MX367046B - Marcadores especificos de via para diagnosticar sindrome del intestino irritable. - Google Patents
Marcadores especificos de via para diagnosticar sindrome del intestino irritable.Info
- Publication number
- MX367046B MX367046B MX2015016196A MX2015016196A MX367046B MX 367046 B MX367046 B MX 367046B MX 2015016196 A MX2015016196 A MX 2015016196A MX 2015016196 A MX2015016196 A MX 2015016196A MX 367046 B MX367046 B MX 367046B
- Authority
- MX
- Mexico
- Prior art keywords
- bowel syndrome
- irritable bowel
- specific markers
- pathway specific
- ibs
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/942—Serotonin, i.e. 5-hydroxy-tryptamine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a un método para ayudar en el diagnóstico del síndrome del intestino irritable (IBS) y/o un subtipo clínico del mismo en un sujeto, el método está caracterizado porque comprende obtener al menos dos de las siguientes puntuaciones (a) a (f): (a) detectar en una muestra obtener una puntuación de microbioma; (b) detectar en la muestra el nivel de al menos un marcador de mastocitos para obtener una puntuación de mastocitos; (c) detectar en la muestra el nivel de al menos un marcador de células inflamatorias para obtener una puntuación inflamatoria; (d) detectar la muestra el nivel de al menos un marcador de malabsorción de ácidos biliares (BAM) para obtener una puntuación de BAM; ( e) detectar en la muestra el nivel de al menos un marcador de kinurenina para obtener una puntuación de estrés oxidante; (f) detectar en la muestra el nivel de al menos un marcador de serotonina para obtener una puntuación de serotonina; (g) aplicar un algoritmo estadístico a las al menos dos de la puntuación de microbioma, la puntuación de mastocitos, la puntuación inflamatoria, la puntuación de BAM, la puntuación de estrés oxidante y la puntuación de serotonina para obtener una puntuación de enfermedad; y (h) determinar un diagnóstico de IBS en el sujeto con base en un algoritmo estadístico que genere una probabilidad de tener IBS con base en la puntuación de enfermedad y un modelo de diagnóstico que comprende las al menos dos de una puntuación de microbioma, puntuación de mastocitos, una puntuación inflamatoria, una puntuación de malabsorción de ácidos biliares, una puntuación de estrés oxidante y una puntuación de serotonina y combinaciones de los mismos a partir de una cohorte retrospectiva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361827506P | 2013-05-24 | 2013-05-24 | |
| PCT/IB2014/061636 WO2014188378A1 (en) | 2013-05-24 | 2014-05-22 | Pathway specific markers for diagnosing irritable bowel syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX367046B true MX367046B (es) | 2019-08-02 |
Family
ID=50884973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015016196A MX367046B (es) | 2013-05-24 | 2014-05-22 | Marcadores especificos de via para diagnosticar sindrome del intestino irritable. |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US9891235B2 (es) |
| EP (2) | EP3004068A2 (es) |
| JP (4) | JP2016521683A (es) |
| KR (2) | KR20160013163A (es) |
| CN (2) | CN105392780A (es) |
| AU (3) | AU2014269961A1 (es) |
| BR (2) | BR112015029318A2 (es) |
| CA (2) | CA2912993A1 (es) |
| HK (2) | HK1223416A1 (es) |
| IL (2) | IL242597B (es) |
| MX (1) | MX367046B (es) |
| RU (2) | RU2015155590A (es) |
| SG (2) | SG11201509371XA (es) |
| WO (2) | WO2014188377A2 (es) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3004068A2 (en) | 2013-05-24 | 2016-04-13 | Nestec S.A. | Pathway specific assays for predicting irritable bowel syndrome diagnosis |
| AU2014284047B2 (en) | 2013-06-21 | 2018-11-22 | Ondek Pty Ltd | Immunotherapy composition and use thereof |
| US10473669B2 (en) * | 2014-05-09 | 2019-11-12 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| MX2017006567A (es) | 2014-11-19 | 2018-01-26 | Nzp Uk Ltd | Esteroides 6.alfa.-alquil-6,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr). |
| CN107108687B (zh) | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的5β-6-烷基-7-羟基-3-酮类固醇 |
| JP6735748B2 (ja) | 2014-11-19 | 2020-08-05 | エヌゼットピー ユーケー リミテッド | ステロイドＦＸＲモジュレーター製造のための中間体としての６α−アルキル−３，７−ジオン−ステロイド |
| AU2015348940A1 (en) | 2014-11-19 | 2017-05-25 | Société des Produits Nestlé S.A. | Antibodies against serotonin, tryptophan and kynurenine metabolites and uses thereof |
| CA2968309A1 (en) | 2014-11-19 | 2016-05-26 | NZP UK Limited | 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators |
| JP2018504584A (ja) * | 2014-12-02 | 2018-02-15 | ネステク ソシエテ アノニム | 過敏性腸疾患患者を治療するためのベドリズマブの投与計画を確立する方法 |
| CN105987995A (zh) * | 2015-02-04 | 2016-10-05 | 东莞博捷生物科技有限公司 | 一种检测人抗酿酒酵母IgG类抗体的酶联免疫试剂盒 |
| CN105987996A (zh) * | 2015-02-09 | 2016-10-05 | 东莞博捷生物科技有限公司 | 一种检测人抗酿酒酵母IgA类抗体的酶联免疫试剂盒 |
| CN105061305A (zh) * | 2015-08-31 | 2015-11-18 | 河南师范大学 | 一步合成3-甲基-2-吡啶甲酸甲酯的方法 |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| CN106399344B (zh) * | 2016-06-01 | 2021-01-01 | 上海领潮生物新材料有限公司 | 一种vin-cdtb融合蛋白的制备方法 |
| WO2018011691A1 (en) * | 2016-07-12 | 2018-01-18 | Nestec S.A. | Competitive immunoassay methods |
| CN106188191A (zh) * | 2016-07-13 | 2016-12-07 | 西安电子科技大学 | 基于gsh响应的诊治一体化有机分子探针及其制备方法 |
| AU2017328927B2 (en) * | 2016-09-15 | 2024-03-07 | Sun Genomics Inc. | Universal method for extracting nucleic acid molecules from a diverse population of one or more types of microbes in a sample |
| US10428370B2 (en) | 2016-09-15 | 2019-10-01 | Sun Genomics, Inc. | Universal method for extracting nucleic acid molecules from a diverse population of one or more types of microbes in a sample |
| US11959125B2 (en) | 2016-09-15 | 2024-04-16 | Sun Genomics, Inc. | Universal method for extracting nucleic acid molecules from a diverse population of one or more types of microbes in a sample |
| US20180206726A1 (en) | 2016-12-07 | 2018-07-26 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| AU2017378406A1 (en) | 2016-12-14 | 2019-06-13 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immunosuppressant |
| CN116712540A (zh) | 2016-12-14 | 2023-09-08 | 比奥拉治疗股份有限公司 | 使用整联蛋白抑制剂治疗胃肠道疾病 |
| EP3554344A1 (en) | 2016-12-14 | 2019-10-23 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tlr modulator |
| WO2018112264A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| US10811126B2 (en) * | 2016-12-14 | 2020-10-20 | Tracy Warren | System and methods for developing and using a microbiome-based action component for patient health |
| CA3045666A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a jak inhibitor and devices |
| US11978543B2 (en) | 2016-12-14 | 2024-05-07 | Astarte Medical Partners Inc. | System and methods for developing and using a microbiome-based action component |
| WO2018112256A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-1 inhibitor |
| WO2018112237A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor |
| WO2018112235A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a smad7 inhibitor |
| WO2018112240A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
| BR112019011702A2 (pt) | 2016-12-14 | 2019-10-22 | Progenity Inc | tratamento de uma doença do trato gastrointestinal com um inibidor de il-12/il-23 liberado usando um dispositivo ingerível |
| WO2018183932A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor |
| EP3600249A1 (en) | 2017-03-30 | 2020-02-05 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chst15 inhibitor |
| WO2018183929A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| JP2020515579A (ja) | 2017-03-30 | 2020-05-28 | プロジェニティ， インコーポレイテッド | 消化管疾病の生菌生物学的製剤による治療 |
| CA3054156A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist |
| US20200306516A1 (en) | 2017-08-14 | 2020-10-01 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with glatiramer or a pharmaceutically acceptable salt thereof |
| EP3750168A1 (en) * | 2018-02-09 | 2020-12-16 | Metabolomic Diagnostics Limited | A system and method of generating a model to detect, or predict the risk of, an outcome |
| US20210041460A1 (en) * | 2018-03-19 | 2021-02-11 | Fujifilm Wako Pure Chemical Corporation | Method for judging psychiatric disorder |
| US20230160911A1 (en) * | 2018-04-24 | 2023-05-25 | Universiteit Gent | Intestinal and fecal biomarkers for intestinal health of poultry |
| US20210386367A1 (en) | 2018-06-01 | 2021-12-16 | Progenity, Inc. | Devices and systems for gastrointestinal microbiome detection and manipulation |
| CA3101541A1 (en) * | 2018-06-07 | 2019-12-12 | 4D Pharma Plc | Method for stratifying ibs patients |
| CN110607335B (zh) * | 2018-06-14 | 2021-08-03 | 中国科学院微生物研究所 | 一种烟酰胺腺嘌呤二核苷酸类化合物生物合成方法 |
| CN109324132A (zh) * | 2018-10-31 | 2019-02-12 | 杭州佰辰医学检验所有限公司 | 高通量检测色氨酸及其代谢产物的试剂盒及其应用 |
| US11488699B1 (en) | 2018-12-09 | 2022-11-01 | Cerner Innovation, Inc. | Microbiota activity sensor and decision support tool |
| US11842795B1 (en) * | 2018-12-17 | 2023-12-12 | Cerner Innovation, Inc. | Irritable bowel syndrome diagnostic sensor and decision support tool |
| FR3094492A1 (fr) * | 2019-04-01 | 2020-10-02 | Polyneuros | Procédé de détection ou de suivi de l’évolution d’une maladie chronique dégénérative par dosage immunologique |
| KR20210149127A (ko) * | 2019-04-03 | 2021-12-08 | 4디 파마 코르크 리미티드 | 질환의 진단 방법 |
| JPWO2020213732A1 (ja) * | 2019-04-18 | 2021-04-30 | 株式会社サイキンソー | 過敏性腸症候群の検査方法 |
| US11884958B2 (en) * | 2019-04-30 | 2024-01-30 | Mayo Foundation For Medical Education And Research | Assessing and treating functional gastrointestinal disorders |
| AU2020275413A1 (en) | 2019-05-14 | 2021-12-23 | Cedars-Sinai Medical Center | TL1A patient selection methods, systems, and devices |
| WO2020232262A1 (en) * | 2019-05-16 | 2020-11-19 | Procisedx Inc. | Assay detection methods for vcam-1 and calprotectin |
| CN111351870A (zh) * | 2019-12-03 | 2020-06-30 | 康美华大基因技术有限公司 | 一种肠易激综合征血清代谢标记物组合及其诊断试剂盒 |
| US20230074127A1 (en) | 2020-01-27 | 2023-03-09 | Immundiagnostik Ag | Test and in vitro diagnosis of irritable bowel syndrome |
| WO2021152586A1 (en) * | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Methods of analyzing microbiome, immunoglobulin profile and physiological state |
| EP3913371A1 (en) | 2020-05-18 | 2021-11-24 | Neuroimmun GmbH | Method and kit for diagnosting irritable bowel syndrome and for its relief through dietary interventions |
| KR102478205B1 (ko) * | 2020-09-24 | 2022-12-15 | 경희대학교 산학협력단 | 크론병 환자에서 상부위장관 침범 진단을 위한 정보 제공 방법 |
| CN114755313B (zh) * | 2021-01-08 | 2024-08-30 | 复旦大学附属华山医院 | 包含尿液nad+代谢物的急性肾损伤标志物 |
| CN115724779B (zh) * | 2021-09-01 | 2024-03-29 | 四川大学 | 酰胺烷二硫化合物、其制备方法和用途 |
| JP2025500321A (ja) * | 2021-12-24 | 2025-01-09 | クレオン リミティド ライアビリティ カンパニー | 多脚型セロトニン作動性化合物ならびにセロトニン受容体アゴニスト及びアンタゴニストのプロドラッグ |
| WO2023180899A1 (en) * | 2022-03-21 | 2023-09-28 | Swain Manish Kumar | Device and method for detecting diarrhea |
| CN116381222A (zh) * | 2023-03-23 | 2023-07-04 | 北京巴瑞医疗器械有限公司 | 一种血清素发光免疫检测方法及血清素检测试剂盒 |
| CN116990498B (zh) * | 2023-09-28 | 2024-08-09 | 山东大学齐鲁医院 | 血浆色氨酸代谢物在儿童偏头痛诊断中的应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| EP1997894B1 (en) | 1992-02-06 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Biosynthetic binding protein for cancer marker |
| JPH08500017A (ja) | 1992-08-17 | 1996-01-09 | ジェネンテク，インコーポレイテッド | 二特異的免疫アドヘジン |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6218129B1 (en) * | 1998-05-15 | 2001-04-17 | Prometheus Laboratories, Inc. | Inflammatory bowel disease first step assay system |
| US6406862B1 (en) | 1998-10-06 | 2002-06-18 | The United States Of America As Represented By The Secretary Of The Army | Dip-stick assay for C-reactive protein |
| US7408025B2 (en) * | 1999-12-15 | 2008-08-05 | Cubist Pharmaceuticals, Inc. | Lipopeptides as antibacterial agents |
| US6838250B2 (en) | 2000-03-31 | 2005-01-04 | Ortho-Clinical Diagnostics, Inc. | Immunoassay for C-reactive protein |
| DE10121217A1 (de) * | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
| CA2549971A1 (en) | 2003-11-03 | 2005-05-12 | Duke University | Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke |
| US20060154276A1 (en) * | 2004-05-13 | 2006-07-13 | Prometheus Laboratories Inc. | Methods of diagnosing inflammatory bowel disease |
| WO2006012472A1 (en) | 2004-07-21 | 2006-02-02 | Qualyst, Inc. | Apparatus, kits and methods for evaluating binding interactions, for detecting and quantifying binding molecules, and for sample preparation |
| WO2007000046A1 (en) * | 2005-06-27 | 2007-01-04 | Holburn Biomedical Corporation | Methods for diagnosing functional bowel disease |
| US7873479B2 (en) | 2005-12-01 | 2011-01-18 | Prometheus Laboratories Inc. | Methods of diagnosing inflammatory bowel disease |
| US20080085524A1 (en) | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| US20100094560A1 (en) | 2006-08-15 | 2010-04-15 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| US8278057B2 (en) | 2007-09-14 | 2012-10-02 | Nestec S.A. | Addressable antibody arrays and methods of use |
| WO2010120814A1 (en) | 2009-04-14 | 2010-10-21 | Prometheus Laboratories Inc. | Inflammatory bowel disease prognostics |
| US20120171672A1 (en) | 2009-04-14 | 2012-07-05 | Prometheus Laboratories Inc. | Inflammatory bowel disease prognostics |
| EP2778685B1 (en) * | 2009-06-25 | 2017-04-26 | Nestec S.A. | Methods for diagnosing irritable bowel syndrome |
| EP2494074A4 (en) * | 2009-10-30 | 2013-06-12 | Nestec Sa | METHOD FOR DIAGNOSING IRRITATION SYNDROME |
| MX2012005995A (es) * | 2009-11-25 | 2012-08-08 | Prometheus Lab Inc | Novedosos biomarcadores genomicos para diagnostico del sindrome de intestino irritable. |
| US8445215B1 (en) * | 2010-07-23 | 2013-05-21 | Nestec S.A. | Assays and methods for the detection of Crohn's disease |
| EP2710383B1 (en) * | 2011-05-16 | 2017-01-11 | The University of Newcastle | Performance of a biomarker panel for irritable bowel syndrome |
| AU2012325798B2 (en) * | 2011-10-21 | 2015-11-26 | Société des Produits Nestlé S.A. | Methods for improving inflammatory bowel disease diagnosis |
| EP2904395B1 (en) | 2012-10-05 | 2018-09-05 | Nestec S.A. | Antibodies to microbiome as diagnostic markers for ibs |
| EP3004068A2 (en) * | 2013-05-24 | 2016-04-13 | Nestec S.A. | Pathway specific assays for predicting irritable bowel syndrome diagnosis |
| CN105980557B (zh) * | 2013-12-04 | 2020-04-07 | 中外制药株式会社 | 抗原结合能力根据化合物的浓度而变化的抗原结合分子及其文库 |
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2014
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