[go: up one dir, main page]

MX375725B - Derivados de hidroxido de bencilo, preparacion de los mismos y uso terapeutico de los mismos. - Google Patents

Derivados de hidroxido de bencilo, preparacion de los mismos y uso terapeutico de los mismos.

Info

Publication number
MX375725B
MX375725B MX2017005669A MX2017005669A MX375725B MX 375725 B MX375725 B MX 375725B MX 2017005669 A MX2017005669 A MX 2017005669A MX 2017005669 A MX2017005669 A MX 2017005669A MX 375725 B MX375725 B MX 375725B
Authority
MX
Mexico
Prior art keywords
preparation
therapeutic use
hydroxide derivatives
benzyl hydroxide
derivatives
Prior art date
Application number
MX2017005669A
Other languages
English (en)
Other versions
MX2017005669A (es
Inventor
Guillaume Barre
Jérôme Meneyrol
Nathalie Alet
Tristan Rousseaux
Valérie Vin
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2017005669A publication Critical patent/MX2017005669A/es
Publication of MX375725B publication Critical patent/MX375725B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La invención se refiere a derivados de hidróxido de bencilo de la fórmula (I): (ver Fórmula) La invención también se refiere a la preparación y el uso terapéutico de los compuestos de la fórmula (I).
MX2017005669A 2014-10-30 2015-10-29 Derivados de hidroxido de bencilo, preparacion de los mismos y uso terapeutico de los mismos. MX375725B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14306747.8A EP3015459A1 (en) 2014-10-30 2014-10-30 Benzylhydroxyde derivatives, preparation thereof and therapeutic use thereof
PCT/EP2015/075112 WO2016066742A1 (en) 2014-10-30 2015-10-29 Benzylhydroxyde derivatives, preparation thereof and therapeutic use thereof

Publications (2)

Publication Number Publication Date
MX2017005669A MX2017005669A (es) 2017-08-07
MX375725B true MX375725B (es) 2025-03-06

Family

ID=51904926

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005669A MX375725B (es) 2014-10-30 2015-10-29 Derivados de hidroxido de bencilo, preparacion de los mismos y uso terapeutico de los mismos.

Country Status (24)

Country Link
US (1) US9878990B2 (es)
EP (2) EP3015459A1 (es)
JP (1) JP6644067B2 (es)
KR (1) KR102598818B1 (es)
CN (1) CN107074777B (es)
AR (1) AR102481A1 (es)
AU (1) AU2015340584B2 (es)
BR (1) BR112017008057B1 (es)
CA (1) CA2963601C (es)
CY (1) CY1121388T1 (es)
DK (1) DK3212622T3 (es)
ES (1) ES2703579T3 (es)
HR (1) HRP20182167T1 (es)
HU (1) HUE041581T2 (es)
IL (1) IL251930B (es)
LT (1) LT3212622T (es)
MX (1) MX375725B (es)
PL (1) PL3212622T3 (es)
PT (1) PT3212622T (es)
RU (1) RU2704017C2 (es)
SG (1) SG11201702555UA (es)
SI (1) SI3212622T1 (es)
TW (1) TWI719952B (es)
WO (1) WO2016066742A1 (es)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010105064A (ko) * 2000-05-18 2001-11-28 함종천 삼백초로부터 추출한 화합물 ｈｎｐ－９８７０１ａ,ｈｎｐ－９８７０１ｂ 및 ｈｎｐ－９８７０１ｃ의항암제로서의 용도와 이의 제조방법 및 이를 유효성분으로함유하는 항암제용 약학적 조성물
ATE529110T1 (de) * 2002-03-05 2011-11-15 Transtech Pharma Inc Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen
JP2006528692A (ja) * 2003-05-08 2006-12-21 ジ ユニバースティ オブ ミシシッピー 低酸素症への細胞応答を阻害するサウルルスセルヌウス化合物
PE20080948A1 (es) * 2006-07-25 2008-09-10 Irm Llc Derivados de imidazol como moduladores de la senda de hedgehog
CN102282142A (zh) * 2008-11-14 2011-12-14 拜耳先灵制药股份公司 取代的芳族化合物和它们的用途
US8946289B2 (en) * 2008-11-19 2015-02-03 Duke University Manassatin compounds and methods of making and using the same
CN102795975B (zh) * 2011-05-27 2016-03-09 中国医学科学院药物研究所 三白脂素结构简化物，其制法和其药物组合物与用途
FR2998307A1 (fr) * 2012-11-19 2014-05-23 Centre Nat Rech Scient Modele chimique d'une maladie neurodegenerative, procede de preparation et utilisations
EP3371791A1 (en) * 2015-11-04 2018-09-12 Telefonaktiebolaget LM Ericsson (publ) Method of providing traffic related information and device, computer program and computer program product

Also Published As

Publication number Publication date
RU2017115036A (ru) 2018-11-30
ES2703579T3 (es) 2019-03-11
TWI719952B (zh) 2021-03-01
BR112017008057A2 (pt) 2017-12-26
LT3212622T (lt) 2019-01-10
US9878990B2 (en) 2018-01-30
SI3212622T1 (sl) 2019-02-28
AU2015340584B2 (en) 2019-11-07
RU2704017C2 (ru) 2019-10-23
CN107074777B (zh) 2020-10-02
HUE041581T2 (hu) 2019-05-28
DK3212622T3 (en) 2019-01-21
PL3212622T3 (pl) 2019-03-29
BR112017008057B1 (pt) 2023-02-07
JP6644067B2 (ja) 2020-02-12
PT3212622T (pt) 2018-12-18
CY1121388T1 (el) 2020-05-29
RU2017115036A3 (es) 2019-04-26
AR102481A1 (es) 2017-03-01
IL251930A0 (en) 2017-06-29
CA2963601A1 (en) 2016-05-06
KR102598818B1 (ko) 2023-11-03
SG11201702555UA (en) 2017-04-27
JP2017532362A (ja) 2017-11-02
AU2015340584A1 (en) 2017-04-27
CA2963601C (en) 2023-01-31
WO2016066742A1 (en) 2016-05-06
MX2017005669A (es) 2017-08-07
EP3212622B1 (en) 2018-09-26
CN107074777A (zh) 2017-08-18
TW201625553A (zh) 2016-07-16
HRP20182167T1 (hr) 2019-02-08
US20170313674A1 (en) 2017-11-02
IL251930B (en) 2018-12-31
EP3212622A1 (en) 2017-09-06
KR20170072226A (ko) 2017-06-26
EP3015459A1 (en) 2016-05-04

Similar Documents

Publication Publication Date Title
ECSP17016797A (es) Indazoles sustituidos con benzilo como inhibidores de bub1
EA201692203A1 (ru) Соединения, ингибирующие tank-связывающую киназу
MX2018003432A (es) Compuestos heterociclicos y usos de los mismos.
EA201692219A1 (ru) Способы получения противовирусных соединений
EA201891024A1 (ru) Соединения-ингибиторы tank-связывающей киназы
EA201790395A1 (ru) Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы
MX2017006266A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas al receptor de interleucina 1(irak) y sus usos.
CR20150524A (es) Compuestos de heteroarilo y sus usos
EA201791304A1 (ru) Производные изохинолина для лечения вич
MX2019013645A (es) Inhibidores de quinasa y usos de los mismos.
MX2015011514A (es) Compuestos de heteroarilo y sus usos.
ECSP15043696A (es) Compuestos de heteroarilo y sus usos
JOP20140114B1 (ar) مركبات حلقية غير متجانسة واستخداماتها
CL2016001973A1 (es) Derivados de nucleosido sustituidos con 4' -difluorometilo como inhibidores de la replicación de arn de la influenza.
MX2015009719A (es) Inhibidores benzoquinolona de vmat2.
MX2018002416A (es) Derivados de 1,7-diaril-1,6-heptadien-3,5-diona, procedimiento para la preparación y uso de los mismos.
CR20170484A (es) Azabenzimidazoles y su uso como moduladores del receptor ampa
MX2015009479A (es) Compuestos y metodos para tratar infecciones bacterianas.
CL2016001349A1 (es) Uso de derivados de bencimidazol-prolina
DOP2019000021A (es) Derivado de triazolopirazinona útil como un inhibidor de pde1 humana
ECSP16096831A (es) Derivados de naftiridinadiona
MX373636B (es) Compuestos de azetidiniloxifenilpirrolidina.
EA201790687A1 (ru) Хинолинкарбоксамиды для применения в лечении множественной миеломы
UY36217A (es) Compuestos piridona sustituídos, composiciones farmacéuticas y métodos de uso.
BR112016027455A2 (pt) moduladores ppar

Legal Events

Date Code Title Description
FG Grant or registration