MX9303245A - NOVEL PHOSPHONATE COMPOUNDS CONTAINING QUATERNARY NITROGEN, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR TREATING ABNORMAL METABOLISM OF CALCIUM AND PHOSPHONATE. - Google Patents
NOVEL PHOSPHONATE COMPOUNDS CONTAINING QUATERNARY NITROGEN, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR TREATING ABNORMAL METABOLISM OF CALCIUM AND PHOSPHONATE.Info
- Publication number
- MX9303245A MX9303245A MX9303245A MX9303245A MX9303245A MX 9303245 A MX9303245 A MX 9303245A MX 9303245 A MX9303245 A MX 9303245A MX 9303245 A MX9303245 A MX 9303245A MX 9303245 A MX9303245 A MX 9303245A
- Authority
- MX
- Mexico
- Prior art keywords
- present
- phosphonate
- pharmaceutical compositions
- quaternary nitrogen
- calcium
- Prior art date
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052791 calcium Inorganic materials 0.000 title abstract 2
- 239000011575 calcium Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Chemical group 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 208000021959 Abnormal metabolism Diseases 0.000 title 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 1
- 230000006371 metabolic abnormality Effects 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- -1 nitrogen containing phosphonate compounds Chemical class 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos fosfonato que contienen nitrógeno cuaternario y a sus sales y ésteres farmacéuticamente aceptables, que tienen ala siguiente fórmula general (I). La presente invención se refiere adicionalmente a composiciones farmacéuticas que tienen una cantidad segura y efectiva de un compuesto de la presente invención, y excipientes farmacéuticamente aceptables. Finalmente, la presente invención se refiere a métodos para tratar o prevenir condiciones patológicas, caracterizadas por metabolismo anormal del calcio y del fosfato, tales como osteoporosis y artritis, especialmente artritis reumatoide, y osteoartritis, en humanos u otros mamíferos. este método comprende administrar a un humano u otro mamífero que necesite de dicho tratamiento, una cantidad segura y efectiva de un compuesto o una composición de la presente invención.The present invention relates to quaternary nitrogen containing phosphonate compounds and their pharmaceutically acceptable salts and esters, having the following general formula (I). The present invention further relates to pharmaceutical compositions having a safe and effective amount of a compound of the present invention, and pharmaceutically acceptable excipients. Finally, the present invention relates to methods for treating or preventing pathological conditions, characterized by abnormal calcium and phosphate metabolism, such as osteoporosis and arthritis, especially rheumatoid arthritis, and osteoarthritis, in humans or other mammals. This method comprises administering to a human or other mammal in need of such treatment, a safe and effective amount of a compound or composition of the present invention.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89135592A | 1992-05-29 | 1992-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9303245A true MX9303245A (en) | 1994-05-31 |
Family
ID=25398040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9303245A MX9303245A (en) | 1992-05-29 | 1993-05-31 | NOVEL PHOSPHONATE COMPOUNDS CONTAINING QUATERNARY NITROGEN, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR TREATING ABNORMAL METABOLISM OF CALCIUM AND PHOSPHONATE. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0642517A1 (en) |
| JP (1) | JPH07507305A (en) |
| KR (1) | KR950701927A (en) |
| CN (1) | CN1085906A (en) |
| AU (1) | AU675224B2 (en) |
| CA (1) | CA2136819A1 (en) |
| CZ (1) | CZ296694A3 (en) |
| FI (1) | FI945598A (en) |
| HU (1) | HUT69732A (en) |
| IL (1) | IL105831A0 (en) |
| MX (1) | MX9303245A (en) |
| NZ (1) | NZ252587A (en) |
| RU (1) | RU94046139A (en) |
| SK (1) | SK144594A3 (en) |
| WO (1) | WO1993024494A1 (en) |
| ZA (1) | ZA933758B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728650A (en) * | 1993-10-07 | 1998-03-17 | Zeneca Limited | Herbicidal aza bisphosphonic acids and compositions containing the same |
| IL115041A0 (en) * | 1995-08-23 | 1995-12-08 | Yissum Res Dev Co | Novel bisphosphonates process for their preparation and pharmaceutical compositions containing them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2534391C2 (en) * | 1975-08-01 | 1983-01-13 | Henkel KGaA, 4000 Düsseldorf | 1-Hydroxy-3-aminoalkane-1,1-diphosphonic acids |
| DE4011777A1 (en) * | 1989-04-14 | 1990-10-18 | Ciba Geigy Ag | New tri:alkyl:ammonio 1-hydroxy-alkane-1,1-di:phosphonic acids - are calcium metabolism regulants e.g. for treating osteoporosis of calcium deposition in blood vessels |
-
1993
- 1993-05-11 HU HU9403406A patent/HUT69732A/en unknown
- 1993-05-11 NZ NZ252587A patent/NZ252587A/en unknown
- 1993-05-11 CZ CZ942966A patent/CZ296694A3/en unknown
- 1993-05-11 RU RU94046139/04A patent/RU94046139A/en unknown
- 1993-05-11 EP EP93911255A patent/EP0642517A1/en not_active Ceased
- 1993-05-11 SK SK1445-94A patent/SK144594A3/en unknown
- 1993-05-11 AU AU42453/93A patent/AU675224B2/en not_active Ceased
- 1993-05-11 JP JP6500570A patent/JPH07507305A/en active Pending
- 1993-05-11 KR KR1019940704304A patent/KR950701927A/en not_active Application Discontinuation
- 1993-05-11 CA CA002136819A patent/CA2136819A1/en not_active Abandoned
- 1993-05-11 WO PCT/US1993/004469 patent/WO1993024494A1/en not_active Application Discontinuation
- 1993-05-28 ZA ZA933758A patent/ZA933758B/en unknown
- 1993-05-28 IL IL105831A patent/IL105831A0/en unknown
- 1993-05-29 CN CN93108225A patent/CN1085906A/en active Pending
- 1993-05-31 MX MX9303245A patent/MX9303245A/en unknown
-
1994
- 1994-11-28 FI FI945598A patent/FI945598A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0642517A1 (en) | 1995-03-15 |
| FI945598A0 (en) | 1994-11-28 |
| AU675224B2 (en) | 1997-01-30 |
| KR950701927A (en) | 1995-05-17 |
| HUT69732A (en) | 1995-09-28 |
| WO1993024494A1 (en) | 1993-12-09 |
| CZ296694A3 (en) | 1995-12-13 |
| CA2136819A1 (en) | 1993-12-09 |
| SK144594A3 (en) | 1995-07-11 |
| HU9403406D0 (en) | 1995-02-28 |
| IL105831A0 (en) | 1993-09-22 |
| AU4245393A (en) | 1993-12-30 |
| RU94046139A (en) | 1996-09-27 |
| ZA933758B (en) | 1994-01-20 |
| CN1085906A (en) | 1994-04-27 |
| NZ252587A (en) | 1997-02-24 |
| JPH07507305A (en) | 1995-08-10 |
| FI945598A (en) | 1995-01-25 |
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