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MX9300875A - Procedimiento para la preparacion de compuestos azabiciclicos. - Google Patents

Procedimiento para la preparacion de compuestos azabiciclicos.

Info

Publication number
MX9300875A
MX9300875A MX9300875A MX9300875A MX9300875A MX 9300875 A MX9300875 A MX 9300875A MX 9300875 A MX9300875 A MX 9300875A MX 9300875 A MX9300875 A MX 9300875A MX 9300875 A MX9300875 A MX 9300875A
Authority
MX
Mexico
Prior art keywords
compounds
azabiciclic
procedure
preparation
formula
Prior art date
Application number
MX9300875A
Other languages
English (en)
Inventor
Mark Jason Hughes
John Kitteringham
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of MX9300875A publication Critical patent/MX9300875A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

Se describe un procedimiento para preparar compuestos de la fórmula (I) que mejoran la función de la acetilcolina vía una acción en los receptores muscarínicos dentro del sistema nervioso central. Por lo tanto estos compuestos son de uso potencial en el tratamiento y/o la profilaxis de la demencia en mamíferos. También varios métodos preparativos. Los compuestos son capaces de existir en un número de formas estoisoméricas, incluyendo isómeros geométricos tales como sin y anti y, para ciertos compuestos, enantiómeros. Las diferentes formas esteroisoméricas se pueden separar una de la otra por los métodos usuales.
MX9300875A 1992-02-20 1992-02-18 Procedimiento para la preparacion de compuestos azabiciclicos. MX9300875A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929203688A GB9203688D0 (en) 1992-02-20 1992-02-20 Novel process

Publications (1)

Publication Number Publication Date
MX9300875A true MX9300875A (es) 1993-08-31

Family

ID=10710781

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9300875A MX9300875A (es) 1992-02-20 1992-02-18 Procedimiento para la preparacion de compuestos azabiciclicos.

Country Status (19)

Country Link
US (2) US5545740A (es)
EP (2) EP0626961B1 (es)
JP (1) JP3288704B2 (es)
KR (1) KR100261530B1 (es)
AT (1) ATE194341T1 (es)
AU (1) AU669355B2 (es)
CA (1) CA2131019C (es)
DE (1) DE69328962T2 (es)
DK (1) DK0626961T3 (es)
ES (1) ES2147749T3 (es)
GB (1) GB9203688D0 (es)
GR (1) GR3034295T3 (es)
HK (1) HK1012366A1 (es)
MX (1) MX9300875A (es)
NZ (1) NZ246940A (es)
PT (1) PT626961E (es)
TW (1) TW224466B (es)
WO (1) WO1993017018A1 (es)
ZA (1) ZA931132B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9300875A (es) 1992-02-20 1993-08-31 Smithkline Beecham Plc Procedimiento para la preparacion de compuestos azabiciclicos.
GB9409705D0 (en) * 1994-05-14 1994-07-06 Smithkline Beecham Plc Novel compounds
GB9421472D0 (en) * 1994-10-25 1994-12-07 Smithkline Beecham Plc Novel methods
GB9615628D0 (en) * 1996-07-25 1996-09-04 Smithkline Beecham Plc Formulation
JP2001520653A (ja) * 1997-04-11 2001-10-30 エリ リリー アンド カンパニー 精神分裂病の治療法
WO1998046227A1 (en) * 1997-04-11 1998-10-22 Eli Lilly And Company Composition for treating pain
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1600969A (en) 1977-01-07 1981-10-21 Acf Chemiefarma Nv Heterocyclic compounds
US4937239A (en) * 1989-02-13 1990-06-26 Warner-Lambert Company Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents
SG48315A1 (en) * 1989-04-13 1998-04-17 Beecham Group Plc Novel compounds
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
MX9300875A (es) 1992-02-20 1993-08-31 Smithkline Beecham Plc Procedimiento para la preparacion de compuestos azabiciclicos.

Also Published As

Publication number Publication date
CA2131019C (en) 2002-12-24
EP0984008A3 (en) 2000-05-03
GB9203688D0 (en) 1992-04-08
ZA931132B (en) 1993-10-14
KR950700292A (ko) 1995-01-16
EP0984008A2 (en) 2000-03-08
CA2131019A1 (en) 1993-08-21
AU3460793A (en) 1993-09-13
NZ246940A (en) 1996-06-25
DE69328962D1 (de) 2000-08-10
KR100261530B1 (ko) 2000-08-01
JPH07504180A (ja) 1995-05-11
DE69328962T2 (de) 2000-12-28
HK1012366A1 (en) 1999-07-30
ES2147749T3 (es) 2000-10-01
TW224466B (es) 1994-06-01
EP0626961B1 (en) 2000-07-05
EP0626961A1 (en) 1994-12-07
PT626961E (pt) 2000-10-31
JP3288704B2 (ja) 2002-06-04
ATE194341T1 (de) 2000-07-15
US6596869B2 (en) 2003-07-22
WO1993017018A1 (en) 1993-09-02
US20020143185A1 (en) 2002-10-03
DK0626961T3 (da) 2000-11-06
US5545740A (en) 1996-08-13
GR3034295T3 (en) 2000-12-29
AU669355B2 (en) 1996-06-06

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