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MX9301505A - Metodo para preparar homo-beta-aminoacidos opticamente activos. - Google Patents

Metodo para preparar homo-beta-aminoacidos opticamente activos.

Info

Publication number
MX9301505A
MX9301505A MX9301505A MX9301505A MX9301505A MX 9301505 A MX9301505 A MX 9301505A MX 9301505 A MX9301505 A MX 9301505A MX 9301505 A MX9301505 A MX 9301505A MX 9301505 A MX9301505 A MX 9301505A
Authority
MX
Mexico
Prior art keywords
beta
amino acids
homo
optically active
preparing optically
Prior art date
Application number
MX9301505A
Other languages
English (en)
Inventor
John Jeffrey Talley
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of MX9301505A publication Critical patent/MX9301505A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención está dirigida a la síntesis de homo-beta-aminoácidos de una pureza óptica suficiente para exhibir actividad óptica cuando se efectúa el rearreglo de Curtius de hemiéster ácido de succinato 3-mono-substituido de una pureza óptica suficiente para exhibir actividad óptica y se atrapa el isocianato incipiente con un alcohol primario o secundario. Los homo-beta-aminoésteres protegidos por carbamato resultantes se saponifican después para producir los correspondientes homo-beta-aminoácidos protegidos por carbamato que se desprotegen para producir homo-beta-aminoácidos de una pureza óptica suficiente para exhibir actividad óptica.
MX9301505A 1992-03-18 1993-03-17 Metodo para preparar homo-beta-aminoacidos opticamente activos. MX9301505A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85356192A 1992-03-18 1992-03-18

Publications (1)

Publication Number Publication Date
MX9301505A true MX9301505A (es) 1993-12-01

Family

ID=25316357

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301505A MX9301505A (es) 1992-03-18 1993-03-17 Metodo para preparar homo-beta-aminoacidos opticamente activos.

Country Status (5)

Country Link
EP (1) EP0561758A3 (es)
JP (1) JPH069515A (es)
CA (1) CA2091788A1 (es)
ES (1) ES2049710T1 (es)
MX (1) MX9301505A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4524015B2 (ja) * 1999-11-17 2010-08-11 キッセイ薬品工業株式会社 （２ｓ）−２−ベンジルコハク酸モノエステルの有機アミン塩およびその製造方法
GB0025310D0 (en) * 2000-10-16 2000-11-29 Pfizer Ltd Process
US6452041B1 (en) 2000-10-16 2002-09-17 Pfizer Inc. Olefination process to itaconate and succinate derivatives
NI200300043A (es) 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
JP2007506729A (ja) 2003-09-25 2007-03-22 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー α２δタンパク質に親和性を有するアミノ酸のプロドラッグ

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02306947A (ja) * 1989-05-01 1990-12-20 Monsanto Co キラルβ―アミノ酸の製造方法

Also Published As

Publication number Publication date
EP0561758A2 (en) 1993-09-22
EP0561758A3 (en) 1995-04-05
JPH069515A (ja) 1994-01-18
ES2049710T1 (es) 1994-05-01
CA2091788A1 (en) 1993-09-19

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