|
US5354768A
(en)
*
|
1988-07-26 |
1994-10-11 |
Sankyo Company, Limited |
Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents
|
|
US6277969B1
(en)
*
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
|
US5356897A
(en)
*
|
1991-09-09 |
1994-10-18 |
Fujisawa Pharmaceutical Co., Ltd. |
3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines
|
|
GB9303993D0
(en)
*
|
1993-02-26 |
1993-04-14 |
Fujisawa Pharmaceutical Co |
New heterocyclic derivatives
|
|
EP0621036B1
(en)
*
|
1993-04-22 |
1999-03-17 |
Senju Pharmaceutical Co., Ltd. |
Aqueous compositions comprising argatroban and cyclodextrin or caffeine
|
|
EP0707585A1
(en)
*
|
1993-07-06 |
1996-04-24 |
Pfizer Inc. |
Bicyclic tetrahydro pyrazolopyridines
|
|
US6642268B2
(en)
|
1994-09-13 |
2003-11-04 |
G.D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
|
|
US6268392B1
(en)
|
1994-09-13 |
2001-07-31 |
G. D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
|
|
US6262277B1
(en)
|
1994-09-13 |
2001-07-17 |
G.D. Searle And Company |
Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
|
|
US6228871B1
(en)
|
1995-07-10 |
2001-05-08 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
|
IL126728A
(en)
|
1996-04-25 |
2009-12-24 |
Nissan Chemical Ind Ltd |
Ethylene derivatives and agrochemical compositions containing said derivatives as an active ingredient
|
|
FR2750048B1
(fr)
*
|
1996-06-21 |
1998-08-14 |
Oreal |
Compositions de teinture des fibres keratiniques contenant des derives pyrazolo-(1, 5-a)-pyrimidine, procede de teinture, nouveaux derives pyrazolo-(1, 5-a)-pyrimidine et leur procede de preparation
|
|
WO1998002430A1
(en)
|
1996-07-11 |
1998-01-22 |
Pfizer Pharmaceuticals Inc. |
Pyridylpyrrole compounds useful as interleukin- and tnf antagonists
|
|
US6060478A
(en)
*
|
1996-07-24 |
2000-05-09 |
Dupont Pharmaceuticals |
Azolo triazines and pyrimidines
|
|
US6191131B1
(en)
|
1997-07-23 |
2001-02-20 |
Dupont Pharmaceuticals Company |
Azolo triazines and pyrimidines
|
|
JP4704521B2
(ja)
*
|
1996-07-24 |
2011-06-15 |
ブリストル−マイヤーズ スクイブ ファーマ カンパニー |
アゾロトリアジン類およびアゾロピリミジン類
|
|
US7094782B1
(en)
|
1996-07-24 |
2006-08-22 |
Bristol-Myers Squibb Company |
Azolo triazines and pyrimidines
|
|
US6124289A
(en)
*
|
1996-07-24 |
2000-09-26 |
Dupont Pharmaceuticals Co. |
Azolo triazines and pyrimidines
|
|
ES2294800T3
(es)
*
|
1996-07-24 |
2008-04-01 |
Bristol-Myers Squibb Pharma Company |
Azolo triazinas y pirimidinas.
|
|
US6313124B1
(en)
|
1997-07-23 |
2001-11-06 |
Dupont Pharmaceuticals Company |
Tetrazine bicyclic compounds
|
|
US6087496A
(en)
|
1998-05-22 |
2000-07-11 |
G. D. Searle & Co. |
Substituted pyrazoles suitable as p38 kinase inhibitors
|
|
US6979686B1
(en)
|
2001-12-07 |
2005-12-27 |
Pharmacia Corporation |
Substituted pyrazoles as p38 kinase inhibitors
|
|
US5932576A
(en)
*
|
1997-05-22 |
1999-08-03 |
G. D. Searle & Company |
3(5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors
|
|
US6514977B1
(en)
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
|
WO1998052941A1
(en)
|
1997-05-22 |
1998-11-26 |
G.D. Searle And Co. |
PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
|
|
US6235741B1
(en)
*
|
1997-05-30 |
2001-05-22 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
|
EP1473292A1
(en)
*
|
1997-11-03 |
2004-11-03 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Aromatic heterocyclic compounds as anti-inflammatory agents
|
|
EP1028953A1
(en)
*
|
1997-11-03 |
2000-08-23 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Aromatic heterocyclic compounds as anti-inflammatory agents
|
|
US6380203B1
(en)
*
|
1998-01-14 |
2002-04-30 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
|
ATE242009T1
(de)
|
1998-12-23 |
2003-06-15 |
Searle Llc |
Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
|
|
EA005815B1
(ru)
|
1998-12-23 |
2005-06-30 |
Джи.Ди.Сирл Ллс |
Комбинация ингибиторов транспорта желчных кислот в подвздошной кишке и ингибиторов белка, переносящего эфиры холестерина, для сердечно-сосудистых показаний
|
|
PT1140185E
(pt)
|
1998-12-23 |
2003-10-31 |
Searle Llc |
Combinacoes de inibidores de proteina de transferencia de ester de colesterilo com agentes sequestrantes de acido biliar para indicacoes cardiovasculares
|
|
HUP0104793A2
(en)
|
1998-12-23 |
2002-06-29 |
Searle Llc |
Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
|
|
IL143943A0
(en)
|
1998-12-23 |
2002-04-21 |
Searle Llc |
Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications
|
|
ATE242007T1
(de)
|
1998-12-23 |
2003-06-15 |
Searle Llc |
Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
|
|
US6462091B1
(en)
|
1998-12-23 |
2002-10-08 |
G.D. Searle & Co. |
Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
|
|
WO2000059908A2
(en)
|
1999-04-06 |
2000-10-12 |
Du Pont Pharmaceuticals Company |
Pyrazolopyrimidines as crf antagonists
|
|
WO2000059907A2
(en)
|
1999-04-06 |
2000-10-12 |
Du Pont Pharmaceuticals Company |
Pyrazolotriazines as crf antagonists
|
|
AU6909600A
(en)
|
1999-08-13 |
2001-03-13 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
|
|
AU2006203676B2
(en)
*
|
1999-08-13 |
2010-04-22 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-JUN N-Terminal Kinases (JNK) and Other Protein Kinases
|
|
US6472416B1
(en)
|
1999-08-27 |
2002-10-29 |
Abbott Laboratories |
Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors
|
|
JP2003508401A
(ja)
*
|
1999-08-27 |
2003-03-04 |
アボット・ラボラトリーズ |
Ｃｏｘ−２阻害薬として有用なスルホニルフェニルピラゾール化合物
|
|
WO2001015525A1
(en)
*
|
1999-08-31 |
2001-03-08 |
Fujisawa Pharmaceutical Co., Ltd. |
Organ preservatives
|
|
IL148905A0
(en)
*
|
1999-09-30 |
2002-09-12 |
Neurogen Corp Pfizer Inc |
Certain alkylene diamine-substituted pyrazolo{1,5,-a}-1,5-pyrimidines and pyrazolo{1,5,-a}-1,3,5-triazines
|
|
AU2001240115A1
(en)
|
2000-03-10 |
2001-09-24 |
Pharmacia Corporation |
Method for the preparation of tetrahydrobenzothiepines
|
|
US6630476B2
(en)
|
2000-07-07 |
2003-10-07 |
Bristol-Myers Squibb Pharma Company |
Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
|
|
DE10153344A1
(de)
*
|
2001-10-29 |
2003-05-15 |
Gruenenthal Gmbh |
Verwendung von substituierten Pyrazolopyrimidinen als Liganden von Nucleosid-Transport-Proteinen und/oder von Purinorezeptoren
|
|
ES2289116T3
(es)
*
|
2001-05-24 |
2008-02-01 |
Eli Lilly And Company |
Nuevos derivados de pirrol como agentes farmaceuticos.
|
|
WO2003004497A1
(fr)
*
|
2001-07-05 |
2003-01-16 |
Sumitomo Pharmaceuticals Company, Limited |
Compose heterocyclique
|
|
WO2003040127A1
(en)
|
2001-11-02 |
2003-05-15 |
G.D. Searle Llc |
Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake
|
|
WO2003053976A1
(en)
*
|
2001-12-20 |
2003-07-03 |
Biovitrum Ab |
PIPAZOLO [1,5-a] PYRIMIDINE DERIVATIVES AS MODULATORS OF PPAR
|
|
WO2003061604A2
(en)
|
2002-01-17 |
2003-07-31 |
Pharmacia Corporation |
Novel alkyl/aryl hydroxy or keto thiepines.
|
|
JP2005529919A
(ja)
*
|
2002-05-10 |
2005-10-06 |
スミスクライン ビーチャム コーポレーション |
治療用化合物
|
|
CZ293015B6
(cs)
*
|
2002-10-25 |
2004-01-14 |
Léčiva, A.S. |
Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu)
|
|
AU2003298611A1
(en)
*
|
2002-11-21 |
2004-06-18 |
Eli Lilly And Company |
Mixed lineage kinase modulators
|
|
UA80571C2
(en)
|
2002-11-22 |
2007-10-10 |
Lilly Co Eli |
Quinolinyl-pyrrolopyrazoles
|
|
WO2004110454A1
(ja)
*
|
2003-06-13 |
2004-12-23 |
Ishihara Sangyo Kaisha, Ltd. |
アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
|
|
DE10332487A1
(de)
*
|
2003-07-16 |
2005-02-10 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Ambroxol für die Behandlung von chronisch nozizeptiven Schmerzen
|
|
US7511065B2
(en)
|
2003-11-12 |
2009-03-31 |
Eli Lilly And Company |
Mixed lineage kinase modulators
|
|
US20110104186A1
(en)
|
2004-06-24 |
2011-05-05 |
Nicholas Valiante |
Small molecule immunopotentiators and assays for their detection
|
|
TW200639163A
(en)
*
|
2005-02-04 |
2006-11-16 |
Genentech Inc |
RAF inhibitor compounds and methods
|
|
WO2007021966A1
(en)
|
2005-08-12 |
2007-02-22 |
Synta Pharmaceuticals Corp. |
Pyrazole compounds that modulate hsp90 activity
|
|
CN101268079B
(zh)
*
|
2005-09-01 |
2011-09-14 |
安斯泰来制药有限公司 |
用于治疗疼痛的哒嗪酮衍生物
|
|
WO2007129195A2
(en)
*
|
2006-05-04 |
2007-11-15 |
Pfizer Products Inc. |
4-pyrimidine-5-amino-pyrazole compounds
|
|
US8034834B2
(en)
*
|
2006-05-25 |
2011-10-11 |
Synta Pharmaceuticals Corp. |
Method for treating proliferative disorders with HSP90 inhibitors
|
|
US20090082354A1
(en)
*
|
2007-09-20 |
2009-03-26 |
Wyeth |
Pyrazolo[5, 1-c] [1,2,4] triazines, methods for preparation and use thereof
|
|
PL2217600T3
(pl)
|
2007-12-12 |
2013-04-30 |
Du Pont |
Grzybobójcze pirazole bicykliczne
|
|
WO2010096115A1
(en)
*
|
2008-10-29 |
2010-08-26 |
Apath, Llc |
Compounds, compositions and methods for control of hepatitis c viral infections
|
|
BR112012021198B1
(pt)
|
2010-02-26 |
2021-12-14 |
Mitsubishi Tanabe Pharma Corporation |
Compostos de pirazolopirimidina, composições relacionadas e seu uso como inibidores de pde10
|
|
WO2011133520A1
(en)
|
2010-04-19 |
2011-10-27 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
|
|
EP2402339A1
(en)
*
|
2010-06-29 |
2012-01-04 |
Basf Se |
Pyrazolopyridine compounds
|
|
EP2402344A1
(en)
*
|
2010-06-29 |
2012-01-04 |
Basf Se |
Pyrazole fused bicyclic compounds
|
|
EP2402345A1
(en)
*
|
2010-06-29 |
2012-01-04 |
Basf Se |
Pyrazole fused bicyclic compounds
|
|
MX355016B
(es)
|
2011-10-06 |
2018-04-02 |
Bayer Ip Gmbh |
Heterociclilpiri(mi)dinilpirazoles como fungicidas.
|
|
EP2773345A1
(en)
|
2011-11-02 |
2014-09-10 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
|
|
CA2853806C
(en)
|
2011-11-02 |
2020-07-14 |
Synta Pharmaceuticals Corp. |
Combination therapy of hsp90 inhibitors with platinum-containing agents
|
|
AU2012339679A1
(en)
|
2011-11-14 |
2014-06-12 |
Synta Pharmaceuticals Corp. |
Combination therapy of Hsp90 inhibitors with BRAF inhibitors
|
|
JO3407B1
(ar)
|
2012-05-31 |
2019-10-20 |
Eisai R&D Man Co Ltd |
مركبات رباعي هيدرو بيرازولو بيريميدين
|
|
KR20150131254A
(ko)
|
2013-03-15 |
2015-11-24 |
크로모셀 코포레이션 |
통증 치료를 위한 소듐 채널 조절자
|
|
RU2016112568A
(ru)
|
2013-09-05 |
2017-10-06 |
Дженентек, Инк. |
Антипролиферативные соединения
|
|
UA120353C2
(uk)
|
2013-09-10 |
2019-11-25 |
Хромоселл Корпорейшн |
Модулятори натрієвого каналу для лікування болю і діабету
|
|
BR112016022105B1
(pt)
|
2014-03-27 |
2023-01-31 |
Janssen Pharmaceutica Nv |
Derivados de 4,5,6,7-tetra-hidro-pirazolo[1,5- a]pirazina substituídos e derivados de 5,6,7,8-tetrahidro-4h-pirazolo[1,5-a][1,4]diazepina como inibidores do ros1 e composição farmacêutica que os compreende
|
|
US10342795B2
(en)
*
|
2014-03-27 |
2019-07-09 |
Janssen Pharmaceutica Nv |
Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives and 2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives as ROS1 inhibitors
|
|
CN104140427A
(zh)
*
|
2014-07-05 |
2014-11-12 |
湖南华腾制药有限公司 |
一种四氢吡唑并[1,5-a]嘧啶的制备方法
|
|
WO2016040315A1
(en)
*
|
2014-09-09 |
2016-03-17 |
Chromocell Corporation |
Selective nav1.7 inhibitors for the treatment of diabetes
|
|
KR102384652B1
(ko)
*
|
2015-02-03 |
2022-04-27 |
솔루스첨단소재 주식회사 |
유기 화합물 및 이를 포함하는 유기 전계 발광 소자
|
|
SG11201901747VA
(en)
|
2016-08-31 |
2019-03-28 |
Agios Pharmaceuticals Inc |
Inhibitors of cellular metabolic processes
|
|
UY38979A
(es)
|
2019-12-06 |
2021-07-30 |
Vertex Pharma |
Tetrahidrofuranos sustituidos como moduladores de canales de sodio
|
|
EP4175572A4
(en)
*
|
2020-08-12 |
2024-03-27 |
Spruce Biosciences, Inc. |
METHODS AND COMPOSITIONS FOR TREATING POLYCYSTIC OVARIAN SYNDROME
|
|
KR20240031300A
(ko)
|
2021-06-04 |
2024-03-07 |
버텍스 파마슈티칼스 인코포레이티드 |
나트륨 채널 조절제로서의 n-(하이드록시알킬 (헤테로)아릴) 테트라하이드로푸란 카르복스아미드
|