MX9203074A - 4-(1h-pirrol-1-il)-imidazoles con actividad antagonista de angiotensina ii. - Google Patents

4-(1h-pirrol-1-il)-imidazoles con actividad antagonista de angiotensina ii.

Info

Publication number: MX9203074A
Authority: MX; Mexico
Prior art keywords: pirrol; angiotensin; imidazoles; antagonist activity; antagonist
Prior art date: 1991-06-21

Application number

MX9203074A

Other languages

English (en)

Inventor

John Cooke Hodges

John Gordon Topliss

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-21

Filing date

1992-06-19

Publication date

1992-12-01

1992-06-19 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1992-12-01 Publication of MX9203074A publication Critical patent/MX9203074A/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

MX9203074A 1991-06-21 1992-06-19 4-(1h-pirrol-1-il)-imidazoles con actividad antagonista de angiotensina ii. MX9203074A (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71927191A	1991-06-21	1991-06-21
US07/883,023 US5210211A (en)	1991-06-21	1992-05-19	4-(1h-pyrrol-1-yl) imidazoles with angiotension ii antagonist activity

Publications (1)

Publication Number	Publication Date
MX9203074A true MX9203074A (es)	1992-12-01

Family

ID=27110051

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX9203074A MX9203074A (es)	1991-06-21	1992-06-19	4-(1h-pirrol-1-il)-imidazoles con actividad antagonista de angiotensina ii.

Country Status (8)

Country	Link
US (2)	US5210211A (es)
EP (1)	EP0643709A1 (es)
JP (1)	JP3161732B2 (es)
AU (1)	AU656612B2 (es)
CA (2)	CA2371012C (es)
IE (1)	IE922002A1 (es)
MX (1)	MX9203074A (es)
WO (1)	WO1993000341A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5354867A (en) *	1988-12-06	1994-10-11	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking imidazoles
US5187271A (en) *	1991-02-28	1993-02-16	G. D. Searle & Co.	N-substituted (α-imidazolyl-toluyl) pyrrole compounds for treatment of circulatory disorders
US5612360A (en) *	1992-06-03	1997-03-18	Eli Lilly And Company	Angiotensin II antagonists
US5401851A (en) *	1992-06-03	1995-03-28	Eli Lilly And Company	Angiotensin II antagonists
CA2115985A1 (en) *	1993-02-25	1994-08-26	Kohei Nishikawa	Vascular hypertrophy suppressor
US5451597A (en) *	1993-05-27	1995-09-19	G.D. Searle & Co.	Treatment of circulatory disorders using n-substituted (α-imidazolyl-toluyl) pyrrole angiotensin II antagonists
US5409926A (en) *	1993-07-19	1995-04-25	Merck & Co., Inc.	AT-2 antagonist inhibition of vascular restenosis
US5728724A (en) *	1995-08-17	1998-03-17	Eli Lilly And Company	Benzothiophene compounds
US5726168A (en) *	1995-10-12	1998-03-10	Eli Lilly And Company	Lipophilic benzothiophenes
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
US7411082B2 (en) *	2004-03-29	2008-08-12	Cambridge University Technical Services Ltd.	Synthesizing method for compound, and catalyst for synthesis reaction
WO2005105719A1 (ja) *	2004-04-28	2005-11-10	Cambridge University Technical Services Limited	化合物の合成方法および合成反応触媒
MX2007004426A (es) *	2004-10-15	2007-06-14	Teva Pharma	Procesos para preparar telmisartan.
DE102006033572A1 (de)	2006-07-20	2008-01-24	Bayer Cropscience Ag	N'-Cyano-N-halogenalkyl-imidamid Derivate
ATE532770T1 (de)	2006-09-05	2011-11-15	Kyowa Hakko Kirin Co Ltd	Imidazolderivat
US20100120694A1 (en)	2008-06-04	2010-05-13	Synergy Pharmaceuticals, Inc.	Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en)	2007-06-04	2011-02-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
EP3004138B1 (en)	2013-06-05	2024-03-13	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase c, method of making and using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1334092C (en) *	1986-07-11	1995-01-24	David John Carini	Angiotensin ii receptor blocking imidazoles
US4820843A (en) *	1987-05-22	1989-04-11	E. I. Du Pont De Nemours And Company	Tetrazole intermediates to antihypertensive compounds
US5064825A (en) *	1989-06-01	1991-11-12	Merck & Co., Inc.	Angiotensin ii antagonists
EP0479892A1 (en) *	1989-06-30	1992-04-15	E.I. Du Pont De Nemours And Company	Fused-ring aryl substituted imidazoles
EP0479903B1 (en) *	1989-06-30	1996-02-21	E.I. Du Pont De Nemours And Company	Substituted imidazoles useful as angiotensin ii blockers

1992
- 1992-05-19 US US07/883,023 patent/US5210211A/en not_active Expired - Lifetime
- 1992-05-28 CA CA002371012A patent/CA2371012C/en not_active Expired - Fee Related
- 1992-05-28 CA CA002110806A patent/CA2110806C/en not_active Expired - Fee Related
- 1992-05-28 EP EP92913624A patent/EP0643709A1/en not_active Withdrawn
- 1992-05-28 AU AU21718/92A patent/AU656612B2/en not_active Ceased
- 1992-05-28 JP JP50148893A patent/JP3161732B2/ja not_active Expired - Fee Related
- 1992-05-28 WO PCT/US1992/004633 patent/WO1993000341A1/en not_active Application Discontinuation
- 1992-06-19 MX MX9203074A patent/MX9203074A/es not_active IP Right Cessation
- 1992-07-01 IE IE200292A patent/IE922002A1/en unknown
- 1992-10-13 US US07/960,037 patent/US5276048A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2371012A1 (en)	1993-01-07
IE922002A1 (en)	1992-12-30
JPH06508370A (ja)	1994-09-22
AU2171892A (en)	1993-01-25
CA2110806A1 (en)	1993-01-07
US5210211A (en)	1993-05-11
JP3161732B2 (ja)	2001-04-25
CA2371012C (en)	2005-04-05
CA2110806C (en)	2002-07-30
US5276048A (en)	1994-01-04
AU656612B2 (en)	1995-02-09
EP0643709A1 (en)	1995-03-22
WO1993000341A1 (en)	1993-01-07

Publication	Publication Date	Title
MX9203074A (es)	1992-12-01	4-(1h-pirrol-1-il)-imidazoles con actividad antagonista de angiotensina ii.
NO932005D0 (no)	1993-06-02	Angiotensin-ii-antagonister
DE69223573D1 (de)	1998-01-29	Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten
NO944421D0 (no)	1994-11-18	Substituerte 1,2,3,4-tetrahydroisokinoliner med angiotensin II reseptoraktivitet
DE69435267D1 (de)	2010-03-18	Proteinkinase C Inhibitoren
ATE233260T1 (de)	2003-03-15	Muscarin-antagonisten
FI932695A (fi)	1993-12-13	Angiotensin i kymas-inhibitorer inklusive humant hjaertkymas
ATE222240T1 (de)	2002-08-15	Hiv - protease inhibitoren
DE69627179D1 (de)	2003-05-08	Substituierte 2-anilino-pyrimidines verwendbar als protein kinase inhibitoren
DE69322254D1 (de)	1999-01-07	Pyridyl-substituierte imidazole
DK154192D0 (da)	1992-12-23	Heterocycliske forbindelser
DE69304243D1 (de)	1996-10-02	Chinolin-Verbindungen als Angiotensin-II-Antagoniste
DE69327720D1 (de)	2000-03-02	Endothelin rezeptor antagonisten
IT8919316A0 (it)	1989-02-06	Benzoderivati di composti eterociclici contenenti azoto.
DE68904083D1 (de)	1993-02-11	Hmg-coa-reduktaseinhibitoren.
NO960473D0 (no)	1996-02-05	Substituerte bifenyl-sulfonamid-endotelin-antagonister
DE69323185D1 (de)	1999-03-04	Proteinkinase c-inhibitor
EP0711162A4 (en)	1996-09-04	POSITION 5 SUBSTITUTED IMIDAZOLES AS ANGIOTENSIN II ANTAGONISTS
DE59209936D1 (de)	2002-01-10	Verwendung von Acetalen
DE68917556D1 (de)	1994-09-22	Quinolyloxazol-2-one, nützlich als Proteinkinase-C-Inhibitoren.
DE69204920D1 (de)	1995-10-26	Angiotensin-II-Antagoniste.
DK0642506T3 (da)	2003-01-06	Heterocyclisk disubstituerede sulfonaminocarbonylforbindelser
ATE116297T1 (de)	1995-01-15	Heterocyclische acetonitrile und ihre verwendung als fungizide.
DE59204051D1 (de)	1995-11-23	Verwendung von polymodalem beta-Oktogen.
FI944905A (fi)	1994-10-19	Endoteliiniantagonistit II

Legal Events

Date	Code	Title	Description
1998-06-12	FG	Grant or registration
2014-04-30	MM	Annulment or lapse due to non-payment of fees