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MX381994B - Inhibidor de janus quinasa. - Google Patents

Inhibidor de janus quinasa.

Info

Publication number
MX381994B
MX381994B MX2017013797A MX2017013797A MX381994B MX 381994 B MX381994 B MX 381994B MX 2017013797 A MX2017013797 A MX 2017013797A MX 2017013797 A MX2017013797 A MX 2017013797A MX 381994 B MX381994 B MX 381994B
Authority
MX
Mexico
Prior art keywords
janus kinase
kinase inhibitor
disclosed
jak
drugs
Prior art date
Application number
MX2017013797A
Other languages
English (en)
Other versions
MX2017013797A (es
Inventor
Lili Fan
Shuhui Chen
Hao Wu
Weiwei Mao
Yiqiang Huang
Original Assignee
Wuxi Fortune Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wuxi Fortune Pharmaceutical Co Ltd filed Critical Wuxi Fortune Pharmaceutical Co Ltd
Publication of MX2017013797A publication Critical patent/MX2017013797A/es
Publication of MX381994B publication Critical patent/MX381994B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describen una serie de inhibidores de Janus quinasa, y particularmente se describe un compuesto o sales farmacéuticamente aceptables del mismo de Fórmula (I) y su uso en la preparación de fármacos para tratar enfermedades relacionadas con Janus quinasa (JAK). (ver Fórmula).
MX2017013797A 2015-05-29 2016-05-26 Inhibidor de janus quinasa. MX381994B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510289933 2015-05-29
CN201610344370 2016-05-23
PCT/CN2016/083426 WO2016192563A1 (zh) 2015-05-29 2016-05-26 Janus激酶抑制剂

Publications (2)

Publication Number Publication Date
MX2017013797A MX2017013797A (es) 2018-03-21
MX381994B true MX381994B (es) 2025-03-13

Family

ID=57440054

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017013797A MX381994B (es) 2015-05-29 2016-05-26 Inhibidor de janus quinasa.

Country Status (17)

Country Link
US (1) US10174056B2 (es)
EP (1) EP3305788B1 (es)
JP (1) JP6564473B2 (es)
KR (1) KR102081272B1 (es)
CN (1) CN107531711B (es)
AU (1) AU2016271904B2 (es)
CA (1) CA2983481C (es)
DK (1) DK3305788T3 (es)
EA (1) EA036063B1 (es)
ES (1) ES2822748T3 (es)
HU (1) HUE050842T2 (es)
MX (1) MX381994B (es)
PL (1) PL3305788T3 (es)
PT (1) PT3305788T (es)
TW (1) TWI692481B (es)
UA (1) UA118822C2 (es)
WO (1) WO2016192563A1 (es)

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UA123709C2 (uk) * 2016-11-23 2021-05-19 Усі Форчун Фармасьютікал Ко., Лтд КРИСТАЛІЧНІ ТА СОЛЬОВІ ФОРМИ 7Н-ПІРОЛО[2,3-d]ПІРИМІДИНІВ І СПОСІБ ЇХ ОДЕРЖАННЯ
WO2019061299A1 (en) * 2017-09-29 2019-04-04 Rhodia Operations PROCESS FOR THE PREPARATION OF AMINOMETHYL-SUBSTITUTED HETEROCYCLOCCANE
CN107602590A (zh) * 2017-10-31 2018-01-19 无锡福祈制药有限公司 具有Janus激酶抑制活性的桥环化合物
CN107573364A (zh) * 2017-10-31 2018-01-12 无锡福祈制药有限公司 一种jak激酶抑制剂
CN107602591A (zh) * 2017-10-31 2018-01-19 无锡福祈制药有限公司 一种Janus激酶3抑制剂
CN107652308A (zh) * 2017-10-31 2018-02-02 无锡福祈制药有限公司 一种Janus激酶3抑制剂
CN107805259A (zh) * 2017-10-31 2018-03-16 无锡福祈制药有限公司 一种吡咯并嘧啶类化合物
CN107778321A (zh) * 2017-10-31 2018-03-09 无锡福祈制药有限公司 一种托法替尼类似物
KR20210120074A (ko) * 2019-01-30 2021-10-06 가르가멜 (주하이) 바이오테크 리미티드 Jak 억제제 및 그 제조 방법
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220017995A (ko) * 2019-06-05 2022-02-14 광조우 조요 파마테크 컴퍼니 리미티드 피롤로피리미딘 화합물 및 그 용도
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
CN110923288A (zh) * 2019-12-19 2020-03-27 卓和药业集团有限公司 一种wxfl10203614中间体的生物学拆分方法
CN111004236B (zh) * 2019-12-19 2022-04-05 卓和药业集团股份有限公司 一种wxfl10203614中间体的动态动力学拆分方法
CN111087412B (zh) * 2019-12-31 2021-04-09 卓和药业集团有限公司 一类吡咯并嘧啶衍生物及其合成方法
CN111039963B (zh) * 2019-12-31 2021-03-19 卓和药业集团有限公司 Wxfl10203614水溶性类似物及其合成方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN112168827A (zh) * 2020-11-03 2021-01-05 卓和药业集团有限公司 一种用于治疗银屑病的药物组合物及其制备方法
CN113372366B (zh) * 2020-12-04 2022-08-30 广州嘉越医药科技有限公司 一种吡咯并嘧啶类化合物的盐、其晶型及其应用
CN113372343B (zh) * 2020-12-04 2022-07-29 广州嘉越医药科技有限公司 一种吡咯并嘧啶类化合物中间体及其制备方法
CN114591333B (zh) * 2020-12-04 2023-08-01 广州嘉越医药科技有限公司 一种吡咯并嘧啶类化合物的制备方法

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Also Published As

Publication number Publication date
UA118822C2 (uk) 2019-03-11
EA201792116A1 (ru) 2018-07-31
HUE050842T2 (hu) 2021-01-28
CN107531711A (zh) 2018-01-02
TW201706277A (zh) 2017-02-16
PT3305788T (pt) 2020-09-25
US20180162879A1 (en) 2018-06-14
KR102081272B1 (ko) 2020-02-25
DK3305788T3 (da) 2020-09-28
US10174056B2 (en) 2019-01-08
TWI692481B (zh) 2020-05-01
CA2983481A1 (en) 2016-12-08
EP3305788A4 (en) 2018-11-07
EA036063B1 (ru) 2020-09-22
JP2018516264A (ja) 2018-06-21
CA2983481C (en) 2020-04-14
PL3305788T3 (pl) 2021-03-08
WO2016192563A1 (zh) 2016-12-08
CN107531711B (zh) 2020-03-31
ES2822748T3 (es) 2021-05-04
JP6564473B2 (ja) 2019-08-21
MX2017013797A (es) 2018-03-21
AU2016271904A1 (en) 2017-11-09
EP3305788A1 (en) 2018-04-11
EP3305788B1 (en) 2020-08-05
KR20170141787A (ko) 2017-12-26
AU2016271904B2 (en) 2018-05-10

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