MX9606114A - Procedimiento para macrolidos de dienona. - Google Patents
Procedimiento para macrolidos de dienona.Info
- Publication number
- MX9606114A MX9606114A MX9606114A MX9606114A MX9606114A MX 9606114 A MX9606114 A MX 9606114A MX 9606114 A MX9606114 A MX 9606114A MX 9606114 A MX9606114 A MX 9606114A MX 9606114 A MX9606114 A MX 9606114A
- Authority
- MX
- Mexico
- Prior art keywords
- microorganism
- mutant
- relates
- rosx
- repromicin
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229940041033 macrolides Drugs 0.000 title 1
- 244000005700 microbiome Species 0.000 abstract 8
- OBUIQEYZGMZXPJ-NPQHDNJNSA-N 2-[(4r,5s,6s,7r,9r,11e,13e,15s,16r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-5,9,13,15-tetramethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde Chemical compound O=CC[C@H]1C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)C[C@@H](C)O1 OBUIQEYZGMZXPJ-NPQHDNJNSA-N 0.000 abstract 2
- 108010017796 epoxidase Proteins 0.000 abstract 2
- 229950005855 repromicin Drugs 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 241000218940 Micromonospora rosaria Species 0.000 abstract 1
- ZUHRLTIPDRLJHR-UHFFFAOYSA-N Rosamicin Natural products CCC1OC(=O)CC(O)C(C)C(OC2OC(C)CC(C2O)N(C)C)C(CC=O)CC(C)C(=O)C=CC3OC3C1C ZUHRLTIPDRLJHR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- IUPCWCLVECYZRV-JZMZINANSA-N rosaramicin Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H]([C@@H]2O[C@@]2(C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O IUPCWCLVECYZRV-JZMZINANSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/29—Micromonospora
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
El procedimiento de esta invencion está dirigido a aislar o de otra manera obtener un microorganismo productor de macrolido olefínico, dicho microorganismo no conteniendo actividad de enzima epoxidasa; esta invencion también se refiere a un procedimiento para preparar dicho macrolido olefínico fermentando un microorganismo mutante que carece de actividad epoxidasa, designada rosX en la presente, dicho mutante siendo obtenido del microorganismo de tipo silvestre; esta invencion también se refiere a un mutante rosX de Micromonospora rosaria; y a cualquier microorganismo que tenga las características de identificacion del mismo, dicho mutante también designado ATCC 55709. Esta invencion también se refiere a un procedimiento para preparar repromicina, el compuesto de la formula II. Mutando un microorganismo de tipo silvestre que puede producir rosamicina para producir un microorganismo mutante que carece de actividad de epoxidasa de tal manera que la repromicina es producida por dicho microorganismo mutante.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US825195P | 1995-12-04 | 1995-12-04 | |
| US008,251 | 1995-12-04 | ||
| US008251 | 1995-12-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MXPA96006114A MXPA96006114A (es) | 1997-08-01 |
| MX9606114A true MX9606114A (es) | 1997-08-30 |
Family
ID=21730592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9606114A MX9606114A (es) | 1995-12-04 | 1996-12-03 | Procedimiento para macrolidos de dienona. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5776735A (es) |
| EP (1) | EP0778345A3 (es) |
| JP (1) | JPH09163982A (es) |
| CA (1) | CA2191833A1 (es) |
| MX (1) | MX9606114A (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4662635B2 (ja) * | 1998-11-20 | 2011-03-30 | コーサン バイオサイエンシーズ， インコーポレイテッド | エポチロンおよびエポチロン誘導体を生成するための組換え方法および材料 |
| US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
| AU7902501A (en) * | 2000-07-25 | 2002-02-05 | Kosan Biosciences Inc | Fermentation process for epothilones |
| US6989131B2 (en) * | 2002-03-12 | 2006-01-24 | Uop Llc | Catalytic reactor with integral evaporator |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3975372A (en) * | 1975-02-28 | 1976-08-17 | Schering Corporation | Preparation of 12,13-desepoxy-12,13-dehydrorosamicin |
| US4357325A (en) * | 1981-04-20 | 1982-11-02 | Eli Lilly And Company | Methods of controlling Pasteurella infections |
| JPH06253853A (ja) * | 1993-03-09 | 1994-09-13 | Asahi Chem Ind Co Ltd | マクロライド抗生物質生合成遺伝子を含有するｄｎａ |
-
1996
- 1996-11-06 EP EP96308042A patent/EP0778345A3/en not_active Withdrawn
- 1996-11-06 US US08/744,474 patent/US5776735A/en not_active Expired - Fee Related
- 1996-12-02 CA CA002191833A patent/CA2191833A1/en not_active Abandoned
- 1996-12-03 MX MX9606114A patent/MX9606114A/es unknown
- 1996-12-04 JP JP8324259A patent/JPH09163982A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0778345A2 (en) | 1997-06-11 |
| EP0778345A3 (en) | 1999-10-13 |
| US5776735A (en) | 1998-07-07 |
| CA2191833A1 (en) | 1997-06-05 |
| JPH09163982A (ja) | 1997-06-24 |
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