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MX9606227A - New taxoids, preparation thereof and pharmaceutical compositions containing them. - Google Patents

New taxoids, preparation thereof and pharmaceutical compositions containing them.

Info

Publication number
MX9606227A
MX9606227A MX9606227A MX9606227A MX9606227A MX 9606227 A MX9606227 A MX 9606227A MX 9606227 A MX9606227 A MX 9606227A MX 9606227 A MX9606227 A MX 9606227A MX 9606227 A MX9606227 A MX 9606227A
Authority
MX
Mexico
Prior art keywords
radical
general formula
alkynyl
cycloalkyl
alkenyl
Prior art date
Application number
MX9606227A
Other languages
Spanish (es)
Other versions
MXPA96006227A (en
Inventor
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Corinne Terrier
Martine Zucco
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Priority claimed from PCT/FR1995/000735 external-priority patent/WO1995033736A1/en
Publication of MXPA96006227A publication Critical patent/MXPA96006227A/en
Publication of MX9606227A publication Critical patent/MX9606227A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New taxoids having general formula (I), (II) preparation thereof and pharmaceutical compositions containing them. In general formula (I): Ra is hydrogen, hydroxy, alkoxy, acyloxy, alkoxyacetoxy, and Rb is hydrogen or Ra and Rb form together with the carbon atom to which they are linked a ketone function, Z is a hydrogen atom or a radical having general formula (II) wherein R1 is an optionally substituted benzoyl radical, a thenyl or furoyl radical or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphtyl or heterocyclic aromatic radical, and R4 and R5, similar or different, represent an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, aryl or heterocyclyl radical, with the condition that R5 does not represent a methyl radical. The new products having general formula (I) wherein Z is a radical having general formula (II) have remarkable antitumoral and antileukaemic properties.
MX9606227A 1995-06-07 1995-06-07 New taxoids, preparation thereof and pharmaceutical compositions containing them. MX9606227A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9407049 1994-06-09
FR94/07049 1994-06-09
PCT/FR1995/000735 WO1995033736A1 (en) 1994-06-09 1995-06-07 New taxoids, preparation thereof and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
MXPA96006227A MXPA96006227A (en) 1998-02-01
MX9606227A true MX9606227A (en) 1998-02-28

Family

ID=39165274

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9606227A MX9606227A (en) 1995-06-07 1995-06-07 New taxoids, preparation thereof and pharmaceutical compositions containing them.

Country Status (1)

Country Link
MX (1) MX9606227A (en)

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