MX9603347A - Derivados de disulfuro de 1,3,4,5-tetrahidro-benzo[c] azepin-3-ona de mercaptoacetilamido novedosos, utiles como inhibidores de encefalinasa y de enzima convertidora de angiotensina. - Google Patents
Derivados de disulfuro de 1,3,4,5-tetrahidro-benzo[c] azepin-3-ona de mercaptoacetilamido novedosos, utiles como inhibidores de encefalinasa y de enzima convertidora de angiotensina.Info
- Publication number
- MX9603347A MX9603347A MX9603347A MX9603347A MX9603347A MX 9603347 A MX9603347 A MX 9603347A MX 9603347 A MX9603347 A MX 9603347A MX 9603347 A MX9603347 A MX 9603347A MX 9603347 A MX9603347 A MX 9603347A
- Authority
- MX
- Mexico
- Prior art keywords
- enkephalinase
- azepin
- ace
- benzo
- tetrahydro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion se refiere a ciertos derivados novedosos de disulfuro de 1,3,4,5-tetrahidro-benzo[c]azepin-3-ona de mercaptoacetilamido (formula I)utiles como inhibidores de encefalinasa y de enzima convertidora de agiotensina.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19540794A | 1994-02-14 | 1994-02-14 | |
| US195407 | 1994-02-14 | ||
| US22679994A | 1994-04-12 | 1994-04-12 | |
| US226799 | 1994-04-12 | ||
| PCT/US1995/000279 WO1995021854A1 (en) | 1994-02-14 | 1995-01-09 | Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9603347A true MX9603347A (es) | 1997-12-31 |
| MXPA96003347A MXPA96003347A (es) | 1998-09-18 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| ES2145267T3 (es) | 2000-07-01 |
| FI963169A0 (fi) | 1996-08-13 |
| HU9602229D0 (en) | 1996-10-28 |
| EP0750631B1 (en) | 2000-04-05 |
| US5731306A (en) | 1998-03-24 |
| NZ279397A (en) | 1997-08-22 |
| WO1995021854A1 (en) | 1995-08-17 |
| AU691243B2 (en) | 1998-05-14 |
| IL112606A0 (en) | 1995-05-26 |
| CN1100785C (zh) | 2003-02-05 |
| IL112606A (en) | 2001-03-19 |
| HUT74385A (en) | 1996-12-30 |
| CN1140454A (zh) | 1997-01-15 |
| AU1600695A (en) | 1995-08-29 |
| FI963169A (fi) | 1996-08-13 |
| JPH09508906A (ja) | 1997-09-09 |
| DE69516128T2 (de) | 2000-12-21 |
| ATE191485T1 (de) | 2000-04-15 |
| CA2183315C (en) | 1999-08-31 |
| CA2183315A1 (en) | 1995-08-17 |
| EP0750631A1 (en) | 1997-01-02 |
| GR3033661T3 (en) | 2000-10-31 |
| DK0750631T3 (da) | 2000-10-23 |
| PT750631E (pt) | 2000-07-31 |
| NO963370L (no) | 1996-10-11 |
| NO963370D0 (no) | 1996-08-13 |
| US5880119A (en) | 1999-03-09 |
| DE69516128D1 (de) | 2000-05-11 |
| KR100364947B1 (ko) | 2003-03-06 |
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