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MX375202B - Composiciones adyuvantes novedosas. - Google Patents

Composiciones adyuvantes novedosas.

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Publication number
MX375202B
MX375202B MX2016016410A MX2016016410A MX375202B MX 375202 B MX375202 B MX 375202B MX 2016016410 A MX2016016410 A MX 2016016410A MX 2016016410 A MX2016016410 A MX 2016016410A MX 375202 B MX375202 B MX 375202B
Authority
MX
Mexico
Prior art keywords
adjuvant compositions
novel adjuvant
formulations
adjuvant
compositions
Prior art date
Application number
MX2016016410A
Other languages
English (en)
Inventor
Cedo Martin Bagi
Tedd Alan Childers
Paul Joseph Dominowski
Richard Lee Krebs
Ramasamy Mannar Mannan
Mary Kathryn Olsen
James Richard Thompson
Risini Dhammika Weeratna
Robert John Yancey Jr
Shucheng Zhang
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of MX375202B publication Critical patent/MX375202B/es

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Abstract

La presente invención se refiere a una composición de adyuvante, caracterizada porque comprende un oligonucleótido inmunoestimulador, un polímero de ácido poliacrílico y al menos dos de los siguientes; a. bromuro de dimetil dioctadeciol amonio (DDA); b. un estero; c. Acetato de N-(2-despxo-2-Lleucilamino-ß-D-glucopiranosil)-N.octadecildodecanamida, en donde l oligonucleótido inmunoestimulador comprende ORNo CpG ODN, y en dond ela composición de adyuvante está libre de saponina.
MX2016016410A 2008-06-27 2009-06-24 Composiciones adyuvantes novedosas. MX375202B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7623208P 2008-06-27 2008-06-27
US21455709P 2009-04-24 2009-04-24
PCT/IB2009/052724 WO2009156960A2 (en) 2008-06-27 2009-06-24 Novel adjuvant compositions

Publications (1)

Publication Number Publication Date
MX375202B true MX375202B (es) 2025-03-06

Family

ID=41445049

Family Applications (6)

Application Number Title Priority Date Filing Date
MX2016016410A MX375202B (es) 2008-06-27 2009-06-24 Composiciones adyuvantes novedosas.
MX2013014771A MX349720B (es) 2008-06-27 2009-06-24 Composiciones adyuvantes novedosas.
MX2010014026A MX2010014026A (es) 2008-06-27 2009-06-24 Composiciones adyuvantes novedosas.
MX2013014772A MX344311B (es) 2008-06-27 2009-06-24 Composiciones adyuvantes novedosas.
MX2016016408A MX368220B (es) 2008-06-27 2009-06-24 Composiciones adyuvantes novedosas.
MX2019011253A MX2019011253A (es) 2008-06-27 2010-12-16 Composiciones adyuvantes novedosas.

Family Applications After (5)

Application Number Title Priority Date Filing Date
MX2013014771A MX349720B (es) 2008-06-27 2009-06-24 Composiciones adyuvantes novedosas.
MX2010014026A MX2010014026A (es) 2008-06-27 2009-06-24 Composiciones adyuvantes novedosas.
MX2013014772A MX344311B (es) 2008-06-27 2009-06-24 Composiciones adyuvantes novedosas.
MX2016016408A MX368220B (es) 2008-06-27 2009-06-24 Composiciones adyuvantes novedosas.
MX2019011253A MX2019011253A (es) 2008-06-27 2010-12-16 Composiciones adyuvantes novedosas.

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US (6) US8580280B2 (es)
EP (4) EP2310046B1 (es)
JP (5) JP5659332B2 (es)
KR (1) KR101333852B1 (es)
CN (4) CN104758929B (es)
AR (1) AR072378A1 (es)
AU (1) AU2009263759B2 (es)
BR (2) BRPI0913954B1 (es)
CA (3) CA2960846C (es)
CL (1) CL2010001360A1 (es)
CO (1) CO6331297A2 (es)
CY (2) CY1117650T1 (es)
DK (2) DK2310046T3 (es)
ES (2) ES2569907T3 (es)
HK (3) HK1201444A1 (es)
HR (1) HRP20190876T1 (es)
HU (2) HUE043493T2 (es)
LT (1) LT3056214T (es)
ME (1) ME01199B (es)
MX (6) MX375202B (es)
NZ (5) NZ727616A (es)
PH (2) PH12014501835A1 (es)
PL (2) PL3056214T3 (es)
PT (1) PT3056214T (es)
RU (1) RU2510280C2 (es)
SI (2) SI2310046T1 (es)
TW (4) TWI622401B (es)
UY (1) UY31942A (es)
WO (1) WO2009156960A2 (es)
ZA (1) ZA201007835B (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8444989B1 (en) * 2008-04-18 2013-05-21 Boehringer Ingelheim Vetmedica Gmbh One dose vaccination against mycoplasma infections of pigs
LT3056214T (lt) * 2008-06-27 2019-06-10 Zoetis Services Llc Naujos adjuvantų kompozicijos
TWI351288B (en) * 2008-07-04 2011-11-01 Univ Nat Pingtung Sci & Tech Cpg dna adjuvant in avian vaccines
US8552165B2 (en) * 2008-12-09 2013-10-08 Heather Davis Immunostimulatory oligonucleotides
NZ593220A (en) * 2008-12-09 2012-10-26 Coley Pharm Group Inc Immunostimulatory oligonucleotides
CN102573802A (zh) * 2009-08-12 2012-07-11 希格默伊德药业有限公司 包含聚合物基质和油相的免疫调节组合物
FR2957803B1 (fr) * 2010-03-24 2012-06-01 Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic Diluants adjuvants de vaccins vivants pour maladies porcines
EP2575878B1 (en) * 2010-05-28 2018-06-13 Zoetis Belgium S.A. Vaccines comprising cholesterol and cpg as sole adjuvant-carrier molecules
MX345704B (es) 2011-06-10 2017-02-10 Novartis Tiergesundheit Ag Vacuna bovinas y métodos.
EP4176871A1 (en) 2011-10-03 2023-05-10 Canqura Oncology Ab Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
US20150044242A1 (en) * 2012-03-12 2015-02-12 Advanced Bioadjuvants Llc Adjuvant and Vaccine Compositions
BR112015015199B1 (pt) * 2012-12-28 2022-09-06 Boehringer Ingelheim Vetmedica Gmbh Composição imunogênica compreendendo antígenos de micoplasma e uso
CN108379571A (zh) 2012-12-28 2018-08-10 勃林格殷格翰动物保健有限公司 支原体疫苗的制备方法
CN103127495B (zh) * 2013-01-28 2015-04-08 重庆市畜牧科学院 二联灭活苗的制剂及其制备方法
US20160199482A1 (en) * 2013-09-05 2016-07-14 Zoetis Services Llc Hendra and nipah virus g glycoprotein immunogenic compositions
CN109675029A (zh) 2013-09-19 2019-04-26 硕腾服务有限责任公司 油基佐剂
WO2015057777A1 (en) 2013-10-17 2015-04-23 Zoetis Llc Methods and compositions for treatment of s. equi infection
EP3074003B1 (en) * 2013-11-26 2023-01-11 Zoetis Services LLC Compositions for induction of immune response
PL3223846T3 (pl) * 2014-11-26 2024-03-11 Huvepharma, Inc. Kompozycje adiuwantowe i powiązane sposoby
US10195261B2 (en) 2014-11-26 2019-02-05 VaxLiant, LLC Adjuvant compositions and related methods
ES2950822T3 (es) * 2015-01-16 2023-10-13 Zoetis Services Llc Vacuna contra la enfermedad de fiebre aftosa
CA2979556C (en) * 2015-03-24 2023-07-18 VaxLiant, LLC Adjuvant compositions and related methods
CN104771754B (zh) * 2015-04-02 2018-02-13 武汉科前生物股份有限公司 一种猪圆环病毒2型灭活疫苗水性佐剂及应用
CN106267183B (zh) * 2015-06-09 2023-02-28 普莱柯生物工程股份有限公司 含有佐剂的活疫苗组合物及其制备方法和应用
CN106344920B (zh) * 2015-07-16 2020-11-27 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
SMT202100414T1 (it) * 2015-07-20 2021-09-14 Zoetis Services Llc Composizioni di adiuvante liposomiale
US10456459B2 (en) * 2015-07-20 2019-10-29 Zoetis Services Llc Liposomal adjuvant compositions
SG10201913547YA (en) * 2015-10-19 2020-02-27 Cadila Healthcare Ltd New adjuvant and vaccine composition containing the same
EP3402878A1 (en) 2016-01-11 2018-11-21 Zoetis Services LLC Novel cross protective vaccine compositions for porcine epidemic diarrhea virus
WO2017165366A1 (en) 2016-03-21 2017-09-28 South Dakota Board Of Regents Orf virus-based platform for vaccine delivery
AU2017274332B2 (en) 2016-06-02 2024-06-27 Zoetis Services Llc Vaccine against infectious bronchitis
EP3558363A1 (en) 2016-12-21 2019-10-30 Amgen Inc. Anti-tnf alpha antibody formulations
GB201703529D0 (en) 2017-03-06 2017-04-19 Cambridge Entpr Ltd Vaccine composition
US10092604B1 (en) * 2017-12-21 2018-10-09 Bioceuticals Pte. Ltd. Methods for treatment of skin infectious diseases using microorganisms
CN112135628B (zh) 2018-03-16 2024-11-22 硕腾服务有限责任公司 抗白介素31的肽疫苗
CN108853493A (zh) * 2018-07-26 2018-11-23 中国人民解放军陆军军医大学 麦冬皂苷d及其纳米乳在制备疫苗佐剂中的应用
WO2020023950A1 (en) 2018-07-27 2020-01-30 Research Development Foundation Chimeric immunogenic polypeptides
EP3849521A1 (en) 2018-09-14 2021-07-21 Massachusetts Institute Of Technology Nanoparticle vaccine adjuvant and methods of use thereof
CN109675028A (zh) * 2019-03-01 2019-04-26 龙阔(苏州)生物工程有限公司 疫苗佐剂及其制备方法和应用及猪繁殖与呼吸综合征疫苗
JP2022540197A (ja) * 2019-07-12 2022-09-14 リサーチ ディベロップメント ファウンデーション エーリキアワクチンおよび免疫原性組成物
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
MX2022015867A (es) * 2020-06-19 2023-03-14 Kimberly Clark Co Composición de pienso animal para reducir la producción de amoníaco.
CA3182453A1 (en) * 2020-06-19 2021-12-23 Ning Wei Saponin containing extracts prepared from hesperaloe useful in the treatment of non-human animals
TW202206098A (zh) * 2020-08-11 2022-02-16 美商碩騰服務公司 抗冠狀病毒疫苗
CN114848807A (zh) * 2021-02-04 2022-08-05 洛阳赛威生物科技有限公司 一种蜂胶佐剂组合物、及其制备方法以及应用
WO2023056117A1 (en) * 2021-10-02 2023-04-06 Massachusetts Institute Of Technology Synergistic combination of alum and non-liposome, non-micelle particle vaccine adjuvants
WO2024170728A1 (fr) * 2023-02-16 2024-08-22 Vaxinano Composition vaccinale comprenant un systeme de delivrance d'une bacterie entiere inactivee via des nanoparticules polysaccharidiques cationiques sans adjuvant
WO2025006564A1 (en) 2023-06-26 2025-01-02 Research Development Foundation Immunoreactive peptides

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264587A (en) * 1979-08-01 1981-04-28 Pedersen Niels C Vaccine for preventing persistent feline leukemia viremia in cats
NZ221306A (en) * 1986-08-15 1990-02-26 Commw Scient Ind Res Org 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof
US5084269A (en) 1986-11-06 1992-01-28 Kullenberg Fred W Adjuvant for dose treatment with antigens
ATE60999T1 (de) 1986-12-19 1991-03-15 Duphar Int Res Dimethyldioctadecylammoniumbromid enthaltende stabilisierte adjuvanssuspension.
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
NZ230747A (en) * 1988-09-30 1992-05-26 Bror Morein Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
RU1615918C (ru) 1989-05-22 1995-07-09 Всероссийский научно-исследовательский институт защиты животных Адъювант
WO1993014190A1 (en) * 1992-01-06 1993-07-22 Smithkline Beecham Corporation Feline leukemia virus vaccines
ZA936095B (en) 1992-08-21 1994-03-14 Univ Melbourne Cytokine applications.
US6764682B1 (en) 1994-06-16 2004-07-20 Aventis Pasteur Limited Adjuvant compositions containing more than one adjuvant
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6846489B1 (en) 1995-04-25 2005-01-25 Smithkline Beecham Biologicals S.A. Vaccines containing a saponin and a sterol
AU4992197A (en) 1996-10-11 1998-05-11 Regents Of The University Of California, The Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
EP0855184A1 (en) 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
AU738513B2 (en) 1997-02-28 2001-09-20 University Of Iowa Research Foundation, The Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
DE69841122D1 (de) 1997-03-10 2009-10-15 Coley Pharm Gmbh Verwendung von nicht-methyliertem CpG Dinukleotid in Kombination mit Aluminium als Adjuvantien
CA2289253A1 (en) 1997-04-30 1998-11-05 Merieux Oravax Anti-helicobacter vaccine composition for use by the subdiaphragmatic systemic route, and combined mucosal/parenteral immunization method
WO1998051278A2 (en) 1997-05-14 1998-11-19 Inex Pharmaceuticals Corporation High efficiency encapsulation of charged therapeutic agents in lipid vesicles
JP4280309B2 (ja) 1997-06-06 2009-06-17 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア Dna免疫刺激配列活性の阻害剤
NZ504035A (en) * 1997-10-20 2002-04-26 Bayer Ag Neospora vaccines comprising Neospora caninum antigens
EP0953641A3 (en) * 1998-03-26 2002-03-13 Pfizer Products Inc. Polynucleotide molecules encoding neospora proteins
AU760795B2 (en) 1998-05-14 2003-05-22 Coley Pharmaceutical Gmbh Methods for regulating hematopoiesis using CpG-oligonucleotides
AU761899B2 (en) 1998-05-22 2003-06-12 Ottawa Health Research Institute Methods and products for inducing mucosal immunity
US20040247662A1 (en) 1998-06-25 2004-12-09 Dow Steven W. Systemic immune activation method using nucleic acid-lipid complexes
CA2340174C (en) 1998-08-10 2011-01-04 Aquila Biopharmaceuticals, Inc. Compositions of cpg and saponin adjuvants and methods thereof
AU769539B2 (en) 1999-01-29 2004-01-29 Zoetis Services Llc Adjuvants for use in vaccines
AU2875700A (en) 1999-02-26 2000-09-14 Chiron Corporation Microemulsions with adsorbed macromoelecules and microparticles
ATE529130T1 (de) 1999-04-08 2011-11-15 Intercell Usa Inc Trockenformulierung für transkutane immunisierung
US6977245B2 (en) 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
IL145982A0 (en) 1999-04-19 2002-07-25 Smithkline Beecham Biolog Vaccines
EP1177439B1 (en) 1999-04-29 2004-09-08 Coley Pharmaceutical GmbH Screening for immunostimulatory dna functional modifiers
EP1322655B1 (en) 2000-01-14 2007-11-14 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Oligodeoxynucleotide and its use to induce an immune response
EP1311288A1 (en) 2000-01-20 2003-05-21 Ottawa Health Research Institute Immunostimulatory nucleic acids for inducing a th2 immune response
AT409085B (de) 2000-01-28 2002-05-27 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen
EE200200444A (et) 2000-02-21 2003-12-15 Pharmexa A/S Meetod autoloogse beeta-amüloidvaigu in vivo mahasurumiseks, amüloidogeense polüpeptiidi analoog, seda kodeeriv nukleiinhappefragment ning kasutamineimmunogeense kompositsiooni valmistamiseks
CA2407942A1 (en) 2000-05-01 2001-11-08 Hybridon, Inc. Modulation of oligonucleotide cpg-mediated immune stimulation by positional modification of nucleosides
AT410173B (de) 2000-06-08 2003-02-25 Cistem Biotechnologies Gmbh Antigene zusammensetzung
GB0025577D0 (en) 2000-10-18 2000-12-06 Smithkline Beecham Biolog Vaccine
AU2001297693A1 (en) 2000-12-08 2002-09-12 Coley Pharmaceutical Gmbh Cpg-like nucleic acids and methods of use thereof
US7244438B2 (en) 2001-01-05 2007-07-17 Intercell Ag Uses for polycationic compounds
US7713942B2 (en) 2001-04-04 2010-05-11 Nordic Vaccine Technology A/S Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
US20030072764A1 (en) 2001-04-05 2003-04-17 O'hagan Derek Mucosal boosting following parenteral priming
US7105495B2 (en) 2001-04-30 2006-09-12 Idera Pharmaceuticals, Inc. Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
JP2005501004A (ja) 2001-05-21 2005-01-13 インターツェル・アクチェンゲゼルシャフト 核酸の安定化法
US20040191214A1 (en) 2001-06-15 2004-09-30 Johnson Lau Nucleoside vaccine adjuvants
ES2312580T5 (es) * 2001-07-02 2017-12-11 Zoetis Services Llc Vacunación en dosis única con l Mycoplasma hyopneumoniae /l
BR0211049A (pt) 2001-07-02 2004-07-20 Pfizer Prod Inc Método de tratamento ou prevenção de doenças ou disfunções e uso de mycoplasma hyopneumoniae
US7666674B2 (en) 2001-07-27 2010-02-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
JP2005518343A (ja) 2001-08-03 2005-06-23 メダレックス, インク. 新規なpgc−1イソフォームおよびその使用媒介型免疫治療を向上させるためのその使用
JP4607452B2 (ja) 2001-08-07 2011-01-05 ダイナバックス テクノロジーズ コーポレイション 免疫調節性組成物、製剤およびその使用方法
US20030138434A1 (en) 2001-08-13 2003-07-24 Campbell Robert L. Agents for enhancing the immune response
KR100991644B1 (ko) 2001-08-17 2010-11-02 콜리 파마슈티칼 게엠베하 활성이 개량된 조합 모티프 면역자극성 올리고뉴클레오티드
WO2003017755A2 (en) 2001-08-28 2003-03-06 Pfizer Products Inc. Mycoplasma bovis challenge model, methods for administering m.bovis and methods for inducing pneumonic lung lesions
JP4516748B2 (ja) 2001-09-14 2010-08-04 サイトス バイオテクノロジー アーゲー ウィルス様粒子中への免疫賦活物質のパッケージ化:調製法および使用法
US7514415B2 (en) 2002-08-01 2009-04-07 The United States Of America As Represented By The Department Of Health And Human Services Method of treating inflammatory arthropathies with suppressors of CpG oligonucleotides
US20030119774A1 (en) 2001-09-25 2003-06-26 Marianna Foldvari Compositions and methods for stimulating an immune response
GB0123580D0 (en) * 2001-10-01 2001-11-21 Glaxosmithkline Biolog Sa Vaccine
CA2471968C (en) 2001-10-06 2013-07-23 Merial Limited Immunostimulatory nucleic acids and use thereof
US7276489B2 (en) 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
JP2005516897A (ja) 2001-11-07 2005-06-09 イネックス ファーマシューティカルズ コーポレイション 改善された粘膜のワクチン及びその使用方法
AU2002358616A1 (en) 2001-12-07 2003-06-17 Intercell Ag Immunostimulatory oligodeoxynucleotides
JP2005526497A (ja) 2002-02-04 2005-09-08 ビオミラ,インコーポレーテッド 免疫刺激性、共有結合性脂質化オリゴヌクレオチド
US8088388B2 (en) 2002-02-14 2012-01-03 United Biomedical, Inc. Stabilized synthetic immunogen delivery system
JP2005517718A (ja) 2002-02-19 2005-06-16 シンセリカ・コーポレイション 免疫応答および輸送の代替抗体による調整のための組成物および方法
JP4846200B2 (ja) 2002-04-04 2011-12-28 コーリー ファーマシューティカル ゲーエムベーハー 免疫賦活性g、u含有オリゴリボヌクレオチド
WO2003089590A2 (en) 2002-04-16 2003-10-30 Vaxin, Inc. TRANSIENT AND/OR PERMANENT MODIFICATION OF SEXUAL BEHAVIOR AND/OR FERTILITY USING RECOMBINANT CHIMERIC GnRH
AU2003219383B2 (en) 2002-04-22 2010-08-26 Bioniche Life Sciences Inc. Oligonucleotide compositions and their use for the modulation of immune responses
KR100456681B1 (ko) 2002-05-22 2004-11-10 주식회사 대웅 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물
CA2487452A1 (en) 2002-05-28 2003-12-04 Robinson Ramirez-Pineda A method for generating antigen-presenting cells
CA2388049A1 (en) 2002-05-30 2003-11-30 Immunotech S.A. Immunostimulatory oligonucleotides and uses thereof
WO2003103586A2 (en) 2002-06-05 2003-12-18 Coley Pharmaceutical Group, Inc. Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids
SE0201701D0 (sv) 2002-06-05 2002-06-05 Gotovax Ab Treatment of epithelial tumors and infections
US20060107872A1 (en) 2002-11-05 2006-05-25 Hong Chen Method and apparatus for producing calcium silicate hydrate
BRPI0407032A (pt) * 2003-01-29 2006-01-17 Pfizer Prod Inc Vacinas caninas contra bordetella bronchiseptica
AU2003900767A0 (en) * 2003-02-21 2003-03-13 St Vincent's Hospital Sydney Limited Idiotypic vaccine
WO2004084940A1 (en) 2003-03-26 2004-10-07 Cytos Biotechnology Ag Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use
RU2541809C2 (ru) 2003-04-04 2015-02-20 Зоетис Пи ЛЛК Микрофлюидизированные эмульсии "масло в воде" и композиции вакцины
SE0301998D0 (sv) 2003-07-07 2003-07-07 Isconova Ab Quil A fraction with low toxicity and use thereof
GB0323965D0 (en) * 2003-10-13 2003-11-19 Glaxosmithkline Biolog Sa Immunogenic compositions
EP1722815A1 (en) 2004-03-09 2006-11-22 Chiron Corporation Influenza virus vaccines
DK1742659T3 (da) * 2004-04-05 2013-06-03 Zoetis P Llc Mikrofluidiserede olie-i-vand-emulsioner og vaccinesammensætninger
NZ554142A (en) * 2004-10-06 2009-12-24 Agri Biotech Pty Ltd Antibody production method comprising inserting antigen releasing device into mammal so antibodies are released into its milk
GB0426481D0 (en) * 2004-12-02 2005-01-05 Vaccine Technology Ltd Composition
CA2604488A1 (en) 2005-04-07 2006-10-12 Pharmacia & Upjohn Company Llc Formulations and process for production of bordetella bronchiseptica p68 antigen and vaccines
EP1899467A2 (en) * 2005-04-26 2008-03-19 Coley Pharmaceutical GmbH Modified oligoribonucleotide analogs with enhances immunostimulatory activity
PH12011502633A1 (en) * 2005-10-07 2012-11-12 Zoetis P Llc Vaccines and methods to treat canine influenza
EP1954252B1 (en) * 2005-12-02 2016-02-03 GlaxoSmithKline Biologicals SA Nanoparticles for use in immunogenic compositions
BRPI0706709B8 (pt) 2006-01-26 2021-05-25 Pah Usa 15 Llc composição e processo para preparar a composição
JP2009524434A (ja) * 2006-01-26 2009-07-02 エイチエックス・ダイアグノスティックス・インコーポレイテッド トリインフルエンザウイルス亜型h5ヘマグルチニンに結合するモノクローナル抗体およびそれらの使用
WO2008076371A2 (en) 2006-12-15 2008-06-26 Schering-Plough Ltd. Method for replicating influenza virus in culture
EP2125031B1 (en) * 2006-12-19 2017-11-01 Marina Biotech, Inc. Lipids and lipid assemblies comprising transfection enhancer elements
US20080292663A1 (en) 2007-05-22 2008-11-27 Gerber Jay D Adjuvant compositions and methods for delivering vaccines
CL2008001806A1 (es) 2007-06-20 2008-09-05 Wyeth Corp Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.
LT3056214T (lt) * 2008-06-27 2019-06-10 Zoetis Services Llc Naujos adjuvantų kompozicijos
AU2010218752B2 (en) 2009-02-27 2015-05-28 Toray Industries, Inc. Immunogenic composition
US10456459B2 (en) * 2015-07-20 2019-10-29 Zoetis Services Llc Liposomal adjuvant compositions

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CO6331297A2 (es) 2011-10-20
JP2014111619A (ja) 2014-06-19
UY31942A (es) 2010-01-29
EP2310046B1 (en) 2016-03-09
CA2960846A1 (en) 2009-12-30
CN104001170A (zh) 2014-08-27
JP5882370B2 (ja) 2016-03-09
RU2510280C2 (ru) 2014-03-27
CN102076358B (zh) 2016-08-17
EP3552625A1 (en) 2019-10-16
CA2960734A1 (en) 2009-12-30
CA2723786A1 (en) 2009-12-30
JP2017061484A (ja) 2017-03-30
WO2009156960A2 (en) 2009-12-30
WO2009156960A9 (en) 2010-09-30
JP5824538B2 (ja) 2015-11-25
PL3056214T3 (pl) 2019-09-30
HK1201444A1 (zh) 2015-09-04
PL2310046T3 (pl) 2016-09-30

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