[go: up one dir, main page]

MX9702665A - Analogos del factor de crecimiento de queratinocitos. - Google Patents

Analogos del factor de crecimiento de queratinocitos.

Info

Publication number
MX9702665A
MX9702665A MX9702665A MX9702665A MX9702665A MX 9702665 A MX9702665 A MX 9702665A MX 9702665 A MX9702665 A MX 9702665A MX 9702665 A MX9702665 A MX 9702665A MX 9702665 A MX9702665 A MX 9702665A
Authority
MX
Mexico
Prior art keywords
growth factor
keratinocyte growth
factor analogs
analogs
kgf
Prior art date
Application number
MX9702665A
Other languages
English (en)
Inventor
Bao-Lu Chen
Tsutomu Arakawa
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX9702665A publication Critical patent/MX9702665A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proveen nuevos análogos de proteínas del factor de crecimiento de los queratinocitos que comprenden un cambio de cargas por la supresion o substitucion de uno o más de los residuos de aminoácidos 41-154 de la Figura 2 (aminoácidos 72-185 de SEC ID NO:2). Estos análogos son más estables que las correspondientes moléculas originales del factor de crecimiento de los queratinocitos.
MX9702665A 1994-10-13 1995-10-12 Analogos del factor de crecimiento de queratinocitos. MX9702665A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32333794A 1994-10-13 1994-10-13
US48782595A 1995-06-07 1995-06-07
PCT/US1995/013075 WO1996011951A2 (en) 1994-10-13 1995-10-12 Keratinocyte growth factor analogs

Publications (1)

Publication Number Publication Date
MX9702665A true MX9702665A (es) 1997-07-31

Family

ID=26983900

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9702665A MX9702665A (es) 1994-10-13 1995-10-12 Analogos del factor de crecimiento de queratinocitos.

Country Status (14)

Country Link
EP (1) EP0785950B1 (es)
JP (2) JP4422210B2 (es)
AT (1) ATE237634T1 (es)
AU (1) AU3893195A (es)
CA (1) CA2202390C (es)
DE (1) DE69530404T2 (es)
DK (1) DK0785950T3 (es)
ES (1) ES2196088T3 (es)
HU (1) HUT78069A (es)
MX (1) MX9702665A (es)
NO (1) NO971621L (es)
PT (1) PT785950E (es)
SI (1) SI0785950T1 (es)
WO (1) WO1996011951A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7084119B2 (en) 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
HUT73453A (en) 1993-06-29 1996-08-28 Chiron Corp A truncated keratinocyte growth factor /kgf/ having increased biological activity
SI0785949T1 (en) * 1994-10-13 2003-08-31 Amgen Inc. Method for purifying keratinocyte growth factors
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
NZ333650A (en) * 1996-07-19 2000-02-28 Amgen Inc Analogs of cationic proteins like NT-3 (neurotrophin-3) and BDNF (brain derived neurotrophic factor) that are circulated more readily due to a lower isoelectric point and a lower protein charge relative to the native protein
SI0935652T1 (en) * 1996-10-15 2004-06-30 Amgen Inc. Keratinocyte growth factor-2 products
ES2218666T3 (es) * 1996-10-15 2004-11-16 Amgen Inc., Producto a base del factor de crecimiento de queratinocitos-2 (kggf-2).
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
CA2316015A1 (en) 1997-12-22 1999-07-01 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6248725B1 (en) 1999-02-23 2001-06-19 Amgen, Inc. Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
CA2457781A1 (en) 2001-08-21 2003-02-27 Chiron Corporation Kgf polypeptide compositions
JP5201992B2 (ja) 2004-12-15 2013-06-05 バイオビトラム・アクテイエボラーグ（パブリツク） ケラチノサイト増殖因子の治療用製剤
KR20230127721A (ko) * 2022-02-25 2023-09-01 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2153816T3 (es) * 1989-01-31 2001-03-16 Jeffrey S Rubin Adn que codifica un factor de crecimiento especifico contra celulas epiteliales.
NZ274667A (en) * 1993-09-24 1997-03-24 American Cyanamid Co Fibroblast growth factor analogue

Also Published As

Publication number Publication date
DE69530404T2 (de) 2003-11-13
NO971621L (no) 1997-06-12
SI0785950T1 (en) 2003-08-31
ES2196088T3 (es) 2003-12-16
JP2007020575A (ja) 2007-02-01
JP4422210B2 (ja) 2010-02-24
CA2202390C (en) 2005-05-17
NO971621D0 (no) 1997-04-09
WO1996011951A2 (en) 1996-04-25
CA2202390A1 (en) 1996-04-25
PT785950E (pt) 2003-09-30
ATE237634T1 (de) 2003-05-15
JP2000511762A (ja) 2000-09-12
AU3893195A (en) 1996-05-06
DK0785950T3 (da) 2003-07-28
WO1996011951A3 (en) 1996-12-12
HUT78069A (hu) 1999-08-30
EP0785950A2 (en) 1997-07-30
EP0785950B1 (en) 2003-04-16
DE69530404D1 (de) 2003-05-22

Similar Documents

Publication Publication Date Title
SI0785950T1 (en) Keratinocyte growth factor analogs
BG101408A (en) Analogs of keratinocyte growth factor
AU6286986A (en) Peptide analogues of mammalian insulin-like growth factor-1
AU7550098A (en) System for expressing hyperthermostable protein
MY123740A (en) Il-13 receptor polypeptide
ES2000216A6 (es) Procedimiento para preparar un polipeptido purificado que tiene propiedades inhibidoras de la coagulacion de la sangre.
RU94045952A (ru) Домен ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена
EP0374044A3 (en) Tgf - beta 1 / beta 2 : a novel chimeric transforming growth factor-beta.
EP1037999A4 (en) POLYPEPTIDES AND NUCLEOTIDES PORPHYROMONAS GINGIVALIS
ES2095255T3 (es) Analogos de sustitucion de peptidos magainina.
AU3258197A (en) Peptides
CA2201944A1 (en) Analogs of keratinocyte growth factor having enhanced temperature stability
CA2133834A1 (en) Process for preparing modified proteins
AU585167B2 (en) Novel substrate peptides
EP0249412A3 (en) C-terminal alpha-amidating enzyme and process for production and use thereof
NZ511618A (en) Kininogen fragment 2 peptides with the formula of at least X-His-Lys-X-Lys-X
GR3021408T3 (en) Cloning of a new member of the fibroblast growth factor (fgf) receptor family
DK0828004T3 (da) Proteindisulfidisomerase-gen afledt af stamme af methylotrof gær
EP1295943A4 (en) POLYPEPTIDES CAPABLE THE POWER TO STIMULATE NEUTROPHILES
EP0625580A4 (en) Novel hirudine variant, process for producing the same, and anticoagulant containing the same as active ingredient.
EP1158052A4 (en) BETA-PRIMEVEROSIDASDE GENE
MX9709921A (es) Alfa-d-galactosidasas de glicina y phaseolus.

Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: BIOVITRUM AB (PUBL)

MM Annulment or lapse due to non-payment of fees