 9703093A MX 9703093 A MX9703093 A MX 9703093A MX 9703093 A MX9703093 A MX 9703093A MX 9703093 A MX9703093 A MX 9703093A
Authority
MX
Mexico
Prior art keywords
carbon atoms
alkyl
hydrogen
amino
fluoro
Prior art date
Application number
MX9703093A
Other languages
English (en)
Other versions
MXPA97003093A (es
Inventor
John Anthony Butera
Schuyler Adam Antane
Bradford Hammond Hirth
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of MX9703093A publication Critical patent/MX9703093A/es
Publication of MXPA97003093A publication Critical patent/MXPA97003093A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Los compuestos de formula (I) en donde R1 es hidrogeno, alquilo C1-10 de cadena ramificada o recta, alquilo C3-10 cíclico o biclíco, alcanoilo de 2 a 7 átomos de carbono, alquilsulfonilo de 1 a 7 átomos de carbono, aorilo de 7 a 12 átomos de carbono, arilaquenoilo de 9 a 20 átomos de carbono, arilsulfonilo de 6 a 12 átomos de carbono, arilalcanoilo de 8 a 12 átomos de carbono o arilalquilsulfonilo de 7 a 12 átomos de carbono; R2 es hidrogeno, alquilo C1-10 de cadena ramificada o recta o alquilo C3-10 cíclico o bíclico, A es un grupo de formula (II), en donde R7 y R8, independientes de cada uno de los otros, son seleccionados de los siguientes: ciano, nitro, amino alquilo C1-6, perfluoroalquilo C1-6, alcoxi C1-6, alcoxi C1-6, perfluoroalcoxi C1-6, amino, mono o dialquilamino C1-12, sulfonamida, alquilsulfonamica C1-6, arilsulfonamida C1-6, alquilcarboxamida C2-6, arilcarboxamido C7-12, alquilsulfonilo C1-6, perfluoroalquilsulfonilo C1-6, arisulfonil C6-12, cloro, bromo, fluoro, yodo, 1-imidazolilo, carboxilo, carboalcoxi de 2 a 7 átomos de carbono, hidroxilo o hidrogeno; o A ES Het donde Het es seleccionado de (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o), (pP), en donde Rg es hidrogeno, alquilo C1-6, perfluoroalquilo C1-6.
MXPA/A/1997/003093A 1994-11-04 1997-04-28 N-arilo y n-heteroarilo-1,2-diaminociclobuten-3,4-dionas con actividades relajantes del musculo liso MXPA97003093A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/334,475 US5466712A (en) 1994-11-04 1994-11-04 Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones
US08334475 1994-11-04
PCT/US1995/014597 WO1996014300A1 (en) 1994-11-04 1995-10-25 N-aryl and n-heteroaryl-1,2-diaminocyclobutene-3,4-diones with smooth muscle relaxing activities

Publications (2)

Publication Number Publication Date
MX9703093A true MX9703093A (es) 1997-07-31
MXPA97003093A MXPA97003093A (es) 1997-12-01

Family

ID=

Also Published As

Publication number Publication date
AU4106096A (en) 1996-05-31
EP0789690A1 (en) 1997-08-20
US5532245A (en) 1996-07-02
US5466712A (en) 1995-11-14
FI971853A (fi) 1997-07-01
AU714911B2 (en) 2000-01-13
HUT77444A (hu) 1998-04-28
NZ296442A (en) 1999-11-29
KR970707096A (ko) 1997-12-01
FI971853A0 (fi) 1997-04-30
US5605909A (en) 1997-02-25
WO1996014300A1 (en) 1996-05-17
JPH10509703A (ja) 1998-09-22

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