MX382488B - Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas. - Google Patents
Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas.Info
- Publication number
- MX382488B MX382488B MX2017005186A MX2017005186A MX382488B MX 382488 B MX382488 B MX 382488B MX 2017005186 A MX2017005186 A MX 2017005186A MX 2017005186 A MX2017005186 A MX 2017005186A MX 382488 B MX382488 B MX 382488B
- Authority
- MX
- Mexico
- Prior art keywords
- neural stem
- growth factor
- stem cells
- exogenous polynucleotide
- methods
- Prior art date
Links
- 210000001178 neural stem cell Anatomy 0.000 title abstract 6
- 239000003102 growth factor Substances 0.000 title abstract 4
- 102000040430 polynucleotide Human genes 0.000 title abstract 3
- 108091033319 polynucleotide Proteins 0.000 title abstract 3
- 239000002157 polynucleotide Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 6
- 230000004770 neurodegeneration Effects 0.000 abstract 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 1
- 108010025020 Nerve Growth Factor Proteins 0.000 abstract 1
- 102000007072 Nerve Growth Factors Human genes 0.000 abstract 1
- 239000003900 neurotrophic factor Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
Abstract
La presente invención se refiere a una célula madre neural humana que comprende un polinucleótido exógeno que codifica un factor de crecimiento tal como IGF-1. También se divulgan métodos de uso de la célula madre neural humana para el tratamiento de enfermedades o trastornos neurodegenerativos que incluyen, por ejemplo, ALS. En general, la presente divulgación se refiere a una célula madre neural humana que comprende un polinucleótido exógeno que codifica un factor de crecimiento que incluye, por ejemplo, un factor neurotrófico. En una modalidad, el factor de crecimiento es expresado establemente por la célula madre neural humana. Tales células madre neurales humanas se pueden usar para el tratamiento de una enfermedad o trastorno neurodegenerativo en un sujeto que lo necesite (por ejemplo, un sujeto humano que tiene una enfermedad o trastorno neurodegenerativo).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462066174P | 2014-10-20 | 2014-10-20 | |
| US201562147950P | 2015-04-15 | 2015-04-15 | |
| PCT/US2015/056226 WO2016064737A1 (en) | 2014-10-20 | 2015-10-19 | Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017005186A MX2017005186A (es) | 2017-07-26 |
| MX382488B true MX382488B (es) | 2025-03-13 |
Family
ID=55761367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017005186A MX382488B (es) | 2014-10-20 | 2015-10-19 | Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9750769B2 (es) |
| EP (1) | EP3209306B1 (es) |
| JP (2) | JP6983069B2 (es) |
| KR (2) | KR102100021B1 (es) |
| CN (1) | CN107148275A (es) |
| AU (2) | AU2015336194B2 (es) |
| CA (1) | CA2964927C (es) |
| MX (1) | MX382488B (es) |
| WO (1) | WO2016064737A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018144441A1 (en) * | 2017-01-31 | 2018-08-09 | Regenxbio Inc. | Treatment of mucopolysaccharidosis i with fully-human glycosylated human alpha-l-iduronidase (idua) |
| KR102245539B1 (ko) * | 2018-02-12 | 2021-04-29 | 주식회사 지앤피바이오사이언스 | 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물 |
| WO2019165306A1 (en) * | 2018-02-23 | 2019-08-29 | Regeneration Biomedical, Inc. | Methods, apparatuses and systems for instilling stem cells and pharmaceuticals into the human ventricular system |
| KR20210052443A (ko) * | 2018-07-17 | 2021-05-10 | 뉴로마이언 주식회사 | Igf-1 이형체를 발현하는 dna 컨스트럭트를 이용한 신경병증의 치료 |
| CA3106085A1 (en) * | 2018-07-17 | 2020-04-23 | Helixmith Co., Ltd. | Treatment of neuropathy with igf-1-encoding dna constructs and hgf-encoding dna constructs |
| KR20210077634A (ko) * | 2019-12-17 | 2021-06-25 | 코아스템(주) | 인간 만능 줄기세포로부터 3d 오가노이드를 이용하여 미세교세포를 다량 확보하는 미세교세포의 분화방법 |
| CN111388654A (zh) * | 2020-05-22 | 2020-07-10 | 南通大学 | 治疗脊髓损伤的药物、药物试剂盒及方法 |
| KR20230123448A (ko) * | 2022-02-15 | 2023-08-23 | 주식회사 헬릭스미스 | 인슐린-유사 성장인자-1의 이형체를 이용한 근감소증 예방 또는 치료용 조성물 |
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-
2015
- 2015-10-19 US US14/886,272 patent/US9750769B2/en active Active
- 2015-10-19 CN CN201580057196.0A patent/CN107148275A/zh active Pending
- 2015-10-19 JP JP2017539525A patent/JP6983069B2/ja active Active
- 2015-10-19 CA CA2964927A patent/CA2964927C/en active Active
- 2015-10-19 AU AU2015336194A patent/AU2015336194B2/en active Active
- 2015-10-19 KR KR1020177013001A patent/KR102100021B1/ko active Active
- 2015-10-19 EP EP15852516.2A patent/EP3209306B1/en active Active
- 2015-10-19 MX MX2017005186A patent/MX382488B/es unknown
- 2015-10-19 WO PCT/US2015/056226 patent/WO2016064737A1/en active Application Filing
- 2015-10-19 KR KR1020197015061A patent/KR20190060016A/ko not_active Withdrawn
-
2017
- 2017-06-16 US US15/624,959 patent/US10702555B2/en active Active
-
2018
- 2018-12-14 AU AU2018279014A patent/AU2018279014A1/en not_active Abandoned
-
2020
- 2020-12-03 JP JP2020201316A patent/JP2021045156A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10702555B2 (en) | 2020-07-07 |
| JP2021045156A (ja) | 2021-03-25 |
| KR20170067884A (ko) | 2017-06-16 |
| AU2015336194B2 (en) | 2019-01-03 |
| AU2015336194A1 (en) | 2017-05-04 |
| AU2018279014A1 (en) | 2019-01-17 |
| CA2964927C (en) | 2019-07-30 |
| CN107148275A (zh) | 2017-09-08 |
| EP3209306A1 (en) | 2017-08-30 |
| MX2017005186A (es) | 2017-07-26 |
| KR20190060016A (ko) | 2019-05-31 |
| KR102100021B1 (ko) | 2020-04-13 |
| EP3209306A4 (en) | 2018-07-04 |
| US20160120942A1 (en) | 2016-05-05 |
| WO2016064737A1 (en) | 2016-04-28 |
| CA2964927A1 (en) | 2016-04-28 |
| US20170319625A1 (en) | 2017-11-09 |
| US9750769B2 (en) | 2017-09-05 |
| EP3209306B1 (en) | 2024-04-24 |
| JP6983069B2 (ja) | 2021-12-17 |
| JP2017532068A (ja) | 2017-11-02 |
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