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MX9605428A - SINTESIS DE 17 beta-CIANO-3-ETOXI-17ALFA-HIDROXI-6-METILANDROSTA-3,5,9(11)-T RIENO. - Google Patents

SINTESIS DE 17 beta-CIANO-3-ETOXI-17ALFA-HIDROXI-6-METILANDROSTA-3,5,9(11)-T RIENO.

Info

Publication number
MX9605428A
MX9605428A MX9605428A MX9605428A MX9605428A MX 9605428 A MX9605428 A MX 9605428A MX 9605428 A MX9605428 A MX 9605428A MX 9605428 A MX9605428 A MX 9605428A MX 9605428 A MX9605428 A MX 9605428A
Authority
MX
Mexico
Prior art keywords
methylandrosta
triene
cyano
beta
alpha
Prior art date
Application number
MX9605428A
Other languages
English (en)
Inventor
John Gregory Reid
Therese Debiak-Krook
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX9605428A publication Critical patent/MX9605428A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se prepara 3-etil éter de 17 beta-ciano-3,17alfa-dihidroxi-6-metilandrosta-3,5,9 (11)-trieno (II) haciendo reaccionar un 3-etil éter de 3-hidroxi-6-metilandrosta-3,5,9(11)-trien-17-ona (I) con cianuro de hidrogeno a un pH de aproximadamente 7 a aproximadamente 11. El producto es un intermediario util en la produccion de esteroides farmacologicamente activos que incluyen metilprednisolona.
MX9605428A 1994-05-09 1995-05-02 SINTESIS DE 17 beta-CIANO-3-ETOXI-17ALFA-HIDROXI-6-METILANDROSTA-3,5,9(11)-T RIENO. MX9605428A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24003694A 1994-05-09 1994-05-09
PCT/US1995/005026 WO1995030684A1 (en) 1994-05-09 1995-05-02 SYNTHESIS OF 17β-CYANO-3-ETHOXY-17α-HYDROXY-6-METHYLANDROSTA-3,5,9(11)-TRIENE

Publications (1)

Publication Number Publication Date
MX9605428A true MX9605428A (es) 1997-12-31

Family

ID=22904843

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9605428A MX9605428A (es) 1994-05-09 1995-05-02 SINTESIS DE 17 beta-CIANO-3-ETOXI-17ALFA-HIDROXI-6-METILANDROSTA-3,5,9(11)-T RIENO.

Country Status (9)

Country Link
EP (1) EP0759928A1 (es)
JP (1) JPH10500946A (es)
KR (1) KR970702873A (es)
CN (1) CN1147816A (es)
AU (1) AU684946B2 (es)
CA (1) CA2187522A1 (es)
HU (1) HUT75517A (es)
MX (1) MX9605428A (es)
WO (1) WO1995030684A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112898365B (zh) * 2021-03-08 2023-02-28 营口德瑞化工有限公司 一种17β-氰基-17α-羟基雄甾-4-烯-3-酮的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2468617A1 (fr) * 1979-10-26 1981-05-08 Roussel Uclaf Nouveaux derives acetyleniques chlores de l'androst-4-ene leur procede de preparation, et leur application a titre de medicament et les compositions pharmaceutiques les renfermant
DE3585547D1 (de) * 1984-02-03 1992-04-16 Upjohn Co Steroide mit einer enamid- oder enimidgruppe sowie ihre herstellung.
DE3427486A1 (de) * 1984-07-23 1986-01-30 Schering AG, Berlin und Bergkamen, 1000 Berlin Verfahren zur herstellung von 6(alpha)-methylsteroiden
DE3434448A1 (de) * 1984-09-17 1986-03-27 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von pregnan-derivaten
DD281394A5 (de) * 1984-12-10 1990-08-08 Jenapharm Veb Verfahren zur herstellung von steroid-c-17 alpha-carbonitrilen
EP0263569B1 (en) * 1986-10-10 1992-12-09 Roussel-Uclaf 9-alpha-hydroxysteroids, process for their preparation and process for the preparation of the corresponding 9(11)-dehydro-derivatives.
CA1317283C (en) * 1986-11-05 1993-05-04 Douglas Alan Livingston Steroidal 17–-silyl ethers and process to corticoids and progesterones

Also Published As

Publication number Publication date
AU2362895A (en) 1995-11-29
CA2187522A1 (en) 1995-11-16
CN1147816A (zh) 1997-04-16
KR970702873A (ko) 1997-06-10
JPH10500946A (ja) 1998-01-27
HU9603110D0 (en) 1997-01-28
AU684946B2 (en) 1998-01-08
HUT75517A (en) 1997-05-28
WO1995030684A1 (en) 1995-11-16
EP0759928A1 (en) 1997-03-05

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