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MX365393B - Formulaciones de inhibidor de histona deacetilasa en combinación con bendamustina y usos de las mismas. - Google Patents

Formulaciones de inhibidor de histona deacetilasa en combinación con bendamustina y usos de las mismas.

Info

Publication number
MX365393B
MX365393B MX2014002942A MX2014002942A MX365393B MX 365393 B MX365393 B MX 365393B MX 2014002942 A MX2014002942 A MX 2014002942A MX 2014002942 A MX2014002942 A MX 2014002942A MX 365393 B MX365393 B MX 365393B
Authority
MX
Mexico
Prior art keywords
bendamustine
formulations
combination
histone deacetylase
deacetylase inhibitor
Prior art date
Application number
MX2014002942A
Other languages
English (en)
Other versions
MX2014002942A (es
Inventor
J Loury David
J Buggy Joseph
D Mody Tarak
J Verner Erik
Purro Norbert
Balasubramanian Sriram
Depil Stéphane
Kloos Ioana
Original Assignee
Pharmacyclics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of MX2014002942A publication Critical patent/MX2014002942A/es
Publication of MX365393B publication Critical patent/MX365393B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen pautas de dosificación, procedimientos de tratamiento, formulaciones de liberación controlada y terapias de combinación que incluyen bendamustina, o una sal farmacéuticamente aceptable de la misma, y un inhibidor de HDAC, o una sal farmacéuticamente aceptable del mismo.
MX2014002942A 2011-09-13 2011-09-13 Formulaciones de inhibidor de histona deacetilasa en combinación con bendamustina y usos de las mismas. MX365393B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/051470 WO2013039488A1 (en) 2011-09-13 2011-09-13 Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof

Publications (2)

Publication Number Publication Date
MX2014002942A MX2014002942A (es) 2014-09-15
MX365393B true MX365393B (es) 2019-05-31

Family

ID=47883567

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014002942A MX365393B (es) 2011-09-13 2011-09-13 Formulaciones de inhibidor de histona deacetilasa en combinación con bendamustina y usos de las mismas.

Country Status (15)

Country Link
US (1) US9492423B2 (es)
EP (1) EP2755648B1 (es)
JP (1) JP6330118B2 (es)
KR (1) KR101892788B1 (es)
CN (1) CN103917231B (es)
AU (1) AU2011376953B2 (es)
CA (1) CA2845806C (es)
ES (1) ES2627820T3 (es)
HK (1) HK1200095A1 (es)
MX (1) MX365393B (es)
NZ (1) NZ621221A (es)
RU (1) RU2609833C2 (es)
SG (1) SG2014014419A (es)
UA (1) UA110853C2 (es)
WO (1) WO2013039488A1 (es)

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TWI573792B (zh) 2012-02-01 2017-03-11 歐陸斯迪公司 新穎治療劑
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EP3976198A4 (en) 2019-05-31 2023-07-19 Viracta Subsidiary, Inc. METHODS OF TREATING VIRUS-ASSOCIATED CANCERS WITH HISTONE DEACETYLASE INHIBITORS
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TW202423402A (zh) * 2022-10-21 2024-06-16 美商維拉克塔股份有限公司 Hdac抑制劑化合物之投藥方法

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UA110853C2 (uk) 2016-02-25
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HK1200095A1 (en) 2015-07-31
RU2014111069A (ru) 2015-10-20
RU2609833C2 (ru) 2017-02-06
EP2755648B1 (en) 2017-03-08
JP6330118B2 (ja) 2018-05-30
KR20140073503A (ko) 2014-06-16
SG2014014419A (en) 2014-07-30
AU2011376953A1 (en) 2014-03-06
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US20140341989A1 (en) 2014-11-20
CA2845806A1 (en) 2013-03-21
JP2014526503A (ja) 2014-10-06
CN103917231A (zh) 2014-07-09
CN103917231B (zh) 2016-09-28
EP2755648A1 (en) 2014-07-23
EP2755648A4 (en) 2015-03-11
US9492423B2 (en) 2016-11-15
ES2627820T3 (es) 2017-07-31
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CA2845806C (en) 2019-06-11
MX2014002942A (es) 2014-09-15

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