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MX373042B - Moleculas para administracion a celulas cancerosas mutantes ros1. - Google Patents

Moleculas para administracion a celulas cancerosas mutantes ros1.

Info

Publication number
MX373042B
MX373042B MX2016010519A MX2016010519A MX373042B MX 373042 B MX373042 B MX 373042B MX 2016010519 A MX2016010519 A MX 2016010519A MX 2016010519 A MX2016010519 A MX 2016010519A MX 373042 B MX373042 B MX 373042B
Authority
MX
Mexico
Prior art keywords
administration
molecules
cancer cells
mutant cancer
ros1
Prior art date
Application number
MX2016010519A
Other languages
English (en)
Other versions
MX2016010519A (es
Inventor
Elena Ardina
Jonathan Lim
Maria Menichincheri
Original Assignee
Ignyta Inc
Nerviano Medical Sciences Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ignyta Inc, Nerviano Medical Sciences Srl filed Critical Ignyta Inc
Publication of MX2016010519A publication Critical patent/MX2016010519A/es
Publication of MX373042B publication Critical patent/MX373042B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se exponen derivados de indazol sustituido de la fórmula (I) o la fórmula 2. (I) y sales farmacéuticamente aceptables de los mismos, como se definen en la especificación, un proceso para su preparación y composiciones farmacéuticas que los comprenden; los compuestos de la invención pueden ser útiles en terapia en el tratamiento de enfermedades asociadas con una actividad desregulada de la proteína cinasa, como el cáncer.
MX2016010519A 2014-02-20 2015-02-19 Moleculas para administracion a celulas cancerosas mutantes ros1. MX373042B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461942287P 2014-02-20 2014-02-20
US201462052994P 2014-09-19 2014-09-19
US201462055450P 2014-09-25 2014-09-25
US201462069999P 2014-10-29 2014-10-29
PCT/EP2015/053544 WO2015124697A1 (en) 2014-02-20 2015-02-19 Compounds for treating patients with ros1 mutant cancer cells

Publications (2)

Publication Number Publication Date
MX2016010519A MX2016010519A (es) 2016-11-16
MX373042B true MX373042B (es) 2020-06-19

Family

ID=52544499

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010519A MX373042B (es) 2014-02-20 2015-02-19 Moleculas para administracion a celulas cancerosas mutantes ros1.

Country Status (20)

Country Link
US (4) US10231965B2 (es)
EP (2) EP3107541B1 (es)
JP (1) JP6636933B2 (es)
KR (2) KR20160117611A (es)
CN (1) CN106029073A (es)
AU (1) AU2015220832B2 (es)
BR (1) BR112016015818A2 (es)
CA (1) CA2933623C (es)
CL (1) CL2016001507A1 (es)
EA (1) EA033457B1 (es)
ES (1) ES2856231T3 (es)
IL (1) IL246544B (es)
MX (1) MX373042B (es)
NL (1) NL301111I2 (es)
PH (1) PH12016501394A1 (es)
PL (1) PL3107541T3 (es)
SG (1) SG11201605816TA (es)
TW (1) TWI672141B (es)
UA (1) UA118773C2 (es)
WO (1) WO2015124697A1 (es)

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Also Published As

Publication number Publication date
MX2016010519A (es) 2016-11-16
UA118773C2 (uk) 2019-03-11
AU2015220832A2 (en) 2016-09-08
CA2933623A1 (en) 2015-08-27
AU2015220832B2 (en) 2020-02-27
KR20220165787A (ko) 2022-12-15
NZ722405A (en) 2021-03-26
CL2016001507A1 (es) 2017-02-10
IL246544A0 (en) 2016-08-31
KR20160117611A (ko) 2016-10-10
WO2015124697A1 (en) 2015-08-27
US10231965B2 (en) 2019-03-19
BR112016015818A2 (pt) 2017-08-08
NL301111I2 (nl) 2021-09-27
US10682348B2 (en) 2020-06-16
ES2856231T3 (es) 2021-09-27
US20180333412A1 (en) 2018-11-22
EP3834827A1 (en) 2021-06-16
EP3107541A1 (en) 2016-12-28
IL246544B (en) 2019-12-31
KR102634514B1 (ko) 2024-02-07
CA2933623C (en) 2022-05-17
EA201691151A1 (ru) 2017-01-30
US20150283132A1 (en) 2015-10-08
CN106029073A (zh) 2016-10-12
AU2015220832A1 (en) 2016-09-08
PL3107541T3 (pl) 2021-09-20
EA033457B1 (ru) 2019-10-31
PH12016501394A1 (en) 2017-02-20
JP2017506255A (ja) 2017-03-02
TW201613593A (en) 2016-04-16
US10561651B2 (en) 2020-02-18
SG11201605816TA (en) 2016-08-30
US20190282564A1 (en) 2019-09-19
JP6636933B2 (ja) 2020-01-29
TWI672141B (zh) 2019-09-21
EP3107541B1 (en) 2020-12-23
NL301111I1 (es) 2021-06-23
US20170007599A1 (en) 2017-01-12

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